22 results on '"Bo Kyeung Jung"'
Search Results
2. COVID-19 유행 전과 후 분리된 호흡기 병원미생물에 대한 항균제 내성 패턴
- Author
-
Ki-Yeon Kim, Jae-Soo Kim, Bo-Kyeung Jung, and Ga-Yeon Kim
- Published
- 2023
3. Comparison of Blood Test Results and Symptoms of Patients with COVID-19 Monoinfection and with COVID-19 and Influenza Virus Co-Infection
- Author
-
Bo Kyeung Jung, Seung Keun Ham, and Jae Kyung Kim
- Published
- 2022
4. Changes in Respiratory Pathogens before and after the COVID-19 Pandemic (2018-2021)
- Author
-
Ki Yeon Kim, Jae Soo Kim, Young Ki Lee, Ga Yeon Kim, and Bo Kyeung Jung
- Subjects
Male ,General Immunology and Microbiology ,Article Subject ,Humans ,COVID-19 ,Female ,General Medicine ,Pandemics ,Moraxella catarrhalis ,General Biochemistry, Genetics and Molecular Biology ,Aged ,Retrospective Studies ,Anti-Bacterial Agents - Abstract
Objective. This study is aimed at investigating the pattern of change occurring in respiratory pathogens before and after the outbreak of COVID-19, a type of viral pneumonia for which a pandemic was declared (March 2020). The results were analyzed by gender and age to identify the association between personal hygiene and prevention of infection by respiratory pathogens. Methods. A retrospective analysis was performed on 39,814 sputum, bronchial aspirate, and transtracheal aspirate samples obtained from 15,398 patients visiting a university hospital, located in Chungcheongnam-do, South Korea, between January 2018 and December 2021. From 4,454 patients whose samples were culture positive for bacteria, 6,389 strains were isolated and further cultured. Results. The mean age of the outpatients with respiratory pathogens was 66.2 years, and the comparison of the culture test results by gender showed that 64.9% (2,892/4,454) were male and 35.1% (1,562/4,454) were female. Compared to the pre-COVID-19 pandemic period, the number of outpatients with a request for respiratory microbial cultures after the onset of the pandemic was reduced by 20.7% and the number of outpatients with a positive culture result was reduced by 23.0%. The number of respiratory samples received was reduced by 6.7% after the pandemic, while the sample positive rate was reduced by 18.3%. Among the isolated microbial strains, there was a significant decrease of 43.1% for the Acinetobacter baumannii complex, 60.5% for Streptococcus pneumoniae, 67.2% for Haemophilus influenzae, and 78.1% for Moraxella catarrhalis when compared with pre-COVID-19 levels. The distribution of respiratory microbial strains by age group showed that the highest percentage of isolated strains was in patients in their 70s. Conclusions. The improvements in personal hygiene due to the COVID-19 pandemic exerted a substantial influence on the pattern of change in other common respiratory microorganisms, which highlights the importance of personal hygiene management in the prevention of respiratory infections.
