6,710 results on '"Blasi, A."'
Search Results
2. Identify Drug-Resistant Pathogens in Patients with Community-Acquired Pneumonia
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Francesco Amati, Francesco Bindo, Anna Stainer, Andrea Gramegna, Marco Mantero, Mattia Nigro, Linda Bussini, Michele Bartoletti, Francesco Blasi, and Stefano Aliberti
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Pulmonary and Respiratory Medicine - Abstract
A substantial increase in broad-spectrum antibiotics as empirical therapy in patients with community-acquired pneumonia (CAP) has occurred over the last 15 years. One of the driving factors leading to that has been some evidence showing an increased incidence of drug-resistant pathogens (DRP) in patients from a community with pneumonia, including methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Research has been published attempting to identify DRP in CAP through the implementation of probabilistic approaches in clinical practice. However, recent epidemiological data showed that the incidence of DRP in CAP varies significantly according to local ecology, healthcare systems and countries where the studies were performed. Several studies also questioned whether broad-spectrum antibiotic coverage might improve outcomes in CAP, as it is widely documented that broad-spectrum antibiotics overuse is associated with increased costs, length of hospital stay, drug adverse events and resistance. The aim of this review is to analyze the different approaches used to identify DRP in CAP patients as well as the outcomes and adverse events in patients undergoing broad-spectrum antibiotics.
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- 2023
3. Liver Transplantation for Porto-sinusoidal Vascular Liver Disorder: Long-term Outcome
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Marta Magaz, Heloïse Giudicelli-Lett, Oana Nicoară-Farcău, Neil Rajoriya, Ashish Goel, Karlien Raymenants, Sophie Hillaire, Gonzalo Crespo, Luis Téllez, Laure Elkrief, Constantino Fondevila, Lara Orts, Filipe Nery, Akash Shukla, Hélène Larrue, Yiliam Fundora, Helena Degroote, Victoria Aguilera, Elba LLop, Laura Turco, Federica Indulti, Stefania Gioia, Giulia Tosetti, Niccolò Bitto, Chiara Becchetti, Edilmar Alvarado, Cristina Roig, Raquel Diaz, Michael Praktiknjo, Anna-Lena Konicek, Guillem Soy, Pol Olivas, José Ignacio Fortea, Helena Masnou, Ángela Puente, Alba Ardèvol, Carmen Álvarez-Navascués, Marta Romero, Bernhard Scheiner, Georg Semmler, Mattias Mandorfer, Filipe Damião, Anna Baiges, Fanny Turon, Macarena Simón-Talero, Carlos González-Alayón, Alba Díaz, Ángeles García-Criado, Andrea de Gottardi, Enric Reverter, Annabel Blasi, Joan Genescà, Olivier Roux, Claire Francoz, Carlos Noronha Ferreira, Thomas Reiberger, Manuel Rodríguez, Rosa María Morillas, Javier Crespo, Jonel Trebicka, Rafael Bañares, Càndid Villanueva, Annalisa Berzigotti, Massimo Primignani, Vincenzo La Mura, Oliviero Riggio, Filippo Schepis, Bogdan Procopet, Xavier Verhelst, José Luis Calleja, Christophe Bureau, Agustín Albillos, Frederik Nevens, Virginia Hernández-Gea, Dhiraj Tripathi, Pierre-Emmanuel Rautou, François Durand, and Juan Carlos García-Pagán
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Transplantation ,610 Medizin und Gesundheit - Abstract
BACKGROUND AND AIMS Porto-sinusoidal vascular liver disorder (PSVD) is a rare disease that occasionally requires liver transplantation (LT), despite usually presenting preserved liver function. There remains a paucity of data pertaining to LT in PSVD. The aim was to identify features associated with post-LT outcomes in PSVD. METHODS Retrospective multicentre study of 79 patients who received LT for PSVD. RESULTS Median post-LT follow-up was 37 (range 1-261) mo. Refractory ascites 24 (30%), hepatic encephalopathy 16 (20%), and hepatopulmonary syndrome 13 (16.3%) were the most frequent indications for LT. Hepatocellular carcinoma was the indication in only 2 patients. Twenty-four patients died, 7 due to liver and 17 to non-liver related causes. Post-LT survival was 82.2%, 80.7%, and 68.6% at 1, 2, and 5 y, respectively. Post-LT survival was significantly better in patients without (n = 58) than in those with a persistent severe PSVD-associated condition (n = 21). Pre-LT hyperbilirubinemia levels and creatinine >100 µmol/L were also independently associated with poor survival. Six patients (7.6%) required a second LT. Recurrence of PSVD was confirmed by liver biopsy in only 1 patient and in 3 further patients it was likely. CONCLUSIONS LT in PSVD is associated with an acceptable outcome in the absence of associated severe conditions. However, persistence of a severe associated condition, pre-LT high bilirubin levels, or creatinine >100 µmol/L impact outcome, and these are features that should be considered when evaluating PSVD patients for LT. PSVD recurrence is possible after LT and needs to be explored, at least, in cases of posttransplant portal hypertension.
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- 2023
4. KR-12 Derivatives Endow Nanocellulose with Antibacterial and Anti-Inflammatory Properties: Role of Conjugation Chemistry
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Anna Blasi-Romero, Molly Ångström, Antonio Franconetti, Taj Muhammad, Jesús Jiménez-Barbero, Ulf Göransson, Carlos Palo-Nieto, and Natalia Ferraz
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General Materials Science - Published
- 2023
5. Uso de los test viscoelásticos en los principales escenarios clínicos de sangrado en los centros españoles
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M. Barquero, G.J. Yanes, A. Blasi, and M.J. Colomina
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Anesthesiology and Pain Medicine ,Critical Care and Intensive Care Medicine - Published
- 2023
6. Staging accuracy of MRI of the prostate with special reference to the influence of the time of last ejaculation on the detection of seminal vesicle invasion
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F. Blasi, A. Malouhi, C.-H. Cho, D. Nißler, F.P. Berger, M.-O. Grimm, M. Abubrig, U. Teichgräber, and T. Franiel
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Radiology, Nuclear Medicine and imaging ,General Medicine - Published
- 2023
7. Contributors
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Steven H. Abman, Noorjahan Ali, Karel Allegaert, Jamie E. Anderson, Deidra A. Ansah, Bhawna Arya, David Askenazi, Susan W. Aucott, Stephen A. Back, Gerri R. Baer, H. Scott Baldwin, Jerasimos Ballas, Maneesh Batra, Cheryl Bayart, Gary A. Bellus, John T. Benjamin, Gerard T. Berry, Zeenia C. Billimoria, Gil Binenbaum, Matthew S. Blessing, Markus D. Boos, Brad Bosse, Maryse L. Bouchard, Heather A. Brandling-Bennett, Colleen Brown, Erin G. Brown, Katherine H. Campbell, Katie Carlberg, Brian S. Carter, Shilpi Chabra, Irene J. Chang, Edith Y. Cheng, Kai-wen Chiang, Robert D. Christensen, Terrence Chun, Ronald I. Clyman, Donna, Maria E. Cortezzo, C.M. Cotten, Sherry E. Courtney, Jonathan M. Davis, Alejandra G. de Alba Campomanes, Benjamin Dean, Ellen Dees, Sara B. De, Mauro, Scott C. Denne, Emöke Deschmann, Carolina Cecilia Di Blasi, Sara A. Di, Vall, Dan Doherty, David J. Durand, Nicolle Fernández Dyess, Eric C. Eichenwald, Kelsey B. Eitel, Rachel M. Engen, Kelly N. Evans, Diana L. Farmer, Emily Fay, Patricia Y. Fechner, Rachel Fleishman, Bobbi Fleiss, Joseph Flynn, Katherine T. Flynn-O’Brien, G. Kyle Fulton, Renata C. Gallagher, Estelle B. Gauda, W. Christopher Golden, Michelle M. Gontasz, Natasha González Estévez, Sidney M. Gospe, Pierre Gressens, Deepti Gupta, Sangeeta Hingorani, Ashley P. Hinson, Susan R. Hintz, W. Alan Hodson, Kara K. Hoppe, Alyssa Huang, Benjamin Huang, Kathy Huen, Katie A. Huff, Cristian Ionita, J. Craig Jackson, Jordan E. Jackson, Tom Jaksic, Patrick J. Javid, Julia Johnson, Cassandra D. Josephson, Emily S. Jungheim, Sandra E. Juul, Mohammad Nasser Kabbany, Heidi Karpen, Gregory Keefe, Jennifer C. Keene, Amaris M. Keiser, Roberta L. Keller, Thomas F. Kelly, Kate Khorsand, Grace Kim, John P. Kinsella, Allison S. Komorowski, Ildiko H. Koves, Joanne