1. Serum suPAR levels help differentiate steroid resistance from steroid-sensitive nephrotic syndrome in children
- Author
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Weizhong Gu, Lizhong Du, Xuejun Chen, Huijun Shen, Aimin Liu, Qiang Shu, Xiujuan Zhu, Jianhua Mao, Xia Jin, Haidong Fu, Zhaoyang Peng, Cai Fengqing, and Jingjing Wang
- Subjects
Nephrology ,Male ,medicine.medical_specialty ,Nephrotic Syndrome ,Steroid-sensitive nephrotic syndrome ,Drug Resistance ,Gastroenterology ,Sensitivity and Specificity ,Receptors, Urokinase Plasminogen Activator ,Adrenal Cortex Hormones ,Internal medicine ,medicine ,Humans ,Age of Onset ,Child ,Immunoassay ,Proteinuria ,Receiver operating characteristic ,business.industry ,Area under the curve ,Infant ,Steroid resistance ,medicine.disease ,Endocrinology ,SuPAR ,ROC Curve ,Area Under Curve ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,business ,Nephrotic syndrome ,Biomarkers - Abstract
Soluble urokinase plasminogen activator receptor (suPAR) has been regarded as a permeability factor in proteinuria, though its role in primary nephrotic syndrome remains to be elucidated further. Plasma samples and clinical information from 176 children with primary nephrotic syndrome were collected and concentrations of suPAR were measured. We evaluated the correlation between suPAR concentrations and clinical features, and the value of the plasma suPAR level in predicting steroid-resistant nephrotic syndrome (SRNS). There is a significant difference in plasma suPAR concentration between SRNS and steroid-sensitive nephrotic syndrome (SSNS) groups (3,744.1 ± 2,226.0 vs. 2,153.5 ± 1,167.0, p
- Published
- 2014