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Gastrointestinal (GI) tumor is a serious disease with high mortality rates and morbidity rates worldwide. Chemotherapy is a key treatment for GI, however, systematic side effects and inevitable drug resistance complicate the situation. In the process of therapy, P-glycoprotein (P-gp) could remove chemotherapy drugs from cells, thus causing multi-drug resistance. Chemodynamic therapy (CDT) utilizing Fenton chemistry has been used for cancer therapy, along with various combination therapies. The reactive oxygen species produced by CDT could inhibit P-gp’s efflux pump function, which reduce chemoagents excretion and reverse drug resistance. In the present study, we developed novel nanocrystals (Cu2O@Pt NCs) to overcome drug resistance by reducing mitochondria-derived ATP through chemo/CDT in GI cancer. Furthermore, in vivo results in tumor-bearing mice demonstrated that treatment with Cu2O@Pt NCs with CDT and chemotherapy could achieve the most effective antitumor therapeutic effect with the least amounts of adverse effects. As a result, Cu2O@Pt NCs could provide a promising strategy for chemo/CDT-synergistic therapy.

BackgroundBlood–brain barrier (BBB) damage is considered an important part of Alzheimer's disease (AD) progression, and cerebral small-vessel disease (CSVD) is commonly associated with AD. However, the relationship between BBB damage, small cerebrovascular lesions, especially cerebral microbleeds (CMBs), and amyloid and tau biomarkers remains controversial. Therefore, our study aimed to further investigate their association in our cohort of patients with AD.MethodsA total of 139 individuals were divided into probable AD (18F-florbetapir PET positive, n = 101) and control group (cognitively normal, n = 38). The levels of cerebrospinal fluid (CSF) and plasma t-tau, p-tau181, Aβ40, Aβ42, and albumin were measured using corresponding commercial assay kits, and the CSF/plasma albumin ratio (Qalb), an indicator of BBB dysfunction, was calculated. CSVD burden and the number of CMBs were defined using magnetic resonance imaging.ResultsPatients with AD had higher Qalb (p = 0.0024), higher numbers of CMBs (p = 0.03), and greater CSVD burden (p < 0.0001). In the AD group, CMBs and CSVD correlated with a higher Qalb (p = 0.03), and the numbers of CMBs negatively correlated with CSF Aβ42 (p = 0.02).ConclusionBlood–brain barrier damage was accompanied by a more severe burden of CSVD, including CMB, in patients with AD.

With the explosive increase of User Generated Content (UGC), UGC video quality assessment (VQA) becomes more and more important for improving users' Quality of Experience (QoE). However, most existing UGC VQA studies only focus on the visual distortions of videos, ignoring that the user's QoE also depends on the accompanying audio signals. In this paper, we conduct the first study to address the problem of UGC audio and video quality assessment (AVQA). Specifically, we construct the first UGC AVQA database named the SJTU-UAV database, which includes 520 in-the-wild UGC audio and video (A/V) sequences, and conduct a user study to obtain the mean opinion scores of the A/V sequences. The content of the SJTU-UAV database is then analyzed from both the audio and video aspects to show the database characteristics. We also design a family of AVQA models, which fuse the popular VQA methods and audio features via support vector regressor (SVR). We validate the effectiveness of the proposed models on the three databases. The experimental results show that with the help of audio signals, the VQA models can evaluate the perceptual quality more accurately. The database will be released to facilitate further research.

Additional file1: Table S1. Time schedule of enrolment, interventions, and assessments.