M. Lagatta, Satyan Lakshminrusimha, Christina Lam, John D. Lantos, Janessa B. Law, Su Yeon Lee, Ofer Levy, David B. Lewis, Philana Ling Lin, Scott A. Lorch, Tiffany L. Lucas, Akhil Maheshwari, Emin Maltepe, Erica Mandell, Winston M. Manimtim, Richard J. Martin, Dennis E. Mayock, Irene Mc, Aleer, Patrick McQuillen, Ann J. Melvin, Paul A. Merguerian, Lina Merjaneh, J. Lawrence Merritt, Valerie Mezger, Marian G. Michaels, Ulrike Mietzsch, Steven P. Miller, Thomas R. Moore, Karen F. Murray, Debika Nandi-Munshi, Niranjana Natarajan, Kathryn D. Ness, Josef Neu, Shahab Noori, Thomas Michael O’Shea, Julius T. Oatts, Nigel Paneth, Thomas A. Parker, Ravi Mangal Patel, Simran Patel, Anna A. Penn, Christian M. Pettker, Shabnam Peyvandi, Catherine Pihoker, Erin Plosa, Brenda Poindexter, Michael A. Posencheg, Mihai Puia-Dumitrescu, Vilmaris Quiñones Cardona, Samuel E. Rice-Townsend, Art Riddle, Elizabeth Robbins, Mark D. Rollins, Mark A. Rosen, Courtney K. Rowe, Inderneel Sahai, Sulagna C. Saitta, Parisa Salehi, Pablo J. Sanchez, Taylor Sawyer, Matthew A. Saxonhouse, Katherine M. Schroeder, David T. Selewski, T. Niroshi Senaratne, Istvan Seri, Emily E. Sharpe, Sarah E. Sheppard, Margarett Shnorhavorian, Robert Sidbury, La, Vone Simmons, Rebecca A. Simmons, Rachana Singh, Martha C. Sola-Visner, Lakshmi Srinivasan, Heidi J. Steflik, Robin H. Steinhorn, Caleb Stokes, Helen Stolp, Jennifer Sucre, Angela Sun, Dalal K. Taha, Jessica Tenney, Janet A. Thomas, George E. Tiller, Benjamin A. Torres, William E. Truog, Kirtikumar Upadhyay, Gregory C. Valentine, John N. van den Anker, Betty Vohr, Linda D. Wallen, Peter (Zhan Tao) Wang, Bradley A. Warady, Robert M. Ward, Jon F. Watchko, Elias Wehbi, Joern-Hendrik Weitkamp, David Werny, Klane K. White, K. Taylor Wild, Susan Wiley, Laurel Willig, George A. Woodward, Clyde J. Wright, Karyn Yonekawa, Elizabeth Yu, and Elaine H. Zackai
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- 2024
8. Prevalence of Non-erosive Esophageal Phenotypes in Children: A European Multicenter Study
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Elisa Blasi, Ettore Stefanelli, Renato Tambucci, Silvia Salvatore, Paola De Angelis, Paolo Quitadamo, Claudia Pacchiarotti, Giovanni Di Nardo, Fanj Crocco, Enrico Felici, Valentina Giorgio, Nicoletta Staropoli, Simona Sestito, Efstratios Saliakellis, Osvaldo Borrelli, and Licia Pensabene
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Gastroenterology ,Neurology (clinical) - Published
- 2023
9. Arterias Sigmoideas: Bases para una Nueva Clasificación
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Melanie Ayelén d’Annibale, Pablo Andrés Martinez-Hinojosa, Bianca Lucía Marchesani, Lola Estevez, Gonzalo Tomás Felix, María de los Milagros Corsiglia, Sergio Alberto Shinzato, Esteban Daniel Blasi, and Vicente Hugo Bertone
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Anatomy - Published
- 2023
10. Portal hypertension has no role in perioperative bleeding during liver transplantation with systematic porto-caval shunt
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Josep M. Sanahuja, Enric Reverter, Ángel Ruiz, Denise Saenz, Julia Martínez-Ocón, Julia Vidal, Natalia Jiménez, Jordi Colmenero, Joan C. García-Pagan, Constantino Fondevila, Juan C. Garcia-Valdecasas, Joan Beltran, and Annabel Blasi
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Hepatology ,Gastroenterology - Published
- 2023
11. Context Matters: Emotional Sensitivity to Probabilities and the Bias for Action in Cancer Treatment Decisions
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Heather P. Lacey, Steven C. Lacey, Prerna Dayal, Caroline Forest, and Dana Blasi
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Health Policy - Abstract
Background Past studies have shown a commission bias for cancer treatment, a tendency to choose active treatment even when watchful waiting is less risky. This bias suggests motivations for action beyond mortality statistics, but recent evidence suggests that individuals differ in their emotional sensitivity to probabilities (ESP), the tendency to calibrate emotional reactions to probability. The current study aims to examine the role of ESP in the commission bias, specifically whether those higher in ESP are more likely to choose watchful waiting when risk probabilities align with that choice. Methods Participants ( N = 1,055) read a scenario describing a hypothetical cancer diagnosis and chose between surgery and watchful waiting, with random assignment between versions where the mortality rate was either lower for surgery or for watchful waiting. We modeled choice using the Possibility Probability Questionnaire (PPQ), a measure of ESP, and several other individual differences in a logistic regression. Results We observed a commission bias as in past studies with most participants choosing surgery both when surgery was optimal (71%) and when watchful waiting was optimal (58%). An ESP × Condition interaction indicated that the predictive role of ESP depended on condition. Those higher in ESP were more likely to choose surgery when probabilities favored surgery, β = 0.57, P < 0.001, but when probabilities favored watchful waiting, ESP had a near-zero relationship with choice, β = 0.05, P < 0.99. Conclusions The role of ESP in decision making is context specific. Higher levels of ESP predict choosing action when that action is warranted but do not predict a shift away from surgery when watchful waiting offers better chances of survival. ESP does not overcome the commission bias. Highlights Past studies have identified a “commission bias,” a tendency to choose active treatment over watchful waiting, even when mortality rate is lower for waiting. Evaluation of risk probabilities is related to individual differences in emotional sensitivity to probabilities (ESP) and has been shown to predict reactions to and decisions about health risk situations. ESP appears to be selectively factored into decision making. ESP was a robust predictor of choosing surgery when probability information supported surgery but did not predict decisions when probability information supported watchful waiting. Those who are most emotionally attuned to probabilities are just as susceptible to the commission bias as those who are less attuned.
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- 2023
12. The New Italian Standard on the Life Assessment of Martensitic Steels—First Results of the Experimental Validation Activity of XRD by Testing P91 and P92 Samples from Interrupted Uniaxial Creep Tests
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Andrea Tonti and Pietro De Blasi
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martensitics ,diffraction ,General Medicine ,creep - Abstract
The Italian Thermotechnical Committee is drafting a new standard for the life assessment of creep-operated pressure equipment, including modern steam boilers. For the evaluation of the spent life ratio several methods are available, even if each of them is not exhaustive. It should be noted that the methods described must be considered in combination with NDTs and other kinds of tests, e.g., hardness tests. X-ray diffraction (XRD) is one of the methods that could be used to assess material evolution under creep conditions. The method allows for the study of phase transitions involving structural variations. It is possible to operate on both massive samples and powders. In this paper, work done with XRD, in the frame of a wider project regarding the study of the high-temperature behavior of welded martensitic steels, is presented. The results of the XRD analysis were compared with the results of the extraction replicas. This work concerns the controls of eight failed crept specimens submitted to XRD examinations. Eight XRD diagrams were produced and subsequently compared with 12 replicas for each specimen; that is, 96 extraction replicas were produced for this work. Then, around 5000 precipitates were analyzed for each specimen; therefore, for this work, around 40,000 precipitates were characterized with their chemical compositions. The average size of the precipitates was around 97 nm.
