Search

Your search keyword '"Callister, Tracy"' showing total 32 results
Start Over Author "Callister, Tracy" Language undetermined
32 results on '"Callister, Tracy"'

1. Sex and age-specific interactions of coronary atherosclerotic plaque onset and prognosis from coronary computed tomography

Author

van Rosendael, Sophie E, Bax, A Maxim, Lin, Fay Y, Achenbach, Stephan, Andreini, Daniele, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chinnaiyan, Kavitha, Chow, Benjamin J W, Cury, Ricardo C, DeLago, Augustin J, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A, Kim, Yong-Jin, Leipsic, Jonathon A, Maffei, Erica, Marques, Hugo, de Araújo Gonçalves, Pedro, Pontone, Gianluca, Raff, Gilbert L, Rubinshtein, Ronen, Villines, Todd C, Chang, Hyuk-Jae, Berman, Daniel S, Min, James K, Bax, Jeroen J, Shaw, Leslee J, et al, and University of Zurich

Subjects
610 Medicine & health, Radiology, Nuclear Medicine and imaging, 10181 Clinic for Nuclear Medicine, General Medicine, Cardiology and Cardiovascular Medicine
Abstract

Aims The totality of atherosclerotic plaque derived from coronary computed tomography angiography (CCTA) emerges as a comprehensive measure to assess the intensity of medical treatment that patients need. This study examines the differences in age onset and prognostic significance of atherosclerotic plaque burden between sexes. Methods and results From a large multi-center CCTA registry the Leiden CCTA score was calculated in 24 950 individuals. A total of 11 678 women (58.5 ± 12.4 years) and 13 272 men (55.6 ± 12.5 years) were followed for 3.7 years for major adverse cardiovascular events (MACE) (death or myocardial infarction). The age where the median risk score was above zero was 12 years higher in women vs. men (64–68 years vs. 52–56 years, respectively, P < 0.001). The Leiden CCTA risk score was independently associated with MACE: score 6–20: HR 2.29 (1.69–3.10); score > 20: HR 6.71 (4.36–10.32) in women, and score 6–20: HR 1.64 (1.29–2.08); score > 20: HR 2.38 (1.73–3.29) in men. The risk was significantly higher for women within the highest score group (adjusted P-interaction = 0.003). In pre-menopausal women, the risk score was equally predictive and comparable with men. In post-menopausal women, the prognostic value was higher for women [score 6–20: HR 2.21 (1.57–3.11); score > 20: HR 6.11 (3.84–9.70) in women; score 6–20: HR 1.57 (1.19–2.09); score > 20: HR 2.25 (1.58–3.22) in men], with a significant interaction for the highest risk group (adjusted P-interaction = 0.004). Conclusion Women developed coronary atherosclerosis approximately 12 years later than men. Post-menopausal women within the highest atherosclerotic burden group were at significantly higher risk for MACE than their male counterparts, which may have implications for the medical treatment intensity.

Published
2023
Full Text
View/download PDF

2. Associations between dyspnoea, coronary atherosclerosis, and cardiovascular outcomes: results from the long-term follow-up CONFIRM registry

Author

van Rosendael, Alexander R, Bax, A Maxim, van den Hoogen, Inge J, Smit, Jeff M, Al'Aref, Subhi J, Achenbach, Stephan, Al-Mallah, Mouaz H, Andreini, Daniele, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J W, Cury, Ricardo C, DeLago, Augustin, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A, Kim, Yong-Jin, Leipsic, Jonathon A, Maffei, Erica, Marques, Hugo, de Araújo Gonçalves, Pedro, Pontone, Gianluca, Raff, Gilbert L, Rubinshtein, Ronen, Villines, Todd C, et al, and University of Zurich

Subjects
2741 Radiology, Nuclear Medicine and Imaging, 610 Medicine & health, 10181 Clinic for Nuclear Medicine, 2705 Cardiology and Cardiovascular Medicine
Published
2022
Full Text
View/download PDF

3. Relationship of Hypertension to Coronary Atherosclerosis and Cardiac Events in Patients With Coronary Computed Tomographic Angiography

Author

Nakanishi, Rine, Baskaran, Lohendran, Gransar, Heidi, Budoff, Matthew J, Achenbach, Stephan, Al-Mallah, Mouaz, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin JW, DeLago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Cury, Ricardo, Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, Kaufmann, Philipp A, Maffei, Erica, Raff, Gilbert, Shaw, Leslee J, Villines, Todd C, Dunning, Allison, Marques, Hugo, Pontone, Gianluca, Andreini, Daniele, Rubinshtein, Ronen, Bax, Jeroen, Jones, Erica, Hindoyan, Niree, Gomez, Millie, Lin, Fay Y, Min, James K, and Berman, Daniel S

Subjects
Male, hypertension, Computed Tomography Angiography, International Cooperation, Clinical Sciences, Myocardial Ischemia, Coronary Artery Disease, Cardiorespiratory Medicine and Haematology, Coronary Angiography, Outcome and Process Assessment, Cardiovascular, Severity of Illness Index, Risk Assessment, Risk Factors, Clinical Research, Humans, 2.1 Biological and endogenous factors, angiography, Registries, Prospective Studies, Heart Disease - Coronary Heart Disease, Proportional Hazards Models, Aged, Middle Aged, Prognosis, Outcome and Process Assessment (Health Care), Atherosclerosis, 4.1 Discovery and preclinical testing of markers and technologies, Health Care, Heart Disease, Cardiovascular System & Hematology, Public Health and Health Services, Biomedical Imaging, Female
Abstract

Hypertension is an atherosclerosis factor and is associated with cardiovascular risk. We investigated the relationship between hypertension and the presence, extent, and severity of coronary atherosclerosis in coronary computed tomographic angiography and cardiac events risk. Of 17 181 patients enrolled in the CONFIRM registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) who underwent ≥64-detector row coronary computed tomographic angiography, we identified 14 803 patients without known coronary artery disease. Of these, 1434 hypertensive patients were matched to 1434 patients without hypertension. Major adverse cardiac events risk of hypertension and non-hypertensive patients was evaluated with Cox proportional hazards models. The prognostic associations between hypertension and no-hypertension with increasing degree of coronary stenosis severity (nonobstructive or obstructive ≥50%) and extent of coronary artery disease (segment involvement score of 1-5, >5) was also assessed. Hypertension patients less commonly had no coronary atherosclerosis and more commonly had nonobstructive and 1-, 2-, and 3-vessel disease than the no-hypertension group. During a mean follow-up of 5.2±1.2 years, 180 patients experienced cardiac events, with 104 (2.0%) occurring in the hypertension group and 76 (1.5%) occurring in the no-hypertension group (hazard ratios, 1.4; 95% confidence intervals, 1.0-1.9). Compared with no-hypertension patients without coronary atherosclerosis, hypertension patients with no coronary atherosclerosis and obstructive coronary disease tended to have higher risk of cardiac events. Similar trends were observed with respect to extent of coronary artery disease. Compared with no-hypertension patients, hypertensive patients have increased presence, extent, and severity of coronary atherosclerosis and tend to have an increase in major adverse cardiac events.

Published
2017

4. Optimized Prognostic Score for Coronary Computed Tomographic Angiography Results From the CONFIRM Registry (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry)

Author

Hadamitzky Martin, Achenbach Stephan, Al-Mallah Mouaz, Berman Daniel, Budoff Matthew, Cademartiri Filippo, Callister Tracy, Chang Hyuk-Jae, Cheng Victor, Chinnaiyan Kavitha, Chow Benjamin J. W., Cury Ricardo, Delago Augustin, Dunning Allison, Feuchtner Gudrun, Gomez Millie, Kaufmann Philipp, Kim Yong-Jin, Leipsic Jonathon, Lin Fay Y., Maffei Erica, Min James K., Raff Gil, Shaw Leslee J., and Villines Todd C.

