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2. Parma consensus statement on metabolic disruptors

Author

Laura Rizzir, Patrizia Bovolin, Maria E. Street, Ronit Machtinger, Michelle A. Mendez, Gemma Calamandrei, Riccardo Volpi, Frederick S. vom Saal, Alberto Mantovani, Jérôme Ruzzin, Juliette Legler, Thaddeus T. Schug, Susan C. Nagel, Jerrold J. Heindel, Alexander Suvorov, Stefano Parmigiani, Laura Molteni, Paola Palanza, Luisa Montanini, Bruce Blumberg, Giancarlo Panzica, Christopher D. Kassotis, Laura Gioiosa, Michele A. La Merrill, Giorgio Sartor, R. Thomas Zoeller, Graziano Ceresini, Valentina Pomatto, Silvia Paterlini, Elena Fabbri, Barbara A. Cohn, Heindel JJ, vom Saal FS, Blumberg B, Bovolin P, Calamandrei G, Ceresini G, Cohn BA, Fabbri E, Gioiosa L, Kassotis C, Legler J, La Merrill M, Rizzir L, Machtinger R, Mantovani A, Mendez MA, Montanini L, Molteni L, Nagel SC, Parmigiani S, Panzica G, Paterlini S, Pomatto V, Ruzzin J, Sartor G, Schug TT, Street ME, Suvorov A, Volpi R, Zoeller RT, Palanza P, Heindel, J, vom Saal, F, Blumberg, B, Bovolin, P, Calamandrei, G, Ceresini, G, Cohn, B, Fabbri, E, Gioiosa, L, Kassotis, C, Legler, J, La Merrill, M, Machtinger, R, Mantovani, A, Mendez, M, Montanini, L, Molteni, L, Nagel, S, Parmigiani, S, Panzica, G, Paterlini, S, Pomatto, V, Ruzzin, J, Sartor, G, Schug, T, Street, M, Suvorov, A, Volpi, R, Zoeller, R, Palanza, P, and Rizzi, L

Subjects
Health, Toxicology and Mutagenesis, Consensus Development Conferences as Topic, Metabolic disruptor, Diabete, Toxicology, Medicine, 2.1 Biological and endogenous factors, Obesogen, State of the science, Metabolic disease, Aetiology, Metabolic Syndrome, Metabolic Syndrome X, Diabetes, Diabetes Mellitu, Environmental exposure, endocrine disruptors, Italy, Public Health and Health Services, Environmental Pollutants, Human, medicine.medical_specialty, brain, Hazardous Substances, Animal model, Medisinske Fag: 700 [VDP], Internal medicine, Environmental health, Diabetes Mellitus, Humans, Obesity, Environmental Pollutant, Metabolic and endocrine, Nutrition, business.industry, Public health, Public Health, Environmental and Occupational Health, Correction, environmental metabolic disrupting chemicals, Research needs, Environmental Exposure, Congresses as Topic, medicine.disease, Endocrinology, Developmental Programming, Hazardous Substance, fat tissue, Metabolic syndrome, business, obesity, endocrine disruptors, environmental metabolic disrupting chemicals, fat tissue, brain
Abstract

© 2015 Heindel et al. A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16-18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to the role of environmental chemicals, referred to as "metabolic disruptors", in obesity and metabolic syndrome with special attention to recent discoveries from animal model and epidemiology studies; 2. Identify conclusions that could be drawn with confidence from existing animal and human data; 3. Develop predictions based on current data; and 4. Identify critical knowledge gaps and areas of uncertainty. The consensus statements are intended to aid in expanding understanding of the role of metabolic disruptors in the obesity and metabolic disease epidemics, to move the field forward by assessing the current state of the science and to identify research needs on the role of environmental chemical exposures in these diseases. We propose broadening the definition of obesogens to that of metabolic disruptors, to encompass chemicals that play a role in altered susceptibility to obesity, diabetes and related metabolic disorders including metabolic syndrome.

Published
2015

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