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32 results on '"Casarotto D"'

1. Laboratory assessment

Author

Gerosa, Gino, DI MARCO, F, Casarotto, D, and Bottio, Tomaso

Published
2004

12. Mid-term results of heart transplantation in diabetic patients

Author

Livi, U., Caforio, A. L. P., Grassi, G., Boffa, G. M., Gambino, A., Aldo Domenico MILANO, Bianco, R., Casula, R., Thiene, G., and Casarotto, D.

Subjects
Adult, Graft Rejection, Immunosuppression Therapy, Male, Cardiac Catheterization, Time Factors, Hemodynamics, Cyclosporins, Middle Aged, Coronary Angiography, Infections, Diabetes Complications, Survival Rate, Diabetes Mellitus, Type 1, Postoperative Complications, Diabetes Mellitus, Type 2, Actuarial Analysis, Azathioprine, Diabetes Mellitus, Heart Transplantation, Humans, Prednisone, Female, Follow-Up Studies
Abstract

Diabetes mellitus (DM) has been considered a relative contraindication to heart transplantation (HTx) because of possible increased infection rates and worsening DM with prednisone immunosuppression. The introduction of cyclosporine has allowed us to reduce the dosage of oral steroids and to accept DM patients (pts) for HTx. We reviewed the mid-term outcome of our DM pts who had undergone HTx.Out of 257 HTx recipients, 19 males and 3 females, aged 53 +/- 8 years, were diabetic. Prior to HTx, DM was controlled with insulin in 5, with oral hypoglycemic agents in 7 and with diet in the remaining patients. Immunosuppression consisted of cyclosporine and azathioprine; low-dose prednisone was added in 10 patients because of repeated rejections.All patients survived HTx and were followed 2 to 75 (mean 38 +/- 21) months. There were 4 late deaths, with actuarial survival of 84% at 5 years. DM was more difficult to control after HTx (12 patients requiring insulin vs 5 pre-HTx), but comparison of diabetic vs non diabetic patients following HTx showed no significant difference in frequency of rejection or infection during the 1st year (2.6 +/- 1.6 vs 2.1 +/- 1.5; 0.5 +/- 0.4 vs 0.4 +/- 0.3 episode/patient respectively) and in 5-year actuarial survival (84% vs 77%). Renal function is preserved in all DM patients, hypertension has developed in 11/18 (61%); annual post-HTx cardiac catheterisation has shown normal graft function and coronary arteries in all but 2 patients.Mid-term results indicate that HTx can be safely performed in diabetic patients; a longer follow-up is required to determine whether DM is no longer a contraindication to HTx.

Published
1994

13. Influence of marginal donors on early results after heart transplantation

Author

Milano, A., Livi, U., Casula, R., Bortolotti, U., Gambino, A., Zenati, M., Marialuisa Valente, Angelini, A., Thiene, G., and Casarotto, D.

Subjects
Adult, Immunosuppression Therapy, Male, Tissue and Organ Procurement, Adolescent, Resuscitation, Age Factors, Infant, Middle Aged, Tissue Donors, Heart Arrest, Survival Rate, Actuarial Analysis, Echocardiography, Child, Preschool, Heart Transplantation, Humans, Female, Child, Retrospective Studies
Published
1993

19. Evolution of focal moderate (International Society for Heart and Lung Transplantation grade 2) rejection of the cardiac allograft

Author

Milano A, Al, Caforio, Ugolino LIVI, Bauce B, Angelini A, Casarotto D, and Thiene G

Subjects
Adult, Graft Rejection, Immunosuppression Therapy, Male, Incidence, Coronary Disease, Stroke Volume, Middle Aged, heart transplantation, Survival Analysis, Ventricular Function, Left, Actuarial Analysis, Disease Progression, Humans, Transplantation, Homologous, Female, Immunosuppressive Agents, Follow-Up Studies, Lung Transplantation, Retrospective Studies
Abstract

In the absence of clinical evidence of cardiac allograft rejection, it is still poorly defined whether the International Society for Heart and Lung Transplantation biopsy grade 2 (e.g., focal moderate rejection) should be treated. Aim of the present study was to retrospectively investigate the evolution of focal moderate rejection, diagnosed during the first postoperative year in patients who had undergone orthotopic heart transplantation.A retrospective analysis was conducted on 256 International Society for Heart and Lung Transplantation grade 2 biopsies from 110 orthotopic heart transplantations; 125 episodes occurred within the first 3 months (group 1), 131 later (group 2). For each grade 2 diagnosis, two biopsies, one immediately before and one after, were analyzed and classified as follows: lower (grade 0 or 1), equal (grade 2), or higher (grade 3 or 4).Evolution of grade 2 rejection was to a lower grade in 66% of cases, an equal grade in 16.8%, and a higher grade in 17.2%, with differences between group 1 and 2 (higher: 25% versus 10%, respectively, p = 0.005). Episodes which progressed into higher grades occurred earlier compared with those which persisted or resolved (9.2 +/- 8.6 weeks versus 20.0 +/- 15.6, p0.001). Five-year actuarial survival and incidence of graft coronary disease were similar in patients whose conditions progressed and those whose conditions did not. However, left ventricular ejection fraction at 1 and 2 years was lower in patients whose conditions progressed compared with those whose conditions persisted or resolved (56% +/- 4% versus 66% +/- 2%, p = 0.004; 56% +/- 10% versus 64% +/- 8%, p = 0.02, respectively).Progression of grade 2 rejection occurred in a minority of cases and did not affect 5-year survival or incidence of coronary disease, but its relationship with long-term cardiac allograft dysfunction warrants further investigation.

24. Heart transplantation for end-stage valvular disease

Author

Ugolino LIVI, Al, Caforio, Grassi G, Gm, Boffa, Barchitta A, Gambino A, Thiene G, and Casarotto D

Subjects
Adult, Graft Rejection, Male, Analysis of Variance, Arteriosclerosis, Heart Valve Diseases, Middle Aged, Survival Rate, Postoperative Complications, Heart Valve Prosthesis, Heart Function Tests, Heart Transplantation, Humans, Female, Immunosuppressive Agents, Retrospective Studies

30. Influence of rejection on late graft function after heart transplantation

Author

Ugolino LIVI, Milano A, Al, Caforio, Grassi G, Feltrin G, Gm, Boffa, D'Agnolo A, Angelini A, Thiene G, and Casarotto D

Subjects
Adult, Graft Rejection, Immunosuppression Therapy, Male, Analysis of Variance, Adolescent, Biopsy, Needle, Middle Aged, Drug Administration Schedule, Survival Rate, Azathioprine, Cyclosporine, Heart Transplantation, Humans, Female, Child, Immunosuppressive Agents, Aged, Antilymphocyte Serum, Retrospective Studies

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