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Introduction The Intolerance of Uncertainty Model (IUM) is a well-tested model of generalized anxiety disorder (GAD). Objective To test an extension of the IUM that suggests that intolerance of uncertainty (IU) contributes to worry not only by leading to a negative problem orientation, but also by leading to a negative emotion orientation. Method A total of two hundred and four non-clinical participants completed self-report measures. A structural equation model, which integrates the double role of negative orientation, was tested. Results The proposed model represents well the relationships between IU, negative problem orientation, limited access to emotion regulation strategies, and worry. Conclusion These preliminary results support the importance to study the relationships between IU and emotion regulation, and the need to develop an integrative theory of worry and GAD.

Author(s): Ajaj, R; Araujo, GR; Batygov, M; Beltran, B; Bina, CE; Boulay, MG; Broerman, B; Bueno, JF; Burghardt, PM; Butcher, A; Cai, B; Cardenas-Montes, M; Cavuoti, S; Chen, M; Chen, Y; Cleveland, BT; Dering, K; Duncan, FA; Dunford, M; Erlandson, A; Fatemighomi, N; Fiorillo, G; Flower, A; Ford, RJ; Gagnon, R; Gallacher, D; Garcia Abia, P; Garg, S; Giampa, P; Goeldi, D; Golovko, VV; Gorel, P; Graham, K; Grant, DR; Hallin, AL; Hamstra, M; Harvey, PJ; Hearns, C; Joy, A; Jillings, CJ; Kamaev, O; Kaur, G; Kemp, A; Kochanek, I; Kuźniak, M; Langrock, S; La Zia, F; Lehnert, B; Li, X; Litvinov, O; Lock, J; Longo, G; Majewski, P; McDonald, AB; McElroy, T; McGinn, T; McLaughlin, JB; Mehdiyev, R; Mielnichuk, C; Monroe, J; Nadeau, P; Nantais, C; Ng, C; Noble, AJ; Ouellet, C; Pasuthip, P; Peeters, SJM; Pesudo, V; Piro, MC; Pollmann, TR; Rand, ET; Rethmeier, C; Retiere, F; Sanchez Garcia, E; Santorelli, R; Seeburn, N; Skensved, P; Smith, B; Smith, NJT; Sonley, T; Stainforth, R; Stone, C; Strickland, V; Sur, B; Vazquez-Jauregui, E | Abstract: The DEAP-3600 experiment is searching for weakly interacting massive particles dark matter with a 3.3 ×103 kg single phase liquid argon (LAr) target, located 2.1 km underground at SNOLAB. The experimental signature of dark matter interactions is kilo electron volt-scale Ar40 nuclear recoils producing 128 nm LAr scintillation photons observed by photomultiplier tubes. The largest backgrounds in DEAP-3600 are electronic recoils (ERs) induced by β and γ rays originating from internal and external radioactivity in the detector material. A background model of the ER interactions in DEAP-3600 was developed and is described in this work. The model is based on several components which are expected from radioisotopes in the LAr, from ex situ material assay measurements, and from dedicated independent in situ analyses. This prior information is used in a Bayesian fit of the ER components to a 247.2 d dataset to model the radioactivity in the surrounding detector materials. Pulse-shape discrimination separates ER and NR events. However, detailed knowledge of the ER background and activity of detector components sets valuable constraints on NR backgrounds including neutrons and alphas. In addition, the activity of Ar42 in LAr in DEAP-3600 is determined by measuring the daughter decay of K42. This cosmogenically activated trace isotope is a relevant background at higher energies for other rare event searches using atmospheric argon, e.g., DarkSide-20k, GERDA, or LEGEND. The specific activity of Ar42 in the atmosphere is found to be 40.4±5.9 μBq/kg of argon.

The most comprehensive study of US community water fluoridation program benefits and costs was published in 2001. This study provides updated estimates using an economic model that includes recent data on program costs, dental caries increments, and dental treatments. In 2013 more than 211 million people had access to fluoridated water through community water systems serving 1,000 or more people. Savings associated with dental caries averted in 2013 as a result of fluoridation were estimated to be $32.19 per capita for this population. Based on 2013 estimated costs ($324 million), net savings (savings minus costs) from fluoridation systems were estimated to be $6,469 million and the estimated return on investment, 20.0. While communities should assess their specific costs for continuing or implementing a fluoridation program, these updated findings indicate that program savings are likely to exceed costs.

