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Further phytochemical studies on the aerial parts of Phlomis viscosa (Lamiaceae) led to the isolation of 24 compounds: 3 iridoid glycosides, 10 phenylethanoid glycosides, a megastigmane glycoside and a hydroquinone glycoside, as well as 2 lignan glucosides and 7 neolignan glucosides, 1 of which is new (17b). Compound 17b was obtained as a minor component of an inseparable mixture (2:1) of 2 neolignan glucosides (17a/b), and characterized as 3',4-O-dimethylcedrusin 9-O-b -glucopyranoside. Full NMR data of the known 8-O-4' neolignan glucoside, erythro-1-(4-O-b-glucopyranosyl-3-methoxyphenyl)- 2-{2-methoxyl-4-[1-(E)-propene-3-ol]-phenoxyl}-propane-1,3-diol (18) are also reported. All isolated compounds were screened for cell growth inhibition versus 3 tumor cell lines (MCF7, NCI-H460, and SF-268) and several phenylethanoid glycosides were found to possess weak antitumoral activity. The phenylethanoid glycosides were also evaluated for their free radical (DPPH) scavenging, antibacterial and antifungal activities. The free radical (DPPH) scavenging activities of verbascoside (4), isoacteoside (5), forsythoside B (10), myricoside (13) and samioside (14) were found to be comparable to that of dl-a -tocopherol. Compounds 4, 5, 10 and 14 (MIC: 500 m g/mL) as well as Leucosceptoside A (8) and 13 (MIC:1000 m g/mL) showed very weak activity against Gram (+) bacteria.

Two new coumarin glycosides along with two known coumarin glycosides, daphnine and daphnetine glucoside were isolated from aerial parts of Cruciata taurica. The structures of the new compounds were elucidated by spectral methods and chemical means as 7-O-(6'-acetoxy-b-D-glucopyranosyl)- 8-hydroxycoumarin, and 7-O-[6'-O-(3'',4''-dihydroxycinnamoyl)-b-D- glucopyranosyl]-8-hydroxycoumarin. The phylogenetic significance of coumarins in C. taurica was discussed.

Two specimens of Euphrasia pectinata collected from different regions of northern Anatolia were studied to determine their iridoid and phenylethanoid glycosides. Four iridoid glucosides, aucubin (1), euphroside (2), ixorodoside (3), and boschnaloside (4), and two phenylethanoid glycosides, acteoside (5) and leucosceptoside A (6), were isolated, and characterized from the aerial parts of E. pectinata} collected from Zigana pass (Trabzon). From the aerial parts of E. pectinata} collected from Kartalkaya (Bolu), a phenethyl alcohol glycoside, decaffeoylacteoside (7), was isolated in addition to previously isolated compounds. The structures of the isolated compounds were established by spectroscopic evidence.

4th International Symposium on the Chemistry of Natural Compounds (SCNC) -- JUN 06-08, 2001 -- ISPARA, TURKEY, WOS: 000174668900010, The compositions of microdistilled and hydrodistilled essential oils of the mastix of Pistacia eurycarpa Yalt. (Anacardiaceae) were compared. The essential oils were analyzed by GC/MS: alpha- and beta-pinenes were found as the major constituents. The antimicrobial activity of the hydrodistilled oil was determined due to the ethnomedical uses of the oleo-gum resin on skin diseases.

… Soc Medicinal Plant Res

… Soc Medicinal Plant Res, Univ Helsinki,Fac Pharm

… Soc Medicinal Plant Res, Univ Helsinki,Fac Pharm