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117 results on '"Cacciola, Emma"'

1. Ropeginterferon Alfa-2b Versus Standard Therapy for Low-Risk Patients with Polycythemia Vera. Final Results of Low-PV Randomized Phase II Trial

Author

Tiziano, Barbui, Alessandro Maria Vannucchi, Valerio De Stefano, Arianna, Masciulli, Alessandra, Carobbio, Arianna, Ghirardi, Greta, Carioli, Elena, Rossi, Fabio, Ciceri, Massimiliano, Bonifacio, Alessandra, Iurlo, Francesca, Palandri, Giulia, Benevolo, Fabrizio, Pane, Alessandra, Ricco, Giuseppe, Carli, Marianna, Caramella, Davide, Rapezzi, Caterina, Musolini, Sergio, Siragusa, Elisa, Rumi, Andrea, Patriarca, Nicola, Cascavilla, Barbara, Mora, Cacciola, Emma, Carmela, Mannarelli, Giuseppe Gaetano Loscocco, Paola, Guglielmelli, Francesca, Gesullo, Silvia, Betti, Francesca, Lunghi, Luigi, Scaffidi, Cristina, Bucelli, Nicola, Vianelli, Marta, Bellini, Maria Chiara Finazzi, Giovanni, Tognoni, and Alessandro, Rambaldi.

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

2. Hemocoagulative Modifications after Laparoscopic Surgery at Different Pneumoperitoneum Pressure Settings

Author

Intagliata, Eva, Vecchio, Rosario, Saitta, Cesare, Vizzini, Clarissa, Lo Presti, Federica, Cacciola Rossella, Rosaria, Cacciola, Emma, and Vecchio, Veronica

Subjects
Surgery
Abstract

Many of the effects of pneumoperitoneum on cardiovascular, respiratory and metabolic systems have been discussed in Literature, but very little is known about the variations of the hemocoagulative parameters in patients undergoing laparoscopic surgery. The purpose of this study is to analyze the variations of the hemocoagulative parameters in patients undergoing elective laparoscopic cholecystectomy for symptomatic gallbladder stones. An eventual statistically significant difference linked to different pressure settings of pneumoperitoneum will allow selecting a specific intrabdominal pressure for a more adequate treatment with a lower incidence of pneumoperitoneum related complications.The clinical trial was conducted on 43 patients assigned in two groups based on the intra-abdominal pressure: group A, 27 patients, 12 mmHg, and group B, 16 patients, 8 mmHg. Hemoglobin, hematocrit, platelets count, PT ratio, aPTT, Fibrinogen, D-dimer, Von Willebrand factor, Factor II, Lupus Anticoagulant, Antithrombin III, Protein C, Protein S, Anticardiolipin IgG and IgM, anti-beta 2-Glicoprotein IgG and IgM were evaluated.For group A, patient's variations were observed for D-dimer, Factor II, von Willembrand factor and protein C reactive, while for patients belonging to group B the parameters most affected were PT ratio, anti-thrombin III and protein C reactive.D-dimer values increased significantly in group A, a statistically significant decrease in anti-thrombin III levels was detected in group B, and a statistically significant difference in PT ratio in patients belonging to group B was observed.The statistical analysis showed no significant difference in the post-operative parameters when comparing the two groups of patients. Alterations of the coagulation parameters were present between pre- and post-operative data within the same group, namely a higher abdominal pressure is linked to a prothrombotic state. The question is worthy of further studies.- Variations of the hemocoagulative parameters in patients undergoing laparoscopy are still a matter of study;- Pneumoperitoneum seems to cause alterations in the hemocoagulative parameters, which could be influenced by the pneumoperitoneum pressure;- An eventual statistically significant difference linked to different pressure settings of pneumoperitoneum will allow selecting a specific intrabdominal pressure for a more adequate surgical treatment with a lower incidence of pneumoperitoneum related complications.