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- 2023
13. Eficacia de la tromboprofilaxis con heparina de bajo peso molecular en pacientes críticos con COVID-19: estudio observacional, prospectivo y multicéntrico
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R. Ferrandis, B. Escontrela, C. Ferrando, M. Hernández, J. Herrera, F. Hidalgo, J. Librero, J.V. Llau, A. Martínez, A. Pajares, B. Tapia, E. Arruti, E. Bassas, A. Blasi, and A. Calvo
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Anesthesiology and Pain Medicine ,Critical Care and Intensive Care Medicine - Published
- 2023
14. Effectiveness of thromboprophylaxis with low molecular weight heparin in critically ill patients with COVID-19. An observational prospective, multicenter study
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R. Ferrandis, B. Escontrela, C. Ferrando, M. Hernández, J. Herrera, F. Hidalgo, J. Librero, J.V. Llau, A. Martínez, A. Pajares, B. Tapia, E. Arruti, E. Bassas, A. Blasi, and A. Calvo
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General Medicine - Published
- 2023
15. Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations
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Liu, Dongjing, Meyer, Dara, Fennessy, Brian, Feng, Claudia, Cheng, Esther, Johnson, Jessica S, Park, You Jeong, Rieder, Marysia-Kolbe, Ascolillo, Steven, de Pins, Agathe, Dobbyn, Amanda, Lebovitch, Dannielle, Moya, Emily, Nguyen, Tan-Hoang, Wilkins, Lillian, Hassan, Arsalan, Burdick, Katherine E, Buxbaum, Joseph D, Domenici, Enrico, Frangou, Sophia, Hartmann, Annette M, Laurent-Levinson, Claudine, Malhotra, Dheeraj, Pato, Carlos N, Pato, Michele T, Ressler, Kerry, Roussos, Panos, Rujescu, Dan, Arango, Celso, Bertolino, Alessandro, Blasi, Giuseppe, Bocchio-Chiavetto, Luisella, Campion, Dominique, Carr, Vaughan, Fullerton, Janice M, Gennarelli, Massimo, González-Peñas, Javier, Levinson, Douglas F, Mowry, Bryan, Nimgaokar, Vishwajit L, Pergola, Giulio, Rampino, Antonio, Cervilla, Jorge A, Rivera, Margarita, Schwab, Sibylle G, Wildenauer, Dieter B, Daly, Mark, Neale, Benjamin, Singh, Tarjinder, O'Donovan, Michael C, Owen, Michael J, Walters, James T, Ayub, Muhammad, Malhotra, Anil K, Lencz, Todd, Sullivan, Patrick F, Sklar, Pamela, Stahl, Eli A, Huckins, Laura M, and Charney, Alexander W
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Genetics - Abstract
Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ study of the protein-coding regions of the genome identified a causal role for ten genes and a concentration of rare variant signals in evolutionarily constrained genes1. This recent study—and most other large-scale human genetics studies—was mainly composed of individuals of European (EUR) ancestry, and the generalizability of the findings in non-EUR populations remains unclear. To address this gap, we designed a custom sequencing panel of 161 genes selected based on the current knowledge of SCZ genetics and sequenced a new cohort of 11,580 SCZ cases and 10,555 controls of diverse ancestries. Replicating earlier work, we found that cases carried a significantly higher burden of rare protein-truncating variants (PTVs) among evolutionarily constrained genes (odds ratio = 1.48; P = 5.4 × 10−6). In meta-analyses with existing datasets totaling up to 35,828 cases and 107,877 controls, this excess burden was largely consistent across five ancestral populations. Two genes (SRRM2 and AKAP11) were newly implicated as SCZ risk genes, and one gene (PCLO) was identified as shared by individuals with SCZ and those with autism. Overall, our results lend robust support to the rare allelic spectrum of the genetic architecture of SCZ being conserved across diverse human populations.
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- 2023
16. Ultrasound-guided SoracteLite™ transperineal laser ablation (TPLA) of the prostate for the treatment of symptomatic benign prostatic hyperplasia (BPH): a prospective single-center experience
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Antonino Laganà, Giovanni Di Lascio, Aldo Di Blasi, Leslie Claire Licari, Antonio Tufano, Rocco Simone Flammia, and Andrea De Carolis
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Urology - Abstract
Purpose To evaluate the efficacy and safety of ultrasound-guided transperineal laser ablation (TPLA) in patients with symptomatic BPH. Materials and methods From January 2020 to January 2022, 63 prospectively enrolled patients underwent TPLA with a 1064-nm continuous-wave diode laser (EchoLaser, Elesta SpA). Primary endpoints were the change in IPSS, QoL, Qmax, PVR and prostate volume at 3 and 12 months. Results At 3 months, IPSS improved from 20.8 ± 7.4 to 11.0 ± 6.6 (p p Qmax from 8.6 ± 3.5 mL/s to 13.2 ± 5.7 mL/s (p = 0.083). PVR decreased from 124.8 ± 115.4 mL to 43.6 ± 53.6 mL (p p = 0.003). At 12 months, IPSS improved from 20.8 ± 7.4 to 8.4 ± 5.9 (p p Qmax from 8.6 ± 3.5 mL/s to 16.2 ± 4.3 mL/s (p = 0.014). PVR decreased from 124.8 ± 115.4 mL to 40.6 ± 53.6 mL (p = 0.003), and prostate volume decreased from 63.6 ± 29.7 mL to 42.8 ± 14.2 mL (p = 0.071). Transient complications consisted of two patients with prostatic abscess (Clavien-Dindo grade IIIa) and one patient with orchitis (Clavien-Dindo grade II). Conclusions TPLA for symptomatic BPH provides clinical benefits at 3 and 12 months, and the treatment is well tolerated.
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- 2023
17. Review of the Nutritional Status in Older Adult Population
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Jose Antonio Latorre, Cristobal Abellan, Alejandro Lopez-Moro, Nuria Gimenez-Blasi, Javier Conde-Pipo, and Miguel Mariscal-Arcas
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Materials Science (miscellaneous) - Abstract
The leading causes of death in older adults involve nutritional risk factors, heart disease, cancer, stroke and diabetes. Prevalence of lifestyle diseases, older adults consider themselves in good, very good or excellent health. Older adults want to remain independent and not burden others; they believe proper nutrition and sufficient exercise will help them maintain their autonomy and independence. To describe the diet, nutrition and general health status of the older adult population in Spain and their adherence to the traditional MD. A bibliographic search was performed in the following databases: PubMed, ScienceDirect, and Google Scholar for original research articles, clinical trials, and observational studies published in the last 10 yrs. The articles were selected using filters and eligibility criteria. Many articles were found, and through applying the selection criteria, 21 articles were chosen for a full review. Older adults present a multitude of pathologies that are treated with drugs that with the help of an optimal diet would promote a better quality of life. Cognitive deterioration leads older adults to suffer a great loss of quality of life and must be alleviated in the best way possible. Most people meet dietary needs, but high body mass indexes are obtained. MD is a reference and a technique put into practice by this part of the population that is developed in most of life and helps them to have better aging.
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- 2023
18. Historical and citizen-reported data show shifts in bumblebee phenology over the last century in Sweden
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Maria Blasi, Romain Carrié, Christoffer Fägerström, Emma Svensson, and Anna S. Persson
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Ecology ,Ecology, Evolution, Behavior and Systematics ,Nature and Landscape Conservation - Abstract
Bumblebees are a key taxon contributing to the provision of crop pollination and ecosystem functioning. However, land use and climate change are two of the main factors causing bee decline across the world. In this study, we investigated how the flight period of bumblebee spring queens has shifted over the last century in Sweden, and to what extent such shifts depended on climate change, landscape context, latitude, and the phenology of bumblebee species. We studied ten species of bumblebees and used observations from museum specimens covering 117 years from the southernmost region in Sweden (Scania), combined with citizen-reported observations during the past 20 years across Sweden. We found that the flight period of bumblebees has advanced by 5 days on average during the last 20 years across Sweden. In the agriculture-dominated region of Scania, we found that in the late 2010s bumblebee spring queen activity in simplified landscapes had advanced by on average 14 days, compared to 100 years ago. In addition, in simplified landscapes the flight period of early species was significantly earlier compared to in complex landscapes. Our results provide knowledge on the intraspecific variation of phenological traits, indicating that early species (often common species) exhibit a higher plastic response to the environment, which may facilitate adaptation to both climate and landscape changes, compared to the late species of which many are declining.
