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PURPOSE: The aim of this study was to determine the prevalence of distress and unmet supportive care needs in post-treatment colorectal cancer (CRC) survivors. Also, to explore the association between both variables and to identify potential associated sociodemographic and cancer-related risk factors. METHODS: A cross-sectional study of 200 CRC survivors who at least 1month before had completed the primary treatment for CRC was conducted. The Brief Symptom Inventory-18 (BSI-18) and the Spanish version of Cancer Survivors' Unmet Needs (S-CaSUN) were used. RESULTS: One in five CRC survivors showed clinical distress and 86% expressed at least one unmet need. Distress was positively associated with the prevalence of needs in all domains. All comprehensive care and information needs were expressed by at least 20% of survivors and some by more than 50%. Other needs also mentioned by 20% of survivors were financial support, ongoing case manager, and concerns about cancer recurrence. The risk factors associated were lower socioeconomic status, younger age, and a primary treatment that includes more than surgery. CONCLUSIONS: The findings highlight the relevance of extending psychosocial care beyond the CRC primary medical treatment. A person-centered approach that addresses informational, emotional, social, and physical needs can increase satisfaction with care and also prevent psychological morbidity in CRC survivors.

The European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN), is dedicated to gathering the best expertise in Europe and provide accessible cross-border healthcare to patients with rare vascular dis-eases. Infantile Hemangiomas (IH) are benign vascular tumors of infancy that rapidly growth in the first weeks of life, followed by stabilization and spontaneous regression. In rare cases the extent, the localization or the number of lesions may cause severe complications that need specific and careful management. Severe IH may be life-threatening due to airway obstruction, liver or cardiac failure or may harbor a risk of functional impairment, severe pain, and/or significant and permanent disfigurement. Rare IHs include syndromic variants associated with extracutaneous abnormalities (PHACE and LUMBAR syndromes), and large segmental hemangiomas. There are publications that focus on evidence-based medicine on propranolol treatment for IH and consensus state -ments on the management of rare infantile hemangiomas mostly focused on PHACES syndrome. The Vascular Anomalies Working Group (VASCA-WG) decided to develop a diagnostic and management pathway for severe and rare IHs with a Nominal Group Technique (NGT), a well-established, structured, multistep, facilitated group meeting technique used to generate consensus statements. The pathway was drawn following two face-to-face

Se han preparado una serie de compuestos de ácido poliláctico (PLA) con celulosa microfibrilada (MFC) con el objetivo de buscar una mejora en las propiedades mecánicas, térmicas y de transporte de gases del polímero. Para ello, en primer lugar, se modificó la superficie de las microfibras para hacerlas más compatibles con la matriz polimérica. Se ensayaron distintos métodos de mezclado, llegando a la conclusión de que es posible obtener buenas dispersiones mediante procesado en fundido, siempre que se parta de un concentrado de microfibras con el polímero. La caracterización de los materiales dio como resultado un aumento en los módulos de almacenamiento respecto del PLA puro, incluso a bajos (4% en peso) contenidos de MFC. La estabilidad térmica no se ve deteriorada por la incorporación de las microfibras y por lo que se refiere a las propiedades barrera, se registraron valores de permeabilidad a distintos gases ligeramente inferiores en comparación con el PLA puro., A series of composites from polylactic acid (PLA) and microfibrillated cellulose (MFC) were prepared with the aim of searching for an improvement in mechanical, thermal and gas barrier properties. Firstly, the microfibers surface was modified to make them more compatible with the polymer matrix. After testing different methods of mixing, the conclusion is that it is possible to achieve fair dispersions by melt compounding if a masterbatch is used. The mechanical characterization of the samples showed that the storage modulus of the composites increased compared to neat PLA even at low MFC content (4 wt.%). On the other hand, the thermal stability did not deteriorate in the composites, and the permeability to different gases was slightly lower than that of neat PLA., Los autores agradecen al Ministerio de Ciencia e Innovación por la concesión del proyecto PID2019-109401GB-I00. Asimismo, agradecen al IVACE (Instituto Valenciano de Competitividad Empresarial) que a través del programa Promece 2022 ha cofinanciado parte de los resultados expuestos en este trabajo.

