19 results on '"C. Brochu"'
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2. Poster session III * Friday 10 December 2010, 08:30-12:30
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D. Guldbrand, O. Goetzsche, B. Eika, N. Watanabe, M. Taniguchi, T. Akagi, N. Koide, S. Sano, B. Orbovic, B. Obrenovic-Kircanski, S. Ristic, L. J. Soskic, F. Alhabshan, A. Jijeh, H. Abo Remsh, A. Alkhaldi, H. K. Najm, Z. Gasior, M. Skowerski, A. Kulach, L. Szymanski, M. Sosnowski, M. Wang, C. W. Siu, K. Lee, W. S. Yue, G. H. Yan, S. Lee, C. P. Lau, H. F. Tse, K. O'connor, M. Rosca, J. Magne, G. Romano, M. Moonen, L. A. Pierard, P. Lancellotti, M. Floria, L. De Roy, D. Blommaert, J. Jamart, F. Dormal, M. Lacrosse, C. Arsenescu Georgescu, V. Mizariene, S. Bucyte, A. Bertasiute, E. Pociute, D. Zaliaduonyte-Peksiene, K. Baronaite-Dudoniene, R. Sileikiene, J. Vaskelyte, R. Jurkevicius, M. Dencker, O. Thorsson, M. K. Karlsson, C. Linden, P. Wollmer, L. B. Andersen, O. Catalano, M. R. Perotti, E. Colombo, M. De Giorgi, M. Cattaneo, F. Cobelli, S. G. Priori, C. Ober, I. A. Iancu Adrian, P. A. Andreea Parv, C. H. Cadis Horatiu, O. M. Ober Mihai, M. Chmielecki, M. Fijalkowski, R. Galaska, W. Dubaniewicz, L. Lewicki, R. Targonski, D. Ciecwierz, W. Puchalski, A. Koprowski, A. Rynkiewicz, K. Hristova, A. La Gerche, T. Z. Katova, V. Kostova, Y. Simova, A. Kempny, G. P. Diller, S. Orwat, G. Kaleschke, G. Kerckhoff, R. Schmidt, R. M. Radke, H. Baumgartner, K. Smarz, B. Zaborska, T. Jaxa-Chamiec, P. Maciejewski, A. Budaj, A. Kiotsekoglou, S. C. Govind, V. Gadiyaram, J. C. Moggridge, M. Govindan, A. S. Gopal, S. S. Ramesh, L. A. Brodin, S. K. Saha, I. S. Ramzy, P. Lindqvist, Y. Y. Lam, A. M. Duncan, M. Y. Henein, I. S. Craciunescu, M. Serban, M. Iancu, C. Revnic, B. A. Popescu, D. Alexandru, D. Rogoz, V. Uscatescu, C. Ginghina, G. Careri, A. Di Monaco, R. Nerla, P. Tarzia, P. Lamendola, A. Sestito, G. A. Lanza, F. Crea, F. Giannini, B. Pinamonti, S. Santangelo, A. Perkan, G. Vitrella, S. Rakar, M. Merlo, E. Della Grazia, A. Salvi, G. Sinagra, P. Scislo, J. Kochanowski, R. Piatkowski, M. Roik, M. Postula, G. Opolski, J. Castillo, N. Herszkowicz, C. Ferreira, M. T. Lonnebakken, E. M. Staal, J. E. Nordrehaug, E. Gerdts, M. Przewlocka-Kosmala, A. Orda, B. Karolko, G. Bajraktari, U. Gustafsson, A. Holmgren, S. Frattini, P. Faggiano, V. Zilioli, E. Locantore, S. Longhi, F. Bellandi, G. Faden, M. Triggiani, L. Dei Cas, S. M. Seo, H. O. Jung, S. H. An, S. Y. Jung, C. S. Park, H. K. Jeon, H. J. Youn, W. B. Chung, J. H. Kim, J. S. Uhm, W. Mampuya, M. C. Brochu, D. H. Do, B. Essadiqi, P. Farand, S. Lepage, M. J. Daly, M. Monaghan, A. Hamilton, C. Lockhart, V. Kodoth, C. Maguire, A. Morton, G. Manoharan, M. S. Spence, W. Streb, K. Mitrega, J. Nowak, A. Duszanska, M. Szulik, M. Kalinowski, T. Kukulski, Z. Kalarus, F. E. Calvo