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- 2023
19. Fitocanabinóides e migrânea: uma revisão integrativa
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Gabriela Ilias Bechara and Sando Blasi Esposito
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Marketing ,Pharmacology ,Organizational Behavior and Human Resource Management ,Strategy and Management ,Drug Discovery ,Pharmaceutical Science - Abstract
Introdução:Nos últimos anos vários estudos mostram uma relação entre o sistema endocanabinóide e o processamento da dor. Levantando a discussão de a forma exógena, os fitocanabinóides serem utilizados para o controle de crises epilépticas, dor neuropática e recentemente sendo analisado para o tratamento das cefaleias primárias do tipo migranosa.Objetivo:Esta revisão visa rever os estudos existentes na literatura que utilizaram fitocanabinóides no tratamento da migrânea, e analisar seus resultados, avaliando a aplicabilidade dos fitocanabinóides no tratamento da migrânea.Método: Baseado na busca da literatura em banco de dados dos últimos vinte anos utilizando como descritores “endocanabinoides and migrânea”, “fitocanabinóides and migrânea” e “migrânea juvenil and canabidiol” encontramos 286 artigos dos quais apenas 23 preencheram o critério de inclusão.Resultados: Houve como resultado da seleção, 23 artigos, dos quais:4 estudos clínicos, 11 revisões de literatura e 8 análises em modelo animal.Conclusões: Embora seja um tema muito pertinente, não há na literatura disponível, número adequado de pesquisas para a avaliação clínica do uso da Cannabis medicinal na migrânea, embora os resultados em modelo animal e os dados de revisões mostrem evidências favoráveis ao uso, não é possível especular a dose, a segurança ou a eficácia do uso clínico, sendo necessárias mais pesquisas clínicas randomizadas em humanos.
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- 2023
20. Characteristics and outcomes of unvaccinated and vaccinated COVID-19 patients with acute respiratory failure treated with CPAP in a medical intermediate care unit
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Silvia Accordino, Ciro Canetta, and Francesco Blasi
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Internal Medicine - Published
- 2023
21. Evaluating the Contribution of Complex International Research-for-Development Programmes to the Sustainable Development Goals
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Arlene Lu-Gonzales, Takuji W. Tsusaka, Sylvia Szabo, Reuben M. J. Kadigi, Camilla Blasi Foglietti, Seree Park, and Zoe Matthews
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Geography, Planning and Development ,Development - Abstract
While evaluation of research-to-policy projects is a fundamental aspect of measuring the impact of new knowledge, limited studies have examined evaluation methods in such projects, as well as how the evaluation can generate learning to facilitate the progress towards the Sustainable Development Goals (SDGs). This study conducted a systematic literature review and found that the most commonly used methods for SDG contribution evaluation were Analytical Hierarchy Process (40.4%), Fuzzy TOPSIS (13.2%) and ELECTRE and SPADE Methodology (3.5% each). Ranking analysis was undertaken to determine priorities among the six “Big Wins” as defined for the UKRI-GCRF Trade Hub Project, as a case, where the ranking was exercised by the project partners across the globe. Results revealed that “nature and social factors” was better considered in international trade agreements as the priority (36.4%) among others. Moreover, among the four “mechanisms” of the project, “knowledge, networks, and connectivity” was ranked as the top priority (56.9%), followed by “capacity building” (28.5%), “metrics, tools and models” (7.2%), and “improving the knowledge base” (4.6%). Mapping and evaluation revealed that the Big Wins of the Trade Hub contributed to ten out of the 17 SDGs. The most fulfilled goals were SDG 12 (Sustainable Consumption and Production), SDG 15 (Life on Land), and SDG 2 (Zero Hunger) in descending order. Furthermore, interaction analysis of the core SDGs revealed both synergy and tradeoff between different outputs. The research articles reviewed for this paper showed no gold standard framework for assessing international development projects against the SDGs. Further research should develop a tool to capture holistic and synergistic contributions of the target outcomes of projects to sustainable development.
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- 2023
22. Blood component requirements in liver transplantation: effect of 2 thromboelastometry-guided strategies for bolus fibrinogen infusion—the TROMBOFIB randomized trial
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Marta Caballero, Antoni Sabate, Rosa Gutierrez, Joan Beltran, Lourdes Pérez, Roger Pujol, Laura Viguera, Marta Costa, Raquel Reyes, Alberto Martinez, Gorka Ojinaga, Ariadna Leon, Antonio Navarro, Marta Barquero, Guillermo Alonso, Guillermo Puig, and Annabel Blasi
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Hematology - Published
- 2023
23. Functionalization of cellulose nanofibrils to develop novel ROS-sensitive biomaterials
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Carlos Palo-Nieto, Anna Blasi-Romero, Corine Sandström, David Balgoma, Mikael Hedeland, Maria Strømme, and Natalia Ferraz
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Nanoteknik ,Chemistry (miscellaneous) ,Nano Technology ,General Materials Science - Abstract
Wood derived cellulose nanofibrils (CNFs) have emerged as an interesting material for biomedical applications. Functionalization of the nanofibrils with bioactive molecules is a potent tool to tailor CNF materials for specific applications in biomedicine. The present work proposes the functionalization of CNFs with a reactive oxygen species (ROS)-sensitive oligopeptide to develop a novel CNF-based material for the treatment of medical conditions associated with high levels of ROS such as chronic wounds. Oligoproline peptides of two different lengths (5 and 10 proline units) were covalently incorporated onto the CNF surface, several water-based chemical approaches were explored and the reaction conditions to maximize peptide substitution and the degree of fibre crosslinking were optimized. The chemical structure, degree of peptide substitution, degree of fibre crosslinking, surface morphology and ROS-sensitivity of the oligoproline–CNF materials were characterized. Double-crosslinked CNF hydrogels (Ca2+–oligoproline–CNF) were further prepared and the ability of the hydrogels to protect cells from an oxidative environment was investigated in vitro with human dermal fibroblasts, as a first evaluation of the potential of the novel CNF material to be used in chronic wound therapies. Optimization of the reaction conditions resulted in a degree of peptide substitution of 102 ± 10 μmol g−1 CNF irrespective of the oligoproline length and a degree of crosslinking of 55–80% depending on the number of proline units. The results showed that the oligoproline covalently attached to CNFs via carbodiimide chemistry maintained its ability to respond to ROS and that the responsiveness in terms of viscoelastic properties depended on the length of the oligopeptide, with the hydrogel being more responsive when functionalized with 10 proline units compared with 5 proline units. Furthermore, the double crosslinked Ca2+–oligoproline–CNF hydrogels promoted the survival of human dermal fibroblasts exposed to high levels of ROS. This study is the first one to provide an insight into the development of ROS-sensitive materials based on CNFs and opens up possibilities for further investigation on the use of these novel materials in chronic wound care.
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- 2023
24. Double laterally moved coronally advanced flap combined with a connective tissue graft plus enamel matrix derivatives for the management of adjacent deep gingival recessions in lower incisors: A case report
- Author
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Javi Vilarrasa and Gonzalo Blasi
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General Engineering ,General Medicine - Published
- 2022
25. Bottlenose dolphins' fin marks comparison highlights limited movements and anthropogenic threats in the waters around Sicily (Italy, Central Mediterranean Sea)
- Author
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Monica Francesca Blasi, Jessica Alessi, Carolina Melodia, Marta Azzolin, Cristina Giacoma, Giuseppa Buscaino, Gaspare Buffa, Maria Ceraulo, Clara Monaco, Fabrizio Bruccoleri, Valentina Cafaro, Alessandra Raffa, and Elena Papale
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Aquatic Science - Published
- 2022
26. A quantitative global test of the complexity trade-off hypothesis: the case of nominal and verbal grammatical marking
- Author
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Olena Shcherbakova, Volker Gast, Damián E. Blasi, Hedvig Skirgård, Russell D. Gray, and Simon J. Greenhill
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Linguistics and Language ,Language and Linguistics - Abstract
Nouns and verbs are known to differ in the types of grammatical information they encode. What is less well known is the relationship between verbal and nominal coding within and across languages. The equi-complexity hypothesis holds that all languages are equally complex overall, which entails trade-offs between coding in different domains. From a diachronic point of view, this hypothesis implies that the loss and gain of coding in different domains can be expected to balance each other out. In this study, we test to what extent such inverse coevolution can be observed in a sample of 244 languages, using data from a comprehensive cross-linguistic database (Grambank) and applying computational phylogenetic modelling to control for genealogical relatedness. We find evidence for coevolutionary relationships between specific features within nominal and verbal domains on a global scale, but not for overall degrees of grammatical coding between languages. Instead, these amounts of nominal and verbal coding are positively correlated in Sino-Tibetan languages and inversely correlated in Indo-European languages. Our findings indicate that accretion and loss of grammatical information in nominal words and verbs are lineage-specific.