Published
2013
Full Text
View/download PDF

5. Long-Term Prognostic Utility of Coronary CT Angiography in Stable Patients With Diabetes Mellitus

Author

Blanke, Philipp, Naoum, Christopher, Ahmadi, Amir, Cheruvu, Chaitu, Soon, Jeanette, Arepalli, Chesnal, Gransar, Heidi, Achenbach, Stephan, Berman, Daniel S, Budoff, Matthew J, Callister, Tracy Q, Al-Mallah, Mouaz H, Cademartiri, Filippo, Chinnaiyan, Kavitha, Rubinshtein, Ronen, Marquez, Hugo, DeLago, Augustin, Villines, Todd C, Hadamitzky, Martin, Hausleiter, Joerg, Shaw, Leslee J, Kaufmann, Philipp A, Cury, Ricardo C, Feuchtner, Gudrun, Kim, Yong-Jin, Maffei, Erica, Raff, Gilbert, Pontone, Gianluca, Andreini, Daniele, Chang, Hyuk-Jae, Chow, Benjamin W, Min, James, and Leipsic, Jonathon

Subjects
Male, Time Factors, Computed Tomography Angiography, Clinical Sciences, Coronary Artery Disease, Kaplan-Meier Estimate, Cardiorespiratory Medicine and Haematology, Coronary Angiography, Cardiovascular, Severity of Illness Index, coronary CT angiography, Risk Factors, Predictive Value of Tests, Clinical Research, Multidetector Computed Tomography, Diabetes Mellitus, Prevalence, Humans, Registries, Prospective Studies, Propensity Score, Heart Disease - Coronary Heart Disease, Metabolic and endocrine, Proportional Hazards Models, Aged, screening and diagnosis, Diabetes, Coronary Stenosis, Middle Aged, Prognosis, Atherosclerosis, Detection, Heart Disease, Good Health and Well Being, Cardiovascular System & Hematology, Multivariate Analysis, Biomedical Imaging, Female, 4.2 Evaluation of markers and technologies
Abstract

ObjectivesThe goal of this study was to determine the long-term prognostic value of coronary computed tomography angiography (CTA) among patients with diabetes mellitus (DM) compared with nondiabetic subjects.BackgroundThe long-term prognostic value of coronary CTA in patients with DM is not well established.MethodsPatients enrolled in the CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter) registry with 5-year follow-up data were identified. The extent and severity of coronary artery disease (CAD) were analyzed at baseline coronary CTA and in relation to outcomes between diabetic and nondiabetic patients. CAD according to coronary CTA was defined as none (0% stenosis), nonobstructive (1% to 49% stenosis), or obstructive (≥50% stenosis). Time to death (and in a subgroup, time to major adverse cardiovascular event) was estimated by using multivariable Cox proportional hazards models.ResultsA total of 1,823 patients were identified as having DM with 5-year clinical follow-up and were propensity-matched to 1,823 patients without DM (mean age 61.8 ± 10.9 years; 54.4% male). Patients with DM did not exhibit a heightened risk of death compared with the propensity-matched nondiabetic subjects in the absence of CAD on coronary CTA (risk-adjusted hazard ratio [HR] of DM: 1.32; 95% confidence interval [CI]: 0.78 to 2.24; p= 0.296). Patients with DM were at increased risk of dying compared with nondiabetic subjects in the setting of nonobstructive CAD (in the propensity-matched cohort: HR, 2.10; 95% CI: 1.43 to 3.09; p< 0.001) with a mortality risk greater than nondiabetic subjects with obstructive disease (p< 0.001). In a risk-adjusted hazard analysis among patients with DM, both per-patient obstructive CAD and nonobstructive CAD conferred an increase in all-cause mortality risk compared with patients without atherosclerosis on coronary CTA (nonobstructive disease-HR: 2.07; 95% CI: 1.33 to 3.24; p= 0.001; obstructive disease-HR: 2.22; 95% CI: 1.47 to 3.36; p< 0.001).ConclusionsAmong patients with DM, nonobstructive and obstructive CAD according to coronary CTA were associated with higher rates of all-cause mortality and major adverse cardiovascular events at 5 years, and this riskwas significantly higher than in nondiabetic subjects. Importantly, patients with DM without CAD according to coronary CTAwere at a risk comparable to that of nondiabetic subjects.

Published
2016

6. Sex-Specific Associations Between Coronary Artery Plaque Extent and Risk of Major Adverse Cardiovascular Events: The CONFIRM Long-Term Registry

Author

Schulman-Marcus, Joshua, Hartaigh, Bríain Ó, Gransar, Heidi, Lin, Fay, Valenti, Valentina, Cho, Iksung, Berman, Daniel, Callister, Tracy, DeLago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Al-Mallah, Mouaz, Budoff, Matthew, Kaufmann, Philipp, Achenbach, Stephan, Raff, Gilbert, Chinnaiyan, Kavitha, Cademartiri, Filippo, Maffei, Erica, Villines, Todd, Kim, Yong-Jin, Leipsic, Jonathon, Feuchtner, Gudrun, Rubinshtein, Ronen, Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, Shaw, Leslee, and Min, James K

Subjects
Male, sex differences, Time Factors, Computed Tomography Angiography, CT coronary angiography, Clinical Sciences, Myocardial Infarction, Coronary Artery Disease, Kaplan-Meier Estimate, Cardiorespiratory Medicine and Haematology, Coronary Angiography, Cardiovascular, Severity of Illness Index, Sex Factors, Risk Factors, Predictive Value of Tests, Clinical Research, Republic of Korea, Multidetector Computed Tomography, Prevalence, Humans, CAD, Registries, Prospective Studies, Sex Distribution, Heart Disease - Coronary Heart Disease, Proportional Hazards Models, Aged, Plaque, Atherosclerotic, screening and diagnosis, Incidence, Prevention, Coronary Stenosis, Middle Aged, Prognosis, Atherosclerosis, Coronary Vessels, Europe, Detection, Heart Disease, Cardiovascular System & Hematology, North America, Disease Progression, Biomedical Imaging, Female, Follow-Up Studies, 4.2 Evaluation of markers and technologies
Abstract

ObjectivesThe purpose of this study was to examine sex-specific associations, if any, between per-vessel coronary artery disease (CAD) extent and the risk of major adverse cardiovascular events (MACE) over a 5-year study duration.BackgroundThe presence and extent of CAD diagnosed by coronary computed tomography angiography (CTA) is associated with increased short-term mortality and MACE. Nevertheless, some uncertainty remains regarding the influence of sex on these findings.Methods5,632 patients (mean age 60.2 ± 11.8 years, 36.5% women) from the CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter) registry were followed for 5 years. Obstructive CAD was defined as≥50% luminal stenosis in a coronary vessel. Using Cox proportional hazards models, we calculated the hazard ratio (HR) for incident MACE among women and men, defined as death or myocardial infarction.ResultsObstructive CAD was more prevalent in men (42% vs. 26%; p< 0.001), whereas women were more likely to have normal coronary arteries (43% vs. 27%; p< 0.001). There were a total of 798 incident MACE events. After adjustment, there was a strong association between increased MACE risk and nonobstructive CAD (HR: 2.16 for women,2.56 for men; p< 0.001 for both), obstructive 1-vessel CAD (HR: 3.69 and 2.66; p< 0.001), 2-vessel CAD (HR:3.92 and 3.55; p< 0.001), and 3-vessel/left main CAD (HR: 5.94 and 4.44; p< 0.001). Further exploratory analyses of atherosclerotic burden did not identify sex-specific patterns predictive of MACE.ConclusionsIn a large prospective coronary CTA cohort followed long-term, we did not observe an interaction of sex for the association between MACE risk and increased per-vessel extent of obstructive CAD. These findings highlight the persistent prognostic significance of anatomic CAD subsets as detected by coronary CTA for the risk of MACE in both women and men.