The possibility to develop neuromorphic computing devices able to mimic the extraordinary data processing capabilities of biological systems spurs the research on memristive systems. Memristors with additional functionalities such as robust memcapacitance can outperform standard devices in key aspects such as power consumption or miniaturization possibilities. In this work, we demonstrate a large memcapacitive response of a perovskite memristive interface, using the topotactic redox ability of La$_{0.5}$Sr$_{0.5}$Mn$_{0.5}$Co$_{0.5}$O$_{3-��}$ (LSMCO, 0 $\leq$ $��$ $\leq$ 0.62). We demonstrate that the multi-mem behaviour originates at the switchable n-p diode formed at the Nb:SrTiO3/LSMCO interface. We found for our Nb:SrTiO$_{3}$/LSMCO/Pt devices a memcapacitive effect C$_{HIGH}$/C$_{LOW}$ ~ 100 at 150 kHz. The proof-of-concept interface reported here opens a promising venue to use topotactic redox materials for disruptive nanoelectronics, with straightforward applications in neuromorphic computing technology., 14 pages, 5 figures, to appear in Appl. Phys. Lett

Catecholaminergic polymorphic ventricular tachycardia is a rare familial arrhythmogenic disease. It usually occurs in juvenile patients with a structurally normal heart and causes exercise-emotion triggered syncope and sudden cardiac death. The main gene associated with catecholaminergic polymorphic ventricular tachycardia is RyR2, encoding the cardiac ryanodine receptor protein which is involved in calcium homeostasis. After the identification of a 16 year-old man presenting with exercise-induced sudden cardiac death, clinically diagnosed as catecholaminergic polymorphic ventricular tachycardia, we collected the family information and performed a comprehensive genetic analysis using Next Generation Sequencing technology. The initial electrocardiogram in the emergency department revealed ventricular fibrillation. On electrocardiogram monitoring, sinus tachycardia degenerated into bidirectional ventricular and into ventricular fibrillation. Catecholaminergic polymorphic ventricular tachycardia was clinically diagnosed in 5 of the 14 family members evaluated. There were no additional reports of seizures, pregnancy loss, neonatal death, or sudden cardiac death in family members. Genetic analysis of the index case identified only one rare novel variant p.Ile11Ser (c.32T>G) in the RyR2 gene. Subsequent familial analysis identified segregation of the genetic variant with the disease. All current evidence supports that novel p.Ile11Ser variant in the RyR2 gene is a potential disease-causing variant in catecholaminergic polymorphic ventricular tachycardia. To our knowledge, there has been no previous case report of catecholaminergic polymorphic ventricular tachycardia associated to this missense variant.

In this work, we use the results from Higgs searches in the $����$ and $����$ decay channels at LHC and indirect bounds as BR$(B \to X_s ��)$ to constrain the parameter space of a generic MSSM Higgs sector. In particular, we include the latest CMS results that look for additional Higgs states with masses up to 1 TeV. We show that the $����$ channel is the best and most accurate weapon in the hunt for new Higgs states beyond the Standard Model. We obtain that present experimental results rule out additional neutral Higgs bosons in a generic MSSM below 300 GeV for any value of $\tan ��$ and, for instance, values of $\tan ��$ above 30 are only possible for Higgs masses above 600 GeV. ATLAS stored data has the potential to render this bound obsolete in the near future., 23 pages, 8 figures

Analgesics can avoid postoperative pain. The aim of this study was to evaluate their prescription after abdominal surgery.Prospective study including patients who had undergone abdominal surgery in two hospitals in Barcelona, in 1993. Prescription and administration of analgesic drugs, and pain severity during the first 48 hours of the postoperative period were evaluated.One hundred and sixty-four patients (83 men) were included. The most frequently prescribed drugs were metamizol (111; 68%), pethidine (83, 51%), and diclofenac (44; 27%). A high percentage of analgesic prescriptions on an "as needed" basis was recorded. Administered doses were lower than those recommended, and lower than those prescribed. Fifty-three percent of patients suffered significant pain during the first day.A too low proportion of analgesic drugs is prescribed in a predetermined schedule, in contrast to "as needed" prescription. Opiate derivatives are underused. All analgesic drugs are prescribed at inadequate dosage. This prescription pattern is associated with a high prevalence of postoperative pain.

