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Interstitial duplications of the short arm of the X chromosome have been rarely described, especially in males. Usually boys present mental retardation, multiple congenital abnormalities and short stature. We describe two sons one with a 2q37.3 deletion and a Xp11.4 duplication and the other with Xp11.4 duplication only, identified by array-CGH. They both presented a phenotype characterized by poor growth, mild facial dysmorphisms, autism and developmental delay. The 2q37.3 identified chromosomal anomaly was inherited from the healthy father and included approximately 8 known genes, while the Xp11.4 duplication resulted inherited from the healthy mother and involved 13 known genes. Of these TSPAN7 and CASK, localized on Xp11.4, genes are of special interest. The alteration on the X chromosome could be more related to the clinical feature presented by the two brothers, while the anomaly on the chromosome 2 is more likely a polymorphism or might influence the phenotype correlated to the Xp11.4 duplication. The healthy phenotype of the mother could be explained by X chromosome inactivation (XCI) phenomenon.

The aim of this paper is to analyse the best practices of a sample of manufacturing companies that have achieved lasting best performance in terms of solvency, growth and profitability. The paper analyses the correlation between size and qualitative-relational growth. Through cluster analysis, three groups of companies were defined with different levels of qualitative and relational contents. The cluster result is the dependent variable of an ordered logit regression, while the explanatory variables are performance and feature variables. The model confirms that size and growth in size significantly influence the probability of qualitative and relational contents in companies. Moreover, the results suggest that other relevant determinants are: management, location, export growth, type of make, and competitiveness factors. The research was funded by the Region of Piedmont and, consequently, focuses on the manufacturing companies located in this Italian region.

At macroeconomic level, the Italian competitiveness is very low: the main international rating agencies put our country in the lower positions of the rankings, at the same level of many less-developed-countries. If we analyse the structural characteristics and the economic performances of Italian firms, the differences with the main European countries are not sohigh. It seems that Italian firms have the internal resources to face with the structural adjustment requested by globalization. The efforts made by entrepreneurs in terms of high investments should be supported by product and financial market reforms.

At Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud (INFN-LNS) - the commissioning of the high intensity Proton Source for the European Spallation Source (PS-ESS) is under way. Preliminary results of plasma diagnostics collected on a testbench called "Flexible Plasma Trap" (FPT) will be correlated to the peculiarities of the magnetic system design and of the microwave injection setup with a view of the possible implications on the beam extraction system. The status of the costruction is presented., Proceedings of the 7th Int. Particle Accelerator Conf., IPAC2016, Busan, Korea