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This paper reports on the design of frequency-dependent feed networks for linear antenna arrays with minimum half-power beamwidth (HPBW) variation in more than one octave of the frequency spectrum. The proposed approach is based on: i) frequency-dependent power dividers that gradually shift the RF power from the outer elements of the array to the inner ones with the increase of frequency and ii) uniformly or non-uniformly-spaced directive antenna elements. The operating principles and design trade-offs of the concept are presented through ideal simulations of four- and six-element antenna arrays shaped by isotropic or directive radiators. It is shown that by employing directive antenna elements and non-uniform spacing, minimum HPBW variation can be obtained in a broad bandwidth (BW, e.g., 3:1). For physical verification purposes, two frequency-dependent feed networks and Vivaldi antenna elements were designed, manufactured, and measured. The first network feeds a uniformly-spaced four-element array of Vivaldi antennas and demonstrates a 58% HPBW variation in a 3:1 of BW. The second network feeds a non-uniformly-spaced six-element Vivaldi array and results in a 67% HPBW variation in a 2.5:1 of BW.

Imperceptible latency, uninterrupted communication, and the availability of inexhaustible bandwidth are conceptualized as essential milestones to revolutionize the modes by which societies generated, circulate, receive, and perceive information. The exponential increase in wireless data traffic has raised concerns to investigate suitable bands in the radio spectrum to satisfy the intensifying user's data rate requirements. Overall the wireless infrastructure needs development and exploitation to synchronize with the massive capacity and connectivity demands. The Terahertz (THz) frequency band (0.1-10 THz) is considered as a pivotal solution to fulfill the needs of applications and devices requiring the high speed transmission, and have received noticeable attention from the research community. Technologies in this spectrum are facing rapid development and hold high potentials in applications like ultra-fast short-range wireless communications, remote sensing, biological detection, and basic material research. The antenna is one of the critical components to support the THz systems and require a considerable attention in terms of precision. Compact high-gain antennas are desirable for low latency and high data rate THz wireless communication systems, specifically for applications having space limitation, for example, in the high speed interlink inside the high density wireless communication base station (BS). Nevertheless, there still exist many challenges, while designing the antenna for THz communications requiring innovative solutions. This paper serves an introductory guideline to address the challenges and opportunities, while designing a THz enabled antenna.

Coherent plane-wave compound imaging (CPWCI) is used as alternative for conventional focused imaging (CFI) to increase frame rates linearly with the ratio number of imaging lines to steering angles. In this study, the image quality was compared between CPWCI and CFI, and the effect of steering angles (range and number) and beamforming strategies was evaluated in CPWCI. In automated breast volume scanners (ABVSs), which suffer from reduced volume rates, CPWCI might be an excellent candidate to replace CFI. Therefore, the image quality of CFI currently in ABVS and CPWCI was also compared in an in vivo breast lesion. Images were obtained by a Siemens Sequoia ultrasound system, and two transducers (14L5 and 10L4) in a CIRS multipurpose phantom (040GSE) and a breast lesion. Phantom results showed that contrast sensitivity and resolution, axial resolution, and generalized contrast-to-noise ratio (gCNR; imaging depths

Autonomous sensory meridian response (ASMR) describes an atypical multisensory experience of calming, tingling sensations in response to a specific subset of social audiovisual triggers. To date, the electrophysiological (EEG) correlates of ASMR remain largely unexplored. Here we sought to provide source-level signatures of oscillatory changes induced by this phenomenon and investigate potential decay effects—oscillatory changes in the absence of self-reported ASMR. We recorded brain activity using EEG as participants watched ASMR-inducing videos and self-reported changes in their state: no change (Baseline); enhanced relaxation (Relaxed); and ASMR sensations (ASMR). Statistical tests in the sensor-space were used to inform contrasts in the source-space, executed with beamformer reconstruction. ASMR modulated oscillatory power by decreasing high gamma (52–80 Hz) relative to Relaxed and by increasing alpha (8–13 Hz) and decreasing delta (1–4 Hz) relative to Baseline. At the source level, ASMR increased power in the low-mid frequency ranges (8–18 Hz) and decreased power in high frequency (21–80 Hz). ASMR decay effects reduced gamma (30–80 Hz) and in the source-space reduced high-beta/gamma power (21–80 Hz). The temporal profile of ASMR modulations in high-frequency power later shifts to lower frequencies (1–8 Hz), except for an enhanced alpha, which persists for up to 45 min post self-reported ASMR. Crucially, these results provide the first evidence that the cortical sources of ASMR tingling sensations may arise from decreases in higher frequency oscillations and that ASMR may induce a sustained relaxation state.