An RF ion-funnel technique has been developed to extract ions from a high-pressure (10 bar) noble-gas environment into a vacuum (10(-6) mbar). Detailed simulations have been performed and a prototype has been developed for the purpose of extracting Ba-136 ions from Xe gas with high efficiency. With this prototype, ions have been extracted for the first time from high-pressure xenon gas and argon gas. Systematic studies have been carried out and compared to simulations. This demonstration of extraction of ions, with mass comparable to that of the gas generating the high-pressure, has applications to Ba tagging from a Xe-gas time-projection chamber for double-beta decay, as well as to the general problem of recovering trace amounts of an ionized element in a heavy (m > 40 u) carrier gas. (C) 2015 Elsevier B.V. All rights reserved.

The Hamamatsu R5912-HQE photomultiplier-tube (PMT) is a novel high-quantum efficiency PMT. It is currently used in the DEAP-3600 dark matter detector and is of significant interest for future dark matter and neutrino experiments where high signal yields are needed. We report on the methods developed for in-situ characterization and monitoring of DEAP's 255 R5912-HQE PMTs. This includes a detailed discussion of typical measured single-photoelectron charge distributions, correlated noise (afterpulsing), dark noise, double, and late pulsing characteristics. The characterization is performed during the detector commissioning phase using laser light injected through a light diffusing sphere and during normal detector operation using LED light injected through optical fibres.

In the current context of climatic variability, it is important to quantify the impact on the environment. This study deals with an analysis of climatic data and land-use changes in terms of the impacts on flood recurrence based on multisource data. The study area covers the mouth of the Saint-Francois River (southern Quebec, Canada), where spring floods and ice jams are a recurring problem. The flood frequency analysis shows an increase in flooding over recent decades, attributable to an increase in winter temperatures that has the effect of causing ice jams earlier in the year. Regarding land-use changes, a small decrease in agricultural surface areas is observed, from 53% to 39%, along with increases in forest and urban surface areas from 27% to 38% (forest) and 3% to 5% (urban) between 1928 and 2005. In a context of continuing climate warming, more pronounced inter-annual variations are to be expected along with a higher incidence of flooding. Editor Z.W. Kundzewicz Citation Ouellet, C., Sain...

EXO-200 is a single phase liquid xenon detector designed to search for neutrinoless double-beta decay of ^(136)Xe. Here, we report on a search for various Majoron-emitting modes based on 100 kg yr exposure of ^(136)Xe. A lower limit of T^(136)Xe_(1/2) > 1.2 × 10^(24) yr at 90% C.L. on the half-life of the spectral index=1 Majoron decay was obtained, corresponding to a constraint on the Majoron-neutrino coupling constant of |⟨g^(M)_(ee)⟩| < (0.8–1.7) × 10^(−5).

We report on an improved measurement of the 2νββ half-life of ^(136)Xe performed by EXO-200. The use of a large and homogeneous time-projection chamber allows for the precise estimate of the fiducial mass used for the measurement, resulting in a small systematic uncertainty. We also discuss in detail the data-analysis methods used for double-β decay searches with EXO-200, while emphasizing those directly related to the present measurement. The ^(136)Xe 2νββ half-life is found to be T^(2νββ)_(1/2) = 2.165±0.016(stat)±0.059(sys)×10^(21) yr. This is the most precisely measured half-life of any 2νββ decay to date.

A pharmacokinetic-pharmacodynamic (PK-PD) model was constructed to describe the kinetics of tolerance development to morphine-induced antinociception. Tail-flick latencies in response to hot water (50 degrees C) were assessed in male Sprague-Dawley rats exposed to a 12-hr iv infusion of either morphine (1.4 to 3.0 mg/kg per hr) or saline. Morphine-induced antinociception, expressed as the percentage of maximum possible response (% MPR), peaked after 120 min of infusion and decreased thereafter despite sustained systemic morphine concentrations. Both the rate and extent of tolerance development increased with increasing concentrations; an overall residual effect of approximately 24% MPR was observed at the end of the infusion regardless of the steady-state morphine concentration. The kinetics of tolerance offset were examined in a separate experiment by assessing tail-flick latency 15 min after morphine iv bolus (2 mg/kg) in tolerant and control rats. Recovery of response neared completion 18.5 days after a 12-hr exposure to morphine (2.0 mg/kg per hr). A PK-PD model was constructed to account for the delay in onset of antinociceptive effect and tolerance development relative to the blood concentration-time profile. According to this model, both the extent and the rate of tolerance development were modulated by the kinetics of the drug in the central compartment. Accumulation of a hypothetical "inhibitor" acting either as a reverse agonist, a competitive or noncompetitive antagonist, or a partial agonist could potentially account for the loss of pharmacologic effect in the presence of an agonist. The rate of tolerance development predicted from the PK-PD model varied widely (28-fold) depending on the type of pharmacologic interaction selected to account for the loss of effect. Using the rate of tolerance offset to discriminate between the different models (t1/2 offset 5.4 days), onset and offset of tolerance was described accurately by postulating that the inhibitor behaves as a partial agonist with low intrinsic activity (5.5% MPR) and high binding affinity for the receptor (IC50 15.0 ng/ml).