Published
2016

7. Prevalence and severity of coronary artery disease and adverse events among symptomatic patients with coronary artery calcification scores of zero undergoing coronary computed tomography angiography: results from the CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter) registry

Author

Villines Todd C, Hulten Edward A, Shaw Leslee J, Goyal Manju, Dunning Allison, Achenbach Stephan, Al-Mallah Mouaz, Berman Daniel S, Budoff Matthew J, Cademartiri Filippo, Callister Tracy Q, Chang Hyuk-Jae, Cheng Victor Y, Chinnaiyan Kavitha, Chow Benjamin J W, Delago Augustin, Hadamitzky Martin, Hausleiter Jörg, Kaufmann Philipp, Lin Fay Y, Maffei Erica, Raff Gilbert L, Min James K, and CONFIRM Registry Investigators

Subjects
nutritional and metabolic diseases, cardiovascular diseases
Abstract

OBJECTIVES The purpose of this study was to describe the prevalence and severity of coronary artery disease (CAD) in relation to prognosis in symptomatic patients without coronary artery calcification (CAC) undergoing coronary computed tomography angiography (CCTA). BACKGROUND The frequency and clinical relevance of CAD in patients without CAC are unclear. METHODS We identified 10037 symptomatic patients without CAD who underwent concomitant CCTA and CAC scoring. CAD was assessed as 0 had a sensitivity specificity and negative and positive predictive values for stenosis =50 of 89 59 96 and 29 respectively. During a median of 2.1 years there was no difference in mortality among patients with a CAC score of 0 irrespective of obstructive CAD. Among 8907 patients with follow up for the composite endpoint 3.9 with a CAC score of 0 and =50 stenosis experienced an event (hazard ratio: 5.7; 95 confidence interval: 2.5 to 13.1; p < 0.001) compared with 0.8 of patients with a CAC score of 0 and no obstructive CAD. Receiver operator characteristic curve analysis demonstrated that the CAC score did not add incremental prognostic information compared with CAD extent on CCTA for the composite endpoint (CCTA area under the curve = 0.825; CAC + CCTA area under the curve = 0.826; p = 0.84). CONCLUSIONS In symptomatic patients with a CAC score of 0 obstructive CAD is possible and is associated with increased cardiovascular events. CAC scoring did not add incremental prognostic information to CCTA.

Published
2011
Full Text
View/download PDF

8. Age- and sex-related differences in all-cause mortality risk based on coronary computed tomography angiography findings results from the International Multicenter CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) of 23,854 patients without known coronary artery disease

Author

Min James K, Dunning Allison, Lin Fay Y, Achenbach Stephan, Al-Mallah Mouaz, Budoff Matthew J, Cademartiri Filippo, Callister Tracy Q, Chang Hyuk-Jae, Cheng Victor, Chinnaiyan Kavitha, Chow Benjamin J W, Delago Augustin, Hadamitzky Martin, Hausleiter Joerg, Kaufmann Philipp, Maffei Erica, Raff Gilbert, Shaw Leslee J, Villines Todd, Berman Daniel S, and CONFIRM Investigators

Abstract

OBJECTIVES We examined mortality in relation to coronary artery disease (CAD) as assessed by =64 detector row coronary computed tomography angiography (CCTA). BACKGROUND Although CCTA has demonstrated high diagnostic performance for detection and exclusion of obstructive CAD the prognostic findings of CAD by CCTA have not to date been examined for age and sex specific outcomes. METHODS We evaluated a consecutive cohort of 24775 patients undergoing =64 detector row CCTA between 2005 and 2009 without known CAD who met inclusion criteria. In these patients CAD by CCTA was defined as none (0 stenosis) mild (1 to 49 stenosis) moderate (50 to 69 stenosis) or severe (=70 stenosis). CAD severity was judged on a per patient per vessel and per segment basis. Time to mortality was estimated using multivariable Cox proportional hazards models. RESULTS At a 2.3 ± 1.1 year follow up 404 deaths had occurred. In risk adjusted analysis both per patient obstructive (hazard ratio [HR]: 2.60; 95 confidence interval [CI]: 1.94 to 3.49; p < 0.0001) and nonobstructive (HR: 1.60; 95 CI: 1.18 to 2.16; p = 0.002) CAD conferred increased risk of mortality compared with patients without evident CAD. Incident mortality was associated with a dose response relationship to the number of coronary vessels exhibiting obstructive CAD with increasing risk observed for nonobstructive (HR: 1.62; 95 CI: 1.20 to 2.19; p = 0.002) obstructive 1 vessel (HR: 2.00; 95 CI: 1.43 to 2.82; p < 0.0001) 2 vessel (HR: 2.92; 95 CI: 2.00 to 4.25; p < 0.0001) or 3 vessel or left main (HR: 3.70; 95 CI: 2.58 to 5.29; p < 0.0001) CAD. Importantly the absence of CAD by CCTA was associated with a low rate of incident death (annualized death rate: 0.28). When stratified by age

Published
2011
Full Text
View/download PDF

9. Prognostic and therapeutic implications of statin and aspirin therapy in individuals with nonobstructive coronary artery disease: results from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry) registry

Author

Chow, Benjamin JW, Small, Gary, Yam, Yeung, Chen, Li, McPherson, Ruth, Achenbach, Stephan, Al-Mallah, Mouaz, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Cheng, Victor Y, Chinnaiyan, Kavitha, Cury, Ricardo, Delago, Augustin, Dunning, Allison, Feuchtner, Gundrun, Hadamitzky, Martin, Hausleiter, Jörg, Karlsberg, Ronald P, Kaufmann, Philipp A, Kim, Yong-Jin, Leipsic, Jonathon, LaBounty, Troy, Lin, Fay, Maffei, Erica, Raff, Gilbert L, Shaw, Leslee J, Villines, Todd C, Min, James K, and CONFIRM Investigators

Subjects
Male, Time Factors, Coronary Artery Disease, Kaplan-Meier Estimate, Cardiorespiratory Medicine and Haematology, Coronary Angiography, Cardiovascular, Severity of Illness Index, Risk Factors, Odds Ratio, Registries, Prospective Studies, Tomography, screening and diagnosis, Middle Aged, X-Ray Computed, Primary Prevention, Europe, Detection, Treatment Outcome, Heart Disease, 6.1 Pharmaceuticals, Female, Patient Safety, 4.2 Evaluation of markers and technologies, Adult, Canada, Asia, aspirin, Clinical Sciences, CONFIRM Investigators, Predictive Value of Tests, Clinical Research, Humans, Heart Disease - Coronary Heart Disease, Proportional Hazards Models, Aged, Coronary Stenosis, statin, Evaluation of treatments and therapeutic interventions, coronary atherosclerosis, Protective Factors, Atherosclerosis, mortality, United States, Good Health and Well Being, Cardiovascular System & Hematology, Multivariate Analysis, prognosis, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Platelet Aggregation Inhibitors
Abstract

ObjectiveWe sought to examine the risk of mortality associated with nonobstructive coronary artery disease (CAD) and to determine the impact of baseline statin and aspirin use on mortality.Approach and resultsCoronary computed tomographic angiography permits direct visualization of nonobstructive CAD. To date, the prognostic implications of nonobstructive CAD and the potential benefit of directing therapy based on nonobstructive CAD have not been carefully examined. A total of 27 125 consecutive patients who underwent computed tomographic angiography (12 enrolling centers and 6 countries) were prospectively entered into the COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry. Patients, without history of previous CAD or obstructive CAD, for whom baseline statin and aspirin use was available were analyzed. Each coronary segment was classified as normal or nonobstructive CAD (1%-49% stenosis). Patients were followed up for a median of 27.2 months for all-cause mortality. The study comprised 10 418 patients (5712 normal and 4706 with nonobstructive CAD). In multivariable analyses, patients with nonobstructive CAD had a 6% (95% confidence interval, 1%-12%) higher risk of mortality for each additional segment with nonobstructive plaque (P=0.021). Baseline statin use was associated with a reduced risk of mortality (hazard ratio, 0.44; 95% confidence interval, 0.28-0.68; P=0.0003), a benefit that was present for individuals with nonobstructive CAD (hazard ratio, 0.32; 95% confidence interval, 0.19-0.55; P

