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4 results on '"Cao Quang Thai"'

1. New insights into malaria susceptibility from the genomes of 17,000 individuals from Africa, Asia, and Oceania

Author

Kate Rowlands, Timothy M. E. Davis, Salimata Konate, Umberto D'Alessandro, Angeliki Kerasidou, Sodiomon B. Sirima, David J. Conway, Fatoumatta Sisay-Joof, S Ademola, Mahamadou A. Thera, Momodou W. Jallow, Edith C. Bougouma, Alexander J. Mentzer, Alphaxard Manjurano, Chris Drakeley, Carolyne M. Ndila, Giorgio Sirugo, Eleanor Drury, Nguyen Hoan Phu, Moses Laman, Anthony Enimil, Pascal Michon, N T Ngoc Quyen, Terrie E. Taylor, Jennifer Evans, Ogobara K. Doumbo, Anita Ghansah, Malcolm E. Molyneux, Alexander T. Dilthey, Sibiry Sissoko, Olukemi K. Amodu, Kalifa Bojang, Yik Ying Teo, Ousmane Touré, Eleanor M. Riley, Dominic P. Kwiatkowski, Angela Allen, Laurens Manning, D Ansong, Peter Siba, Stephen Allen, Thomas N. Williams, Christina Hubbart, Tobias O. Apinjoh, Cao Quang Thai, Hugh Reyburn, Q S Le, Melanie Bahlo, Geraldine M. Clarke, Spencer Cca., Ivo Mueller, Anna E. Jeffreys, Gil McVean, Valentina D. Mangano, Jj J. Farrar, Victoria Cornelius, Busby Gbj., Kevin Marsh, Jim Stalker, David Modiano, Tran Tinh Hien, Michael T. Wilson, Tsiri Agbenyega, A Hodgson, Sarah J. Dunstan, Harin Karunajeewa, L. Amenga-Etego, Ellen M. Leffler, Katja Kivinen, Eric A. Achidi, Kirk A. Rockett, Kwadwo A. Koram, and J Shelton

Subjects
Genetics, Host resistance, biology, Plasmodium falciparum, Disease, Heritability, Hla association, biology.organism_classification, medicine.disease, Genome, Cerebral Malaria, parasitic diseases, medicine, Malaria
Abstract

We conducted a genome-wide association study of host resistance to severePlasmodium falciparummalaria in over 17,000 individuals from 11 malaria-endemic countries, undertaking a wide ranging analysis which identifies five replicable associations with genome-wide levels of evidence. Our findings include a newly implicated variant on chromosome 6 associated with risk of cerebral malaria, and the discovery of an erythroid-specific transcription start site underlying the association inATP2B4. Previously reported HLA associations cannot be replicated in this dataset. We estimate substantial heritability of severe malaria (h2~ 23%), of which around 10% is explained by the currently identified associations. Our dataset will provide a major building block for future research on the genetic determinants of disease in these diverse human populations.

Published
2019

2. Reappraisal of known malaria resistance loci in a large multicenter study

Author

Malcolm E. Molyneux, Peter Siba, Andre Ndi, Valentina D. Mangano, Cao Quang Thai, Vysaul Nyirongo, Subulade A. Olaniyan, Angie Green, Mahamadou A. Thera, Timothy M. E. Davis, Síle F. Molloy, Kathryn Fitzpatrick, Giorgio Sirugo, Edith C. Bougouma, Chris Drakeley, Anthony Enimil, Angela Allen, Olukemi K. Amodu, Christina Hubbart, Nuno Sepúlveda, Nguyen Hoan Phu, M Jallow, Carolyne M. Ndila, Stanley Usen, Kimberly J. Johnson, Hugh Reyburn, Taane G. Clark, Dominic P. Kwiatkowski, Si Quang Le, Tobias O. Apinjoh, Kalifa Bojang, Jennifer R Evans, Michael D. Wilson, Lee Hart, Sophie Uyoga, Angeliki Kerasidou, Eric A. Achidi, Steve Allen, Kirk A. Rockett, Pascal Michon, Ivo Mueller, Anna E. Jeffreys, Belco Poudiougou, Anita Ghansah, Norbert Peshu, Fatoumatta Sisay-Joof, David Kachala, Sodiomon B. Sirima, David J. Conway, Geraldine M. Clarke, Regina N. Mugri, Moses Laman, Aaron Vanderwal, Miguel A. Sanjoaquin, Sibiry Sissoko, Ousmane Touré, Laurens Manning, Chris C. A. Spencer, Matti Pirinen, David Modiano, Sarah J. Dunstan, Harin Karunajeewa, Alexander Macharia, Tran Tinh Hien, Tsiri Agbenyega, Gavin Band, Kate Rowlands, Salimata Konate, Rachel Craik, L. Amenga-Etego, Nguyen Ngoc Quyen, Kwadwo A. Koram, Amadou Niangaly, Margaret Pinder, Alphaxard Manjurano, Terrie E. Taylor, Ogobara K. Doumbo, Eleanor M. Riley, Jeremy Farrar, Victoria Cornelius, Kevin Marsh, and Thomas N. Williams