Several properties of neutrinos, such as their absolute mass, their possible Majorana nature or the mechanisms that lead to small neutrino masses, are still unknown. The EXO-200 experiment is trying to answer some of these questions by searching for the hypothetical neutrinoless double beta decay of the isotope 136 Xe. This thesis describes an analysis of two years of detector data, which yields a lower limit on the half-life of neutrinoless double beta decay of 136 Xe of 1.1·10 25 years.

We report the observation of two-neutrino double-beta decay in ^(136)Xe with T_(1/2)=2.11±0.04(stat)±0.21(syst)×10^(21) yr. This second-order process, predicted by the standard model, has been observed for several nuclei but not for ^(136)Xe. The observed decay rate provides new input to matrix element calculations and to the search for the more interesting neutrinoless double-beta decay, the most sensitive probe for the existence of Majorana particles and the measurement of the neutrino mass scale.

We report the observation of two-neutrino double-beta decay in (136)Xe with T(1/2) = 2.11 ± 0.04(stat) ± 0.21(syst) × 10(21) yr. This second-order process, predicted by the standard model, has been observed for several nuclei but not for (136)Xe. The observed decay rate provides new input to matrix element calculations and to the search for the more interesting neutrinoless double-beta decay, the most sensitive probe for the existence of Majorana particles and the measurement of the neutrino mass scale.

Results are reported from the complete salt phase of the Sudbury Neutrino Observatory experiment in which NaCl was dissolved in the {sup 2}H{sub 2}O (''D{sub 2}O'') target. The addition of salt enhanced the signal from neutron capture as compared to the pure D{sub 2}O detector. By making a statistical separation of charged-current events from other types based on event-isotropy criteria, the effective electron recoil energy spectrum has been extracted. In units of 10{sup 6}cm{sup -2}s{sup -1}, the total flux of active-flavor neutrinos from {sup 8}B decay in the Sun is found to be 4.94{sub -0.21}{sup +0.21}(stat){sub -0.34}{sup +0.38}(syst) and the integral flux of electron neutrinos for an undistorted {sup 8}B spectrum is 1.68{sub -0.06}{sup +0.06}(stat){sub -0.09}{sup +0.08}(syst); the signal from ({nu}{sub x},e) elastic scattering is equivalent to an electron-neutrino flux of 2.35{sub -0.22}{sup +0.22}(stat){sub -0.15}{sup +0.15}(syst). These results are consistent with those expected for neutrino oscillations with the so-called large mixing angle parameters and also with an undistorted spectrum. A search for matter-enhancement effects in the Earth through a possible day-night asymmetry in the charged-current integral rate is consistent with no asymmetry. Including results from other experiments, the best-fit values for two-neutrino mixing parameters are {delta}m{sup 2}=(8.0{sub -0.4}{sup +0.6})x10{sup -5}more » eV{sup 2} and {theta}=33.9{sub -2.2}{sup +2.4} degrees.« less

The Sudbury Neutrino Observatory has precisely determined the total active (nu(x)) B-8 solar neutrino flux without assumptions about the energy dependence of the nu(e) survival probability. The measurements were made with dissolved NaCl in heavy water to enhance the sensitivity and signature for neutral-current interactions. The flux is found to be 5.21+/-0.27(stat)+/-0.38(syst)x10(6) cm(-2) s(-1), in agreement with previous measurements and standard solar models. A global analysis of these and other solar and reactor neutrino results yields Deltam(2)=7.1(-0.6)(+1.2)x10(-5) eV(2) and theta= 32.5(-2.3)(+2.4) degrees. Maximal mixing is rejected at the equivalent of 5.4 standard deviations.

