Search

Mkn 421 was observed for about two days with BeppoSAX, prior to and partly overlapping the start of a 1 week continuous exposure with ASCA in April 1998, as part of a world-wide multiwavelength campaign. A pronounced, well defined, flare observed in X-rays was also observed simultaneously at TeV energies by the Whipple Observatory's 10 m gamma-ray telescope. These data provide the first evidence that the X-ray and TeV intensities are well correlated on time-scales of hours., Comment: 4 pages, 1 figure, presented at the VERITAS Workshop on the TeV Astrophysics of Extragalactic Objects

We present results from observations taken with the Whipple 10 m very high energy gamma-ray telescope with maximal sensitivity at 400 GeV during 39 hr between 2000 and 2003 in the direction of the giant radio galaxy M87. Using the entire data set, we derive a 99% confidence level upper limit on the flux of gamma-ray emission above 400 GeV from M87 to be less than or equal to 6: 9; 10(-1)2 cm(-2) s(-1). This suggests variability at the 90% confidence level when compared to the flux measured by the HEGRA collaboration in 1999 if the differential spectrum is steeper than a power law of index 3.75. Our search for a correlation between the Rossi X-Ray Timing Explorer all-sky monitor observation and a potential gamma-ray signal is inconclusive.

In 1998 and 1999 the Whipple Observatory 10 m telescope was used to search for diffuse gamma ray emission from the Galactic Plane. No signifiant evidence of emission was found. Assuming the TeV emission profile matches EGRET observations above 1 GeV with a differential spectral index of 2.4, we derive an upper limit of {$\rm {3.0\cdot10^{-8}cm^{-2}s^{-1}sr^{-1}}$} for the average diffuse emission above {$\rm500 GeV$} in the galactic latitude range from {$\rm-2^o$ to $\rm +2^o$} at galactic longitude {$\rm 40^o$}. Comparisons with EGRET observations provide a lower limit of 2.31 for the differential spectral index of the diffuse emission, assuming there is no break in the spectrum between 30 GeV and 500 GeV. This constrains models for diffuse emission with a significant inverse Compton contribution., 18 pages, 9 figures, other comments

We present the results of a search for pulsed TeV emission from the Crab pulsar using the Whipple Observatory's 10m gamma-ray telescope. The direction of the Crab pulsar was observed for a total of 73.4 hours between 1994 November and 1997 March. Spectral analysis techniques were applied to search for the presence of a gamma-ray signal from the Crab pulsar over the energy band 250GeV to 4TeV. At these energies we do not see any evidence of the 33ms pulsations present at lower energies from the Crab pulsar. The 99.9% confidence level upper limit for pulsed emission above 250GeV is derived to be 4.8 10^-12 cm^-2 s^-1 or, 4 pages, 2 figures, to be published in the proceedings of 26th International Cosmic Ray Conference (Salt Lake City, 1999)

The close relation between ground-based TeV observations and satellite borne $\gamma$-ray measurements has been important for the understanding of blazars. The observations which involve the TeV component in blazar studies are reviewed., Comment: 8 Pages, 6 figures

We have used data from the TeV gamma-ray flare associated with the active galaxy Markarian 421 observed on 15 May 1996 to place bounds on the possible energy-dependence of the speed of light in the context of an effective quantum gravitational energy scale. The possibility of an observable time dispersion in high energy radiation has recently received attention in the literature, with some suggestions that the relevant energy scale could be less than the Planck mass and perhaps as low as 10^16 GeV. The limits derived here indicate this energy scale to be in excess of 4x10^16 GeV at the 95% confidence level. To the best of our knowledge, this constitutes the first convincing limit on such phenomena in this energy regime., Comment: 6 pages, including 2 figures

If supernova remnants (SNRs) are the sites of cosmic-ray acceleration, the associated nuclear interactions should result in observable fluxes of TeV gamma-rays from the nearest SNRs. Measurements of the gamma-ray flux from six nearby, radio-bright, SNRs have been made with the Whipple Observatory gamma-ray telescope. No significant emission has been detected and upper limits on the $>$300 GeV flux are reported. Three of these SNRs (IC443, gamma-Cygni and W44) are spatially coincident with low latitude unidentified sources detected with EGRET. These upper limits weaken the case for the simplest models of shock acceleration and energy dependent propagation., 4 pages, 2 figures, to appear in proceedings of 25 ICRC (Durban)

A next generation atmospheric Cherenkov observatory is described based on the Whipple Observatory $\gamma$-ray telescope. A total of nine such imaging telescopes will be deployed in an array that will permit the maximum versatility and give high sensitivity in the 50 GeV - 50 TeV band (with maximum sensitivity from 100 GeV to 10 TeV)., Comment: 4 pages, 2 figures, to appear in proceedings of 25th ICRC (Durban)

We present the discovery of >350 GeV gamma-ray emission from the BL Lacertae object 1ES 2344+514 with the Whipple Observatory 10m gamma-ray telescope. This is the third BL Lac object detected at gamma-ray energies above 300 Gev, the other two being Markarian 421 (Mrk 421) and Mrk501. These three active galactic nuclei are all X-ray selected and have the lowest known redshifts of any BL Lac objects currently identified. The evidence for emission derives primarily from an apparent flare on December 20, 1995 when a 6 sigma excess was detected with a flux approximately 63% of the very high energy gamma-ray emission from the Crab Nebula, the standard candle for TeV gamma-ray sources. Excluding the flare, observations between October 1995 and January 1996 yield a 4 sigma detection corresponding to 11% of the VHE Crab Nebula flux. Observations spanning September 1996 to January 1997 failed to yield a significant detection of a steady flux or any flaring. For this period, the 99.9% confidence level upper limit is, 19 pages, 6 Postscript figures

The human scavenger class B type 1 receptor (SR-B1/Cla1) was identified as a putative receptor for hepatitis C virus (HCV) because it binds to soluble recombinant HCV envelope glycoprotein E2 (sE2). High-density lipoprotein (HDL), a natural SR-B1 ligand, was shown to increase the in vitro infectivity of retroviral pseudoparticles bearing HCV envelope glycoproteins and of cell culture-derived HCV (HCVcc), suggesting that SR-B1 promotes viral entry in an HDL-dependent manner. To determine whether SR-B1 participates directly in HCV infection or facilitates HCV entry through lipoprotein uptake, we generated a panel of monoclonal antibodies (MAbs) against native human SR-B1. Two of them, 3D5 and C167, bound to conformation-dependent SR-B1 determinants and inhibited the interaction of sE2 with SR-B1. These antibodies efficiently blocked HCVcc infection of Huh-7.5 hepatoma cells in a dose-dependent manner. To examine the role of HDL in SR-B1-mediated HCVcc infection, we set up conditions for HCVcc production and infection in serum-free medium. HCVcc efficiently infected Huh-7.5 cells in the absence of serum lipoproteins, and addition of HDL led to a twofold increase in infectivity. However, the HDL-induced enhancement of infection had no impact on the neutralization potency of MAb C167, despite its ability to inhibit both HDL binding to cells and SR-B1-mediated lipid transfer. Of note, MAb C167 also potently blocked Huh-7.5 infection by an HCV strain recovered from HCVcc-infected chimpanzees. These results demonstrate that SR-B1 is essential for infection with HCV produced in vitro and in vivo and suggest the possible use of anti-SR-B1 antibodies as therapeutic agents.