Iglesias, I. Solla-Ruiz, I. Villanueva-Benito, E. Paredes-Galan, M. Bravo-Amaro, A. Iniguez-Romo, O. Yildirimturk, F. F. Helvacioglu, Y. Tayyareci, S. Yurdakul, I. C. Demiroglu, S. Aytekin, R. Enache, R. Piazza, D. Muraru, A. Roman-Pognuz, A. Calin, E. Leiballi, F. Antonini-Canterin, G. L. Nicolosi, C. Ridard, A. Bellouin, C. Thebault, M. Laurent, E. Donal, A. Sutandar, B. B. Siswanto, I. Irmalita, G. Harimurti, A. Saxena, S. Ramakrishnan, A. Roy, A. Krishnan, P. Misra, B. Bhargava, P. A. Poole-Wilson, B. B. Loegstrup, H. R. Andersen, S. H. Poulsen, K. E. Klaaborg, H. E. Egeblad, X. Gu, X. Y. Gu, Y. H. He, Z. A. Li, J. C. Han, J. Chen, N. Mansencal, E. Mitry, P. Rougier, O. Dubourg, H. Villarraga, K. Adjei-Twum, T. K. M. Cudjoe, A. Clavell, R. M. Schears, F. Cabrera Bueno, M. J. Molina Mora, J. Fernandez Pastor, A. Linde Estrella, J. L. Pena Hernandez, G. Isasti Aizpurua, F. Carrasco Chinchilla, A. Barrera Cordero, F. J. Alzueta Rodriguez, E. De Teresa Galvan, G. C. Gaetano Contegiacomo, F. P. Francesco Pollice, P. P. Paolo Pollice, M. C. Kontos, D. H. Shin, S. Y. Yoo, C. K. Lee, J. K. Jang, S. I. Jung, S. I. Song, S. I. Seo, S. S. Cheong, J. Peteiro, A. Perez-Perez, A. Bouzas-Mosquera, M. Pineiro, P. Pazos, R. Campo, A. Castro-Beiras, N. Gaibazzi, F. Rigo, D. Sartorio, C. Reverberi, S. Sitia, L. Tomasoni, L. Gianturco, L. Ghio, D. Stella, P. Greco, V. De Gennaro Colonna, M. Turiel, S. Cicala, V. Magagnin, E. Caiani, S. Kyrzopoulos, D. Tsiapras, G. Domproglou, E. Avramidou, V. Voudris, K. Wierzbowska-Drabik, P. Lipiec, L. Chrzanowski, N. Roszczyk, K. Kupczynska, J. D. Kasprzak, V. Sachpekidis, A. Bhan, S. Gianstefani, J. Reiken, M. Paul, P. Pearson, D. Harries, M. J. Monaghan, K. Dale, A. Stoylen, V. Kodali, R. Toole, P. Raju, R. A. Mcintosh, J. Silberbauer, O. Baumann, N. R. Patel, N. Sulke, U. Trivedi, J. Hyde, G. Venn, G. Lloyd, P. Wejner-Mik, K. Wierzbowska, J. A. Lowenstein, C. Caniggia, A. Garcia, M. Amor, N. Casso, D. Lowenstein Haber, C. Porley, G. Zambrana, V. Daru, M. Deljanin Ilic, S. Ilic, D. Kalimanovska Ostric, V. Stoickov, M. Zdravkovic, I. Paraskevaidis, I. Ikonomidis, J. Parissis, C. Papadopoulos, V. Stasinos, V. Bistola, M. Anastasiou-Nana, M. Gudin Uriel, J. R. Balaguer Malfagon, J. L. Perez Bosca, F. Ridocci Soriano, N. Martinez Alzamora, R. Paya Serrano, Q. Ciampi, L. Pratali, M. Della Porta, B. Petruzziello, B. Villari, E. Picano, R. Sicari, A. Rosner, D. Avenarius, S. Malm, A. Iqbal, A. Baltabaeva, G. R. Sutherland, B. Bijnens, T. Myrmel, M. Andersen, F. Gustafsson, N. H. Secher, P. Brassard, A. S. Jensen, C. Hassager, P. L. Madsen, J. E. Moller, M. Coutu, D. Greentree, D. Normandin, H. Brun, A. Dipchand, L. Koopman, C. T. Fackoury, S. Truong, C. Manlhiot, L. Mertens, M. Baroni, M. Mariani, H. K. Chabane, S. Berti, A. Ripoli, S. Storti, M. Glauber, P. A. Scopelliti, G. B. Antongiovanni, D. Personeni, A. Saino, M. Tespili, P. Jung, M. Mueller, F. Jander, H. Y. Sohn, J. Rieber, P. Schneider, V. Klauss, E. Agricola, M. Slavich, S. Stella, M. Ancona, M. Oppizzi, L. Bertoglio, G. Melissano, A. Margonato, R. Chiesa, L. Cejudo