Published
2015

10. Prognostic significance of calcified plaque among symptomatic patients with nonobstructive coronary artery disease

Author

Shah, Sana, Bellam, Naveen, Leipsic, Jonathon, Berman, Daniel S, Quyyumi, Arshed, Hausleiter, Jörg, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Fillippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chow, Benjamin JW, Cury, Ricardo C, Delago, Augustin J, Dunning, Allison L, Feuchtner, Gudrun M, Hadamitzky, Martin, Karlsberg, Ronald P, Kaufmann, Philipp A, Lin, Fay Y, Chinnaiyan, Kavitha M, Maffei, Erica, Raff, Gilbert L, Villines, Todd C, Gomez, Millie J, Min, James K, Shaw, Leslee J, and CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry) Investigators

Subjects
Adult, Male, Internationality, Comorbidity, Cardiorespiratory Medicine and Haematology, Cardiovascular, Risk Assessment, Sensitivity and Specificity, Coronary calcification, Age Distribution, Clinical Research, Prevalence, 80 and over, Animals, Humans, Registries, Sex Distribution, Radionuclide Imaging, Vascular Calcification, Heart Disease - Coronary Heart Disease, nonobstructive coronary artery disease, Proportional Hazards Models, Aged, screening and diagnosis, Prevention, Coronary Stenosis, Reproducibility of Results, An InteRnational Multicenter Registry) Investigators [CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes], Middle Aged, Prognosis, Atherosclerosis, Survival Rate, Causality, Detection, Heart Disease, Good Health and Well Being, Cardiovascular System & Hematology, Cats, Female, Symptom Assessment, 4.2 Evaluation of markers and technologies
Abstract

BackgroundCoronary artery calcium (CAC) is a well-established predictor of clinical outcomes for population screening. Limited evidence is available as to its predictive value in symptomatic patients without obstructive coronary artery disease (CAD). The aim of the current study was to assess the prognostic value of CAC scores among symptomatic patients with nonobstructive CAD.MethodsFrom the COronary Computed Tomographic Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry, 7,200 symptomatic patients with nonobstructive CAD (0% but