Published
2022

3. Laparoscopic surgery: A randomised controlled trial comparing intraoperative hemodynamic parameters and arterial-blood gas changes at two different pneumoperitoneal pressure values

Author

Intagliata Eva, Vecchio Rosario, Rosolia Guglielmo, Vizzini Clarissa, Lo Presti Federica, Cacciola Emma, Cacciola Rossella Rosaria, and Vecchio Veronica

Subjects
Surgery, General Medicine
Abstract

The benefits of laparoscopic surgery are well known. However, clinic and metabolic consequences of pneumoperitoneum, achieved by insufflation of gas carbon dioxide, are still debated. Cardiovascular system suffering due to the compression of intra-abdominal venous structures can cause life-threatening complications. Increased partial pressure of carbon dioxide induces metabolic acidosis with further vascular suffering. Pneumoperitoneum reduces the pulmonary exchange volumes and bring renal suffering.The aim of this study is to evaluate the alterations in hemodynamic and hemogasanalysis parameters during the laparoscopic surgery at different pressure settings of pneumoperitoneum in order to assess the best pressure value.We evaluated and compared intraoperative hemodynamic and hemogasanalytic alterations in two groups of patients respectively subdue to laparoscopic cholecystectomy at a pneumoperitoneum pressure of 12 mmHg (group A) and at a pressure of 8 mmHg (group B).In both groups, after the induction of anesthesia we observed a flexion in the heart rate, with no significant difference between the two groups. During the intervention, group A showed a significantly higher respiratory rate than the group B. The average blood pressure decreased mostly in group B. The oxygen saturation increased at the end of the procedure in group A, more than in the group B. The pH value was higher in group B. The hydrogen carbonate ion settled at lower levels in group A.Although significant differences between the two groups were appreciated on several parameters, they were never of such magnitude to prefer the induction of pneumoperitoneum at 8 mmHg.

Published
2022

5. Studies on Antiphospholipid Syndrome

Author

Cacciola Rossella, Gentilini Cacciola Elio, and Cacciola Emma

Subjects
Lupus anticoagulant, medicine.medical_specialty, Pregnancy, biology, business.industry, Autoantibody, Warfarin, medicine.disease, Thrombosis, Gastroenterology, Venous thrombosis, immune system diseases, Antiphospholipid syndrome, Internal medicine, medicine, biology.protein, Antibody, business, medicine.drug
Abstract

The antiphospholidid syndrome (APS) is a rare and poorly understood clinical condition with potentially devastating consequences. It is defined by the presence of so-called antiphospholipid antibodies (aPL). These autoantibodies are not directed against anionic phospholipids but rather against plasma proteins with high affinity for anionic phospholipids. The cardinal manifestations are arterial and venous thrombosis and pregnancy morbidity. Other manifestations include catastrophic APS or immune thrombocytopenia. The laboratory tests exploring the presence of aPL include lupus anticoagulant (LA), anticardiolipin (aCL), and anti-b-2-glycoprotein I (a-b2GPI) antibodies. Laboratory tests may be positive in different combinations and in individuals having positivity for all 3 laboratory tests (triple positivity) are at the highest risk for a first thrombotic event and recurrence. The indefinite anticoagulant treatment with warfarin prevent the thrombotic recurrences.

Published
2021

7. Ropeginterferon alfa-2b vs Phlebotomy in Low-Risk Patients with Polycythemia Vera (Low-PV): A Randomized Phase II Clinical Trial

Author

Tiziano, Barbui, Alessandro Maria Vannucchi, Valerio De Stefano, Arianna, Masciulli, Alessandra, Carobbio, Alberto, Ferrari, Arianna, Girardi, Elena, Rossi, Fabio, Ciceri, Massimiliano, Bonifacio, Alessandra, Iurlo, Francesca, Palandri, Giulia, Benevolo, Fabrizio, Pane, Alessandra, Ricco, Giuseppe, Carli, Marianna, Caramella, Davide, Rapezzi, Caterina, Musolino, Sergio, Siragusa, Elisa, Rumi, Andrea, Patriarca, Nicola, Cascavilla, Barbara, Mora, Cacciola, Emma, Carmela, Mannarelli, Giuseppe Gaetano Loscocco, Paola, Guglielmelli, Silvia, Betti, Francesca, Lunghi, Luigi, Scaffidi, Cristina, Bucelli, Nicola, Vianelli, Marta, Bellini, Maria Chiara Finazzi, Gianni, Tognoni, and Alessandro, Rambaldi

Published
2020

15. Elective laparoscopic cholecystectomy

Author

Rosario, Vecchio, Cacciola, Emma, MARCELLO DI MARTINO, Antonio, V, Gambelunghe, Murabito, Paolo, and Cacciola, Rossella Rosaria

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Gallbladder, General surgery, medicine.medical_treatment, Gallbladder Stone, Hepatology, medicine.disease, Sickle cell anemia, Surgery, medicine.anatomical_structure, Internal medicine, Medicine, Cholecystectomy, business, Complication, Laparoscopy, Abdominal surgery
Abstract

Background Gallbladder stones are very common in patients with sickle cell disease and are the cause of recurrent abdominal pain. Their management has been highly controversial, especially for children. Nonoperated patients and those treated on an emergency basis have a very high rate of morbidity (>50%).

