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Supplemental material, sj-docx-1-jcn-10.1177_08830738231187010 for Corticomuscular Coherence in Children with Unilateral Cerebral Palsy: A Feasibility and Preliminary Protocol Study by Rachana R. Gangwani, Jasper I. Mark, Rachel M. Vaughn, Holly Holland, Deborah E. Thorpe, Joshua J. Alexander, Swati M. Surkar and Jessica M. Cassidy in Journal of Child Neurology

Supplemental material, sj-doc-2-jcn-10.1177_08830738231187010 for Corticomuscular Coherence in Children with Unilateral Cerebral Palsy: A Feasibility and Preliminary Protocol Study by Rachana R. Gangwani, Jasper I. Mark, Rachel M. Vaughn, Holly Holland, Deborah E. Thorpe, Joshua J. Alexander, Swati M. Surkar and Jessica M. Cassidy in Journal of Child Neurology

Supplemental material, sj-docx-1-jcn-10.1177_08830738231187010 for Corticomuscular Coherence in Children with Unilateral Cerebral Palsy: A Feasibility and Preliminary Protocol Study by Rachana R. Gangwani, Jasper I. Mark, Rachel M. Vaughn, Holly Holland, Deborah E. Thorpe, Joshua J. Alexander, Swati M. Surkar and Jessica M. Cassidy in Journal of Child Neurology

Background Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper-limb sensorimotor impairment. We investigated associations between non-lesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment. Methods and Results Cross-sectional T1-weighted magnetic resonance images of the brain were pooled from 357 participants with chronic stroke from 18 research cohorts of the ENIGMA (Enhancing NeuoImaging Genetics through Meta-Analysis) Stroke Recovery Working Group. Sensorimotor impairment was estimated from the FMA-UE (Fugl-Meyer Assessment of Upper Extremity). Robust mixed-effects linear models were used to test associations between poststroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferroni-corrected, P

Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of spared subcortical nuclei and sensorimotor behaviour at different timepoints after stroke. We pooled high-resolution T1-weighted MRI brain scans and behavioural data in 828 individuals with unilateral stroke from 28 cohorts worldwide. Cross-sectional analyses using linear mixed-effects models related post-stroke sensorimotor behaviour to non-lesioned subcortical volumes (Bonferroni-corrected, P

Background and Purpose- Injury to the corticospinal tract (CST) has been shown to have a major effect on upper extremity motor recovery after stroke. This study aimed to examine how well CST injury, measured from neuroimaging acquired during the acute stroke workup, predicts upper extremity motor recovery. Methods- Patients with upper extremity weakness after ischemic stroke were assessed using the upper extremity Fugl-Meyer during the acute stroke hospitalization and again at 3-month follow-up. CST injury was quantified and compared, using 4 different methods, from images obtained as part of the stroke standard-of-care workup. Logistic and linear regression were performed using CST injury to predict ΔFugl-Meyer. Injury to primary motor and premotor cortices were included as potential modifiers of the effect of CST injury on recovery. Results- N=48 patients were enrolled 4.2±2.7 days poststroke and completed 3-month follow-up (median 90-day modified Rankin Scale score, 3; interquartile range, 1.5). CST injury distinguished patients who reached their recovery potential (as predicted from initial impairment) from those who did not, with area under the curve values ranging from 0.70 to 0.8. In addition, CST injury explained ≈20% of the variance in the magnitude of upper extremity recovery, even after controlling for the severity of initial impairment. Results were consistent when comparing 4 different methods of measuring CST injury. Extent of injury to primary motor and premotor cortices did not significantly influence the predictive value that CST injury had for recovery. Conclusions- Structural injury to the CST, as estimated from standard-of-care imaging available during the acute stroke hospitalization, is a robust way to distinguish patients who achieve their predicted recovery potential and explains a significant amount of the variance in poststroke upper extremity motor recovery.

Supplemental material, Online_Supplement_Methods for Comparing CST Lesion Metrics as Biomarkers for Recovery of Motor and Proprioceptive Impairments After Stroke by Sonja E. Findlater, Rachel L. Hawe, Erin L. Mazerolle, Abdulaziz S. Al Sultan, Jessica M. Cassidy, Stephen H. Scott, G. Bruce Pike and Sean P. Dukelow in Neurorehabilitation and Neural Repair

Supplemental material, SupplementalTable2 for Comparing CST Lesion Metrics as Biomarkers for Recovery of Motor and Proprioceptive Impairments After Stroke by Sonja E. Findlater, Rachel L. Hawe, Erin L. Mazerolle, Abdulaziz S. Al Sultan, Jessica M. Cassidy, Stephen H. Scott, G. Bruce Pike and Sean P. Dukelow in Neurorehabilitation and Neural Repair

Supplemental material, SupplementalTable1 for Comparing CST Lesion Metrics as Biomarkers for Recovery of Motor and Proprioceptive Impairments After Stroke by Sonja E. Findlater, Rachel L. Hawe, Erin L. Mazerolle, Abdulaziz S. Al Sultan, Jessica M. Cassidy, Stephen H. Scott, G. Bruce Pike and Sean P. Dukelow in Neurorehabilitation and Neural Repair