Published
2014

11. Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial

Author

Maggioni, Aldo P., Greene, Stephen J., Fonarow, Gregg C., Böhm, Michael, Zannad, Faiez, Solomon, Scott D., Lewis, Eldrin F., Baschiera, Fabio, Hua, Tsushung A., Gimpelewicz, Claudio R., Lesogor, Anastasia, Gheorghiade, Mihai, Ramos, Silvina, Luna, Alejandra, Miriuka, Santiago, Diez, Mirta, Perna, Eduardo, Luquez, Hugo, Pinna, Jorge Garcia, Castagnino, Jorge, Alvarenga, Pablo, Ibañez, Julio, Blumberg, Eduardo Salmon, Dizeo, Claudio, Guerrero, Rodolfo Ahuad, Schygiel, Pablo, Milesi, Rodolfo, Sosa, Carlos, Hominal, Miguel, Marquez, Lilia Lobo, Poy, Carlos, Hasbani, Eduardo, Vico, Marisa, Fernandez, Alberto, Vita, Nestor, Vanhaecke, Johan, De Keulenaer, Gilles, Striekwold, Harry, Vervoort, Geert, Vrolix, Mathias, Henry, Philippe, Dendale, Paul, Smolders, Walter, Marechal, Patrick, Vandekerckhove, Hans, Oliveira, Mucio, Neuenschwande, Fernando, Reis, Gilmar, Saraiva, Jose, Bodanese, Luiz, Canesin, Manoel, Greco, Oswaldo, Bassan, Roberto, Marino, Roberto Luis, Giannetti, Nadia, Moe, Gordon, Sussex, Bruce, Sheppard, Richard, Huynh, Thao, Stewart, Robert, Haddad, Haissam, Echeverria, Luis, Quintero, Adalberto, Torres, Adriana, Jaramillo, Mónica, Lopez, Mónica, Mendoza, Fernan, Florez, Noel, Cotes, Carlos, Garcia, Magali, Belohlavek, Jan, Hradec, Jaromir, Peterka, Martin, Gregor, Pavel, Monhart, Zdenek, Jansky, Petr, Kettner, Jiri, Reichert, Petr, Spinar, Jindrich, Brabec, Tomas, Hutyra, Martin, Solar, Miroslav, Pietilä, Mikko, Nyman, Kai, Pajari, Risto, Cohen, Ariel, Galinier, Michel, Gosse, Philippe, Livarek, Bernard, Neuder, Yannick, Jourdain, Patrick, Picard, François, Isnard, Richard, Hoppe, Uta, Kaeaeb, Stefan, Rosocha, Stefan, Prondzinsky, Roland, Felix, Stephan, Duengen, Hans-Dirk, Figulla, Hans-Reiner, Fischer, Sven, Behrens, Steffen, Stawowy, Philipp, Kruells-Muench, Juergen, Knebel, Fabian, Nienaber, Christoph, Werner, Dierk, Aron, Wilma, Remppis, Bjoern, Hambrecht, Rainer, Kisters, Klaus, Werner, Nikos, Hoffmann, Stefan, Rossol, Siegbert, Geiss, Ernst, Graf, Kristof, Hamann, Frank, von Scheidt, Wolfgang, Schwinger, Robert, Tebbe, Ulrich, Costard-Jaeckle, Angelika, Lueders, Stephan, Heitzer, Thomas, Leutermann-Oei, Marie-Louise, Braun-Dullaeus, Ruediger, Roehnisch, Jens-Uwe, Muth, Gerhard, Goette, Andreas, Rotter, Achim, Ebelt, Henning, Olbrich, Hans-Georg, Mitrovic, Veselin, Hengstenberg, Christian, Schellong, Sebastian, Zamolyi, Karoly, Vertes, Andras, Matoltsy, Andras, Palinkas, Attila, Herczeg, Bela, Apro, Dezso, Lupkovics, Geza, Tomcsanyi, Janos, Toth, Kalman, Mathur, Atul, Banker, Darshan, Bharani, Anil, Arneja, Jaspal, Khan, Aziz, Gadkari, Milind, Hiremath, Jagdish, Patki, Nitin, Kumbla, Makund, Santosh, M.J., Ravikishore, A.G., Abhaichand, Rajpal, Maniyal, Vijayakukmar, Nanjappa, Manjunath, Reddy, P. Naveen, Chockalingam, Kulasekaran, Premchand, Rajendra, Mahajan, Vijay, Lewis, Basil, Wexler, Dov, Shochat, Michael, Keren, Andre, Omary, Muhamad, Katz, Amos, Marmor, Alon, Lembo, Giuseppe, Di Somma, Salvatore, Boccanelli, Alessandro, Barbiero, Mario, Pajes, Giuseppe, De Servi, Stefano, Greco, Dott Cosimo, De Santis, Fernando, Floresta, Agata, Visconti, Luigi Oltrona, Piovaccari, Giancarlo, Cavallini, Claudio, Di Biase, Matteo, Masini, Dott Franco, Vassanelli, Corrado, Viecca, Maurizio, Cangemi, Dott Francesco, Pirelli, Salvatore, Borghi, Claudio, Volpe, Massimo, Branzi, Angelo, Percoco, Dott Giovanni, Severi, Silvia, Santini, Alberto, De Lorenzi, Ettore, Metra, Marco, Zacà, Valerio, Mortara, Andrea, Tranquilino, Francisco P., Babilonia, Noe A., Ferrolino, Arthur M., Manlutac, Benjamin, Dluzniewski, Miroslaw, Dzielinska, Zofia, Nowalany-Kozie, Ewa, Mazurek, Walentyna, Wierzchowiecki, Jerzy, Wysokinski, Andrzej, Szachniewicz, Joanna, Romanowski, Witold, Krauze-Wielicka, Magdalena, Jankowski, Piotr, Berkowski, Piotr, Szelemej, Roman, Kleinrok, Andrzej, Kornacewicz-Jac, Zdzislawa, Vintila, Marius, Vladoianu, Mircea, Militaru, Constantin, Dan, Gheorghe, Dorobantu, Maria, Dragulescu, Stefan, Kostenko, Victor, Vishnevsky, Alexandr, Goloschekin, Boris, Tyrenko, Vadim, Gordienko, Alexander, Kislyak, Oxana, Martsevich, Sergey, Kuchmin, Alexey, Karpov, Yurii, Fomin, Igor, Shvarts, Yury, Orlikova, Olga, Ershova, Olga, Berkovich, Olga, Sitnikova, Maria, Pakhomova, Inna, Boldueva, Svetlana, Tyurina, Tatiana, Simanenkov, Vladimir, Boyarkin, Mikhail, Novikova, Nina, Tereschenko, Sergey, Zadionchenko, Vladimir, Shogenov, Zaur, Gordeev, Ivan, Moiseev, Valentin, Wong, Raymond, Ong, Hean Yee, Le Tan, Ju, Goncalvesova, Eva, Kovar, Frantisek, Skalina, Ivan, Kasperova, Viera, Hojerova, Silvia, Szentivanyi, Miroslav, Stancak, Branislav, Babcak, Marian, Kycina, Peter, Poliacik, Pavol, Toth, Peter, Sirotiakova, Jana, de Sa, Esteban Lopez, Bueno, Manuel Gomez, Selles, Manuel Martinez, Cabrera, Jose Angel, Freire, Ramon Bover, Gonzalez Juanatey, Jose Ramon, Comin, Josep, Soriano, FranciscoRidocci, Lopez, Alejandro, Vicho, Raul, Lama, Manuel Geraldia, Schaufelberger, Maria, Brunotte, Richard, Ullman, Bengt, Hagerman, Inger, Cizinsky, Stella, Cherng, Wen-Jin, Yu, Wen-Chung, Kuo, Chi-Tai, Chang, Kuan-Cheng, Lai, Wen-Ter, Kuo, Jen-Yuan, Ural, Dilek, Badak, Ozer, Akin, Mustafa, Yigit, Zerrin, Yokusoglu, Mehmet, Yilmaz, Mehmet, Abaci, Adnan, Ebinc, Haksun, Perlman, Richard, Parish, David, Bergin, James, Burnham, Kenneth, Brown, Christopher, Lundbye, Justin, Williams, Celeste, Eisen, Howard, Juneman, Elizabeth, Joseph, Susan, Peberdy, Mary Ann, Peura, Jennifer, Gupta, Vishal, Habet, Kalim, French, William, Mody, Freny, Graham, Susan, Hazelrigg, Monica, Chung, Eugene, Dunlap, Stephanie, Nikolaidis, Lazaros, Najjar, Samer, Katz, Richard, Murali, Srinivas, Izzo, Joseph L., Callister, Tracy, Phillips, Roland, Lippolis, Nicholas, Winterton, John, Meymandi, Sheba, Heilman, Karl, Oren, Ron, Zolty, Ronald, Brottman, Michael, Gunawardena, D.R., Adams, Kirkwood, Barnard, Denise, Klapholz, Marc, Fulmer, James, Maggioni AP, Greene SJ, Fonarow GC, Böhm M, Zannad F, Solomon SD, Lewis EF, Baschiera F, Hua TA, Gimpelewicz CR, Lesogor A, Gheorghiade M, Ramos S, Luna A, Miriuka S, Diez M, Perna E, Luquez H, Pinna JG, Castagnino J, Alvarenga P, Ibañez J, Blumberg ES, Dizeo C, Guerrero RA, Schygiel P, Milesi R, Sosa C, Hominal M, Marquez LL, Poy C, Hasbani E, Vico M, Fernandez A, Vita N, Vanhaecke J, De Keulenaer G, Striekwold H, Vervoort G, Vrolix M, Henry P, Dendale P, Smolders W, Marechal P, Vandekerckhove H, Oliveira M, Neuenschwande F, Reis G, Saraiva J, Bodanese L, Canesin M, Greco O, Bassan R, Marino RL, Giannetti N, Moe G, Sussex B, Sheppard R, Huynh T, Stewart R, Haddad H, Echeverria L, Quintero A, Torres A, Jaramillo M, Lopez M, Mendoza F, Florez N, Cotes C, Garcia M, Belohlavek J, Hradec J, Peterka M, Gregor P, Monhart Z, Jansky P, Kettner J, Reichert P, Spinar J, Brabec T, Hutyra M, Solar M, Pietilä M, Nyman K, Pajari R, Cohen A, Galinier M, Gosse P, Livarek B, Neuder Y, Jourdain P, Picard F, Isnard R, Hoppe U, Kaeaeb S, Rosocha S, Prondzinsky R, Felix S, Duengen HD, Figulla HR, Fischer S, Behrens S, Stawowy P, Kruells-Muench J, Knebel F, Nienaber C, Werner D, Aron W, Remppis B, Hambrecht R, Kisters K, Werner N, Hoffmann S, Rossol S, Geiss E, Graf K, Hamann F, von Scheidt W, Schwinger R, Tebbe U, Costard-Jaeckle A, Lueders S, Heitzer T, Leutermann-Oei ML, Braun-Dullaeus R, Roehnisch JU, Muth G, Goette A, Rotter A, Ebelt H, Olbrich HG, Mitrovic V, Hengstenberg C, Schellong S, Zamolyi K, Vertes A, Matoltsy A, Palinkas A, Herczeg B, Apro D, Lupkovics G, Tomcsanyi J, Toth K, Mathur A, Banker D, Bharani A, Arneja J, Khan A, Gadkari M, Hiremath J, Patki N, Kumbla M, Santosh MJ, Ravikishore AG, Abhaichand R, Maniyal V, Nanjappa M, Reddy PN, Chockalingam K, Premchand R, Mahajan V, Lewis B, Wexler D, Shochat M, Keren A, Omary M, Katz A, Marmor A, Lembo G, Di Somma S, Boccanelli A, Barbiero M, Pajes G, De Servi S, Greco DC, De Santis F, Floresta A, Visconti LO, Piovaccari G, Cavallini C, Di Biase M, Masini DF, Vassanelli C, Viecca M, Cangemi DF, Pirelli S, Borghi C, Volpe M, Branzi A, Percoco DG, Severi S, Santini A, De Lorenzi E, Metra M, Zacà V, Mortara A, Tranquilino FP, Babilonia NA, Ferrolino AM, Manlutac B, Dluzniewski M, Dzielinska Z, Nowalany-Kozie E, Mazurek W, Wierzchowiecki J, Wysokinski A, Szachniewicz J, Romanowski W, Krauze-Wielicka M, Jankowski P, Berkowski P, Szelemej R, Kleinrok A, Kornacewicz-Jac Z, Vintila M, Vladoianu M, Militaru C, Dan G, Dorobantu M, Dragulescu S, Kostenko V, Vishnevsky A, Goloschekin B, Tyrenko V, Gordienko A, Kislyak O, Martsevich S, Kuchmin A, Karpov Y, Fomin I, Shvarts Y, Orlikova O, Ershova O, Berkovich O, Sitnikova M, Pakhomova I, Boldueva S, Tyurina T, Simanenkov V, Boyarkin M, Novikova N, Tereschenko S, Zadionchenko V, Shogenov Z, Gordeev I, Moiseev V, Wong R, Ong HY, Le Tan J, Goncalvesova E, Kovar F, Skalina I, Kasperova V, Hojerova S, Szentivanyi M, Stancak B, Babcak M, Kycina P, Poliacik P, Toth P, Sirotiakova J, Lopez de Sa E, Bueno MG, Selles MM, Cabrera JA, Freire RB, Gonzalez Juanatey JR, Comin J, Soriano F, Lopez A, Vicho R, Lama MG, Schaufelberger M, Brunotte R, Ullman B, Hagerman I, Cizinsky S, Cherng WJ, Yu WC, Kuo CT, Chang KC, Lai WT, Kuo JY, Ural D, Badak O, Akin M, Yigit Z, Yokusoglu M, Yilmaz M, Abaci A, Ebinc H, Perlman R, Parish D, Bergin J, Burnham K, Brown C, Lundbye J, Williams C, Eisen H, Juneman E, Joseph S, Peberdy MA, Peura J, Gupta V, Habet K, French W, Mody F, Graham S, Hazelrigg M, Chung E, Dunlap S, Nikolaidis L, Najjar S, Katz R, Murali S, Izzo JL, Callister T, Phillips R, Lippolis N, Winterton J, Meymandi S, Heilman K, Oren R, Zolty R, Brottman M, Gunawardena DR, Adams K, Barnard D, Klapholz M, and Fulmer J