Published
2001

19. Cytoreductive combination therapy in essential trhombocythemia: preliminary report of the Registro Italiano trombocitemia (RIT)

Author

Gugliotta, L, Scalzulli, P, Tighi, A, Codeluppi, K, Valvano, R, Candoni, A, Chiozzotto, E, Liberati, M, Apolloni, V, Specchia, G, Cacciola, Emma, Cacciola, Rossella Rosaria, Mastrullo, R, Villa, M, Prugnola, M, Martinelli, V, Ciancia, R, Mazzucconi, Mg, Santoro, C, Campana, P, Randi, Ml, De Biasi, E, Maschio, N, Lanza, F, Antonioli, E, Pierri, I, Di Ianni, M, Iurlo, A, Piccin, A, and Cascavilla, N.

Published
2012

21. Leukocytosis is a risk factor for recurrent arterial thrombosis in young patients with polycthemia vera and essential thrombocythemia

Author

Valerio De STefano, Tommaso, Za, Elena, Rossi, Vannucchi, Alessandro M., Marco, Rugeri, Elena, Elli, Caterina, Micò, Alessia, Tieghi, Cacciola, Rossella R., Cacciola, Emma, Cristinasantoro, Giancarla, Gerli, Paolo, Guglielmelli, Lisa, Pieri, Francesca, Scognamiglio, Francesco, Rodeghiero, Pogòiani, Enrico M., Guido, Finazzi, Luigi, Gugliotta, Giuseppe, Leone, Tiziano, Barbui, For the GIMEMA Chronic Myeloproliferative Neoplasms Working Party, De Stefano, V, Za, T, Rossi, E, Vannucchi, A, Ruggeri, M, Elli, E, Micò, C, Tieghi, A, Cacciola, R, Santoro, C, Gerli, G, Guglielmelli, P, Pieri, L, Scognamiglio, F, Rodeghiero, F, Pogliani, E, Finazzi, G, Gugliotta, L, Leone, G, and Barbui, T

Subjects
Male, Adult, medicine.medical_specialty, Adolescent, Leukocytosis, Gastroenterology, Leukocyte Count, Polycythemia vera, Risk Factors, Retrospective Studie, MED/15 - MALATTIE DEL SANGUE, Internal medicine, medicine, Humans, Age Factor, Risk factor, Polycythemia Vera, Retrospective Studies, Aged, Aged, 80 and over, Vascular disease, Essential thrombocythemia, business.industry, Risk Factor, Hazard ratio, Age Factors, Leukocytosis is a risk factor for recurrent arterial thrombosis in young patients with polycythemia vera and essential thrombocythemia, Thrombosis, Retrospective cohort study, Hematology, Middle Aged, medicine.disease, Surgery, Thrombosi, Female, medicine.symptom, business, Human, Thrombocythemia, Essential
Abstract

There is evidence that leukocytosis is associated with an increased risk of first thrombosis in patients with polycythemia vera (PV) and essential thrombocythemia (ET). Whether it is a risk factor for recurrent thrombosis too is currently unknown. In the frame of a multicenter retrospective cohort study, we recruited 253 patients with PV (n = 133) or ET (n = 120), who were selected on the basis of a first arterial (70%) or venous major thrombosis (27.6%) or both (2.4%), and who were not receiving cytoreduction at the time of thrombosis. The probability of recurrent thrombosis associated with the leukocyte count recorded at the time of the first thrombosis was estimated by a receiver operating characteristic analysis and a multivariable Cox proportional hazards regression model. Thrombosis recurred in 78 patients (30.7%); multivariable analysis showed an independent risk of arterial recurrence (hazard ratio [HR] 2.16, 95% CI 1.12-4.18) in patients with a leukocyte count that was >12.4 x 109/L at the time of the first thrombotic episode. The prognostic role for leukocytosis was age-related, as it was only significant in patients that were aged

Published
2010

22. Recurent thrombosis in patients with polycythemia vera and essential thrombocythemia: incidence, risk factors, and effect of treatments

