1. Electro-Acupuncture at GV.4 Improves Functional Recovery in paralyzed rats after a Traumatic Spinal Cord Injury
- Author
-
Alvarado Sanchez B, Salgado Ceballos H, Torres Castillo S, Juarez Becerril O, Anguiano Solis C, Diaz Ruiz A, and Lopez Hernandez Me
- Subjects
0301 basic medicine ,Traumatic spinal cord injury ,Electroacupuncture ,medicine.medical_treatment ,Electro acupuncture ,Stimulation ,medicine.disease_cause ,Lipid peroxidation ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Paralysis ,medicine ,business.industry ,General Neuroscience ,Spinal cord ,030104 developmental biology ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Complementary and alternative medicine ,chemistry ,Anesthesia ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Oxidative stress - Abstract
In the present study, the effect of electro-acupuncture (EA) on the oxidative stress, the spinal cord tissue preservation and the recovery of motor function was evaluated after a traumatic spinal cord injury (TSCI). Long Evans rats were randomized into five groups: 1. Sham; 2. TSCI without treatment; 3. TSCI + EA (acupoint GV.4); 4. TSCI + EA (acupoint GV.26) and 5. TSCI + EA (GV.4 + GV.26). The EA was performed with an Electro-Acupunctoscope, AWQ-104L Digital, wave dense-dispersed, current intensity 2.5mA and frequency 2-100Hz for 30 minutes. The biochemical results showed a significant increase in the hydroxyl radical concentration in group 2 (3.1±1.4nmol) compared with groups 1 (1.8±0.5nmol) and 4 (2.4±1.1nmol) (p2) than in groups 2 (5262.4±20μm2), 4 (3995.6±26μm2) and 5 (4266.7±22μm2). Although EA in GV.26 decreases hydroxyl radical concentration (50%), it significantly increases lipid peroxidation (45%), while stimulation of GV.4 decreases oxidative stress (15%), preserves spinal cord tissue (25%) and improves recovery of motor function in the hind limbs of rats with paralysis (18.1%) compared with untreated group. These findings suggest that EA in GV.4 may be a therapeutic alternative on TSCI.
- Published
- 2016
- Full Text
- View/download PDF