Diaz Del Campo, D. Mesa Rubio, M. Ruiz Ortiz, M. Delgado Ortega, E. Villanueva Fernandez, J. Lopez Aguilera, F. Toledano Delgado, M. Pan Alvarez-Ossorio, J. Suarez De Lezo Cruz Conde, M. Lafuente, T. Butz, A. Meissner, C. N. Lang, M. W. Prull, G. Plehn, H. J. Trappe, S. V. Nair, L. Lee, I. Mcleod, G. Whyte, J. Shrimpton, D. Hildick Smith, P. R. James, J. Slikkerveer, Y. E. A. Appelman, G. Veen, T. R. Porter, O. Kamp, P. Colonna, F. J. Ten Cate, D. Bokor, A. Daponte, M. Cocciolo, M. Bona, S. Sacchi, H. Becher, S. C. Chai, P. J. Tan, Y. S. Goh, S. H. Ong, J. Chow, L. L. Lee, P. P. Goh, K. L. Tong, R. Kakihara, C. Naruse, H. Hironaka, T. Tsuzuku, K. Ozawa, A. Tomaszuk-Kazberuk, B. Sobkowicz, J. Malyszko, J. S. Malyszko, R. Sawicki, T. Hirnle, S. Dobrzycki, M. Mysliwiec, W. J. Musial, W. Mathias, I. Kowatsch, A. L. R. Saroute, A. F. F. Osorio, J. C. N. Sbano, J. A. F. Ramires, J. M. Tsutsui, K. Sakata, H. Ito, K. Ishii, T. Sakuma, K. Iwakura, H. Yoshino, J. Yoshikawa, K. Shahgaldi, A. Lopez, B. Fernstrom, A. Sahlen, R. Winter, S. Kovalova, J. Necas, B. H. Amundsen, R. Jasaityte, G. Kiss, D. Barbosa, J. D'hooge, H. Torp, C. A. Szmigielski, J. D. Newton, K. Rajpoot, J. A. Noble, R. Kerber, L. P. Koopman, C. Slorach, N. Chahal, W. Hui, T. Sarkola, T. J. Bradley, E. T. Jaeggi, B. W. Mccrindle, A. Staron, M. Jasinski, S. Wos, P. Sengupta, D. Hayat, M. Kloeckner, J. Nahum, C. Dussault, J. L. Dubois Rande, P. Gueret, P. Lim, G. J. King, A. Brown, E. Ho, I. Amuntaser, K. Bennet, N. Mc Elhome, R. T. Murphy, R. M. Cooper, J. D. Somauroo, R. E. Shave, K. L. Williams, J. Forster, C. George, T. Bett, K. P. George, A. D'andrea, L. Riegler, R. Cocchia, E. Golia, R. Gravino, G. Salerno, R. Citro, P. I. O. Caso, E. Bossone, R. Calabro', F. Crispi, F. Figueras, J. Bartrons, E. Eixarch, F. Le Noble, A. Ahmed, E. Gratacos, Q. Shang, W. K. Yip, L. S. Tam, Q. Zhang, C. M. Li, T. Wang, C. Y. Ma, K. M. Li, C. M. Yu, T. Dahlslett, I. Helland, T. Edvardsen, H. Skulstad, L. S. Magda, M. Florescu, A. Ciobanu, R. Dulgheru, R. Mincu, D. Vinereanu, M. Luckie, S. Chacko, S. Nair, M. Mamas, R. S. Khattar, M. El-Omar, A. Kuch-Wocial, P. Pruszczyk, M. Szulc, G. Styczynski, M. Sinski, A. Kaczynska, Z. Vela, E. Haliti, V. Hyseni, R. Olloni, N. Rexhepaj, S. Elezi, J. J. Onaindia, O. Quintana, A. Cacicedo, S. Velasco, J. J. Alarcon, M. Morillas, J. R. Rumoroso, J. Zumalde, I. Lekuona, E. Laraudogoitia Zaldumbide, A. Poniku, A. Ahmeti, R. F. Duncan, J. M. Mccomb, J. Pemberton, S. W. Lord, D. Leong, C. Plummer, G. Macgowan, N. Grubb, M. Leung, A. Kenny, C. Prinz, J. U. Voigt, A. Zaidi, M. Heatley, S. Z. Abildstrom, A. Hvelplund, J. Berning, S. Govind, L. Brodin, A. Gopal, B. Castaldi, G. Di Salvo, G. Santoro, G. Gaio, M. T. Palladino, C. Iacono, G. Pacileo, M. G. Russo, R. Calabro, Y. S. Wang, L. L. Dong, X. H. Shu, C. Z. Pan, D. X. Zhou, T. Sen, O. Tufekcioglu, M. Ozdemir, A. Tuncez, B. Uygur, Z. Golbasi, H. Kisacik, L. Delfino, F. D. De