The productivity of lexical categories was studied longitudinally in a sample of 17 young hearing-impaired French-speaking children with cochlear implants. Age of implantation ranged from 22 months to 76 months. Spontaneous speech samples were collected at six-month intervals over a period of 36 months, starting at the one-word stage. Four general measures of their linguistic production (number of utterances, verbal fluency, vocabulary, and grammatical production) as well as 36 specific lexical categories, according to the CHILDES codes, were computed in terms of tokens, i.e., total number of words. Cochlear-implanted children (CI) were compared to a French database of normally hearing children aged 2–4 compiled by the first author. Follow-up results indicate that, at the two-year post-implantation follow-up, noun, and verb morphology was significantly impaired. At the three-year follow-up, the cochlear-implanted group had recovered on adjectives, determiners and nouns, main verbs, and auxiliaries. The two groups differed significantly in processing locative adverbs, prepositions, pronouns, and verbs (infinitive verb, modal, and modal lexical), but individual variability within the cochlear-implanted group was substantial. Results are discussed in terms of recovery and developmental trends and variability in the acquisition of lexical categories by French children two years and three years post-implantation.

We describe a system to transport and identify barium ions produced in liquid xenon, as part of R&D towards the second phase of a double beta decay experiment, nEXO. The goal is to identify the Ba ion resulting from an extremely rare nuclear decay of the isotope $^{136}$Xe, hence providing a confirmation of the occurrence of the decay. This is achieved through Resonance Ionization Spectroscopy (RIS). In the test setup described here, Ba ions can be produced in liquid xenon or vacuum and collected on a clean substrate. This substrate is then removed to an analysis chamber under vacuum, where laser-induced thermal desorption and RIS are used with time-of-flight (TOF) mass spectroscopy for positive identification of the barium decay product., 12 pages, 13 figures

A series of potent inhibitors of P-selectin as potential anti-inflammatory agents is reported. These compounds are derivatives of galactocerebrosides bearing a malonate side chain in positions 2 and 3 of the galactose moiety. Based on the binding mode of sialyl Lewis X, the two acidic groups of the malonate are designed to form ionic interactions with two important lysines in the active site of P-selectin, Lys113 and Lys111. On the other hand, the 4- and 6-hydroxy groups on the galactose ring are arranged to chelate the calcium ion in the P-selectin active site. The synthesis and the biological activity of this series of compounds are described. Lead compounds having a greater potency than sialyl Lewis X are identified.

A longitudinal study was conducted to document and compare evolution of children with linguistic acquisition impairment. To determine whether development of the analytic mechanisms underlying linguistic processing occured in similar fashion, two children with mixed developmental dysphasia were assessed from 4 to 5:6 years of age with psycholinguistic tests at 6-months interval. Spontaneous speech and language production (consonant repertory in initial word position, MLU, and lexical diversity) were investigated in a standardized symbolic play context. The phonologic and lexico-morphologic evolution analyses revealed a marked improvement in motor control of phonology and in the application of morphosyntaxic rules in child 1, whereas child 2 was still impaired in phonology and morphosyntax. The singular developmental changes in spontaneous speech results indicate dynamic relationships between various language production facets and variability in the kind of deficit and lexical automation presented by these children. These contrasts in the evolution of language production profiles between child 1 and child 2 also underline the importance of longitudinal studies in the analysis of the atypical linguistic processing paths used by children with developmental dysphasia.

Objective The purpose of this study was to determine the outcome at birth for fetuses in which echogenic dilated bowel loops (EDBL) are detected before 21 weeks of gestation. Materials and methods A retrospective study was undertaken of 45 patients with EDBL. Sonographic criteria included dilated bowel with an echogenic wall. EDBL was divided into two categories: the isolated and the complex (associated with other abnormalities). When the EDBL affected only one quadrant of the fetal abdomen, it was referred to as the local form, and when it was observed in more than one quadrant, it was termed the diffuse form. Results Intestinal dilatation of 2-8 mm was revealed on sonography in 21 fetuses with the isolated form of EDBL. Follow-up sonography showed resolution of EDBL in 20 cases. The outcome at birth was normal in 19 (90%) cases. The 20th fetus was born with jejunal atresia, and the remaining fetus died after cordocentesis. Twenty-four fetuses with the complex form of EDBL also had intestinal dilatation of 2-8 mm shown on sonography. Nine (38%) of these fetuses were born alive: six had gastroschisis; two had meconium peritonitis; and one had vertebral defects, imperforate anus, tracheoesophageal fistula, and radial and renal dysplasia (VATER). In these cases, resolution of EDBL was noticed at sonographic follow-up. Fourteen (58%) of the 24 fetuses were aborted. The remaining fetus died after amniocentesis. The incidence of normalcy is comparable in both local and diffuse dilatation. Amniocentesis was performed in 15 cases. Disaccharidase activity was measured in 13 patients. Low disaccharidase activity was detected in 10 (77%) of 13 cases. We saw cystic fibrosis in none of the 45 fetuses. Infection was detected before and at birth in five (11%) cases. Conclusion EDBL is a new entity that is most likely related to temporary obstruction. A fetus with the isolated form has a good prognosis, whereas a fetus with the complex form has an outcome directly related to the severity of associated abnormalities.