- Published
- 2022
5. Prevalence and Antimicrobial Susceptibility of Streptococcus pneumoniae Isolated from Clinical Samples in the Past 8 Years in Korea
- Author
-
Ga Yeon Kim, Jae Soo Kim, Jong-Wan Kim, and Bo Kyeung Jung
- Subjects
Male ,0301 basic medicine ,medicine.disease_cause ,0302 clinical medicine ,Levofloxacin ,Drug Resistance, Multiple, Bacterial ,Prevalence ,030212 general & internal medicine ,Child ,Aged, 80 and over ,General Medicine ,Middle Aged ,Anti-Bacterial Agents ,Pneumococcal infections ,Streptococcus pneumoniae ,Child, Preschool ,Ceftriaxone ,Medicine ,Female ,Seasons ,medicine.symptom ,Research Article ,medicine.drug ,Adult ,medicine.medical_specialty ,Article Subject ,Adolescent ,030106 microbiology ,Erythromycin ,Microbial Sensitivity Tests ,General Biochemistry, Genetics and Molecular Biology ,Young Adult ,03 medical and health sciences ,Age Distribution ,Antibiotic resistance ,Internal medicine ,Republic of Korea ,medicine ,Humans ,Aged ,General Immunology and Microbiology ,business.industry ,Infant, Newborn ,Infant ,Clindamycin ,medicine.disease ,Sputum ,business - Abstract
Pneumococcal infection is the main causative agent of pneumonia, meningitis, and sepsis in immunocompromised and elderly people. The samples in this study were collected from subjects in an 800-bed hospital in Chungnam province, Korea, over the past 8 years. Of the 473,230 samples obtained for microbial culture from 2012 to 2019, Streptococcus pneumoniae was isolated from 714 samples collected from 702 patients, with a pneumococcal-positive rate of 0.15%. We investigated the temporal, demographic, and specimen-specific distributions, as well as the antibiotic susceptibility pattern for S. pneumonia. The age of patients ranged from 0 days to 98 years, with an average age of 64.7 years. The distribution among the sexes was 2.4 : 1 (male : female), with more samples isolated from male patients. We observed that spring was the predominant season in which the infection occurred, accounting for 37.6% of the cases. Pneumococci were most frequently isolated from sputum (608 cases, 85.2%). Invasive infections were detected at a rate of 66% (in blood cultures), and noninvasive infections were detected at a rate of 91% (in sputum cultures). Antimicrobial resistance to ceftriaxone, cefotaxime, erythromycin, tetracycline, clindamycin, cotrimoxazole, levofloxacin, and penicillin, based on noninvasive infections, was observed in 21.6%, 27.2%, 79.2%, 73.2%, 68.0%, 51.3%, 9.8%, and 18.1% of cases, respectively. Additionally, on average, 66.9% of multidrug-resistant bacteria showed resistance to three or more antimicrobial agents, and 2.8% showed resistance to all other antibacterial agents except vancomycin. These results might facilitate the administration of appropriate empirical antibacterial therapy for pneumococcal infections.
- Published
- 2021
6. Screening of A1555G mDNA Variant Using U-TOP™HL Genotyping Kit in Korean Family with Progressive Hearing Loss
- Author
-
Kwang Hyun Byun, Min Young Lee, Bo Kyeung Jung, and Jung Hyun Ahn
- Subjects
Oncology ,0303 health sciences ,medicine.medical_specialty ,Hearing loss ,business.industry ,Progressive hearing loss ,03 medical and health sciences ,0302 clinical medicine ,Otorhinolaryngology ,Internal medicine ,medicine ,Surgery ,medicine.symptom ,030223 otorhinolaryngology ,business ,Genotyping ,030304 developmental biology - Abstract
Recently, real-time polymerase chain reaction (PCR) using the U-TOP™HL Genotyping Kit has been introduced to detect genetic hearing loss caused by certain type of gene variants popularly found in Korea. The mitochondrial 12S ribosomal ribonucleic acid (rRNA) genes are related to aminoglycoside induced or non-syndromic, sensorineural hearing loss. Among them, 1555A>G is commonly found and reported worldwide. We are presenting the case of a mother and a son, who were screened by real-time PCR using the U-TOP™HL Genotyping Kit and were found both to have the mitochondrial 12s rRNA 1555A>G variant with a different hearing loss phenotype. This report encourages clinicians to use this or similar screen methods for patients with familial hearing loss.
