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2. Interstitial cystitis/painful bladder syndrome: epidemiology, pathophysiology and evidence-based treatment options

Author

T. Creagh, C. M. Brady, and Niall F. Davis

Subjects
medicine.medical_specialty, Evidence-Based Medicine, Evidence-based practice, business.industry, Incidence (epidemiology), Cystitis, Interstitial, Obstetrics and Gynecology, Interstitial cystitis, medicine.disease, Pathophysiology, Surgery, Reproductive Medicine, Quality of life, Internal medicine, Epidemiology, Cohort, medicine, Humans, Adverse effect, business
Abstract

Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic debilitating condition that can have a severely negative impact on a patient's quality of life. Its prevalence ranges from 52 to 500/100,000 in females compared to 8-41/100,000 in males, and its incidence is increasing globally. Treatment algorithms are sub-classified into behavioural, pharmacological, intravesical, interventional and surgical therapies. Short-term (i.e.

Published
2014
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3. Trigonal versus extratrigonal botulinum toxin-A: a systematic review and meta-analysis of efficacy and adverse events

Author

H. D. Flood, John P. Burke, E. J. Redmond, C. M. Brady, S. Elamin, and Niall F. Davis

Subjects
medicine.medical_specialty, business.industry, Urinary retention, Urinary Bladder, Overactive, Urology, Urinary system, Incidence (epidemiology), Acetylcholine Release Inhibitors, Obstetrics and Gynecology, Odds ratio, Gastroenterology, Confidence interval, Administration, Intravesical, Refractory, Anesthesia, Meta-analysis, Internal medicine, Medicine, Humans, medicine.symptom, Botulinum Toxins, Type A, business, Adverse effect
Abstract

Botulinum toxin-A (BoNT-A) is a potent neurotoxin that is an effective treatment for patients with pharmacologically refractory detrusor overactivity (DO). Data assessing the effectiveness of trigonal BoNT-A are limited. This study evaluates adverse events (AEs) and short-term efficacy associated with trigonal and extratrigonal BoNT-A. Electronic databases (PubMed, EMBASE, and the Cochrane database) were searched for studies comparing trigonal and extratrigonal BoNT-A for DO. Meta-analyses were performed using the random effects model. Outcome measures included incidence of AEs and short-term efficacy. Six studies describing 258 patients met the inclusion criteria. The meta-analysis did not show significant differences between trigonal and extratrigonal BoNT-A for acute urinary retention (AUR; 4.2 vs 3.7 %; odds ratio [OR]: 1.068, 95 % confidence interval [CI]: 0.239–4.773; P = 0.931) or high post-void residual (PVR; 25.8 vs 22.2 %; OR: 0.979; 95 % CI: 0.459–2.088; P = 0.956). The incidence of urinary tract infection (UTI; 7.5 vs 21.0 %; OR: 0.670; 95 % CI: 0.312–1.439; P = 0.305), haematuria (15.8 vs 25.9 %; OR: 0.547; 95 % CI: 0.264–1.134; P = 0.105) and post-operative muscle weakness (9.2 vs 11.3 %; OR: 0.587; 95 % CI: 0.205–1.680, P = 0.320) was similar in both groups. Finally, differences in short-term cure rates between two study arms were not statistically significant (52.9 vs 56.9 %; OR: 1.438; 95 % CI: 0.448–4.610; P = 0.542). Although data are limited, no significant differences between trigonal and extratrigonal BoNT-A in terms of AEs and short-term efficacy were observed. Additional randomised controlled trials are required to define optimal injection techniques and sites for administering intra-vesical BoNT-A.