While substantial noise reduction and speech enhancement can be achieved with multiple microphones organized in an array, in some cases, such as when the microphone spacings are quite close, it can also be quite limited. This degradation can, however, be resolved by the introduction of one or more external microphones ( $\text{XM}$ s) into the same physical space as the local microphone array ( $\text{LMA}$ ). In this paper, three methods of extending an $\text{LMA}$ -based generalized sidelobe canceller ( $\text{GSC-LMA}$ ) with multiple $\text{XM}$ s are proposed in such a manner that the relative transfer function pertaining to the $\text{LMA}$ is treated as a priori knowledge. Two of these methods involve a procedure for completing an extended blocking matrix, whereas the third uses the speech estimate from the $\text{GSC-LMA}$ directly with an orthogonalized version of the $\text{XM}$ signals to obtain an improved speech estimate via a rank-1 generalized eigenvalue decomposition. All three methods were evaluated with recorded data from an office room and it was found that the third method could offer the most improvement. It was also shown that in using this method, the speech estimate from the $\text{GSC-LMA}$ was not compromised and would be available to the listener if so desired, along with the improved speech estimate that uses both the $\text{LMA}$ and $\text{XM}$ s.

This paper proposes a new technique for improving a generalized sidelobe canceller (GSC) for dual-microphone speech enhancement to be applied in an auditory device such as a hearing aid. Here, the GSC is implemented on a 32-channel uniform polyphase discrete Fourier transform filter bank, where the overall algorithm processing delay is 8 ms to meet hearing aid requirements. The proposed method can improve the fixed beamformer (FBF) and control the adaptive algorithm in the noise canceller (NC) using the phase difference obtained from dual-microphone signals. For this, spatial cues such as the phase differences are used to estimate the target-to-non-target directional signal ratio (TNR). A target-directional speech enhancing spectral gain-attenuator is calculated based on the estimated TNR, which is then incorporated to improve the FBF in the GSC. Furthermore, the weight update of the adaptive NC in the GSC is formulated using the phase difference-based TNR. The experimental results show that the auditory speech enhancement system that employs the proposed dual-microphone GSC algorithm provides better perceptual quality and intelligibility scores than conventional methods such as a beamformer, phase-error-based filter (PEF), GSC, or PEF-controlled GSC under multiple noise conditions of signal-to-noise ratio range 0-20 dB.

Optically pumped magnetometer-based magnetoencephalography (OP-MEG) can be used to measure neuromagnetic fields while participants move in a magnetically shielded room. Head movements in previous OP-MEG studies have been up to 20 cm translation and ∼30° rotation in a sitting position. While this represents a step-change over static MEG systems, naturalistic head movement is likely to exceed these limits, particularly when participants are standing up. In this proof-of-concept study, we sought to push the movement limits of OP-MEG even further. Using a 90 channel (45-sensor) whole-head OP-MEG system and concurrent motion capture, we recorded auditory evoked fields while participants were: (i) sitting still, (ii) standing up and still, and (iii) standing up and making large natural head movements continuously throughout the recording – maximum translation 120 cm, maximum rotation 198°. Following pre-processing, movement artefacts were substantially reduced but not eliminated. However, upon utilisation of a beamformer, the M100 event-related field localised to primary auditory regions. Furthermore, the event-related fields from auditory cortex were remarkably consistent across the three conditions. These results suggest that a wide range of movement is possible with current OP-MEG systems. This in turn underscores the exciting potential of OP-MEG for recording neural activity during naturalistic paradigms that involve movement (e.g. navigation), and for scanning populations who are difficult to study with static MEG (e.g. young children). Highlights Data were collected from a wearable, whole-head 45-sensor, 90 channel OP-MEG system Participants were standing up and continually moving their head Head movement exceeded 120cm translation and 190° rotation We successfully measured auditory evoked fields despite the continuous head movements This was facilitated by data pre-processing steps and beamforming