- Published
- 2021
7. Performance evaluation of four rapid antibody tests for the detection of severe acute respiratory syndrome coronavirus 2
- Author
-
Jae Kyung Kim, Sook Won Ryu, Jae Soo Kim, and Bo Kyeung Jung
- Subjects
Microbiology (medical) ,SARS-CoV-2 ,Biochemistry (medical) ,Clinical Biochemistry ,Public Health, Environmental and Occupational Health ,COVID-19 ,Hematology ,Antibodies, Viral ,Sensitivity and Specificity ,Medical Laboratory Technology ,Immunoglobulin M ,Immunoglobulin G ,Humans ,Immunology and Allergy - Abstract
The prompt detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is important in the therapeutic management of infected patients. Rapid diagnostic tests are widely used for this purpose. This study aimed to evaluate the clinical performance of four SARS-CoV-2 immunoglobulin IgG/IgM rapid diagnostic tests in the detection of SARS-CoV-2.Nasopharyngeal and oropharyngeal swabs and/or sputum were collected from 30 patients infected with SARS-CoV-2 and 30 healthy volunteers. All specimens were tested using four SARS-CoV-2 IgG/IgM rapid diagnostic tests and real-time polymerase chain reaction. We assessed the clinical sensitivity and specificity of the tests.The clinical sensitivity of FREND™, SsmarTest™, BIOCREDIT™, and IVDLAB™ was 96.67%, 100.00%, 100.00%, and 96.67%, respectively, compared to real-time polymerase chain reaction. The clinical specificity was 96.67%, 100.00%, 86.67%, and 96.67%, respectively.These findings could expedite the detection of SARS-CoV-2 and thus reduce the risk of further transmission of the virus.
- Published
- 2022
8. Laboratory Investigation of Human Rhinovirus Infection in Cheonan, Korea
- Author
-
Jae Kyung Kim and Bo Kyeung Jung
- Subjects
Rhinovirus infection ,business.industry ,Medicine ,Respiratory virus ,business ,Virology - Published
- 2019
9. Non-hemolytic, Mucinous, Coagulase Negative MRSA Isolated from Urine
- Author
-
Bo Kyeung Jung, Jae Soo Kim, Jong-Wan Kim, Ga Yeon Kim, and Qute Choi
- Subjects
0303 health sciences ,03 medical and health sciences ,business.industry ,0402 animal and dairy science ,Medicine ,04 agricultural and veterinary sciences ,Urine ,Coagulase ,business ,040201 dairy & animal science ,030304 developmental biology ,Microbiology - Abstract
84세 여성이 항문까지 욕창이 번져 응급실에 내원하였다. 그녀는 근처의 요양기관에서 전원되었고, 입원시 소변 도뇨관을 달고 있었으며 열은 없었다. 그람염색에서 많은 수의 포도상구균과 >25의 호중구 (×1000배 렌즈)가 관찰되었다. 24시간 배양한 혈액한천배지에서 용혈이 없는 점액성의 집락이 관찰되었으며 배양 48시간에는 점액성이 더욱 확대되었다. India ink로 염색하여 협막의 모습을 관찰하였으며, 카타라제 양성, 라텍스법 혈액응고효소 음성, 시험관법 혈액응고효소 음성소견을 보였다. Vitek-2와 질량분석기인 Vitek MS V-3 IVD에서 S.aureus로 나타났으며, 16S rRNA 유전자 염기서열 분석 및 Multilocus sequencing typing (MLST)에서 S. aureus로 표준균주인 ATCC 29213과 99.9% 일치를 보였다. 본 증례는 용혈성이 없고, 점액성이 강하며, 라텍스법 혈액응고효소 음성, 시험관법 혈액응고효소 음성소견을 보이는 MRSA를 동정하여 이를 보고한다.
