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1. MOESM1 of Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site

Author

Meenakshisundaram Balasubramaniam, Parcon, Paul, Bose, Chhanda, Liu, Ling, Jones, Richard, Farlow, Martin, Mrak, Robert, Barger, Steven, and W. Griffin

Subjects
inorganic chemicals, enzymes and coenzymes (carbohydrates), bacteria, macromolecular substances, environment and public health
Abstract

Additional file 1: Figure S1. Non-phosphorylated ubiquitin (A) does not interact with critical residues in the P-Ub binding-site (yellow), and does not lead to opening of the parkin UBL domain, compared to phosphorylated ubiquitin (B, and NEDD8, not shown).

Published
2019
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