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- 2022
27. Integrated phylogenomic analyses unveil reticulate evolution in Parthenocissus (Vitaceae), highlighting speciation dynamics in the <scp>Himalayan–Hengduan</scp> Mountains
- Author
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Jinren Yu, Yanting Niu, Yichen You, Cymon J. Cox, Russell L. Barrett, Anna Trias‐Blasi, Jing Guo, Jun Wen, Limin Lu, and Zhiduan Chen
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Phylogenetic discordance ,Biogeography ,Physiology ,Parthenocissus ,Comprehensive approach ,Plant Science ,Himalayan-Hengduan Mountains region ,Speciation reversal ,Reticulation - Abstract
Hybridization caused by frequent environmental changes can lead both to species diversification (speciation) and to speciation reversal (despeciation), but the latter has rarely been demonstrated. Parthenocissus, a genus with its trifoliolate lineage in the Himalayan-Hengduan Mountains (HHM) region showing perplexing phylogenetic relationships, provides an opportunity for investigating speciation dynamics based on integrated evidence.We investigated phylogenetic discordance and reticulate evolution in Parthenocissus based on rigorous analyses of plastome and transcriptome data. We focused on reticulations in the trifoliolate lineage in the HHM region using a population-level genome resequencing dataset, incorporating evidence from morphology, distribution, and elevation.Comprehensive analyses confirmed multiple introgressions within Parthenocissus in a robust temporal-spatial framework. Around the HHM region, at least three hybridization hot spots were identified, one of which showed evidence of ongoing speciation reversal.We present a solid case study using an integrative methodological approach to investigate reticulate evolutionary history and its underlying mechanisms in plants. It demonstrates an example of speciation reversal through frequent hybridizations in the HHM region, which provides new perspectives on speciation dynamics in mountainous areas with strong topographic and environmental heterogeneity. info:eu-repo/semantics/publishedVersion
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- 2022
28. Impact of an agrivoltaic system on Aloe vera growth in a semi-arid climate
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V. Hernández, J. Cos, R. Andrés, M. Di Blasi, M. Genovese, P. Hellín, F. Contreras, A. Guevara, J. Fenoll, and P. Flores
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Horticulture - Published
- 2022
29. Crossing the Boundaries of Treatment of Valvular Heart Disease in Patients With Liver Cirrhosis
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Marc Giménez-Milà, Annabel Blasi, Manel Sabaté, and Ander Regueiro
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Liver Cirrhosis ,Anesthesiology and Pain Medicine ,Heart Valve Diseases ,Humans ,Cardiology and Cardiovascular Medicine - Published
- 2022
30. Reduced magnetic mismatch negativity: a shared deficit in psychosis and related risk
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Christian Valt, Tiziana Quarto, Angelantonio Tavella, Fabiola Romanelli, Leonardo Fazio, Giorgio Arcara, Mario Altamura, Giuseppe Barrasso, Antonello Bellomo, Giuseppe Blasi, Flora Brudaglio, Angela Carofiglio, Enrico D'Ambrosio, Flavia Antida Padalino, Antonio Rampino, Alessandro Saponaro, Domenico Semisa, Domenico Suma, Giulio Pergola, and Alessandro Bertolino
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Psychiatry and Mental health ,Applied Psychology - Abstract
Background Abnormal auditory processing of deviant stimuli, as reflected by mismatch negativity (MMN), is often reported in schizophrenia (SCZ). At present, it is still under debate whether this dysfunctional response is specific to the full-blown SCZ diagnosis or rather a marker of psychosis in general. The present study tested MMN in patients with SCZ, bipolar disorder (BD), first episode of psychosis (FEP), and in people at clinical high risk for psychosis (CHR). Methods Source-based MEG activity evoked during a passive auditory oddball task was recorded from 135 patients grouped according to diagnosis (SCZ, BD, FEP, and CHR) and 135 healthy controls also divided into four subgroups, age- and gender-matched with diagnostic subgroups. The magnetic MMN (mMMN) was analyzed as event-related field (ERF), Theta power, and Theta inter-trial phase coherence (ITPC). Results The clinical group as a whole showed reduced mMMN ERF amplitude, Theta power, and Theta ITPC, without any statistically significant interaction between diagnosis and mMMN reductions. The mMMN subgroup contrasts showed lower ERF amplitude in all the diagnostic subgroups. In the analysis of Theta frequency, SCZ showed significant power and ITPC reductions, while only indications of diminished ITPC were observed in CHR, but no significant decreases characterized BD and FEP. Conclusions Significant mMMN alterations in people experiencing psychosis, also for diagnoses other than SCZ, suggest that this neurophysiological response may be a feature shared across psychotic disorders. Additionally, reduced Theta ITPC may be associated with risk for psychosis.
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- 2022
31. Comparison of [18F]fluorocholine PET/CT with [99mTc]sestamibi and ultrasonography to detect parathyroid lesions in primary hyperparathyroidism: a prospective study
- Author
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Marti Manyalich-Blasi, Paula Domínguez-Garijo, David Saavedra-Pérez, Nuria Sánchez-Izquierdo, Sebastián Casanueva Eliceiry, Andrés Perissinotti, Mireia Mora Porta, Ana de Hollanda, Felicia A. Hanzu, Miquel A. López-Boado Serrat, Antonio R. Rull Ortuño, Jordi Ardid, Sergi Vidal-Sicart, and Òscar Vidal Pérez
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Surgery - Published
- 2022
32. Il mandato valutativo e il disegno organizzativo: il caso dell'ANVUR
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Brigida Blasi
- Subjects
General Earth and Planetary Sciences ,General Environmental Science - Published
- 2022
33. Playing 'hide and seek' with the Mediterranean monk seal: a citizen science dataset reveals its distribution from molecular traces (eDNA)
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Elena Valsecchi, Giacomo Tavecchia, Ginevra Boldrocchi, Emanuele Coppola, Denise Ramella, Livia Conte, Monica Blasi, Antonia Bruno, Paolo Galli, Valsecchi, E, Tavecchia, G, Boldrocchi, G, Coppola, E, Ramella, D, Conte, L, Blasi, M, Bruno, A, and Galli, P
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qPCR ,Multidisciplinary ,Monachus monachu ,environmental DNA ,biodiversity - Abstract
Animal conservation relies on assessing the distribution and habitat use of species, but for endangered/elusive animals this can prove difficult. The Monk Seal, Monachus monachus, is one of the world's most endangered species of pinniped, and the only one endemic to the Mediterranean Sea. During recent decades, direct observations have been few and scattered, making it difficult to determine its distribution away from the Aegean Sea (core distribution area of the post-decline relict population). This study relies on environmental DNA (eDNA) analysis to detect the presence of the Monk Seal in 135 samples collected in 120 locations of the central/western Mediterranean Sea, spanning about 1500 km longitudinally and 1000 km latitudinally. A recently described species-specific qPCR assay was used on marine-water samples, mostly collected during 2021 by a Citizen Science (CS) project. Positive detections occurred throughout the longitudinal range, including the westernmost surveyed area (Balearic archipelago). The distribution of the positive detections indicated six “hotspots”, mostly overlapping with historical Monk Seal sites, suggesting that habitat-specific characteristics play a fundamental role. We applied single-season occupancy models to correct for detection probability and to assess the importance of site-specific characteristics. The distance from small islets and protected (or access-restricted) areas was correlated negatively with the detection probability. This novel molecular approach, applied here for the first time in an extensive CS study, proved its potential as a tool for monitoring the distribution of this endangered/elusive species.