Leo, L. C. Chiappa, B. Abdel Ghani, R. Schiavina, P. Salvade, A. Morganti, F. Bedogni, P. Mahia, L. Gutierrez, V. Pineda, B. Garcia, I. Otaegui, J. F. Rodriguez, M. T. Gonzalez, M. Descalzo, A. Evangelista, D. Garcia-Dorado, H. A. C. M. Bruin De- Bon, R. B. A. Van Den Brink, S. Surie, P. Bresser, J. Vleugels, H. M. Eckmann, D. A. Samson, B. J. Bouma, C. Dedobbeleer, M. Antoine, M. Remmelink, P. Unger, B. Roosens, I. Hmila, S. Hernot, S. Droogmans, G. Van Camp, T. Lahoutte, S. Muyldermans, B. Cosyns, G. Feltes, V. Serra, O. Azevedo, J. Barbado, J. Herrera, A. Rivera, J. Paniagua, V. Valverde, J. Torras, G. Arriba, T. Christodoulides, M. Ioannides, K. Simamonian, K. Yiangou, M. Myrianthefs, E. Nicolaides, M. Pandolfo, S. A. Kleijn, M. F. A. A. Aly, C. B. Terwee, A. C. Van Rossum, V. Delgado, M. Shanks, H. M. Siebelink, A. Sieders, H. Lamb, N. Ajmone Marsan, J. Westenberg, A. De Roos, J. D. Schuijf, J. J. Bax, A. M. Anwar, Y. Nosir, H. Chamsi-Pasha, H. D. Tschernich, J. Seeburger, M. Borger, C. Mukherjee, F. W. Mohr, J. Ender, K. Obase, H. Okura, R. Yamada, Y. Miyamoto, K. Saito, K. Imai, A. Hayashida, and K. Yoshida
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medicine.medical_specialty ,business.industry ,Physical therapy ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Session (computer science) ,Cardiology and Cardiovascular Medicine ,business - Published
- 2010
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3. Éléments contextuels associés à l'émission de comportements d'agitation verbale présentés par des personnes âgées institutionnalisées atteintes de démence
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J. Aubert, P. Landreville, J. Vézina, C. Laplante, C. Brochu, G. Primeau, and S. Imbeault
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Applied Psychology - Abstract
Resume La presente recherche etudie dans quel contexte sont emis des comportements d'agitation verbale (AV). L'etude a ete realisee aupres de 15 participants atteints de demence, residant en institution et presentant des comportements agites. Les participants ont fait l'objet d'une observation assistee par un ordinateur de main. La frequence et la duree des episodes d'agitation ont ete calculees. L'heure, le lieu, l'activite pratiquee, la presence d'autres personnes et l'utilisation de contention ont ete notes. Au total, 180 heures d'observation ont ete realisees, chaque participant etant observe pendant 12 heures, soit de 8 h00 a 20 h00. Les resultats montrent que les participants sont verbalement agites 10 % du temps. L'AV est emise lorsque les participants sont dans leur chambre (94 %), non engages dans une activite particuliere (81 %), seuls (80 %) et contentionnes (78 %). L'AV emerge surtout apres 14 h00 (73 %). Certaines caracteristiques contextuelles sont associees a de plus grandes concentrations d'AV que d'autres.
