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2 results on '"Caso, MARIA FEDERICA"'

1. Highly Stereoselective Synthesis of Lamivudine (3TC) and Emtricitabine (FTC) by a Novel N-Glycosidation Procedure

Author

Stefano D'Errico, Maria Federica Caso, Giovanni Palumbo, Daniele D'Alonzo, Annalisa Guaragna, Caso, MARIA FEDERICA, D'Alonzo, Daniele, D'Errico, Stefano, Palumbo, Giovanni, and Guaragna, Annalisa

Subjects
Glycosylation, Silanes, Molecular Structure, Stereochemistry, Medicine (all), Organic Chemistry, Substrate (chemistry), Lamivudine, Stereoisomerism, Emtricitabine, Deoxycytidine, Biochemistry, chemistry.chemical_compound, chemistry, Reagent, Anhydrous, medicine, Stereoselectivity, Physical and Theoretical Chemistry, Cytosine, medicine.drug
Abstract

The combined use of silanes (Et3SiH or PMHS) and I2 as novel N-glycosidation reagents for the synthesis of bioactive oxathiolane nucleosides 3TC and FTC is reported. Both systems (working as anhydrous HI sources) were devised to act as substrate activators and N-glycosidation promoters. Excellent results in terms of chemical efficiency and stereoselectivity of the reactions were obtained; surprisingly, the nature of the protective group at the N4 position of (fluoro)cytosine additionally influenced the stereochemical reaction outcome.

Published
2015
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2. Eumelanin Coating of Silica Aerogel by Supercritical Carbon Dioxide Deposition of a 5,6-Dihydroxyindole Thin Film

Author

Maria Federica Caso, Alessandro Pezzella, Ludovico Migliaccio, Irene Bonadies, Giuseppe Caputo, Caputo, Giuseppe, Bonadies, Irene, Migliaccio, Ludovico, Caso, Maria Federica, and Pezzella, Alessandro

Subjects
eumelanins, Materials science, 02 engineering and technology, engineering.material, 010402 general chemistry, lcsh:Technology, 01 natural sciences, Article, supercritical CO2, law.invention, Coating, law, General Materials Science, Thin film, silica aerogel, lcsh:Microscopy, Electron paramagnetic resonance, lcsh:QC120-168.85, Eumelanin, Supercritical carbon dioxide, lcsh:QH201-278.5, lcsh:T, Aerogel, 021001 nanoscience & nanotechnology, Supercritical fluid, 0104 chemical sciences, Polymerization, Chemical engineering, lcsh:TA1-2040, engineering, lcsh:Descriptive and experimental mechanics, Materials Science (all), lcsh:Electrical engineering. Electronics. Nuclear engineering, Supercritical adsorption, lcsh:Engineering (General). Civil engineering (General), 0210 nano-technology, lcsh:TK1-9971
Abstract

Eumelanin integration in silica aerogel (SA) was achieved via supercritical adsorption of 5,6-dyhydroxyindole (DHI) from CO2. Notably, after the supercritical treatment, DHI evolved towards spontaneous polymerization, which resulted in uniform pigment development over the SA. The new material was characterized for its morphological and physicochemical properties, disclosing the formation of a eumelanin-like coating, as confirmed by UV&ndash, vis and electron paramagnetic resonance (EPR) spectroscopy.

Published
2018
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