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- 2023
34. Lung Transplantation From Controlled and Uncontrolled Donation After Circulatory Death (DCD) Donors With Long Ischemic Times Managed by Simple Normothermic Ventilation and Ex-Vivo Lung Perfusion Assessment
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Palleschi, A., Zanella, A., Citerio, G., Musso, V., Rosso, L., Tosi, D., Fumagalli, J., Bonitta, G., Benazzi, E., Lopez, G., Rossetti, V., Morlacchi, L.C., Uslenghi, C., Cardillo, M., Blasi, F., Grasselli, G., Valenza, F., Nosotti, M., Palleschi, A, Zanella, A, Citerio, G, Musso, V, Rosso, L, Tosi, D, Fumagalli, J, Bonitta, G, Benazzi, E, Lopez, G, Rossetti, V, Morlacchi, L, Uslenghi, C, Cardillo, M, Blasi, F, Grasselli, G, Valenza, F, and Nosotti, M
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donation after circulatory death donors ,Transplantation ,chronic lung allograft dysfunction ,ischemia time ,lung preservation ,lung transplantation ,primary graft dysfunction ,donation after circulatory death donor ,Settore MED/10 - Malattie dell'Apparato Respiratorio ,Settore MED/21 - Chirurgia Toracica ,Settore MED/41 - Anestesiologia - Abstract
Donation after cardiac death (DCD) donors are still subject of studies. In this prospective cohort trial, we compared outcomes after lung transplantation (LT) of subjects receiving lungs from DCD donors with those of subjects receiving lungs from donation after brain death (DBD) donors (ClinicalTrial.gov: NCT02061462). Lungs from DCD donors were preserved in-vivo through normothermic ventilation, as per our protocol. We enrolled candidates for bilateral LT ≥14 years. Candidates for multi-organ or re-LT, donors aged ≥65 years, DCD category I or IV donors were excluded. We recorded clinical data on donors and recipients. Primary endpoint was 30-day mortality. Secondary endpoints were: duration of mechanical ventilation (MV), intensive care unit (ICU) length of stay, severe primary graft dysfunction (PGD3) and chronic lung allograft dysfunction (CLAD). 121 patients (110 DBD Group, 11 DCD Group) were enrolled. 30-day mortality and CLAD prevalence were nil in the DCD Group. DCD Group patients required longer MV (DCD Group: 2 days, DBD Group: 1 day, p = 0.011). ICU length of stay and PGD3 rate were higher in DCD Group but did not significantly differ. LT with DCD grafts procured with our protocols appears safe, despite prolonged ischemia times.
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- 2023
35. COVID-19 and CAR T cells: a report on current challenges and future directions from the EPICOVIDEHA survey by EHA-IDWP
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Johan Maertens, Austin Kulesekararaj, Carolina Garcia-Vidal, Nina Khanna, Ildefonso Espigado, Alessandro Busca, Martin Hoenigl, Philipp Koehler, Anna Guidetti, Nikolai Klimko, Ramón García-Sanz, Josip Batinić, Alba Cabirta, Antonio Pagliuca, Rémy Duléry, Francesca Farina, Oliver A. Cornely, Jon Salmanton-García, Sylvain Lamure, Anna Nordlander, Francesco Passamonti, Lubos Drgona, Francesco Marchesi, Barbora Weinbergerova, Alberto Lopez-Garcia, Iker Falces-Romero, Livio Pagano, Paolo Corradini, Roberta Di Blasi, Institut Català de la Salut, [Busca A] Stem Cell Transplant Center, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Turin, Italy. [Salmanton-García J] Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, Cologne, Germany. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University Hospital Cologne, Cologne, Germany. [Corradini P] University of Milan and Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy. [Marchesi F] Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy. [Cabirta A] Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Di Blasi R] Hôpital Saint Louis, Assistance Publique–Hopitaux de Paris (AP-HP), Paris, France, and Vall d'Hebron Barcelona Hospital Campus
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medicine.medical_specialty ,CAR-T cells ,Coronavirus disease 2019 (COVID-19) ,T-Lymphocytes ,medicine.medical_treatment ,Adoptive ,Psychological intervention ,MEDLINE ,registry ,Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunization::Immunization, Passive::Adoptive Transfer::Immunotherapy, Adoptive [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,COVID-19 (Malaltia) ,Immunotherapy, Adoptive ,terapéutica::terapia biológica::inmunomodulación::inmunoterapia::inmunización::inmunización pasiva::transferencia adoptiva::inmunoterapia adoptiva [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Receptors ,Case fatality rate ,virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES] ,Humans ,Medicine ,Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes [ANATOMY] ,030304 developmental biology ,0303 health sciences ,Receptors, Chimeric Antigen ,Hematology ,business.industry ,Prevention ,Teràpia cel·lular ,Risk of infection ,Chimeric Antigen ,COVID-19 ,Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES] ,Immunosuppression ,Stimulus Report ,Chimeric antigen receptor ,3. Good health ,Settore MED/15 - MALATTIE DEL SANGUE ,Good Health and Well Being ,Cèl·lules T ,030220 oncology & carcinogenesis ,Immunotherapy ,Infection ,business ,células::células sanguíneas::leucocitos::leucocitos mononucleares::linfocitos::linfocitos T [ANATOMÍA] - Abstract
Patients receiving chimeric antigen receptor T cells (CAR-T cells) therapy may be particularly susceptible to coronavirus disease 2019 (COVID-19) because of several factors including the immunosuppression associated to the underlying disease and delayed cytopenias. Regrettably, data on outcomes of CAR-T recipients with COVID-19 are extremely scarce. The aim of this study was to investigate the characteristics and outcomes of COVID-19 in patients treated with CAR-T therapy. The European Hematology Association - Scientific Working Group Infection in Hematology endorsed a survey to collect and analyze data from patients developing COVID-19 after CAR-T therapy. Overall, 459 patients treated with CAR-T cells were reported from 18 European centers. The prevalence of COVID-19 cases was 4.8%. Median time from CAR-T therapy and COVID-19 diagnosis was 169 days. Severe infection occurred in 66.7% of patients and 43.3% of the subjects required admission to ICU. The COVID-19 mortality was 33%. In multivariable analysis, the disease status at the time of COVID-19 trended marginally towards adverse outcome (P=0.075). In conclusion, we documented a high fatality rate for CAR-T patients with COVID-19, supporting the need to design successful interventions to mitigate the risk of infection in this vulnerable group of patients.
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- 2022
36. Electrocatalysis of Oxygen on Bifunctional Nickel‐Cobaltite Spinel
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Alessandra Di Blasi, Vincenzo Antonucci, Vincenzo Baglio, Cinthia Alegre, C. Busacca, Antonino S. Aricò, Orazio Di Blasi, Governo Italiano, Alegre Gresa, Cinthia, Di Blasi, Alessandra, Aricò, Antonino Salvatore, Antonucci, Vincenzo, Baglio, Vincenzo, Alegre Gresa, Cinthia [0000-0003-1221-6311], Di Blasi, Alessandra [0000-0002-2847-3075], Aricò, Antonino Salvatore [0000-0001-8975-6215], Antonucci, Vincenzo [0000-0001-6090-3939], and Baglio, Vincenzo [0000-0002-0541-7169]
- Subjects
inorganic chemicals ,Materials science ,Oxygen reduction ,Carbon nanofiber ,Bifunctional oxygen electrodes ,Inorganic chemistry ,Spinel ,Oxygen evolution ,Carbon nanofibres ,chemistry.chemical_element ,engineering.material ,Electrocatalyst ,Oxygen ,Catalysis ,Cobaltite ,Nickel ,chemistry.chemical_compound ,chemistry ,carbon nanofibers ,Electrochemistry ,engineering ,Bifunctional - Abstract
7 Figures, 2 Tables.-- This article also appears in: Giornate dell’Elettrochimica Italiana (GEI 2019)., Transition‐metal‐based materials are among the most active and durable catalysts for the effective electrocatalysis of oxygen‐related reactions. Herein, we present a study on bifunctional catalysts as air electrodes aimed at metal‐air batteries based on nickel and cobalt spinel (NiCo2O4) supported on electrospun carbon nanofibers. The physicochemical features of these transition‐metal‐based catalysts are essential for the understanding of their electrochemical activity. Results show that the major presence of oxidized Ni and Co species (Ni3+ and Co3+) produces higher activity for the oxygen evolution reaction (OER), whereas lower oxidation states of the metals (Ni2+, Co2+, Ni0 and Co0) together with the presence of N‐doped carbon lead to enhanced oxygen reduction reaction (ORR) performance. This study highlights the importance of designing catalysts in terms of crystallographic structure and proper oxidation states of the elements for maximizing their performance., The research leading to these results has received funding from the “Accordo di Programma CNR‐MiSE, Gruppo tematico Sistema Elettrico Nazionale e Progetto: Sistemi elettrochimici per l′accumulo di energia”.