Published
2014

4. Sylvester o’halloran surgical scientific meeting

Author

N. Relihan, G. McGreal, M. Murray, E. W. McDermott, N. J. O’Higgins, M. J. Duffy, D. A. McNamara, J. Harmey, J. H. Wang, D. Donovan, T. N. Walsh, D. J. Bouchier-Hayes, E. Kay, J. D. Kelly, H. P. Weir, P. F. Keane, S. R. Johnston, K. E. Williamson, P. W. Hamilton, D. McManus, M. Morrin, P. V. Delaney, D. C. Winter, B. J. Harvey, J. P. Geibel, G. C. O’Sullivan, C. P. Delaney, R. Coffey, T. F. Gorey, J. M. Fitzpatrick, N. F. Fanning, W. Kirwan, T. Cotter, D. Bouchier-Hayes, H. P. Redmond, G. Pidgeon, F. Fennessy, C. Kelly, R. Flavin, A. M. Rasheed, A. Leahy, E. E. Lang, M. T. P. Caldwell, W. A. Tanner, P. D. Kiely, M. O’Reilly, S. Tierney, M. Barry, J. Drumm, P. A. Grace, C. M. Gallagher, D. C. Grant, P. Connell, M. K. Barry, O. Traynor, J. M. P. Hyland, M. J. O’Sullivan, D. Evoy, W. O. Kirwan, B. Cannon, L. Kenny-Walshe, M. J. Whelton, H. O’Grady, S. O’Neill, J. M. Hyland, S. H. Teh, S. O’Ceallaigh, M. K. O’Donohoe, F. B. Keane, G. C. O’Toole, J. Calleary, L. Basso, S. B. Amjad, Z. Khan, L. McMullin, W. P. Joyce, P. J. Balfe, M. T. Caldwell, S. Teahan, K. Al-Brekeit, A. Rasheed, A. Cullen, C. O’Keane, J. MacFarlane, M. Walsh, T. McGloughlin, P. Grace, D. Colgan, P. Madhavan, S. Sultan, M. P. Colgan, D. Moore, G. Shanik, N. McEniff, M. Molloy, E. Eguare, C. Fiuza, P. Burke, R. Maher, M. Creamer, C. J. Cronin, H. H. Sigurdsso, W. Kim, G. Linklater, K. S. Cross, W. G. Simpson, J. A. M. Shaw, D. W. M. Pearson, P. Fitzgerald, P. Quinn, C. M. Brady, S. M. A. Shah, M. Ehtisham, M. S. Khan, H. D. Flood, M. Loubani, K. Sweeney, B. Lenehan, V. Lynch, A. Joy, D. Reidy, K. Mahalingam, W. Cashman, E. D. Mulligan, T. Purcell, B. Dunne, M. Griffin, N. Noonan, D. Hollywood, N. Keeling, J. V. Reynolds, T. P. J. Hennessy, D. O’Halloran, P. Neary, D. Hamilton, N. Haider, N. Aherne, R. G. K. Watson, D. Walsh, M. Murphy, M. Joyce, S. Johnston, O. Clinton, H. F. Given, A. Brannigan, M. O’Donohoe, J. Donohoe, T. Corrigan, M. Bresnihan, T. M. Feeley, M. P. McMonagle, D. Quinlan, D. Kelly, P. K. Hegarty, B. Tan, C. Cronin, M. P. Brady, M. Zeeshan, D. J. McAvinchey, C. Mooney, D. Coyle, G. Khayyat, E. Masterson, T. Thambi-Pillai, K. Farah, M. B. Codd, G. G. Tsiotos, C. D. Johnson, M. G. Sarr, M. R. Kell, M. Lynch, D. Ryan, A. O’Donovan, M. Cassidy, M. Doyle, G. Fulton, P. R. O’Connell, R. Kingston, M. Dillon, E. McDermott, N. O’Higgins, R. G. O’Sullivan, and J. A. O’Donnell

Subjects
business.industry, Foundation (engineering), Medicine, Library science, General Medicine, business
Published
1998
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5. Sylvester o’halloran surgical scientific meeting