- Published
- 2019
10. Comparative evaluation of Plateletworks, Multiplate analyzer and Platelet function analyzer-200 in cardiology patients
- Author
-
Bo Kyeung Jung, Chae Seung Lim, Chi Hyun Cho, Jeonghun Nam, Jeeyong Kim, Sehyun Shin, and Hong Seog Seo
- Subjects
Blood Platelets ,Male ,Spectrum analyzer ,medicine.medical_specialty ,Platelet Function Tests ,Physiology ,Diagnostic Techniques, Cardiovascular ,macromolecular substances ,030204 cardiovascular system & hematology ,Comparative evaluation ,03 medical and health sciences ,0302 clinical medicine ,Cohen's kappa ,Physiology (medical) ,Internal medicine ,Humans ,Medicine ,Platelet ,business.industry ,Hematology ,Middle Aged ,biochemical phenomena, metabolism, and nutrition ,equipment and supplies ,Platelet function test ,Cardiovascular Diseases ,030220 oncology & carcinogenesis ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Kappa - Abstract
The objective of this study was to comparatively evaluate three commercial whole-blood platelet function analyzer systems: Platelet Function Analyzer-200 (PFA; Siemens Canada, Mississauga, Ontario, Canada), Multiplate analyzer (MP; Roche Diagnostics International Ltd., Rotkreuz, Switzerland), and Plateletworks Combo-25 kit (PLW; Helena Laboratories, Beaumont, TX, USA). Venipuncture was performed on 160 patients who visited a department of cardiology. Pairwise agreement among the three platelet function assays was assessed using Cohen's kappa coefficient and percent agreement within the reference limit. Kappa values with the same agonists were poor between PFA-collagen (COL; agonist)/adenosine diphosphate (ADP) and MP-ADP (-0.147), PFA-COL/ADP and PLW-ADP (0.089), MP-ADP and PLW-ADP (0.039), PFA-COL/ADP and MP-COL (-0.039), and between PFA-COL/ADP and PLW-COL (-0.067). Nonetheless, kappa values for the same assay principle with a different agonist were slightly higher between PFA-COL/ADP and PFA-COL/EPI (0.352), MP-ADP and MP-COL (0.235), and between PLW-ADP and PLW-COL (0.247). The range of percent agreement values was 38.7% to 73.8%. Therefore, various measurements of platelet function by more than one method were needed to obtain a reliable interpretation of platelet function considering low kappa coefficient and modest percent agreement rates among 3 different platelet function tests.
- Published
- 2018
11. Climate Factors and Their Effects on the Prevalence of Rhinovirus Infection in Cheonan, Korea
- Author
-
Bo Kyeung Jung, Dong Kyu Lim, and Jae Kyung Kim
- Subjects
Rhinovirus infection ,business.industry ,Medicine ,business ,Applied Microbiology and Biotechnology ,Microbiology ,Virology ,Biotechnology - Published
- 2021
12. Viral Kinetics of SARS-CoV-2 Over the Preclinical, Clinical and Postclinical Period
- Author
-
Sukbin Jang, Ji-Young Rhee, and Bo Kyeung Jung
- Published
- 2020
13. Pattern of change of C-reactive protein levels and its clinical implication in patients with acute poisoning
- Author
-
Yong Oh Kim, Hyung Il Kim, and Bo Kyeung Jung
- Subjects
Acute-phase proteins ,Medicine (General) ,R5-920 ,inflammation ,Original Research Article ,General Medicine ,metabolism - Abstract
Objectives: C-reactive protein is well known as an inflammatory indicator in injury, infection, and cancer. However, little is known about its role in poisoning. C-reactive protein levels first increase and then decrease within several days during poisoning management. This study aimed to verify the C-reactive protein change pattern and its clinical co-infection possibility in patients with poisoning. Methods: Daily C-reactive protein levels of the patients with poisoning, who were admitted for more than 5 days, were measured. Microbial cultures were conducted, and fever (⩾38°C) and infection-related symptoms were investigated. Results: In the enrolled 56 patients, the initial median C-reactive protein levels at hospital day 1, 2, 3, 4, and 5 were 0.28, 4.85, 10.91, 10.57, and 6.68 mg/dL, respectively. C-reactive protein level was the highest at hospital day 3 and decreased thereafter. No statistical difference was observed in the daily and maximal C-reactive protein levels between the culture-positive and culture-negative groups. The levels at hospital days 3–5 and the maximal level were 8.4, 9.2, 5.49, and 11.02 mg/dL, respectively, in non-fever group. The levels at hospital days 3–5 and the maximal level were 7.4, 9.2, 4.74, and 10.81 mg/dL, respectively, in non-symptoms group. Levels at hospital days 3–5 and the maximal level were 5.21, 4.93, 3.7, and 5.28 mg/dL, respectively, in all-negative (culture-negative without fever or infection symptoms) group. Conclusions: Acute rise and fall of C-reactive protein levels can be observed in the infection-unlikely patients with poisoning. The levels were similar to bacterial infection levels, possibly due to the drug reaction itself, rather than for superimposed infections.