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- 2007
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4. Novel Benzimidazole Derivatives as Selective CB2 Inverse Agonists
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Stephane St-Onge, Hua Yang, D. Salois, M.-C. Brochu, E. Martin, Page Daniel, and William Brown
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Benzimidazole ,chemistry.chemical_compound ,chemistry ,Drug Discovery ,Pharmaceutical Science ,Molecular Medicine ,Inverse agonist ,Combinatorial chemistry - Published
- 2006
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5. Mathematical Modeling of the Magnesium Refining Furnace
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Y. M. Rybukhin, R. Hachette, C. Brochu, G. Simard, D. Argo, R.T. Bui, R. Sheng, and M. Smith
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Materials science ,chemistry ,Waste management ,Magnesium ,Metallurgy ,chemistry.chemical_element ,Refining (metallurgy) ,Electric arc furnace - Published
- 2013
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6. Réponse de la flore bactérienne de l'estuaire du Saint-Laurent à un éventuel déversement de pétrole
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Daniel Delille, Robert Siron, C. Brochu, and Émilien Pelletier
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Environmental science ,Water Science and Technology - Abstract
Résumé Un groupe de cinq mésocosmes de 3,5 m3 chacun, permettant de travailler en eaux froides, a été utilisé pour étudier l’évolution de la flore bactérienne de l’estuaire du Saint-Laurent sous différentes conditions de contamination (pétrole dispersé chimiquement, non traité ou relargué à partir d’un substrat) et à différentes saisons (températures de l’eau de mer variant de −1,8 à 16°C). Des concentrations en pétrole de
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- 1993
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7. Suivi d’une contamination pétrolière accidentelle dans l’estuaire moyen du Saint-Laurent: Le cas de l’Ile-aux-Grues
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R. Siron, Émilien Pelletier, and C. Brochu
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Environmental science ,Water Science and Technology - Abstract
Le sédiment superficiel (0-3cm), l’eau interstitielle, les particules en suspension et l’eau de surface autour de l’Ile-aux-Grues (Québec, Canada) ont été échantillonnés en mai 1988 (11 jours après le déversement du pétrolier Czantoria) et en juin 1990. Les concentrations en hydrocarbures totaux mesurées par spectrofluorescence révèlent l’enrichissement des particules en suspension relativement à la fraction dissoute et au sédiment. Les analyses en chromatographie en phase gazeuse montrent que la contamination pétrolière du sédiment a été très ponctuelle. En mai 88, seulement deux stations montraient les indices d’une forte contamination pétrolière du sédiment, qui n’était plus décelée significativement deux ans après. A l’une de ces stations, la biodégradation des hydrocarbures semblait très avancée dans le sédiment, alors que l’eau interstitielle était enrichie en dérivés naphtaléniques. Des résidus de type émulsions “d’eau-dans-1’huile” non altérés étaient retrouvés adsorbés sur des rochers aux deux extrémités de l’ile, 11 jours après l’accident. Dans le sédiment prélevé en mai 88, l’origine fossile des hydrocarbures se superpose à un “bruit de fond” dans lequel on peut distinguer une importante contribution biogénique (n-alcanes à chaînes impaires, rétène, pérylène). Durant les deux séries d’échantillonnage, tous les hydrocarbures aromatiques polycycliques (HAP) dérivés de combustion ont été retrouvés à des niveaux relativement faibles dans le sédiment, confirmant la légère contamination pyrogénique à laquelle le site étudié est soumis.