Subjects
Male, medicine.medical_specialty, Cardiotonic Agents, ASTRONAUT, Diabetic Cardiomyopathies, Administration, Oral, Kaplan-Meier Estimate, Placebo, Diabete, chemistry.chemical_compound, Double-Blind Method, Fumarates, Internal medicine, Diabetes mellitus, Troponin I, Renin, Clinical endpoint, medicine, Humans, Prospective Studies, Heart Failure, Ejection fraction, business.industry, Surrogate endpoint, Aliskiren, Middle Aged, medicine.disease, Amides, Hospitalization, Endocrinology, Death, Sudden, Cardiac, Treatment Outcome, chemistry, Heart failure, Female, Cardiology and Cardiovascular Medicine, business, aliskiren
Abstract

Aims The objective of the Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT) was to determine whether alis- kiren, a direct renin inhibitor, would improve post-discharge outcomes in patients with hospitalization for heart failure (HHF) with reduced ejection fraction. Pre-specified subgroup analyses suggested potential heterogeneity in post- discharge outcomes with aliskiren in patients with and without baseline diabetes mellitus (DM). Methods and results ASTRONAUT included 953 patients without DM (aliskiren 489; placebo 464) and 662 patients with DM (aliskiren 319; placebo 343) (as reported by study investigators). Study endpoints included the first occurrence of cardiovascular death or HHF within 6 and 12 months, all-cause death within 6 and 12 months, and change from baseline in N-terminal pro-B- type natriuretic peptide (NT-proBNP) at 1, 6, and 12 months. Data regarding risk of hyperkalaemia, renal impairment, and hypotension, and changes in additional serum biomarkers were collected. The effect of aliskiren on cardiovascular death or HHF within 6 months (primary endpoint) did not significantly differ by baseline DM status (P ¼ 0.08 for interaction), but reached statistical significance at 12 months (non-DM: HR: 0.80, 95% CI: 0.64-0.99; DM: HR: 1.16, 95% CI: 0.91-1.47; P ¼ 0.03 for interaction). Risk of 12-month all-cause death with aliskiren significantly differed by the presence of baseline DM (non-DM: HR: 0.69, 95% CI: 0.50-0.94; DM: HR: 1.64, 95% CI: 1.15-2.33; P , 0.01 for interaction). Among non-diabetics, aliskiren significantly reduced NT-proBNP through 6 months and plasma troponin I and aldosterone through 12 months, as compared to placebo. Among diabetic patients, aliskiren reduced plasma troponin I and aldoster- one relative to placebo through 1 month only. There was a trend towards differing risk of post-baseline potassium ≥6 mmol/L with aliskiren by underlying DM status (non-DM: HR: 1.17, 95% CI: 0.71-1.93; DM: HR: 2.39, 95% CI: 1.30-4.42; P ¼ 0.07 for interaction). Conclusion This pre-specified subgroup analysis from the ASTRONAUT trial generates the hypothesis that the addition of aliskiren to standard HHF therapy in non-diabetic patients is generally well-tolerated and improves post-discharge outcomes and biomarker profiles. In contrast, diabetic patients receiving aliskiren appear to have worse post-discharge outcomes. Future prospective investigations are needed to confirm potential benefits of renin inhibition in a large cohort of HHF patients without DM.

Published
2013

12. Differences in Prevalence, Extent, Severity, and Prognosis of Coronary Artery Disease Among Patients With and Without Diabetes Undergoing Coronary Computed Tomography Angiography Results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes): an InteRnational Multicenter Registry

Author

Rana, Jamal S, Dunning, Allison, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Cheng, Victor Y, Chinnaiyan, Kavitha, Chow, Benjamin JW, Cury, Ricardo, Delago, Augustin, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Jörg, Kaufmann, Philipp, Karlsberg, Ronald P, Kim, Yong-Jin, Leipsic, Jonathon, Labounty, Troy M, Lin, Fay Y, Maffei, Erica, Raff, Gilbert, Villines, Todd C, Shaw, Leslee J, Berman, Daniel S, Min, James K, Radiology & Nuclear Medicine, University of Zurich, and Min, James K

Subjects
Male, 2902 Advanced and Specialized Nursing, 610 Medicine & health, Coronary Artery Disease, Coronary Angiography, Cardiovascular, Medical and Health Sciences, Endocrinology & Metabolism, SDG 3 - Good Health and Well-being, Clinical Research, Diabetes Mellitus, Prevalence, Humans, Heart Disease - Coronary Heart Disease, Aged, screening and diagnosis, Prevention, Diabetes, 10181 Clinic for Nuclear Medicine, Middle Aged, Prognosis, Atherosclerosis, Detection, 2712 Endocrinology, Diabetes and Metabolism, Heart Disease, Good Health and Well Being, 2724 Internal Medicine, Biomedical Imaging, Female, 4.2 Evaluation of markers and technologies
Abstract

ObjectiveWe examined the prevalence, extent, severity, and prognosis of coronary artery disease (CAD) in individuals with and without diabetes (DM) who are similar in CAD risk factors.Research design and methodsWe identified 23,643 consecutive individuals without known CAD undergoing coronary computed tomography angiography. A total of 3,370 DM individuals were propensity matched in a 1-to-2 fashion to 6,740 unique non-DM individuals. CAD was defined as none, nonobstructive (1-49% stenosis), or obstructive (≥ 50% stenosis). All-cause mortality was assessed by risk-adjusted Cox proportional hazards models.ResultsAt a 2.2-year follow-up, 108 (3.2%) and 115 (1.7%) deaths occurred among DM and non-DM individuals, respectively. Compared with non-DM individuals, DM individuals possessed higher rates of obstructive CAD (37 vs. 27%) and lower rates of having normal arteries (28 vs. 36%) (P < 0.0001). CAD extent was higher for DM versus non-DM individuals for obstructive one-vessel disease (19 vs. 14%), two-vessel disease (9 vs. 7%), and three-vessel disease (9 vs. 5%) (P < 0.0001 for comparison), with higher per-segment stenosis in the proximal and mid-segments of every coronary artery (P < 0.001 for all). Compared with non-DM individuals with no CAD, risk of mortality for DM individuals was higher for those with no CAD (hazard ratio 3.63 [95% CI 1.67-7.91]; P = 0.001), nonobstructive CAD (5.25 [2.56-10.8]; P < 0.001), one-vessel disease (6.39 [2.98-13.7]; P < 0.0001), two-vessel disease (12.33 [5.622-27.1]; P < 0.0001), and three-vessel disease (13.25 [6.15-28.6]; P < 0.0001).ConclusionsCompared with matched non-DM individuals, DM individuals possess higher prevalence, extent, and severity of CAD. At comparable levels of CAD, DM individuals experience higher risk of mortality compared with non-DM individuals.