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- 2020
37. 'Not Private at All:' Comparative Perspectives on Privacy of Genomic Data, Family History Data, Health-Related Data, and Other Personal Data
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Nora B. Henrikson, Paula R. Blasi, Marlaine Figueroa Gray, Lorella Palazzo, Aaron Scrol, and Stephanie M. Fullerton
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Genetics ,Molecular Medicine ,Cell Biology ,Molecular Biology - Abstract
People choose how and if to generate and disclose not just personal genomic data, but also multiple other types of personal health and non-health related data. To contextualize choices about genetic testing and genetic data disclosure, we explored perspectives of genomic data privacy and disclosure compared to other types of data. We conducted a qualitative focus group study with adult members of an integrated U.S. health system, using administrative data to stratify our sample by age and by race/ethnicity. Discussion topics included qualities, rights, benefits and harms of disclosure of genomic, health, family history and non-health related data. We conducted thematic template analysis using verbatim transcripts. The sample (n = 24) was 67% female, mean age 54.1 years (range 23-88), and 37% people of color; 71% reported college degree. Participants considered genetic data, but not other data types, as a permanent, core part of the individual self and as protected health information under current laws. Participants did not feel that individuals had a right to family medical history disclosure from their relatives. Participants assumed high levels of privacy protections of genetic and other health-related data, but no perceived privacy or protection around other personal data. Participants weighed benefits and risks of generation and disclosure of all data types; harms were more far-reaching for non-health data, possibly related to the perceived lack of protections around these data. People make privacy-related choices about genetic testing in the context of related considerations for multiple types of data and rely on perceived privacy protections under current U.S. health privacy laws. Genetic research and screening programs should consider providing clear guidance on privacy protections afforded to genetic information in U.S. clinical settings. Future research should examine connections between privacy-related views on genetic and multiple other types of personal data.
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- 2022
38. A Report on the Translation into Kiswahili and Subsequent Validation, of Three Positive Psychology Scales
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Mike Murphy, Geoffrey Wango, Jonas Jackson Kinanda, David O’Sullivan, Zelda Di Blasi, and Carmen Moret-Tatay
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Translation ,Positive psychology ,Kiswahili ,Gratitude questionnaire ,Validation ,Satisfaction With Life Scale ,Multidimensional Scale of Perceived Social Support ,Scale - Abstract
Whilst positive psychology has grown as a strand of the discipline internationally, very little positive psychology research has been conducted in East Africa. It is likely that one reason for this is the scarcity of relevant validated Kiswahili-language psychometric scales. This paper reports the process and outcomes of translation into Kiswahili, refinement, and validation of three commonly-used scales from the positive psychology domain – the Gratitude Questionnaire, Satisfaction With Life Scale, and Multidimensional Scale of Perceived Social Support – among students of the Universities of Nairobi and Dar es Salaam. Cronbach’s alpha values, mean inter-item correlations, and correlations with one another and with related measures, all yielded acceptable results. The final versions – K-GQ5, K-SWLS and K-MSPSS – appear valid and reliable, and suitable for use in research. We recommend larger scale investigation of these translations, the translation of further scales, and the development of positive psychology research in East Africa.
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- 2022
39. Revealing the effects of the ball milling pretreatment on the ethanosolv fractionation of lignin from walnut and pistachio shells
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Davide Blasi, Davide Mesto, Pietro Cotugno, Cosima D. Calvano, Marco Lo Presti, and Gianluca M. Farinola
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Environmental Chemistry ,General Chemistry - Published
- 2022
40. Nontuberculous mycobacteria infection and pulmonary disease in bronchiectasis
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Kseniia Suska, Francesco Amati, Giovanni Sotgiu, Andrea Gramegna, Marco Mantero, Margherita Ori, Maurizio Ferrarese, Luigi Ruffo Codecasa, Anna Stainer, Francesco Blasi, and Stefano Aliberti
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Pulmonary and Respiratory Medicine ,Settore MED/10 - Malattie dell'Apparato Respiratorio - Abstract
BackgroundAlthough interest in nontuberculous mycobacteria (NTM) infection has increased in the last decades, published data vary according to different geographical areas, diagnostic facilities and quality of study design. This study aims at assessing both prevalence and incidence of NTM infection and NTM pulmonary disease (NTM-PD) among adults with bronchiectasis, to describe patients’ characteristics, therapeutic options and clinical outcomes.MethodsBronchiectasis adults who had been tested for NTM were enrolled at the Bronchiectasis Program of the Policlinico Hospital in Milan, Italy, from 2016 to 2018.ResultsAmong the 373 patients enrolled, 26.1% had at least one respiratory sample positive for NTM and 12.6% reached a diagnosis of NTM-PD. Incidence rates for NTM infection and NTM-PD were 13 (95% CI 10–16) and 4 (95% CI 2–6) per 100 person-years, respectively. The most prevalent NTM species causing NTM-PD wereM. intracellulare(38.3%),M. avium(34.0%),M. abscessus(8.5%) andM. kansasii(8.5%). Once treatment for NTM-PD was initiated, a favourable outcome was documented in 52.2% of the patients, while a negative outcome was recorded in 32.6%, including recurrence (17.4%), treatment failure (10.9%), re-infection (2.2%) and relapse (2.2%). Treatment halted was experienced in 11 (23.9%) patients.ConclusionsNTM infection is frequent in bronchiectasis patients and the presence of NTM-PD is relevant. The low success rate of NTM-PD treatment in bronchiectasis patients requires a call to action to identify new treatment modalities and new drugs to improve patients’ outcomes.
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- 2022
41. In-plane and out-of-plane model for retrofitted infill walls in reinforced concrete framed buildings
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Gianni Blasi, Daniele Perrone, and Maria Antonietta Aiello
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Geophysics ,Building and Construction ,Geotechnical Engineering and Engineering Geology ,Civil and Structural Engineering - Published
- 2022
42. A real-world comparison of tisagenlecleucel and axicabtagene ciloleucel CAR T cells in relapsed or refractory diffuse large B cell lymphoma
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Emmanuel Bachy, Steven Le Gouill, Roberta Di Blasi, Pierre Sesques, Guillaume Manson, Guillaume Cartron, David Beauvais, Louise Roulin, François Xavier Gros, Marie Thérèse Rubio, Pierre Bories, Jacques Olivier Bay, Cristina Castilla Llorente, Sylvain Choquet, René-Olivier Casasnovas, Mohamad Mohty, Stéphanie Guidez, Magalie Joris, Michaël Loschi, Sylvain Carras, Julie Abraham, Adrien Chauchet, Laurianne Drieu La Rochelle, Bénédicte Deau-Fischer, Olivier Hermine, Thomas Gastinne, Jean Jacques Tudesq, Elodie Gat, Florence Broussais, Catherine Thieblemont, Roch Houot, Franck Morschhauser, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 (GRITA), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Lille, CHU Lille, Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille], and Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
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Biological Products ,Receptors, Chimeric Antigen ,T-Lymphocytes ,[SDV]Life Sciences [q-bio] ,Antigens, CD19 ,Clinical Studies as Topic ,Humans ,Lymphoma, Large B-Cell, Diffuse ,General Medicine ,Cytokine Release Syndrome ,Immunotherapy, Adoptive ,General Biochemistry, Genetics and Molecular Biology ,Retrospective Studies - Abstract
Axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) have both demonstrated impressive clinical activity in relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL). In this study, we analyzed the outcome of 809 patients with R/R DLBCL after two or more previous lines of treatment who had a commercial chimeric antigen receptor (CAR) T cells order for axi-cel or tisa-cel and were registered in the retrospective French DESCAR-T registry study (NCT04328298). After 1:1 propensity score matching (n = 418), the best overall response rate/complete response rate (ORR/CRR) was 80%/60% versus 66%/42% for patients treated with axi-cel compared to tisa-cel, respectively (P P = 0.0003). Overall survival (OS) was also significantly improved after axi-cel infusion compared to after tisa-cel infusion (1-year OS 63.5% versus 48.8%; HR = 0.63; 95% CI, 0.45–0.88; P = 0.0072). Similar findings were observed using the inverse probability of treatment weighting statistical approach. Grade 1–2 cytokine release syndrome was significantly more frequent with axi-cel than with tisa-cel, but no significant difference was observed for grade ≥3. Regarding immune effector cell-associated neurotoxicity syndrome (ICANS), both grade 1–2 and grade ≥3 ICANS were significantly more frequent with axi-cel than with tisa-cel. In conclusion, our matched comparison study supports a higher efficacy and also a higher toxicity of axi-cel compared to tisa-cel in the third or more treatment line for R/R DLBCL.