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- 1991
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8. Preliminary evidence of safety following administration of L-DOPA and buspirone in an incomplete monoplegic patient
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C Brochu and Pierre A. Guertin
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Adult ,Male ,Levodopa ,Central Nervous System Venous Angioma ,Movement ,Treatment outcome ,Cerebral palsy ,Buspirone ,Antiparkinson Agents ,Postoperative Complications ,Anti-Anxiety Agents ,medicine ,Humans ,Leg ,Dose-Response Relationship, Drug ,business.industry ,Cerebral Palsy ,General Medicine ,medicine.disease ,nervous system diseases ,Treatment Outcome ,Neurology ,Regional Blood Flow ,Anesthesia ,Drug Therapy, Combination ,Neurology (clinical) ,business ,Administration (government) ,medicine.drug - Abstract
Case report.To report a case where a monoplegic patient received L-DOPA and/or buspirone. These compounds, normally used in the treatment of Parkinson's disease and anxiety respectively, were recently shown to induce spinal locomotor network activity and reflex stepping-like movements in animal models of spinal cord injury (SCI). However, the safety of these drugs as potential treatments for Central Pattern Generator (CPG) activation in paralyzed individuals remain unclear.St-Jean-Chrysostome, Quebec, Canada.The acute effects induced by these compounds were qualitatively assessed by the patient, a 38-year-old man who underwent surgery 17 years ago to remove an intracavernous angioma located at the mid-thoracic level (T5-T6) of the spinal cord.Self-administration every 2 days of L-DOPA (200, 400 and 600 mg, p.o.) and buspirone (5, 10 and 15 mg, p.o.) either separately or combined led to no atypical side effects (that is, occasional sleepiness, nervousness, insomnia or mild headaches). No movement was induced ipsilaterally although some sensations referred to by the patient as an increased blood flow in the lower back and upper leg regions were reported shortly after administration of the combined treatment.The results show no significant side effects following acute administration of L-DOPA and/or buspirone. This constitutes the first report providing preliminary evidence of safety following administration of these drugs in incompletely paralyzed individuals. The sensations of increased blood flow ipsilaterally with the combined treatment may also suggest that the dose regimen was not optimal or sub-threshold for inducing detectable CPG-mediated leg movements.
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- 2008
9. Lack of suppressive effects of mixtures containing low levels of methylmercury (MeHg), polychlorinated dibenzo-p-dioxins (PCDDS), polychlorinated dibenzofurans (PCDFS), and aroclor biphenyls (PCBS) on mixed lymphocyte reaction, phagocytic, and natural killer cell activities of rat leukocytes in vitro
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Francine Denizeau, C. Brochu, Edouard F. Potworowski, Felix Olima Omara, Denis Flipo, Pauline Brousseau, and Michel Fournier
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Male ,Aroclors ,Polychlorinated Dibenzodioxins ,Phagocyte ,Cell Survival ,Health, Toxicology and Mutagenesis ,Lymphocyte ,T-Lymphocytes ,Toxicology ,Natural killer cell ,chemistry.chemical_compound ,In vivo ,medicine ,Splenocyte ,Animals ,Soil Pollutants ,Methylmercury ,Benzofurans ,Phagocytes ,Dibenzofurans, Polychlorinated ,Methylmercury Compounds ,Molecular biology ,Polychlorinated Biphenyls ,Rats, Inbred F344 ,Rats ,Killer Cells, Natural ,medicine.anatomical_structure ,chemistry ,Environmental chemistry ,Toxicity ,Lymphocyte Culture Test, Mixed ,Polychlorinated dibenzofurans ,Spleen - Abstract
Rat splenocyte mixed leukocyte reaction (MLR), splenic natural killer (NK) cell activity, and phagocytic activities of splenic, peritoneal, and peripheral blood leukocytes (PBLs) were evaluated in vitro to determine the immunotoxicity of mixtures containing low levels of methylmercury (MeHg), polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and Aroclor polychlorinated biphenyls (PCBs). The mixtures were based on the concentrations of the chemicals in fish flesh. Leukocytes from male Fischer rats were exposed to MeHg (0.1-2 microg/ml), PCDD/PCDF mixtures (1-15 pg/ml) of three PCDDs (2,3,7,8-tetrachlorodibenzo-p-dioxin, 1,2,3,7,8-pentachlorodibenzo-p-dioxin, and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin) and two PCDFs (2,3,7,8-tetrachlorodibenzofuran and 1,2,3,7,8-pentachlorodibenzofuran), three Aroclor PCB (Aroclor 1242, 1254, and 1260) mixtures (0.01-0.5 microg/ml), or combinations of MeHg/PCB/PCDD/PCDF mixtures for 24 or 72 h before immunological assays. Phagocytosis and NK cell cytotoxicity were evaluated with a flow cytometer, and MLR of Fischer rat responder splenocytes cultured with mitomycin C-treated Long-Evans splenocytes by [3H]thymidine uptake. Exposure to MeHg (2 microg/ml) alone or with PCB/ PCDD/PCDF resulted in significant cytolethality in rat splenocytes, peritoneal leukocytes, and PBLs at 24 h exposure. Treatment with Aroclor PCB mixtures, PCDD/PCDF mixtures, 0.1 microg MeHg/ml (noncytolethal), or PCB/PCDD/PCDF mixtures with 0.1 microg MeHg/ml caused no suppression of splenocyte MLR response, splenic NK cell-mediated lysis of Yac-l cells, or phagocytosis of fluorescent beads by splenic, peritoneal, and peripheral blood phagocytic cells. The results indicate that in vitro exposure of rat leukocytes to low levels of MeHg, Aroclor PCB mixtures, PCDD/PCDF mixtures, or MeHg/PCB/PCDD/PCDF mixtures had no suppressive effects on the immune functions assayed, and thus produced no additive immunotoxicity. However, in order to predict the potential risk of these chemical mixtures to the human immune system, in vivo animal studies with blood (tissue) levels compatible with the levels of MeHg, PCBs, and PCDDs/PCDFs in exposed human populations should be evaluated.