Published
2012

13. Incremental prognostic value of cardiac computed tomography in coronary artery disease using CONFIRM: COroNary computed tomography angiography evaluation for clinical outcomes: an InteRnational Multicenter registry

Author

Chow Benjamin J W, Small Gary, Yam Yeung, Chen Li, Achenbach Stephan, Al-Mallah Mouaz, Berman Daniel S, Budoff Matthew J, Cademartiri Filippo, Callister Tracy Q, Chang Hyuk-Jae, Cheng Victor, Chinnaiyan Kavitha M, Delago Augustin, Dunning Allison, Hadamitzky Martin, Hausleiter Jörg, Kaufmann Philipp, Lin Fay, Maffei Erica, Raff Gilbert L, Shaw Leslee J, Villines Todd C, Min James K, CONFIRM Investigators, University of Zurich, and Chow, B J W

Subjects
Male, medicine.medical_specialty, Time Factors, 610 Medicine & health, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Global Health, Risk Assessment, Severity of Illness Index, 2705 Cardiology and Cardiovascular Medicine, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, Cause of Death, Severity of illness, 2741 Radiology, Nuclear Medicine and Imaging, Medicine, Humans, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, 030212 general & internal medicine, Myocardial infarction, Prospective Studies, Registries, Proportional Hazards Models, Ejection fraction, business.industry, Incidence, Hazard ratio, 10181 Clinic for Nuclear Medicine, Middle Aged, medicine.disease, Prognosis, Confidence interval, 3. Good health, Transplantation, ROC Curve, Predictive value of tests, Cardiology, Female, Radiology, Cardiology and Cardiovascular Medicine, business, Tomography, X-Ray Computed, Follow-Up Studies
Abstract

Background— Large multicenter studies validating the prognostic value of coronary computed tomographic angiography (CCTA) and left ventricular ejection fraction (LVEF) are lacking. We sought to confirm the independent and incremental prognostic value of coronary artery disease (CAD) severity measured using 64-slice CCTA over LVEF and clinical variables. Methods and Results— A large international multicenter registry (CONFIRM Registry) was queried, and CCTA patients with LVEF data on CCTA were screened. Patients with a history of myocardial infarction, coronary revascularization, or cardiac transplantation were excluded. The National Cholesterol Education Program-Adult Treatment Panel III risk was calculated for each patient, and CCTA was evaluated for CAD severity (normal, nonobstructive, non–high-risk, or high-risk CAD) and LVEF Conclusions— Our results demonstrate that CCTA measures of CAD severity and LVEF have independent prognostic value. Incorporation of CAD severity provides incremental value for predicting all-cause death over routine clinical predictors and LVEF in patients with suspected obstructive CAD.

Published
2011

14. Reply

Author

Min, James K., Shaw, Leslee J., Devereux, Richard B., Okin, Peter M., Weinsaft, Jonathan W., Russo, Donald J., Lippolis, Nicholas J., Berman, Daniel S., and Callister, Tracy Q.

Subjects
Cardiology and Cardiovascular Medicine
Published
2008
Full Text
View/download PDF

15. Rates and Predictors of Invasive Coronary Angiography and Coronary Revascularization Following Coronary Computed Tomographic Angiography: Results From 15,223 Patients within the CONFIRM Registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An InteRnational Multicenter Registry)

Author

Shaw, Leslee J., Berman, Daniel S., Achenbach, Stephan, Al-Mallah, Mouaz, Matthew Budoff, Cademartiri, Fillippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Cheng, Victor, Chow, Benjamin, Delago, Ausustin, Dunning, Allison, Hadamitzky, Martin, Hausleiter, Jorg, Kaufmann, Philipp, Lin, Fay, Maffei, Erica, Raff, Gilbert, Villines, Todd C., and Min, James K.

16. Abnormal Left ventricular Volumes Identified by Computed Tomography Improves Risk Stratification and Discrimination of Patients At Risk of Increased Mortality: Results from 3706 Patients in the Prospective Multicenter International CONFIRM Study

Author

Arsaniani, Reza, Labounty, Troy, Cheng, Victor Y., Lin, Fay Y., Achenbach, Stephen, Al-Mallah, Mouaz, Matthew Budoff, Cademartiri, Filippo, Callister, Tracy Q., Chinnaiyan, Kavitha, Chow, Benjamin J., Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Shaw, Leslee J., Villines, Todd C., Berman, Daniel S., and Min, James K.

17. Assessment of Coronary Artery Disease Severity by Coronary Computed Tomography Angiography for Reclassifying Statin Eligibility Based on 2013 American College of Cardiology/American Heart Association Guidelines in Asymptomatic Individual

Author

Han, Donghee, Hartaigh, Brain O., Gransar, Heidi, Lee, Ji Hyun, Rizvi, Asim, Baskaran, Lohendran, Schulman-Marcus, Joshua, Kaufmann, Philipp, Chow, Benjamin, Raff, Gilbert, Chinnaiyan, Kavitha, Filippo Cademartiri, Maffei, Erica, Villines, Todd, Kim, Yong-Jin, Leipsic, Jonathon, Feuchtner, Gudrun, Cury, Ricardo, Pontone, Gianluca, Andreini, Daniele, Callister, Tracy, Marques, Hugo, Rubinshtein, Ronen, Delago, Augustin, Berman, Daniel, Achenbach, Stephan, Shaw, Leslee, Hadamitzky, Martin, Hausleiter, Joerg, Dunning, Allison, Al-Mallah, Mouaz, Budoff, Matthew, Lin, Fay Y., Chang, Hyuk-Jae, and Min, James K.

18. Risk of Myocardial Infarction Among Women versus Men With Nonobstructive Left Main Coronary Artery Disease

Author

Xie, Joe X., Varghese, Tina, Mehta, Puja K., Leipsic, Jonathon, Merz, C. Noel Bairey, Berman, Daniel S., Matthew Budoff, Achenbach, Stephan, Dunning, Allison, Gransar, Heidi, Callister, Tracy Q., Delago, Augustin, Marques, Hugo, Rubinshtein, Ronen, Al-Mallah, Mouaz H., Andreini, Daniele, Pontone, Gianluca, Cademartiri, Filippo, Maffei, Erica, Chinnaiyan, Kavitha Kavitha, Raff, Gilbert, Hadamitzky, Martin, Hausleiter, Joerg, Feuchtner, Gudrun, Kim, Yong-Jin, Kaufmann, Philipp A., Villines, Todd C., Chow, Benjamin, Min, James K., and Shaw, Leslee J.

19. Potential Benefit of Statin Therapy in Patients with Non-Obstructive Coronary Artery Disease

Author

Chow, Benjamin J., Small, Gary R., Achenbach, Stephan, Al-Mallah, Mouaz, Berman, Daniel, Matthew Budoff, Cademartiri, Filippo, Callister, Tracy, Chang, Hyuk-Jae, Cheng, Victor Y., Chinnaiyan, Kavitha, Defago, Augustin, Dunning, Allison M., Gomez, Millie J., Hadamitzky, Martin, Hausleiter, Joerg, Karlsberg, Ronald P., Kaufmann, Phillip A., Labounty, Troy M., Lin, Fay Y., Maffei, Erica, Nasir, Khurram, Pencina, Micheal J., Raff, Gilbert L., Shaw, Leslee J., Villines, Todd C., and Min, James K.

20. Invasive Coronary Angiography, Revascularization, and Adverse Cardiac Events Following CCTA: A Matched Analysis of Women and Men in the Prospective Multinational CONFIRM Registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry)

Author

Lin, Fay Y., Shaw, Leslee J., Dunning, Allison M., Chinnaiyan, Kavitha, Achenbach, Stephan, Al-Mallah, Mouaz, Berman, Daniel S., Matthew Budoff, Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor Y., Chow, Benjamin J., Delago, Augustin J., Hadamitzky, Martin, Hausleiter, Joerg, Karlsberg, Ronald P., Kaufmann, Philipp A., Leipsic, Jonathon, Maffei, Erica, Raff, Gilbert L., Villines, Todd C., and Min, James K.

21. RELATIONSHIP BETWEEN LOW- AND HIGH-DENSITY LIPOPROTEINS AND CORONARY PLAQUE COMPOSITION: RESULTS FROM CONFIRM (CORONARY CT ANGIOGRAPHY EVALUATION FOR CLINICAL OUTCOMES: AN INTERNATIONAL MULTICENTER REGISTRY)

Author

Nakazato, Ryo, Berman, Daniel, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew, Filippo Cademartiri, Callister, Tracy, Cheng, Victor, Chinnaiyan, Kavitha, Chow, Benjamin, Delago, Augustin, Dunning, Allison, Feuchtner, Gudrun, Gomez, Millie, Gransar, Heidi, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Lin, Fay, Raff, Gilbert, Shaw, Leslee, Villines, Todd, Labounty, Troy, and Min, James

22. Absence of Coronary Artery Disease by Coronary Computed Tomographic Angiography and the Warranty Period Associated With All-Cause Mortality: Findings From the CONFIRM Long-Term Follow-Up Registry

Author

Cho, Lksung, Hartaigh, Briain O., Gransar, Heidi, Marcus, Joshua Schulman, Valenti, Valentina, Berman, Daniel S., Matthew Budoff, Achenbach, Stephan, Al-Mallah, Mouaz, Andreini, Daniele, Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Cury, Ricardo, Delago, Augustin, Gomez, Millie, Hadamitzky, Martin, Hausleiter, Joerg, Hindoyan, Niree, Feuchtner, Gudrun, Kim, Yong-Jin, Kaufmann, Philipp A., Leipsic, Jonathon, Lin, Fay Y., Maffei, Erica, Pontone, Gianluca, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison, and Min, James K.

