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Lead Zirconate Titanate [(ZrxTi1-x)O3 ]is used to make ultrasound transducers, sensors, and actuators due to its large piezoelectric coefficient. Several surfaces and subsurface micro defects develop within the Lead Zirconate Titanate (PZT) sensor due to delamination, corrosion, huge temperature fluctuation, etc., causing a decline in its performance. It is thus necessary to identify, locate, and quantify the defects. Non-Destructive Structural Health Monitoring (SHM) is the most optimal and economical method of evaluation. Traditional ultrasound SHM techniques have a huge impedance mismatch between air and any solid material. And most of the popular signal processing methods define time-series signals in only one domain which gives sub-optimal results. Thus to improve the accuracy of detection point contact excitation and detection methods have been implemented to determine the interaction of ultrasonic waves with microscale defects in the PZT. And Haar Discrete Wavelet Transformation (DWT) is applied to the time series data obtained from the Coulomb coupling setup. Using the above process, defect up to 100 um in diameter could be successfully distinguished and localized., Comment: 12 pages, 4 figures

Metabolic alterations are increasingly recognized as important novel anti‐cancer targets. Among several regulators of metabolic alterations, fructose 2,6 bisphosphate (F2,6BP) is a critical glycolytic regulator. Inhibition of the active form of PFKFB3ser461 using a novel inhibitor, PFK158 resulted in reduced glucose uptake, ATP production, lactate release as well as induction of apoptosis in gynecologic cancer cells. Moreover, we found that PFK158 synergizes with carboplatin (CBPt) and paclitaxel (PTX) in the chemoresistant cell lines, C13 and HeyA8MDR but not in their chemosensitive counterparts, OV2008 and HeyA8, respectively. We determined that PFK158‐induced autophagic flux leads to lipophagy resulting in the downregulation of cPLA2, a lipid droplet (LD) associated protein. Immunofluorescence and co‐immunoprecipitation revealed colocalization of p62/SQSTM1 with cPLA2 in HeyA8MDR cells uncovering a novel pathway for the breakdown of LDs promoted by PFK158. Interestingly, treating the cells with the autophagic inhibitor bafilomycin A reversed the PFK158‐mediated synergy and lipophagy in chemoresistant cells. Finally, in a highly metastatic PTX‐resistant in vivo ovarian mouse model, a combination of PFK158 with CBPt significantly reduced tumor weight and ascites and reduced LDs in tumor tissue as seen by immunofluorescence and transmission electron microscopy compared to untreated mice. Since the majority of cancer patients will eventually recur and develop chemoresistance, our results suggest that PFK158 in combination with standard chemotherapy may have a direct clinical role in the treatment of recurrent cancer., What's new? Ovarian and cervical cancer patients experience high rates of chemoresistance and tumor recurrence. To improve patient outcome, greater understanding of mechanisms behind these phenomena is needed. Here, activity of PFKFB3, a glycolytic regulator overexpressed in cancer, was found to be positively correlated with chemoresistance and lipid droplet (LD) biogenesis in ovarian and cervical cancer cells. PFK‐158, a PFKFB3 inhibitor, sensitized chemoresistant cells to drug‐induced cytotoxicity by simultaneously targeting both glycolytic and lipogenic pathways to inhibit tumor growth and LDs in a drug‐resistant xenograft model. The findings warrant further investigation of PFK158 as a treatment for recurrent gynecological malignancy.

On one side of India, we have multi-specialty hospitals which satisfy the healthcare needs of people with specialized and speedy treatments. On the other side, a large part of the population in India resides in rural areas where basic medical facility is sometimes unavailable. People in the rural areas do not get proper treatment due to the non availability of required number of registered medical practitioners. This paper presents the architecture of Context Aware Health Monitoring System developed for connecting Primary Healthcare Centres in the rural areas with the sophisticated hospitals in the urban areas of India through mobile communication and IT infrastructure. The system aims to provide affordable, efficient and sustainable healthcare service by leveraging mobile communication and information technology. The system monitors and delivers patient's physiological readings to the hospitals and provides an alert mechanism triggered by the patient's vital signs which is linked to a medical practitioner's mobile device.