This panelling system offers the market solutions for dwellings, schools, health centers and, in general, for all cases in which urgent delivery and eventual recuperation are needed, notably reducing transportation costs, due to the possibility of shipping in manageable packages of small size. The light modules can be grouped in various manners, insofar as floorplan and height, thus obtaining real buildings, in advantageous competition with traditional construction in some aspects, besides contributing great mobility and speed. In exchange, a more detailed study is required, as well as a carefully prepared project, as the result is from an industrial process. The article describes all of the operations, building procedures, technical - structural aspects, joints, aerodynamic transport phenomena, preparation of the site, etc. which make up this interesting pre-fabrication system., Mediante este sistema panelizado se ofrecen al mercado soluciones para viviendas, escuelas, centros sanitarios y, en general, para todos aquellos casos en que se precise una urgente entrega y una eventual recuperabilidad, reduciéndose notablemente los gastos de transporte, dada la posibilidad de su envío en paquetes manejables y de escaso tamaño. Los módulos ligeros pueden agruparse de formas diversas, en planta y en altura, lográndose así verdaderos edificios, en ventajosa competencia, en algunos aspectos, con la construcción tradicional, aportando además una gran movilidad y rapidez. A cambio de ello se requiere un estudio más detallado y un minucioso proyecto al ser el resultado de un proceso industrial. Se describen en el artículo todas las operaciones, procedimientos constructivos, aspectos técnico-estructurales, uniones, fenómenos aerodinámicos de transporte, preparación del terreno, etc., que configuran este interesante sistema de prefabricación.

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To establish the interrelationship between protein synthesis and degradation, we have developed a simple procedure. We have chosen the mitochondrial proteins, because most of them are synthesized outside mitochondria and are then imported into the organelle. This fact allows to separate easily the synthesis steps from the general turnover. By using this system we have some evidences suggesting that the in vitro protein concentration in mitochondria may be regulated by the entry of mitochondrial protein precursors. Also, we are studying the factors that regulate the import of mitochondrial protein precursors into the organelle, because this step may be essential in the regulation of the turnover of mitochondrial proteins.

England.To investigate the proportion of tuberculosis (TB) cases attributable to recent transmission and factors associated with clustering.Demographic, clinical and microbiological surveillance data were collated from all new culture-confirmed cases in 1998. Using insertion sequence (IS) 6110 restriction fragment length polymorphism (RFLP) typing, strains were classified as clustered (identical patterns) or unique and risk factors were determined using multivariable logistic regression.RFLP patterns were available for 2265 of 3713 (61%) cases: 1808 hador=5 IS6110 copies, while 372 cases were in 152 clusters, giving an estimated proportion due to recent transmission of 12.2%.Pulmonary disease (aOR 1.6; 95%CI 1.1-2.2), previous treatment (aOR 3.7; 2.2-6.5) and homelessness (aOR 5.5; 1.2-24.1) were independent risk factors for clustering. Fourteen per cent of patients of Indian subcontinent origin were clustered compared with 27% of white patients. Many clusters spanned ethnic groups (45%) and geographical regions (47%).The calculated proportion of TB cases due to recent transmission is low.Adjusting for missed cases and study duration, it increases to 27.6%. Many cases may arise from reactivation or acquisition outside England. Transmission within England accounted for approximately one in four cases and occurred over wide geographic areas, between ethnic groups and among the homeless. Molecular epidemiology can inform local and national public health action.