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Supplemental material, sj-docx-1-wso-10.1177_17474930221085443 for Long-term anxiety in spontaneous intracerebral hemorrhage survivors by Giuseppe Scopelliti, Barbara Casolla, Grégoire Boulouis, Grégory Kuchcinski, Solène Moulin, Didier Leys, Hilde Hénon, Charlotte Cordonnier and Marco Pasi in International Journal of Stroke

Supplemental material, sj-docx-1-wso-10.1177_17474930221085443 for Long-term anxiety in spontaneous intracerebral hemorrhage survivors by Giuseppe Scopelliti, Barbara Casolla, Grégoire Boulouis, Grégory Kuchcinski, Solène Moulin, Didier Leys, Hilde Hénon, Charlotte Cordonnier and Marco Pasi in International Journal of Stroke

Supplemental material, sj-pdf-2-wso-10.1177_17474930211059636 for Early-onset delirium after spontaneous intracerebral hemorrhage by Federico Marrama, Ma��va Kyheng, Marco Pasi, Matthieu Pierre Rutgers, Sol��ne Moulin, Marina Diomedi, Didier Leys, Charlotte Cordonnier, Hilde H��non and Barbara Casolla in International Journal of Stroke

Supplemental material, sj-pdf-1-wso-10.1177_17474930211059636 for Early-onset delirium after spontaneous intracerebral hemorrhage by Federico Marrama, Ma��va Kyheng, Marco Pasi, Matthieu Pierre Rutgers, Sol��ne Moulin, Marina Diomedi, Didier Leys, Charlotte Cordonnier, Hilde H��non and Barbara Casolla in International Journal of Stroke

Supplemental material, sj-pdf-1-wso-10.1177_17474930211059636 for Early-onset delirium after spontaneous intracerebral hemorrhage by Federico Marrama, Ma��va Kyheng, Marco Pasi, Matthieu Pierre Rutgers, Sol��ne Moulin, Marina Diomedi, Didier Leys, Charlotte Cordonnier, Hilde H��non and Barbara Casolla in International Journal of Stroke

Supplemental material, sj-pdf-2-wso-10.1177_17474930211059636 for Early-onset delirium after spontaneous intracerebral hemorrhage by Federico Marrama, Ma��va Kyheng, Marco Pasi, Matthieu Pierre Rutgers, Sol��ne Moulin, Marina Diomedi, Didier Leys, Charlotte Cordonnier, Hilde H��non and Barbara Casolla in International Journal of Stroke

Objectives Pre-stroke dependency (PSD) is associated with poor outcome after stroke. The aim of the study was to evaluate the clinical outcomes and safety of mechanical thrombectomy (MT) in pre-stroke dependent patients compared to pre-stroke independent patients. Material and Methods We included consecutive patients with anterior circulation acute ischaemic stroke related to large vessel occlusion (AIS-LVO), treated by MT between January 1st 2015 and July 1st 2018 in our single comprehensive stroke center. PSD was defined as a mRS score of 3 to 5 before stroke onset. We studied outcome variables in pre-stroke dependent vs. independent patients, by using logistic regression models. Clinical outcomes included clinical favorable outcome at 3 months (defined as modified Rankin Score 0-2 or equal to pre-stroke mRS score), successful recanalization rates and safety outcomes. Results Of 922 patients with anterior circulation AIS-LVO, 155 (16.8%) had PSD. Favorable outcome was less often achieved in patients with PSD (25.8% vs. 44.7%, p Conclusions One out of four patients with PSD had a favorable outcome after MT. Despite higher mortality rates compared to pre-stroke independent patients, PSD alone should not be used alone to deny mechanical thrombectomy.

We evaluated recurrent intracerebral hemorrhage (ICH) risk in ICH survivors, stratified by the presence, distribution, and number of cerebral microbleeds (CMBs) on MRI (i.e., the presumed causal underlying small vessel disease and its severity). This was a meta-analysis of prospective cohorts following ICH, with blood-sensitive brain MRI soon after ICH. We estimated annualized recurrent symptomatic ICH rates for each study and compared pooled odds ratios (ORs) of recurrent ICH by CMB presence/absence and presumed etiology based on CMB distribution (strictly lobar CMBs related to probable or possible cerebral amyloid angiopathy [CAA] vs non-CAA) and burden (1, 2-4, 5-10, and >10 CMBs), using random effects models. We pooled data from 10 studies including 1,306 patients: 325 with CAA-related and 981 CAA-unrelated ICH. The annual recurrent ICH risk was higher in CAA-related ICH vs CAA-unrelated ICH (7.4%, 95% confidence interval [CI] 3.2-12.6 vs 1.1%, 95% CI 0.5-1.7 per year, respectively; p = 0.01). In CAA-related ICH, multiple baseline CMBs (versus none) were associated with ICH recurrence during follow-up (range 1-3 years): OR 3.1 (95% CI 1.4-6.8; p = 0.006), 4.3 (95% CI 1.8-10.3; p = 0.001), and 3.4 (95% CI 1.4-8.3; p = 0.007) for 2-4, 5-10, and >10 CMBs, respectively. In CAA-unrelated ICH, only >10 CMBs (versus none) were associated with recurrent ICH (OR 5.6, 95% CI 2.1-15; p = 0.001). The presence of 1 CMB (versus none) was not associated with recurrent ICH in CAA-related or CAA-unrelated cohorts. CMB burden and distribution on MRI identify subgroups of ICH survivors with higher ICH recurrence risk, which may help to predict ICH prognosis with relevance for clinical practice and treatment trials.