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- 1998
10. Environmental factors influencing the biodegradation of petroleum hydrocarbons in cold seawater
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R. Siron, Émilien Pelletier, and C. Brochu
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chemistry.chemical_classification ,Detritus ,Ecology ,Health, Toxicology and Mutagenesis ,General Medicine ,Contamination ,Biodegradation ,Toxicology ,Pollution ,Mesocosm ,chemistry.chemical_compound ,Hydrocarbon ,chemistry ,Environmental chemistry ,Petroleum ,Seawater ,Water pollution - Abstract
A group of five mesocosms (3.5 m3 each) located at Pointe-au-Pere (St. Lawrence Estuary), Canada, was used to study the biodegradation of crude oil dispersed in cold and icy seawater (−1.8 to 5.5°C) under various environmental conditions. Experiments took place during autumn, winter, and spring and lasted from 2 weeks to 2 months. The bacterial response to the oil was assessed by recording the growth of total bacteria, viable heterotrophic bacteria, and oil-degrading bacteria. Some hydrocarbon ratios were calculated from gas chromatography in aliphatic and aromatic oil fractions and were used as biodegradation indices. A “Combined Index of Biodegradation” is proposed for assessing the overall biodegradation advancement. The winter period appeared critical for an oil spill in arctic/subarctic environments because of the reduced biodegradation under icy conditions. Crude oil adsorbed onto a substrate was found more degraded on its immersed part than on the emerged section exposed to winter conditions. Under more favorable environmental conditions (temperatures >0°C, effective chemical dispersion, oil release, spring microalgal bloom), the bacterial degradation would significantly alter the dissolved/dispersed oil within a few days. Under such conditions, half-life times of dissolved petroleum PAH ranged from 1.5–1.7 days (naphthalene) to 2.4–7.5 days (dimethylphenanthrenes), depending on the contamination level. In microenvironments where oil residues accumulated with biological detritus (surface microlayer, settling matter), the oil biodegradation was naturally enhanced. In contrast, water-in-oil emulsions recovered at the surface of mesocosms were unaltered after one month exposure in autumn.