Author

Valerio De Stefano, Tommaso, Za, Elena, Rossi, Vannucchi, Alessandro M., Marco, Ruggeri, Elena, Elli, Caterina, Micò, Alessia, Tieghi, Cacciola, Rossella R., Cacciola, Emma, Cristina, Santoro, Giancarla, Gerli, Nicola, Vianelli, Paola, Guglielmelli, Lisa, Pieri, Francesca, Scognamiglio, Francesco, Rodeghiero, Pogliani, Enrico M., Guido, Finazzi, Luigi, Gugliotta, Roberto, Marchioli, Giuseppe, Leone, and and Tiziano Barbui fore the GIMEMA CMD-Working Party

Published
2008

27. Peg Interferon a- 2b (Peg Intron) in essential Thrombocythemia

Author

Gugliotta, L, Bulgarelli, S, Vinelli, N, Russo, D, Gamberi, B, Candoni, A, Ruoli, S, Barulli, S, Latagliata, R, Frattarelli, N, Sacchi, S, Serbano, S, Martinelli, V, Ciancia, R, Molinari, A. L, DE BIASI, E, Bucalossi, A, Tabilio, A, Marcomigni, L, Passamonti, F, Miglino, M, Varaldo, R, Grossi, A, Cacciola, Emma, Cacciola, Rossella Rosaria, Pisapia, G, Gentili, S, Pogliani, E, Fincato, G, Baccarani, M., L., Gugliotta, S., Bulgarelli, N., Vianelli, D., Russo, B., Gamberi, A., Candoni, S., Rupoli, S., Barulli, R., Latagliata, N., Frattarelli, S., Sacchi, S., Nerbano, Martinelli, Vincenzo, R., Ciancia, A. L., Molinari, E., DE BIASI, A., Bucalossi, A., Tabilio, L., Marcamigni, F., Passamonti, M., Miglino, R., Varaldo, A., Grossi, E., Cacciola, R., Cacciola, G., Pisapia, S., Gentili, E., Pogliani, G., Fincato, and M., Baccarani

Abstract

BLOOD, VOL 100 N.RO 11

Published
2002

28. Peg-Interferon -2b in essential thrombocythemia: phase II study for de- termination of the minimum effective, safe and tolerated dose. Prelimina- ry data

Author

Gugliotta, L, Russo, D, Bulgarelli, S, Vianelli, N, Caglio, S, Martinelli, V, Sacchi, S, Rupoli, S, Passamonti, F, Bucalossi, A, De Biasi, E, Cacciola, Rossella Rosaria, Cacciola, Emma, Candoni, A, Valdrè, L, Ciancia, R, Barulli, L, Agostini, V, Finazzi, G, Latagliata, R, Tabilio, A, Marcomigni, L, Miglino, M, Palazzo, G, Molinari, A, Grossi, A, Mazzucconi, Mg, Gobbi, M, Martelli, M, Zaccaria, A, Mazza, P, Boccadoro, M, Giustolisi, R, Lauria, F, Lazzarino, M, Leoni, P, Rotoli, B, Fanin, R, Rossi Ferrini PL, Barbui, T, Mandelli, F, Fincato, G, and Baccarani, M.

Published
2001

31. Essential Thrombocythaemia: prognostic factors in the italian series of two thousand patients

Author

Gugliotta, L, Lazzarino, M, Marchioli R, R., Ambrosetti, A, Baravelli, S, Bazzan, M, Cacciola, Emma, Calori, R, Ciocca Vasino, A, De Vivo, A, Fiacchini, M, Finazzi, G, Gargantini, L, Grossi, A, Iannacaro, Pg, Leva, T, Magrini, U, Marfisi, Mr, Martinelli, V, Mazzucconi, Mg, Morelli, A, Novarino, A, Palmieri, F, Pogliani, E, Radaelli, F, Randi, L, Rege Cambrin, G, Ronco, F, Ruggeri, M, Rupoli, S, Russo, D, Sacchi, S, Valdrè, L, Vianelli, N, Rodeghiero, F, Barbui, T, and for the GIMMC, Tura S.

Published
1999

36. Trombocitemia essenziale: aspetti diagnostici e terapeutici nella casistica ita- liana

Author

Gugliotta, L, Vianelli, N, Baravelli, S, Fiacchini, M, Marchioli, R, Marfisi, Rm, Valdrè, L, Radaelli, F, Gargantini, L, Finazzi, G, Grossi, A, Zaccaria, A, Ambrosetti, A, Mazzucconi, Mg, Ruggeri, M, Cacciola, Emma, Randi, L, Bazzan, M, Morelli, A, Volpe, E, Martinelli, V, Fasano, A, Specchia, G, Pardini, S, Iannaccaro, P, Ronco, F, Russo, D, and per il GIMMC, Rupoli S. e. Lazzarino M.

Published
1997

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