Previous experiments suggested that rats can learn to discriminate between adjacent arms of an eight-arm radial maze if they have an intact hippocampal system and are allowed to move around on the maze. These requirements are consistent with the hypothesis that this discrimination involves hippocampus-based spatial learning. We examined the importance of self-generated movement in this form of learning by moving rats manually ("passive movement") between two adjacent maze arms within a single training trial. Rats moved passively between arms (only one of which contained food) within trials learned to discriminate between the arms, as measured by a conditioned preference for the food arm when both arms were empty. This form of learning was impaired by lesions of fimbria-fornix, but was unaffected by lesions of the lateral nucleus of the amygdala. Normal rats that were picked up and replaced on the same arm within trials and experienced their food and no food arms on different daily trials failed to learn the same discrimination. These findings suggest that self-generated movement is not required for spatial learning that may be mediated by a hippocampal system; rather, movement may simply serve to provide information from different locations about the cues in an environment.

EXO-200 is an experiment designed to search for double beta decay of $^{136}$Xe with a single-phase, liquid xenon detector. It uses an active mass of 110 kg of xenon enriched to 80.6% in the isotope 136 in an ultra-low background time projection chamber capable of simultaneous detection of ionization and scintillation. This paper describes the EXO-200 detector with particular attention to the most innovative aspects of the design that revolve around the reduction of backgrounds, the efficient use of the expensive isotopically enriched xenon, and the optimization of the energy resolution in a relatively large volume.

Tagging events with the coincident detection of a barium ion would greatly reduce the background for a neutrino-less double beta decay search in xenon. This paper describes progress towards realizing this goal. It outlines a source that can produce large quantities of Ba++ in gas, shows that this can be extracted to vacuum, and demonstrates a mechanism by which the Ba++ can be efficiently converted to Ba+ as required for laser identification.

ISSUE: An infection control practitioner who underwent enhanced CT scanning noticed multiple patient infusions of contrast dye from a single infusion syringe. High costs and large volumes of the dye drive this practice. A review was conducted to determine current practices and assess patient risk. PROJECT: Advisories and alerts related to enhanced CT delivery systems were researched, and the enhanced CT practices at two local hospitals were evaluated. For this review, the “extension tubing” is the delivery system between the dye container and the patient IV connection. A “sprung” type backflow valve is any valve for which significant pressure (3.4 psi) is required to open the valve. An “unsprung” valve is any valve that can be opened with less pressure, indicating that it is less effective in protecting against backflow. RESULTS: A 1995 Health Canada Advisory recommends placement of two “sprung” type, backflow valves in the extension tubing to substantially reduce (but not necessarily to eliminate) the risk of contamination. Review of two local hospitals revealed that both used two “sprung” valves in the extension tubing as recommended; the extension tubing with valves are single use only. However, differences were found in the set-up for flushing the patient IV which may allow for contamination. In one hospital, the set-up was pre-primed for all patients at the beginning of the day. In the other hospital, the set-up involved a single normal saline bag with IV tubing repeatedly used throughout the day and additional IV tubing with an “unsprung” valve, single use only. The value of protection from backflow of blood and bloodborne pathogens by the single “unsprung” valves has not been described. LESSONS LEARNED: Differences in contrast dye IV delivery systems exist between hospitals. Both hospitals reviewed used two “sprung” type, backflow valves in their extension tubing, but methods of flushing lines between procedures were inconsistent. Further studies are needed to document the risks of contamination with the use of “sprung” and “unsprung” backflow valves for multidosing of contrast dye. National standards are needed to ensure consistency of practice between hospitals.

