1. Thalamo-hippocampal pathway regulates incidental memory capacity in mice
- Author
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G. Torromino, V. Loffredo, D. Cavezza, G. Sonsini, F. Esposito, A. H. Crevenna, M. Gioffrè, M. De Risi, A. Treves, M. Griguoli, E. De Leonibus, Torromino, G., Loffredo, V., Cavezza, D., Sonsini, G., Esposito, F., Crevenna, A. H., Gioffrè, M., De Risi, M., Treves, A., Griguoli &, M., and De Leonibus, E. more...
- Subjects
Male ,Multidisciplinary ,Memory, Long-Term ,General Physics and Astronomy ,General Chemistry ,Hippocampus ,General Biochemistry, Genetics and Molecular Biology ,Inhibition, Psychological ,Mice ,Settore M-PSI/02 - Psicobiologia e Psicologia Fisiologica ,Memory, Short-Term ,Animals ,Female ,Memory Consolidation - Abstract
Incidental memory can be challenged by increasing either the retention delay or the memory load. The dorsal hippocampus (dHP) appears to help with both consolidation from short-term (STM) to long-term memory (LTM), and higher memory loads, but the mechanism is not fully understood. Here we find that female mice, despite having the same STM capacity of 6 objects and higher resistance to distraction in our different object recognition task (DOT), when tested over 1 h or 24 h delays appear to transfer to LTM only 4 objects, whereas male mice have an STM capacity of 6 objects in this task. In male mice the dHP shows greater activation (as measured by c-Fos expression), whereas female mice show greater activation of the ventral midline thalamus (VMT). Optogenetic inhibition of the VMT-dHP pathway during off-line memory consolidation enables 6-object LTM retention in females, while chemogenetic VMT-activation impairs it in males. Thus, removing or enhancing sub-cortical inhibitory control over the hippocampus leads to differences in incidental memory. more...
- Published
- 2021