- Published
- 1995
- Full Text
- View/download PDF
11. A294 INTENSIVE CARE UNIT OUTCOME OF PATIENTS RECEIVING CHRONIC HEMODIALYSIS
- Author
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C Brochu, H L Corwin, and A Gettinger
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Intensive care unit ,Outcome (game theory) ,law.invention ,Anesthesiology and Pain Medicine ,law ,Critical care nursing ,medicine ,Chronic hemodialysis ,Hemodialysis ,Intensive care medicine ,business - Published
- 1990
- Full Text
- View/download PDF
12. A238 CLINICAL ACCURACY OF A NEW MODULAR MIXED-VENOUS SATURATION OXIMETER
- Author
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I Mroz, P Wager, A Gettinger, and C Brochu
- Subjects
Anesthesiology and Pain Medicine ,business.industry ,Medicine ,Modular design ,Saturation (chemistry) ,business ,Biomedical engineering - Published
- 1990
- Full Text
- View/download PDF
13. FP 5 Immunotoxicity of complex mixtures in rat and human
- Author
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F. Denizeau, P. Brousseau, Felix Olima Omara, C. Brochu, D. Flipo, Edouard F. Potworowski, and Michel Fournier
- Subjects
Immunology ,Pharmacology ,Biology ,Developmental Biology - Published
- 1997
- Full Text
- View/download PDF
14. FP 3 Validation of mouse fetal thymic organ culture as bioassay to monitor immunotoxic potential of xenobiotics
- Author
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C. Beauchemin, Edouard F. Potworowski, C. Brochu, F. Denizeau, Michel Fournier, and P. Brousseau
- Subjects
chemistry.chemical_compound ,chemistry ,Immunology ,Bioassay ,Pharmacology ,Biology ,Xenobiotic ,Developmental Biology ,Fetal Thymic Organ Culture - Published
- 1997
- Full Text
- View/download PDF
15. Quantitative Budget of Chemically Dispersed Crude Oil in ICY Seawater: An Experimental Approach
- Author
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R. Siron, C. Brochu, and E. Pelletier
- Subjects
Petroleum engineering ,Seawater ,Crude oil ,Geology - Published
- 1991
- Full Text
- View/download PDF
16. The Effects of Chemical Dispersion on Long-Term Weathering of Crude Oil in Cold Seawater
- Author
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J. Desnoyers, Émilien Pelletier, C. Brochu, and J. H. Vandermeulen
- Subjects
Hydrology ,chemistry.chemical_compound ,Water column ,chemistry ,Oil droplet ,Environmental chemistry ,Petroleum ,Seawater ,Weathering ,Biodegradation ,Crude oil ,Dispersion (chemistry) ,Geology - Abstract
The effects of chemical dispersion on crude oil weathering in cold seawater have been studied in a mesoscale simulator (1,675 L) under ambient air conditions. Oil droplets dispersed in the contained water column were rapidly biodegraded during the fall experiment whereas the bacterial activity was reduced by at least one order of magnetude in experiments conducted below an ice cover. Undispersed oil formed a water in oil emulsion (chocolate mousse) very resistant to weathering processes. During winters mousses were trapped in ice and recovered almost unchanged 3 to 4 months later.
- Published
- 1987
- Full Text
- View/download PDF
17. NEW PROTECTED EXPERIMENTAL TANKS FOR ENVIRONMENTAL STUDIES UNDER SEVERE WEATHER CONDITIONS
- Author
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S. Roy, Émilien Pelletier, C. Brochu, and P. Mayzaud
- Subjects
Environmental studies ,Severe weather ,Environmental science ,Environmental planning - Published
- 1989
- Full Text
- View/download PDF
18. LONG-TERM OIL WEATHERING UNDER SEA ICE IN EXPERIMENTAL MESOSCALE SIMULATOR
- Author
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C. Brochu, J. H. Vandermeulen, and Émilien Pelletier
- Subjects
geography ,geography.geographical_feature_category ,Oceanography ,Mesoscale meteorology ,Sea ice ,Weathering ,Geology ,Term (time) - Published
- 1987
- Full Text
- View/download PDF
19. Doppler Spreading of Reverberation in Shallow Water
- Author
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J. M. Ross and C. Brochu
- Subjects
Reverberation ,Acoustics and Ultrasonics ,Scattering ,Acoustics ,Mineralogy ,Surface conditions ,Waves and shallow water ,symbols.namesake ,Transducer ,Arts and Humanities (miscellaneous) ,Thermal ,symbols ,Doppler effect ,Geology - Abstract
Reverberation data have been gathered with a narrow‐beam transducer, which transmitted a 1.4 sec CW pulse at 9.5 khz. The transducer was towed through the waters of the Scotian Shelf and Gulf of St. Lawrence at various depths. Conditions exist in these relatively shallow water areas where surface, volume, and bottom are all, at different times, the dominant backscattering mechanism. In winter, because of the typically strong positive thermal gradients, surface reverberation dominates. In summer, two common situations exist: (1) a strong negative gradient, where bottom is the dominant backscatterer, and (2) a pronounced sound channel where volume may be the dominant backscatterer if leakage is small. If sufficient leakage occurs, contributions from bottom and volume reverberation can both be significant. When surface reverberation dominates, spectral bandwidths are a function of the sea surface conditions. When bottom reverberation is dominant, the spectral spreading is greater than that associated with the system resolution, probably due to variations in shear currents. The spreading associated with volume reverberation lies between that of bottom and surface backscattering, but the scattering strength is significantly lower.
- Published
- 1973
- Full Text
- View/download PDF
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