Liver cells isolated from newborn rats and seeded on a non-adherent plastic substratum were found to spontaneously re-aggregate and to form, within a few days, spheroidal aggregates that eventually reached a plateaued diameter of 150-175 micron. Analyses on frozen sections from these spheroids by immunofluorescence microscopy using antibodies to various cytoskeletal elements and extracellular matrix components revealed a sorting out and a histotypic reorganization of three major cell types. A first type consisted of cells that segregated out on the aggregate surface forming a monolayer cell lining; a second type was identified as hepatocytes that regrouped in small islands often defining a central lumen; and a third group of cells reorganized into bile duct-like structures. This intercellular organization in the aggregates was paralleled by the accumulation of extracellular matrix components (laminin, fibronectin, and collagen) and their deposition following a specific pattern around each cell population structure. Determinations of albumin secretion and tyrosine aminotransferase induction by dexamethasone and glucagon at various times after the initiation of the cultures revealed a maintenance of the hepatocyte-differentiated functions for at least up to 2 mo at the levels measured at 3-5 d. It is concluded that cells dispersed as single cells from newborn rat liver conserve in part the necessary information to reconstruct a proper three-dimensional cyto-architecture and that the microenvironment so generated most likely represents a basic requirement for the optimal functioning of these differentiated cells.

The kinetics of the decomposition of hydrogen peroxide in the vapour state have been studied by a manometric method, with pure hydrogen peroxide at a concentration of about 99.5%. The temperature coefficient of the reaction has been measured for the first time. The pressures ranged from 1 to 2 cm. of mercury and the temperatures from 70° to 200 °C. Pyrex reaction vessels of various sizes and shapes, and also a fused Pyrex and a soda-glass vessel, were used. The reaction was purely heterogeneous, of the first order up to 140 °C. but more complicated at higher temperatures. Identical vessels yielded consistent results. The rates were not affected by air, carbon dioxide, or water vapour, but they varied greatly with the size and shape of the vessel. The reaction was very slow on fused Pyrex and very rapid on soda-glass. In one vessel, the temperature coefficient became negligible above 120 °C. No explosion was detected up to 335 °C. at a pressure of 18 cm. of mercury. The apparent activation energies in various vessels ranged from 13.5 to 18.5 kcal. per mole. A tentative reaction mechanism is suggested.

The emission of mitogenetic rays has been reported from a great variety of cells and tissues but the most powerful source appears to be material which is in a high state of mitotic, metabolic, nervous or mechanical activity (Gurwitsch, 1932). A cursor survey of the literature shows that there is no general agreement concerning the reality of the phenomenon. In most cases, neither the source of the rays nor the means adopted for their detection has been defined with sufficient accuracy to permit consistent results to lie obtained by independent workers. To some extent this difficulty has been met by using photo-electric cells as a means of detecting the rays. Using a potassium cell, Schrieber and Friedlich (1930) failed to detect any radiation know yeast cultures. Seyfert (1932) using a cell of the counter type failed to find any emission of rays from onion roots, yeast cultures, and embryonic tissues. Frank and Rodionov (1932) on the other hand, obtained positive results from active preparations of the frog's sartorius and heart.

A mass spectrometer equipped for continuous sampling and capable of producing 60 spectra per second has been used to follow the oxidation of acetaldehyde at temperatures in the region of 250 °C. In normal slow oxidation peracetic acid was formed and then decomposed into carbon dioxide, methanol, and water. Under flame conditions peracetic acid built up in an autocatalytic manner during the induction period and vanished suddenly at the onset of the flame. Possible reaction mechanisms are discussed. Temperature surges during cool and hot flames are estimated.

The sorption of deuterium oxide by cellulose at 23.4 °C. was investigated over the whole range of vapor pressures and found to show the same characteristics as that of water. The molar quantities sorbed at a given pressure are equal, and the kinetic curves exhibit the same features. After desorption of deuterium oxide, a small but permanent increase in the weight of the cellulose was observed. This suggested an exchange reaction between deuterium and hydrogen atoms.

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The calcium antagonists are presently accepted as the treatment of choice for vasospastic angina. They are accepted by some as a good second choice therapy in the treatment of stable angina pectoris, while by others as an excellent first choice in its treatment. When introduced to the North American market, warning was given of the risk of left ventricular failure and/or atrioventricular block from their combination with beta-blockers. Perhaps now a deeper knowledge of their hemodynamic and electrophysiologic properties allows us to conceptualize potent and safe anti-anginal associations by use, in specific patients, of differing combinations. Thus we must learn to use with care and flair this new form of treatment which offers our severely afflicted patients much greater symptomatic relief.

The conclusions which have been drawn from the results of C{sup 14}O{sub 2} fixation experiments with a variety of plants are developed in this paper. The evidence for thermochemical reduction of carbon dioxide fixation intermediates is presented and the results are interpreted from such a viewpoint.