23. Mortality Risk and Therapeutic Benefit of Coronary Revascularization versus Medical Therapy in 15,223 Patients Without Known Coronary Artery Disease Undergoing Coronary CT Angiography: Results from the CONFIRM Registry (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry)

Author

Min, James K., Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk J., Cheng, Victor Y., Chow, Benjamin J., Delago, Augustin J., Dunning, Allison M., Hadamitzky, Martin, Leipsic, Jonathon, Hausleiter, Joerg, Kaufmann, Philipp A., Lin, Fay Y., Erica Maffei, Raff, Gilbert L., Villines, Todd C., Shaw, Leslee J., and Berman, Daniel S.

24. Coronary Artery Disease Burden by Coronary CT Angiography Predicts Mortality and Myocardial Infarction Across Multiple Ethnicities: Results from the CONFIRM Registry

Author

Hulten, Edward, Villines, Todd C., Dunning, Allison L., Chinnaiyan, Kavitha, Achenbach, Stephan, Al-Mallah, Mouaz, Berman, Daniel, Matthew Budoff, Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor Y., Chow, Benjamin J., Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A., Labounty, Troy, Lin, Fay Y., Maffei, Erica, Nasir, Khurram, Raff, Gil, Shaw, Leslee, and Min, James K.

25. Prognostic Value of Plaque Composition For the Prediction of Major Adverse Cardiovascular Events in Patients Without Known Coronary Artery Disease Undergoing 64-Detector Row Coronary CT Angiography: Results from 6,335 Patients in the Prospective Multinational CONFIRM Registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry

Author

Wilson, Sean R., Lin, Fay Y., Dunning, Allison M., Erica Maffei, Achenbach, Stephan, Al-Mallah, Mouaz, Berman, Daniel S., Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor Y., Chinnaiyan, Kavitha M., Chow, Benjamin J., Delago, Augustin, Gomez, Millie J., Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A., Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., and Min, James K.

26. Increased Body Mass Index is Associated with Greater Prevalence, Extent, and Severity of Coronary Artery Disease and Increased Adverse Events

Author

Labounty, Troy M., Gomez, Millie, Achenbach, Stephen, Al-Mallah, Mouaz, Berman, Daniel S., Matthew Budoff, Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor, Chinnaiyan, Kavitha M., Chow, Benjamin J., Delago, Augustin, Dunning, Allison M., Hadamitzky, Martin, Hausleiter, Joerg, Karlsberg, Ronald P., Kaufmann, Philipp A., Leipsic, Jonathon, Lin, Fay Y., Maffei, Erica, Raff, Gilbert, Shaw, Leslee J., Villines, Todd, and Min, James K.

27. Prevalence, Characteristics, and Early Treatment Strategies of Patients with Chronic Total Occlusions Undergoing Coronary Computed Tomography Angiography

Author

Opolski, Maksymilian P., Hartaigh, Briain O., Gransar, Heidi, Schulman-Marcus, Joshua, Truong, Quynh A., Berman, Daniel S., Budoff, Matthew J., Achenbach, Stephan, Al-Mallah, Mouaz, Andreini, Daniele, Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J., Cury, Ricardo, Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Feuchtner, Gudrun, Kim, Yong-Jin, Kaufmann, Philipp A., Leipsic, Jonathon, Lin, Fay Y., Erica Maffei, Pontone, Gianluca, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison, and Min, James K.

28. Incremental Prognostic Value of Coronary CT Angiography over Coronary Calcium Score in Symptomatic Patients with Suspected Coronary Disease: Results from the CONFIRM Registry (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry)

Author

Al-Mallah, Mouaz, Achenbach, Stephan, Berman, Daniel, Matthew Budoff, Cademartiri, Filippo, Callister, Tracy, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J., Delago, Augustin, Dunning, Allison, Gomez, Millie J., Hadamitzky, Martin, Hausleiter, Joerg, Karlsberg, Ronald P., Kaufmann, Philipp, Lin, Fay Y., Maffei, Erica, Min, James K., Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., and Cheng, Victor Y.

29. UTILIZATION OF READILY AVAILABLE CLINICAL CHARACTERISTICS FOR THE ESTIMATION OF THE CORONARY ARTERY CALCIUM SCORE

Author

Alaref, Subhi, Anchouche, Khalil, Wang, Hao, Kolli, Kranthi, Berman, Daniel, Callister, Tracy, Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Al-Mallah, Mouaz, Matthew Budoff, Kaufmann, Philipp, Raff, Gilbert, Chinnaiyan, Kavitha, Cademartiri, Filippo, Maffei, Erica, Villines, Todd C., Kim, Yong-Jin, Leipsic, Jonathon, GudrunFeuchtner, Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, Rubinshtein, Ronen, Achenbach, Stephan, Shaw, Leslee J., Dunning, Allison M., Gomez, Millie, Hindoyan, Niree, Lin, Fay Y., Pena, Jessica M., Min, James K., and Jones, Erica C.

30. Anatomical Data Defined by 64-Slice CT Angiography Predicts Prognosis of Coronary Artery by-Pass Patients More Accurately That Clinical Risk Predictors

Author

Small, Gary R., Yam, Yeung, Chen, Li, Ahmed, Osman, Al-Mallah, Mouaz, Berman, Daniel S., Cheng, Victor Y., Chinnaiyan, Kavitha, Raff, Gilbert L., Villines, Todd C., Achenbach, Stephan, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Delago, Augustin, Dunning, Allison, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Lin, Fay Y., Erica Maffei, Min, James K., Shaw, Leslee J., and Chow, Benjamin J.

31. Improvement in Discrimination and Risk Reclassification in Asymptomatic Individuals with Diabetes by Coronary Computed Tomographic Angiography

Author

Labounty, Troy M., Rana, Jamal, Achenbach, Stephen, Al-Mallah, Mouaz, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor, Chinnaiyan, Kavitha M., Chow, Benjamin J., Delago, Augustin, Dunning, Allison M., Gomez, Millie, Hadamitzky, Martin, Hausleiter, Joerg, Karlsberg, Ronald P., Kaufmann, Philipp A., Leipsic, Jonathon, Lin, Fay Y., Erica Maffei, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Berman, Daniel S., and Min, James K.

32. Effect of Non-Statin Lipid-Lowering Drug Therapy on Coronary Plaque Composition as Assessed by Coronary Computed Tomography Angiography

Author

Su, Amanda, Den Hoogen, Inge, Lu, Yao, Rizvi, Asim, Berman, Daniel, Callister, Tracy, Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Al-Mallah, Mouaz, Matthew Budoff, Kaufmann, Philipp, Raff, Gilbert, Chinnaiyan, Kavitha, Cademartiri, Filippo, Maffei, Erica, Villines, Todd, Kim, Yong-Jin, Leipsic, Jonathon, Feuchtner, Gudrun, Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, Rubinshtein, Ronen, Achenbach, Stephan, Shaw, Leslee, Dunning, Allison, Chang, Hyuk-Jae, Chow, Benjamin, Cury, Ricardo, Gomez, Millie, Hindoyan, Niree, Jones, Erica C., Pena, Jessica M., Lin, Fay Y., Min, James K., and Al Aref, Subhi J.

Catalog

Books, media, physical & digital resources
See catalog results