- Published
- 2022
14. A Case of Primary Anti-D Alloimmunization byRHD(c.1227G>A) DEL Red Blood Cell Transfusion
- Author
-
Jeeyong Kim, Young Eun Koh, Ha Nui Kim, Chae Seung Lim, Bo Kyeung Jung, Deok Ja Oh, Jung Yoon, and Sun Ah Lee
- Subjects
03 medical and health sciences ,0302 clinical medicine ,business.industry ,Anti-d antibody ,Red Blood Cell Transfusion ,Immunology ,Medicine ,030204 cardiovascular system & hematology ,business ,030215 immunology - Published
- 2016
15. Actual Incidence of Transfusion-Related Adverse Reactions Compared with Transfusion-Related Signs or Symptoms and by Each Blood Product
- Author
-
Young Eun Koh, Keun Young Ryu, Chae Seung Lim, Jeeyong Kim, Bo Kyeung Jung, Jung Yoon, and Mi-Ae Jang
- Subjects
03 medical and health sciences ,Pediatrics ,medicine.medical_specialty ,0302 clinical medicine ,Blood product ,business.industry ,Incidence (epidemiology) ,Medicine ,030212 general & internal medicine ,030204 cardiovascular system & hematology ,business ,Reporting system - Published
- 2016
16. Performance evaluation of four rapid antigen tests for the detection ofRespiratory syncytial virus
- Author
-
Jong Han Lee, Jung Hwa Lee, Sung Hyuk Choi, Chae Seung Lim, and Bo Kyeung Jung
- Subjects
0301 basic medicine ,business.industry ,viruses ,030106 microbiology ,Clinical performance ,virus diseases ,respiratory system ,medicine.disease ,Antigen test ,Virology ,Virus ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,Real-time polymerase chain reaction ,Antigen ,Rapid antigen test ,Lower respiratory tract infection ,Immunology ,medicine ,030212 general & internal medicine ,Respiratory system ,business - Abstract
Rapid identification of Respiratory syncytial virus (RSV) is important in the management of infected patients. Rapid diagnostic tests (RDT) are widely used for this purpose. This study aimed to evaluate the clinical performance of four RSV antigen tests including the BinaxNow RSV Card test, SD Bioline RSV test, BD Veritor RSV test, and Humasis RSV antigen test in comparison with real-time RT-PCR as the reference method. Nasopharyngeal swabs were collected from 280 patients with symptoms of lower respiratory tract infection and stored at -80°C. All swabs were tested for RSV using four rapid antigen tests and real time RT-PCR. The sensitivity of the BinaxNow RSV Card test, SD Bioline RSV test, BD Veritor RSV test, and Humasis RSV Antigen tests were 62.5%, 61.3%, 65.0%, and 67.5% for RSV A, and 61.3%, 65.0%, 61.3%, and 67.5% for RSV B compared to real time RT-PCR, respectively. The specificity of BD Veritor RSV test was 95.8% and those of the other three RDTs was 100%. Commercial RSV antigen detection assays are useful tools for the rapid diagnosis of RSV infection. However, confirmatory testing is always recommended. J. Med. Virol. 88:1720-1724, 2016. © 2016 Wiley Periodicals, Inc.
