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Additional file 1. Supplementary Table 1. Cohorts construction: exclusion criteria. Supplementary Table 2. Drugs by therapeutic group. Supplementary Figure 1. Cumulative quantity of etanercept (originator or biosimilar) dispensed (mg per patient) over the follow-up period, by cohort. Supplementary Figure 2. Cumulative number of days on conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs) per patient, over the follow-up period, by cohort. Supplementary Figure 3. Cumulative number of days on oral steroids per patient, over the follow-up period, by cohort. Supplementary Figure 4. Cumulative number of days on nonsteroidal anti-inflammatory drugs (NSAIDs) per patient, over the follow-up period, by cohort.