Subjects
medicine.medical_specialty, Genome-wide association study, Glucosephosphate Dehydrogenase, Polymorphism, Single Nucleotide, Article, Papua New Guinea, Plasma Membrane Calcium-Transporting ATPases, Polymorphism (computer science), ABO blood group system, parasitic diseases, Epidemiology, Genetics, medicine, Humans, Malaria, Falciparum, Africa South of the Sahara, Genetic Association Studies, Disease Resistance, biology, Transmission (medicine), Case-control study, Plasmodium falciparum, medicine.disease, biology.organism_classification, 3. Good health, Glucosephosphate Dehydrogenase Deficiency, Logistic Models, Vietnam, Genetic Loci, Case-Control Studies, Malaria
Abstract

Many human genetic associations with resistance to malaria have been reported, but few have been reliably replicated. We collected data on 11,890 cases of severe malaria due to Plasmodium falciparum and 17,441 controls from 12 locations in Africa, Asia and Oceania. We tested 55 SNPs in 27 loci previously reported to associate with severe malaria. There was evidence of association at P < 1 × 10(-4) with the HBB, ABO, ATP2B4, G6PD and CD40LG loci, but previously reported associations at 22 other loci did not replicate in the multicenter analysis. The large sample size made it possible to identify authentic genetic effects that are heterogeneous across populations or phenotypes, with a striking example being the main African form of G6PD deficiency, which reduced the risk of cerebral malaria but increased the risk of severe malarial anemia. The finding that G6PD deficiency has opposing effects on different fatal complications of P. falciparum infection indicates that the evolutionary origins of this common human genetic disorder are more complex than previously supposed.

Published
2014

3. Author response: Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

Author

Gavin Band, Salimata Konate, Muminatou Jallow, Thomas N. Williams, Sibiry Sissoko, Nguyen Hoan Phu, Hugh Reyburn, Nuno Sepúlveda, Ousmane Touré, Christina Hubbart, Chris Drakeley, Dominic P. Kwiatkowski, Sophie Uyoga, Regina N. Mugri, Ivo Mueller, Anna E. Jeffreys, Timothy M. E. Davis, Olukemi K. Amodu, Lee Hart, Geraldine M. Clarke, Anita Ghansah, Eleanor M. Riley, Ogobara K. Doumbo, Kate Rowlands, Tobias O. Apinjoh, Eric A. Achidi, Steve Allen, Kirk A. Rockett, Fatoumatta Sisay-Joof, Síle F. Molloy, Taane G. Clark, Jeremy Farrar, Valentina D. Mangano, Victoria Cornelius, Kevin Marsh, Shivang S. Shah, Kalifa Bojang, Vysaul Nyirongo, Pascal Michon, Alexander Macharia, Angela Allen, Peter Siba, Cao Quang Thai, Carolyne M. Ndila, Subulade A. Olaniyan, Stanley Usen, Andre Ndi, Laurens Manning, Jennifer Evans, Chris C. A. Spencer, Mahamadou A. Thera, Margaret Pinder, Malcolm E. Molyneux, David Kachala, Alphaxard Manjurano, Norbert Peshu, Terrie E. Taylor, Amadou Niangaly, Moses Laman, Katja Kivinen, Tsiri Agbenyega, Lucas Amenga-Etego, Edith C. Bougouma, Nguyen Ngoc Quyen, Giorgio Sirugo, Anthony Enimil, David Modiano, Angeliki Kerasidou, Tran Tinh Hien, Michael D. Wilson, Susana Campino, Sodiomon B. Sirima, David J. Conway, Sarah J. Dunstan, Kwadwo A. Koram, Harin Karunajeewa, and Belco Poudiougou

Subjects
Cerebral Malaria, business.industry, Immunology, Medicine, business
Published
2016

4. Large scale screening for haemoglobin disorders in southern Vietnam: implications for avoidance and management

Author

Sean, O'Riordan, Tran Tinh, Hien, Katie, Miles, Angela, Allen, Nguyen Ngoc, Quyen, Nguyen Quoc, Hung, Do Quang, Anh, Luc Nguyen, Tuyen, Dao Bach, Khoa, Cao Quang, Thai, Dao Minh, Triet, Nguyen Hoan, Phu, Sarah, Dunstan, Tim, Peto, John, Clegg, Jeremy, Farrar, and David, Weatherall

Subjects
Blood Specimen Collection, Genotype, Hemoglobin E, beta-Thalassemia, Glycogen Storage Disease Type I, Hemoglobinopathies, Gene Frequency, Vietnam, alpha-Thalassemia, Mutation, Prevalence, Humans, Mass Screening, Needs Assessment
Abstract

In order to obtain an approximate assessment of the public health burden that will be posed by the inherited disorders of haemoglobin in southern Vietnam, several thousand individuals were screened for these conditions. A smaller sample was screened for glucose-6-phosphate dehydrogenase (G6PD) deficiency. The important haemoglobin disorders identified were beta thalassaemia, haemoglobin E and a variety of different forms of alpha thalassaemia. There were sufficient G6PD-deficient individuals to materially affect malaria control programme design. The most remarkable finding was wide variation in the gene frequencies of these conditions among the ethnic groups sampled. The approximate number of babies expected to be born with clinically significant haemoglobin disorders in Vietnam was estimated from the gene-frequency data. This study emphasizes the importance of wide-scale population screening, including ethnic subgroups, to establish the requirements for inherited haemoglobin disorder programmes in resource-limited settings.

Published
2010

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