- Published
- 2016
17. Comparison of Quantitation of Cytomegalovirus DNA by Real-Time PCR in Whole Blood with the Cytomegalovirus Antigenemia Assay
- Author
-
Chang Kyu Lee, Yunjung Cho, Seonhee Kwon, Sun Young Ko, and Bo Kyeung Jung
- Subjects
Ganciclovir ,Concordance ,Clinical Biochemistry ,Congenital cytomegalovirus infection ,Cytomegalovirus ,Real-Time Polymerase Chain Reaction ,Antiviral Agents ,Cytomegalovirus DNA ,Viral Matrix Proteins ,Virology ,medicine ,Humans ,Whole blood ,Immunoassay ,business.industry ,Biochemistry (medical) ,virus diseases ,Organ Transplantation ,General Medicine ,Gold standard (test) ,Phosphoproteins ,medicine.disease ,Quantitative correlation ,Antigenemia assay ,Clinical Microbiology ,Real-time polymerase chain reaction ,Cytomegalovirus Infections ,DNA, Viral ,Immunology ,Original Article ,business ,Real-time PCR ,medicine.drug - Abstract
Background: Quantitation of cytomegalovirus (CMV) DNA using real-time PCR has been utilized for monitoring CMV infection. However, the CMV antigenemia assay is still the ‘gold standard’ assay. There are only a few studies in Korea that compared the efficacy of use of real-time PCR for quantitation of CMV DNA in whole blood with the antigenemia assay, and most of these studies have been limited to transplant recipients. Method: 479 whole blood samples from 79 patients, falling under different disease groups, were tested by real-time CMV DNA PCR using the Q-CMV real-time complete kit (Nanogen Advanced Diagnostic S.r.L., Italy) and CMV antigenemia assay (CINA Kit, ArgeneBiosoft, France), and the results were compared. Repeatedly tested patients were selected and their charts were reviewed for ganciclovir therapy. Results: The concordance rate of the two assays was 86.4% (Cohen’s kappa coefficient value=0.659). Quantitative correlation between the two assays was a moderate (r=0.5504, P
- Published
- 2015
18. ABO*Ael03/O Genotype with ABO Discrepancy: The First Case in Korea
- Author
-
Hye Nan Cho, Myung Hyun Nam, Jong Jin Hyun, Ji Seon Choi, Jung Hee Chang, Chaeseung Lim, Bo Kyeung Jung, and Gye Ryung Choi
- Subjects
Male ,medicine.medical_specialty ,DNA Mutational Analysis ,Clinical Biochemistry ,Case Report ,Polymerase Chain Reaction ,ABO subgroup ,Genetic analysis ,ABO Blood-Group System ,Disease course ,Molecular genetics ,ABO blood group system ,Republic of Korea ,Genotype ,medicine ,Humans ,Ael ,Allele ,Frameshift Mutation ,Alleles ,Genetics ,Base Sequence ,business.industry ,Korean population ,Biochemistry (medical) ,Exons ,General Medicine ,Middle Aged ,Pedigree ,Molecular analysis ,Phenotype ,Ael03 ,business ,Diagnostic Genetics - Abstract
The Ael subgroup expresses the least amount of A antigens and could only be detected by performing the adsorption-elution test. The frequency of the Ael subgroup is about 0.001% in Koreans, and the Ael02 allele, which originates from A102, is the most frequently identified allele in the Korean population. We report a Korean family with the Ael03 allele identified by molecular genetic analysis. To the best of our knowledge, this is the first such report in Korea to date.
- Published
- 2015
19. Detection of Platelet-Monocyte Aggregates by the ADAM® Image Cytometer
- Author
-
Jeong Ah Yoon, Bo Kyeung Jung, Kyung Chul Moon, Chi Hyun Cho, Soo Young Yoon, and Dae Sung Hur
- Subjects
Adult ,Blood Platelets ,Male ,Pathology ,medicine.medical_specialty ,Adolescent ,Platelet Aggregation ,Monocytes ,Flow cytometry ,Young Adult ,medicine ,Humans ,Platelet ,Platelet activation ,Child ,Aged ,Cell Aggregation ,Fluorescent Dyes ,Whole blood ,Alternative methods ,Reproducibility ,Short Research Communication ,medicine.diagnostic_test ,business.industry ,Monocyte ,Reproducibility of Results ,Thrombosis ,General Medicine ,Middle Aged ,Flow Cytometry ,Platelet Activation ,Peripheral blood ,carbohydrates (lipids) ,medicine.anatomical_structure ,ADAM® ,Child, Preschool ,Female ,platelet-monocyte aggregates ,image cytometer ,business ,Algorithms ,Biomedical engineering - Abstract