Author

G. J. Fulton, M. G. Davies, P. O’Hagen, A. Rasheed, C. Kelly, E. Kay, S. Fitzgerald, D. Bouchier-Hayes, A. Leahy, F. Fennessy, P. Fitzgerald, K. Khosraviani, H. P. Weir, K. Williamson, R. Wilson, R. J. Moorehead, B. J. Rowlands, D. Morrissey, J. O’Connell, D. Lynch, C. O’Sullivan, F. Shanahan, J. K. Collins, J. L. Kelly, C. C. Soberg, A. Lyons, J. A. Mannick, J. A. Lederer, C. Chen, D. J. Bouchier-Hayes, H. Fitzsimons, D. M. O’Hanlon, C. Curran, M. Canney, S. Morris, O. Clinton, H. F. Given, E. Coveney, H. K. Lyerly, F. L. Murphy, C. J. Kelly, D. H. Osborne, P. Kelly, D. S. O’Riordan, P. G. Horgan, F. B. V. Keane, W. A. Tanner, P. Kilmartin, C. P. Delaney, S. M. Johnston, J. M. Fitzpatrick, T. F. Gorey, J. Mehigan, M. G. O/rsRiordan, N. Shines, A. Hill, C. O. McDonnell, F. Murphy, S. M. Javadpour, Y. Alhadi, R. Waldron, R. G. Watson, A. Tarrant, T. K. Neelamekam, J. Mathias, J. Geoghegan, T. Boyle, O. Traynor, S. Hayes, B. O’Donovan, N. Ajmal, J. McCann, N. T. Corrigan, M. G. O’Riordan, P. Ross, M. O’Donohoe, M. Bresnihan, T. M. Feeley, C. Fiuza-Castineira, D. Coleman, H. Fisher, A. Butt, E. Ghumman, P. Grace, P. Burke, S. A. Martin, M. K. Fox-Talbot, P. A. Lipsett, K. D. Lillemoe, H. A. Pitt, D. A. O’Keeffe, A. D. K. Hill, K. Sheahan, F. Ryan, D. Barton, R. Fitzgerald, E. W. McDermott, N. J. O’Higgins, E. Kavanagh, P. Kiely, D. O’Driscoll, M. Ramesh, W. O. Kirwan, D. C. Winter, K. Nally, J. O’Callaghan, J. B. Matthews, B. J. Harvey, G. C. O’Sullivan, L. S. Young, M. C. Regan, P. Sweeney, D. M. Bouchier-Hayes, R. Dardis, P. Broe, M. G. O’Brien, P. Neary, P. Ridgeway, C. Condron, J. H. Wang, H. P. Redmond, D. R. M. Redfern, R. K. S. Strachan, J. M. Hollingdale, P. A. Grace, A. Acheson, A. Graham, C. Weir, B. Lee, C. O’Donnell, D. Buckley, J. A. O’Donnell, E. Purcell, M. O’Donoghue, S. Sultan, M. Colgan, M. Molloy, D. Moore, G. Shanik, P. T. McCollum, Z. Raza, S. Naidu, P. A. Stonebridge, M. P. Colgan, D. J. Moore, D. G. Shanik, J. Dowdall, C. Williams, S. G. Shering, G. Duffy, R. Greengrass, D. Iglehart, G. Little, H. Kim Lyerly, M. Fynes, A. Cahill, C. O’Herlihy, P. R. O’Connell, I. Ahmad, M. Etisham, J. Drumm, H. Flood, K. Mulhall, K. Murray, S. O’Rian, N. Garvey, J. Johnston, G. T. McGreal, M. P. Brady, M. M. Duffy, M. Regan, M. G. Harrington, M. Javadpour, C. McDonnell, E. Eguare, M. C. Barry, G. C. O’Toole, N. O’Higgins, E. McDermott, C. M. Brady, S. A. Sultan, M. K. O’Donoghue, M. P. Molloy, G. D. Shanik, R. J. Holdsworth, M. Fehily, C. Doran, F. Keane, J. F. Rothwell, M. J. Staunton, L. O’Mahony, E. F. Gaffney, K. Mealy, T. P. J. Hennessy, and J. Geibel

Subjects
business.industry, Art history, Medicine, General Medicine, business
Published
1998
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6. A prospective evaluation of the efficiency of early postoperative bladder emptying after the Stamey procedure or pubovaginal sling for stress urinary incontinence

Author

C M, Brady, I, Ahmed, J, Drumm, and H D, Flood

Subjects
Urodynamics, Postoperative Complications, Urinary Incontinence, Stress, Urinary Bladder, Humans, Urination, Urologic Surgical Procedures, Female, Prospective Studies, Length of Stay, Middle Aged, Urinary Catheterization, Urination Disorders
Abstract

The pubovaginal sling has been criticized as having a higher incidence of postoperative voiding dysfunction than other surgical approaches for the management of stress urinary incontinence. In 2 similar patient groups we prospectively compared the rates of early postoperative voiding dysfunction after the pubovaginal sling or Stamey procedure.Between June 1995 and January 1997, 50 consecutive patients underwent the pubovaginal sling or Stamey procedure. Emptying efficiency was measured 48 hours postoperatively by suprapubic catheter in the Stamey group and intermittent catheterization in the pubovaginal sling group. When emptying efficiency was greater than 75%, intermittent catheterization was stopped or the suprapubic catheter was removed.There was no statistically significant difference in emptying efficiency for the first 3 voids using the Dunn multiple comparison method. Median voiding efficiencies were 37%, 43% and 61% with the Stamey procedure in group 1 (mean 43%, 45% and 54%), and 60%, 75% and 75% with the pubovaginal sling in group 2 (mean 49%, 68% and 69%), respectively. The mean number of intermittent catheterizations performed in patients with the pubovaginal sling was 5.7 in less than 1 day. In the Stamey group the suprapubic catheter was removed an average of 6 days postoperatively. The mean duration of hospital stay was similar for the sling and Stamey groups (5.4 versus 6 days, respectively). There were 2 patients in each group who were voiding inefficiently after day 7. Voiding efficiency was restored at 53 and 86 days in the 2 patients with slings and at 18 days in 1 of the 2 who underwent the Stamey procedure, respectively. The second patient who underwent the Stamey procedure was able to void without using the catheter at all, and it was removed 30 days postoperatively when emptying efficiency was confirmed greater than 75%.These data show that early postoperative voiding dysfunction, measured using bladder emptying efficiency, after the pubovaginal sling is no more common than after the Stamey procedure and help justify the broadened indications for pubovaginal sling for treatment of stress urinary incontinence.

Published
2001

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