5 results on '"Castelnovo, Veronica"'
Search Results
2. Brain Functional Connectivity Associated with the Right Temporal Degeneration
- Author
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Canu, Elisa, Agosta, Federica, Leocadi, Michela, Calderaro, Davide, Castelnovo, Veronica, Caroppo, Paola, SARA PRIONI, Tremolizzo, Lucio, Appollonio, Ildebrando, Valsasina, Paola, and Filippi, Massimo
3. Mathematical Modeling Reveals the Correlates of Cognitive Impairment Across the FTLD Spectrum
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Agosta, Federica, Cividini, Camilla, Basaia, Silvia, Edoardo Gioele Spinelli, Castelnovo, Veronica, Canu, Elisa, Riva, Nilo, Magnani, Giuseppe, Caso, Francesca, and Filippi, Massimo
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology
4. Amyotrophic Lateral Sclerosis-Frontotemporal Dementia: Shared and Divergent Neural Correlates Across the Clinical Spectrum
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Camilla Cividini, Giuseppe Magnani, Nilo Riva, Elisa Canu, Veronica Castelnovo, Federica Agosta, Silvia Basaia, Giordano Cecchetti, Francesca Caso, Massimo Filippi, Edoardo G. Spinelli, Andrea Falini, Cividini, Camilla, Basaia, Silvia, Spinelli, Edoardo G, Canu, Elisa, Castelnovo, Veronica, Riva, Nilo, Cecchetti, Giordano, Caso, Francesca, Magnani, Giuseppe, Falini, Andrea, Filippi, Massimo, and Agosta, Federica
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Neural correlates of consciousness ,business.industry ,Functional connectivity ,Cognition ,Disease ,medicine.disease ,Phenotype ,medicine ,Neurology (clinical) ,Amyotrophic lateral sclerosis ,business ,Neuroscience ,Pathological ,Frontotemporal dementia ,Research Article - Abstract
Background and ObjectivesA significant overlap between amyotrophic lateral sclerosis (ALS) and behavioral variant of frontotemporal dementia (bvFTD) has been observed at clinical, genetic, and pathologic levels. Within this continuum of presentations, the presence of mild cognitive or behavioral symptoms in patients with ALS has been consistently reported, although it is unclear whether this is to be considered a distinct phenotype or rather a natural evolution of ALS. Here, we used mathematical modeling of MRI connectomic data to decipher common and divergent neural correlates across the ALS–frontotemporal dementia (FTD) spectrum.MethodsWe included 83 patients with ALS, 35 patients with bvFTD, and 61 healthy controls, who underwent clinical, cognitive, and MRI assessments. Patients with ALS were classified according to the revised Strong criteria into 54 ALS with only motor deficits (ALS-cn), 21 ALS with cognitive or behavioral involvement (ALS-ci/bi), and 8 ALS with bvFTD (ALS-FTD). First, we assessed the functional and structural connectivity patterns across the ALS-FTD spectrum. Second, we investigated whether and where MRI connectivity alterations of patients with ALS with any degree of cognitive impairment (i.e., ALS-ci/bi and ALS-FTD) resembled more the pattern of damage of one (ALS-cn) or the other end (bvFTD) of the spectrum, moving from group-level to single-subject analysis.ResultsAs compared with controls, extensive structural and functional disruption of the frontotemporal and parietal networks characterized bvFTD (bvFTD-like pattern), while a more focal structural damage within the sensorimotor-basal ganglia areas characterized ALS-cn (ALS-cn-like pattern). ALS-ci/bi patients demonstrated an ALS-cn-like pattern of structural damage, diverging from ALS-cn with similar motor impairment for the presence of enhanced functional connectivity within sensorimotor areas and decreased functional connectivity within the bvFTD-like pattern. On the other hand, patients with ALS-FTD resembled both structurally and functionally the bvFTD-like pattern of damage with, in addition, the structural ALS-cn-like damage in the motor areas.DiscussionOur findings suggest a maladaptive role of functional rearrangements in ALS-ci/bi concomitantly with similar structural alterations compared to ALS-cn, supporting the hypothesis that ALS-ci/bi might be considered as a phenotypic variant of ALS, rather than a consequence of disease worsening.
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- 2021
5. Structural and functional brain connectome in motor neuron diseases: A multicenter MRI study
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Yuri Matteo Falzone, Camilla Cividini, Silvia Basaia, Maria Rosaria Monsurrò, Francesca Trojsi, Andrea Falini, Gioacchino Tedeschi, Elisa Canu, Cristina Moglia, Nilo Riva, Edoardo G. Spinelli, Adriano Chiò, Veronica Castelnovo, Massimo Filippi, Cinzia Femiano, Federica Agosta, Basaia, Silvia, Agosta, Federica, Cividini, Camilla, Trojsi, Francesca, Riva, Nilo, Spinelli, Edoardo G, Moglia, Cristina, Femiano, Cinzia, Castelnovo, Veronica, Canu, Elisa, Falzone, Yuri, Monsurrò, Maria Rosaria, Falini, Andrea, Chiò, Adriano, Tedeschi, Gioacchino, Filippi, Massimo, Basaia, S., Agosta, F., Cividini, C., Trojsi, F., Riva, N., Spinelli, E. G., Moglia, C., Femiano, C., Castelnovo, V., Canu, E., Falzone, Y., Monsurro, M. R., Falini, A., Chio, A., Tedeschi, G., and Filippi, M.
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Adult ,Male ,Connectomics ,Neuropsychological Tests ,Article ,030218 nuclear medicine & medical imaging ,Muscular Atrophy, Spinal ,03 medical and health sciences ,0302 clinical medicine ,Basal ganglia ,medicine ,Connectome ,Humans ,Cognitive Dysfunction ,Prospective Studies ,Amyotrophic lateral sclerosis ,Motor Neuron Disease ,Primary Lateral Sclerosis ,Aged ,Aged, 80 and over ,business.industry ,Amyotrophic Lateral Sclerosis ,Neuropsychology ,Brain ,Motor neuron ,Progressive muscular atrophy ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Case-Control Studies ,Female ,Neurology (clinical) ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
ObjectiveTo investigate structural and functional neural organization in amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and progressive muscular atrophy (PMA).MethodsA total of 173 patients with sporadic ALS, 38 patients with PLS, 28 patients with PMA, and 79 healthy controls were recruited from 3 Italian centers. Participants underwent clinical, neuropsychological, and brain MRI evaluations. Using graph analysis and connectomics, global and lobar topologic network properties and regional structural and functional brain connectivity were assessed. The association between structural and functional network organization and clinical and cognitive data was investigated.ResultsCompared with healthy controls, patients with ALS and patients with PLS showed altered structural global network properties, as well as local topologic alterations and decreased structural connectivity in sensorimotor, basal ganglia, frontal, and parietal areas. Patients with PMA showed preserved global structure. Patient groups did not show significant alterations of functional network topologic properties relative to controls. Increased local functional connectivity was observed in patients with ALS in the precentral, middle, and superior frontal areas, and in patients with PLS in the sensorimotor, basal ganglia, and temporal networks. In patients with ALS and patients with PLS, structural connectivity alterations correlated with motor impairment, whereas functional connectivity disruption was closely related to executive dysfunction and behavioral disturbances.ConclusionsThis multicenter study showed widespread motor and extramotor network degeneration in ALS and PLS, suggesting that graph analysis and connectomics might represent a powerful approach to detect upper motor neuron degeneration, extramotor brain changes, and network reorganization associated with the disease. Network-based advanced MRI provides an objective in vivo assessment of motor neuron diseases, delivering potential prognostic markers.
- Published
- 2020
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