Background: Inappropriate platelet activation is known to be associated with various thrombotic disorders. Platelet-monocyte aggregates (PMAs), whose formation is mediated by platelet surface P-selectin (CD62P), can be used as a reliable marker to detect platelet activation. Previous studies have generally detected PMAs through flow cytometry-based approaches. Recently, the ADAM ® image cytometer (Nanoentek Inc., Seoul, Korea) was developed for image-based cellular analysis. In this study, we detected PMAs with the ADAM ® cytometer, evaluated the reproducibility of the measurements made by the ADAM ® cytometer, and compared the abilities of the ADAM ® cytometer and a flow cytometric assay to detect PMAs. Methods: Whole blood samples were collected from patients. Within 5 minutes of collection, anticoagulated whole blood samples were fixed in 10% paraformaldehyde and 5% glyoxal. Nineteen clinical specimens were collected; each was analyzed three times with the ADAM ® cytometer in order to assess the reproducibility of its measurements. To compare the ability of the ADAM ® cytometer with that of a flow cytometer to detect PMAs, each cytometer was used for 23 clinical samples and the correlation of the measurements was determined. Results: The PMA measurements made by the ADAM ® cytometer showed good reproducibility (CV < 10% for all specimens). Moreover, the PMA measurements made by the ADAM ® cytometer exhibited a high correlation with those made by a flow cytometric assay (R = 0.944). Conclusions: The ADAM ® cytometer is a suitable alternative method to the flow cytometry-based assays. Since the ADAM cytometer does not need specialized instrument knowledge or software proficiency (unlike flow cytometry), the ADAM ® cytometer can be used as a rapid and reliable POCT device to measure platelet activation in peripheral blood. This, in turn, will provide valuable information regarding patient propensities to thrombotic diseases. ® , platelet-monocyte aggregates, platelet activation
- Published
- 2014
20. Performance evaluation of four rapid antigen tests for the detection of Respiratory syncytial virus
- Author
-
Bo Kyeung, Jung, Sung Hyuk, Choi, Jong Han, Lee, JungHwa, Lee, and Chae Seung, Lim
- Subjects
Adult ,Aged, 80 and over ,Male ,Adolescent ,Reverse Transcriptase Polymerase Chain Reaction ,Infant, Newborn ,Infant ,Respiratory Syncytial Virus Infections ,Middle Aged ,Real-Time Polymerase Chain Reaction ,Sensitivity and Specificity ,Young Adult ,Child, Preschool ,Nasopharynx ,Respiratory Syncytial Virus, Human ,Humans ,RNA, Viral ,Female ,Serologic Tests ,Reagent Kits, Diagnostic ,Child ,Antigens, Viral ,Respiratory Tract Infections ,Aged - Abstract
Rapid identification of Respiratory syncytial virus (RSV) is important in the management of infected patients. Rapid diagnostic tests (RDT) are widely used for this purpose. This study aimed to evaluate the clinical performance of four RSV antigen tests including the BinaxNow RSV Card test, SD Bioline RSV test, BD Veritor RSV test, and Humasis RSV antigen test in comparison with real-time RT-PCR as the reference method. Nasopharyngeal swabs were collected from 280 patients with symptoms of lower respiratory tract infection and stored at -80°C. All swabs were tested for RSV using four rapid antigen tests and real time RT-PCR. The sensitivity of the BinaxNow RSV Card test, SD Bioline RSV test, BD Veritor RSV test, and Humasis RSV Antigen tests were 62.5%, 61.3%, 65.0%, and 67.5% for RSV A, and 61.3%, 65.0%, 61.3%, and 67.5% for RSV B compared to real time RT-PCR, respectively. The specificity of BD Veritor RSV test was 95.8% and those of the other three RDTs was 100%. Commercial RSV antigen detection assays are useful tools for the rapid diagnosis of RSV infection. However, confirmatory testing is always recommended. J. Med. Virol. 88:1720-1724, 2016. © 2016 Wiley Periodicals, Inc.