Significance: Coherence, a fundamental property of waves and fields, plays a key role in photoacoustic image reconstruction. Previously, techniques such as short-lag spatial coherence (SLSC) and filtered delay, multiply, and sum (FDMAS) have utilized spatial coherence to improve the reconstructed resolution and contrast with respect to delay-and-sum (DAS). While SLSC uses spatial coherence directly as the imaging contrast, FDMAS employs spatial coherence implicitly. Despite being more robust against noise, both techniques have their own drawbacks: SLSC does not preserve a relative signal magnitude, and FDMAS shows a reduced contrast-to-noise ratio. Aim: To overcome these limitations, our aim is to develop a beamforming algorithm—generalized spatial coherence (GSC)—that unifies SLSC and FDMAS into a single equation and outperforms both beamformers. Approach: We demonstrated the application of GSC in photoacoustic computed tomography (PACT) through simulation and experiments and compared it to previous beamformers: DAS, FDMAS, and SLSC. Results: GSC outperforms the imaging metrics of previous state-of-the-art coherence-based beamformers in both simulation and experiments. Conclusions: GSC is an innovative reconstruction algorithm for PACT, which combines the strengths of FDMAS and SLSC expanding PACT’s applications.

Orientador: Prof. Dr. Ricardo Suyama Co-orientador: Prof. Dr. Kenji Nose Filho Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Engenharia da Informação, Santo André, 2021.

This paper reports a dual-wavelength photonic beamformer implementing optical true time delay (OTTD) to realize microwave beam steering. The beamformer is capable of providing independent delay tuning to two separate beams modulated on different optical carriers. The integrated TTD chip includes a multiplexer that combines the two input wavelengths, an optical sideband filter (OSBF) and optical ring resonators (ORRs) that induce different optical delays. The ORRs are thermo-optically tuned to change the coupling ratio and obtain an incremental delay in each optical path. The experimental demonstration includes a full-compliant WiFi channel (at 5 GHz or 18 GHz RF bands) transmitted in one optical carrier and a WiMAX channel (at 5.4 GHz or 19 GHz RF) in another optical carrier operating in the resonance slope of the ORRs. The different antenna elements are connected with 1-km of 7-core fiber, achieving EVM-compliant levels at the antennas with beam-steering angles ranging from -40° to +80°. The performance comparison considering single-carrier broadband RF signals at the same frequency bands is also reported in this work.

One of the primary technical challenges facing magnetoencephalography (MEG) is that the magnitude of neuromagnetic fields is several orders of magnitude lower than interfering signals. Recently, a new type of sensor has been developed - the optically pumped magnetometer (OPM). These sensors can be placed directly on the scalp and move with the head during participant movement, making them wearable. This opens up a range of exciting experimental and clinical opportunities for OPM-based MEG experiments, including paediatric studies, and the incorporation of naturalistic movements into neuroimaging paradigms. However, OPMs face some unique challenges in terms of interference suppression, especially in situations involving mobile participants, and when OPMs are integrated with electrical equipment required for naturalistic paradigms, such as motion capture systems. Here we briefly review various hardware solutions for OPM interference suppression. We then outline several signal processing strategies aimed at increasing the signal from neuromagnetic sources. These include regression-based strategies, temporal filtering and spatial filtering approaches. The focus is on the practical application of these signal processing algorithms to OPM data. In a similar vein, we include two worked-through experiments using OPM data collected from a whole-head sensor array. These tutorial-style examples illustrate how the steps for suppressing external interference can be implemented, including the associated data and code so that researchers can try the pipelines for themselves. With the popularity of OPM-based MEG rising, there will be an increasing need to deal with interference suppression. We hope this practical paper provides a resource for OPM-based MEG researchers to build upon., Comment: 56 pages, 19 figures, supplementary materials available on request