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- 2022
43. Dependency-length minimization and its limits: A possible role for a probabilistic version of the final-over-final condition
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Yingqi Jing, Damián E. Blasi, and Balthasar Bickel
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Linguistics and Language ,Humanities and the Arts ,Humaniora och konst ,Language and Linguistics - Published
- 2022
44. Clinical guide of the Spanish Society of Nephrology on the prevention and treatment of peritoneal infection in peritoneal dialysis
- Author
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Miguel Pérez Fontán, Mercedes Moreiras Plaza, Mario Prieto Velasco, Carlos Quereda Rodriguez-Navarro, María Auxiliadora Bajo Rubio, Mercè Borràs Sans, Verónica de la Espada Piña, Javier Pérez Contreras, Gloria del Peso Gilsanz, Esther Ponz Clemente, Pedro Quirós Ganga, César Remón Rodríguez, Ana Rodríguez-Carmona, Emilio Sánchez Alvarez, Nicanor Vega Díaz, Manel Vera Rivera, Nuria Aresté Fosalba, Ana Bordes Benítez, María José Castro Notario, Antonio Fernández Perpén, María José Fernández Reyes, Oriol Gasch Blasi, José Manuel Gil Cunquero, Juan Carlos Julián Mauro, José Ignacio Minguela Pesquera, María Antonia Munar Vila, Miguel Núñez del Moral, Teresa Pérez López, Jose Portolés Pérez, Maite Rivera Gorrín, Carmen Rodríguez Suarez, Mario Sánchez Camargo, and María Sagrario Soriano Cabrer
- Subjects
Nephrology - Published
- 2022
45. The Conometric Connection for the Implant-Supported Fixed Prosthesis: A Narrative Review
- Author
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Saturnino Marco Lupi, Claudia Todaro, Dario De Martis, Paola Blasi, Ruggero Rodriguez y Baena, and Stefano Storelli
- Subjects
fixed partial denture ,conometric connection ,Settore MED/28 - Malattie Odontostomatologiche ,implant-supported dental prosthesis ,dental implant abutment design ,General Medicine - Abstract
Aim: The conometric concept was proposed as a possible connection between the abutment and the prosthetic coping. This research aimed to review the features and possible clinical uses of this connection in an implant-supported fixed prosthesis. Methods: An electronic search was conducted on an online database for the topic in object; articles published in international literature were considered and the research gave 17 results, and 6 parameters were analyzed. Results: This connection eliminated the possibility of cement residues in the subgingival region, reducing the risk of inflammation of peri-implant soft and hard tissues; not having to remove the cement residues, it is possible to place the margins in more apical portions, improving the aesthetics outcomes of the rehabilitations. It is also known that the retention by means of a screw causes a weakening of the restoration. The retentive force is adequate for fixed rehabilitation even after a high number of insertion–disengagement cycles; in vitro studies have also shown a high bacterial sealing. Implant rehabilitation using preformed components, such as conometric hoods, is helpful for CAD/CAM, so a digital workflow is possible. Several types of prosthesis were presented, all of which demonstrated adequate clinical performance in the follow-up observation. Conclusions: This type of connection seems to be suitable to support fixed implant rehabilitations, but long-term clinical studies are needed to validate this system.
- Published
- 2022
46. LC/MS Q-TOF Metabolomic Investigation of Amino Acids and Dipeptides in Pleurotus ostreatus Grown on Different Substrates
- Author
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Roberto Maria Pellegrino, Francesca Blasi, Paola Angelini, Federica Ianni, Husam B. R. Alabed, Carla Emiliani, Roberto Venanzoni, and Lina Cossignani
- Subjects
multivariate statistical analysis ,Pleurotus ostreatus mushroom ,data analysis ,untargeted metabolomics profiling, Pleurotus ostreatus mushroom, polar metabolites, data analysis, multivariate statistical analysis, functional ingredients ,untargeted metabolomics profiling ,General Chemistry ,functional ingredients ,General Agricultural and Biological Sciences ,polar metabolites - Published
- 2022
47. The longest recorded movement of an inshore common bottlenose dolphin (Tursiops truncatus)
- Author
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Tilen Genov, Jure Železnik, Chiara Bruno, Davide Ascheri, Elena Fontanesi, Monica Francesca Blasi, and University of St Andrews. Sea Mammal Research Unit
- Subjects
MCC ,QL ,QH301 Biology ,Bottlenose dolphin ,3rd-DAS ,QL Zoology ,NIS ,QH301 ,Tursiops truncatus ,Mediterranean Sea ,Animal Science and Zoology ,Photo-identification ,Long-distance movements ,Ecology, Evolution, Behavior and Systematics - Abstract
Funding: MFB’s participation at the meeting of the ACCOBAMS-ASCOBANS Joint Bycatch Working Group was in the framework of the Life DELFI project, co-financed by the European Community under the LIFE programme. Information on movements and connectivity among populations of animals is important for the delineation of units to conserve, so that demographic parameters, such as abundance, fecundity and mortality, can be placed in an appropriate population and conservation context. Common bottlenose dolphins (Tursiops truncatus) are often considered relatively ‘resident’ and demonstrating strong site fidelity to specific areas. However, this perception may partly be an artefact of the distribution and ‘habitat use’ of cetacean researchers, rather than animals themselves, and bottlenose dolphins have been shown to be capable of substantial movements, often in relatively short periods of time. Here, we report on two long-distance movements of a common bottlenose dolphin within the Mediterranean Sea, across the Tyrrhenian, Ionian and Adriatic Seas, and subsequently back across all three seas to Ligurian Sea, making these the two longest recorded movement for this species in the Mediterranean Sea to date and some of the longest in the world. We also review published records of long-distance movements in this species worldwide. This study highlights the utility of photo-identification and the importance of regional data sharing. We argue that photo-identification comparisons are always worthwhile and the results are informative regardless of the presence or absence of matches, especially with the ongoing advances in automated matching software. Publisher PDF
- Published
- 2022
48. Correction to: Ensete nepalense, a new combination, lectotypification and recognition as a distinct species endemic to Nepal
- Author
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Gaurav Parmar, Dipak Lamichhane, Hem Raj Paudel, and Anna Trias-Blasi
- Subjects
Plant Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2023
49. Updating the ATS/ERS Task Force Report on Outcomes for COPD Pharmacological Trials
- Author
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Mario Cazzola, Paola Rogliani, Peter J Barnes, Francesco Blasi, Bartolome Celli, Nicola A Hanania, Fernando J. Martinez, Bruce E Miller, Marc Miravitlles, Clive P. Page, Ruth Tal-Singer, and Maria Gabriella Matera
- Subjects
Pulmonary and Respiratory Medicine ,Critical Care and Intensive Care Medicine - Published
- 2023
50. Modern air, englacial and permafrost temperatures at high altitude on Mt. Ortles, (3905 m a.s.l.) in the Eastern European Alps
- Author
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Luca Carturan, Fabrizio De Blasi, Roberto Dinale, Gianfranco Dragà, Paolo Gabrielli, Volkmar Mair, Roberto Seppi, David Tonidandel, Thomas Zanoner, Tiziana Lazzarina Zendrini, and Giancarlo Dalla Fontana
- Abstract
The climatic response of mountain permafrost and glaciers located in high-elevation mountain areas has major implications for the stability of mountain slopes and related geomorphological hazards, water storage and supply, and preservation of paleoclimatic archives. Despite a good knowledge of physical processes that govern the climatic response of mountain permafrost and glaciers, there is a lack of observational datasets from summit areas. This represents a crucial gap in knowledge and a serious limit for model-based projections of future behaviour of permafrost and glaciers. A new observational dataset is available for the summit area of Mt. Ortles, which is the highest summit of South Tyrol, Italy. This paper presents a series of air, englacial, soil surface and rock wall temperature collected between 2010 and 2016. Details are provided regarding instrument type and characteristics, field methods, data quality control and assessment. The obtained data series are available through an open data repository. In the observation period the mean annual air temperature at 3830 m a.s.l. was between −7.8 and −8.6 °C. The most shallow layers of snow and firn (down to a depth of about 10 m) froze during winter. However melt water percolation restored isothermal conditions during the ablation season and the entire firn layer was found at the melting pressure point. Glacier ice is cold, however only from about 30 m depth. Englacial temperature decreases with depth reaching a minimum of almost −3 °C close to the bedrock, at 75 m depth. A small glacier located on a rocky ridge of Mt. Ortles at 3470 m a.s.l., without firn cover, was also found in cold conditions from the surface down to a depth of 9.5 m. The mean annual ground surface temperature was negative for all but one monitored sites, indicating cold ground conditions and the existence of permafrost in nearly all debris-mantled slopes of the summit. Similarly, the mean annual rock wall temperature was negative at most monitored sites, except the lowest one at 3030 m a.s.l. This suggests that the rock faces of the summit are affected by permafrost at all exposures.
- Published
- 2023
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