- Published
- 2016
21. Report on the Project for Establishment of the Standardized Korean Laboratory Terminology Database, 2015
- Author
-
Ju Yeon Kim, Kap No Lee, Chang-Seok Ki, Eun Youn Rho, Myung Hyun Nam, Min Jung Park, Sollip Kim, Heungsup Sung, Soo Young Yoon, Bo Kyeung Jung, Chi Hyun Cho, Bong Kyung Shin, Jeeyong Kim, and Shinyoung Kim
- Subjects
MEDCIN ,Databases, Factual ,020205 medical informatics ,Computer science ,Laboratory Medicine Terminology ,Medical laboratory ,02 engineering and technology ,computer.software_genre ,Terminology ,Tertiary Care Centers ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,K-LOINC ,Terminology as Topic ,Republic of Korea ,0202 electrical engineering, electronic engineering, information engineering ,Humans ,030212 general & internal medicine ,Electronic data interchange ,Database ,LOINC ,business.industry ,General Medicine ,Identifier ,Laboratory test ,Clinical microbiology ,Laboratory Medicine ,Original Article ,Logical Observation Identifiers Names and Codes ,Standard Terminology ,Laboratories ,business ,computer - Abstract
The National Health Information Standards Committee was established in 2004 in Korea. The practical subcommittee for laboratory test terminology was placed in charge of standardizing laboratory medicine terminology in Korean. We aimed to establish a standardized Korean laboratory terminology database, Korea-Logical Observation Identifier Names and Codes (K-LOINC) based on former products sponsored by this committee. The primary product was revised based on the opinions of specialists. Next, we mapped the electronic data interchange (EDI) codes that were revised in 2014, to the corresponding K-LOINC. We established a database of synonyms, including the laboratory codes of three reference laboratories and four tertiary hospitals in Korea. Furthermore, we supplemented the clinical microbiology section of K-LOINC using an alternative mapping strategy. We investigated other systems that utilize laboratory codes in order to investigate the compatibility of K-LOINC with statistical standards for a number of tests. A total of 48,990 laboratory codes were adopted (21,539 new and 16,330 revised). All of the LOINC synonyms were translated into Korean, and 39,347 Korean synonyms were added. Moreover, 21,773 synonyms were added from reference laboratories and tertiary hospitals. Alternative strategies were established for mapping within the microbiology domain. When we applied these to a smaller hospital, the mapping rate was successfully increased. Finally, we confirmed K-LOINC compatibility with other statistical standards, including a newly proposed EDI code system. This project successfully established an up-to-date standardized Korean laboratory terminology database, as well as an updated EDI mapping to facilitate the introduction of standard terminology into institutions.
- Published
- 2017
22. Performance of the Elecsys HIV combi PT Assay Compared to the ARCHITECT HIV Ag/Ab Combo Assay
- Author
-
Yunjung Cho, Chang Kyu Lee, Kyunghee Shin, Ha Nui Kim, Bo Kyeung Jung, and Ji Seon Choi
- Subjects
business.industry ,Human immunodeficiency virus (HIV) ,Medicine ,business ,medicine.disease_cause ,Virology - Abstract
eISSN 2093-6338 치료가 가능하게 할 수 있도록 하기 위해서는 HIV 조기진단이 매 우 중요하다. HIV 감염 후 항체가 출현하기 전까지의 혈청전환 창 기간(window period)을 줄이기 위해 p24 항원과 HIV-1, -2 항체를 동시에 검출하는 제4세대 HIV 검사가 개발되어 1997년 소개되면 서 기존의 3세대 시약보다 4-8일 정도 일찍 HIV 감염 검출이 가능 하다는 보고가 이어졌다[1, 2]. 또한, 3세대 HIV 검사와 비교하여 4 세대 HIV 검사의 민감도가 우월하다는 국내외 여러 보고가 있었 고 4세대 HIV 검사법의 경우도 시약에 따라 민감도는 98.1-100%, 특이도는 98-100%로 다양하다[3-11]. 최근에 유럽 성병클리닉과 WHO에서는 HIV 조기진단을 위해 4세대 HIV 스크리닝검사를 사 용할 것을 권장하고 있다[12, 13]. 최근 기존의 4세대 시약인 Elecsys HIV Ag/Ab Combi (Roche Diagnostics GmbH, Penzberg, Germany) 검사의 기능을 향상시킨 Elecsys HIV combi PT (Roche Diagnostics GmbH, Penzberg, Ger서 론
- Published
- 2014
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.