Bilateral hearing in early development protects auditory cortices from reorganizing to prefer the better ear. Yet, such protection could be disrupted by mismatched bilateral input in children with asymmetric hearing who require electric stimulation of the auditory nerve from a cochlear implant in their deaf ear and amplified acoustic sound from a hearing aid in their better ear (bimodal hearing). Cortical responses to bimodal stimulation were measured by electroencephalography in 34 bimodal users and 16 age-matched peers with normal hearing, and compared with the same measures previously reported for 28 age-matched bilateral implant users. Both auditory cortices increasingly favoured the better ear with delay to implanting the deaf ear; the time course mirrored that occurring with delay to bilateral implantation in unilateral implant users. Preference for the implanted ear tended to occur with ongoing implant use when hearing was poor in the non-implanted ear. Speech perception deteriorated with longer deprivation and poorer access to high-frequencies. Thus, cortical preference develops in children with asymmetric hearing but can be avoided by early provision of balanced bimodal stimulation. Although electric and acoustic stimulation differ, these inputs can work sympathetically when used bilaterally given sufficient hearing in the non-implanted ear., Graphical abstract Image 2, Highlights • Children with asymmetric hearing develop cortical preference for the better ear. • Cortical preference can be avoided by early cochlear implantation of the deaf ear. • Electrical implant stimulation can work sympathetically with acoustic hearing. • The implanted ear is preferred with poor acoustic hearing in the unimplanted ear.

The optically pumped magnetometer (OPM) is a viable means to detect magnetic fields generated by human brain activity. Compared to conventional detectors (superconducting quantum interference devices) OPMs are small, lightweight, flexible, and operate without cryogenics. This has led to a step change in instrumentation for magnetoencephalography (MEG), enabling a “wearable” scanner platform, adaptable to fit any head size, able to acquire data whilst subjects move, and offering improved data quality. Although many studies have shown the efficacy of ‘OPM-MEG’, one relatively untapped advantage relates to improved array design. Specifically, OPMs enable the simultaneous measurement of magnetic field components along multiple axes (distinct from a single radial orientation, as used in most conventional MEG systems). This enables characterisation of the magnetic field vector at all sensors, affording extra information which has the potential to improve source reconstruction. Here, we conduct a theoretical analysis of the critical parameters that should be optimised for effective source reconstruction. We show that these parameters can be optimised by judicious array design incorporating triaxial MEG measurements. Using simulations, we demonstrate how a triaxial array offers a dramatic improvement on our ability to differentiate real brain activity from sources of magnetic interference (external to the brain). Further, a triaxial system is shown to offer a marked improvement in the elimination of artefact caused by head movement. Theoretical results are supplemented by an experimental recording demonstrating improved interference reduction. These findings offer new insights into how future OPM-MEG arrays can be designed with improved performance.

This paper presents a unified speech enhancement system to remove both background noise and interfering speech in serious noise environments by jointly utilizing the parabolic reflector model and neural beamformer. First, the amplification property of paraboloid is discussed, which significantly improves the Signal-to-Noise Ratio (SNR) of a desired signal. Therefore, an appropriate paraboloid channel is analyzed and designed through the boundary element method. On the other hand, a time-frequency masking approach and a mask-based beamforming approach are discussed and incorporated in an enhancement system. It is worth noticing that signals provided by the paraboloid and the beamformer are exactly complementary. Finally, these signals are employed in a learning-based fusion framework to further improve the system performance in low SNR environments. Experiments demonstrate that our system is effective and robust in five different noisy conditions (speech interfered with factory, pink, destroyer engine, volvo, and babble noise), as well as in different noise levels. Compared with the original noisy speech, significant average objective metrics improvements are about &Delta, STOI = 0.28, &Delta, PESQ = 1.31, &Delta, fwSegSNR = 11.9.

Objective: In presurgical evaluation of temporal lobe epilepsy (TLE), selection of the resection side is challenging when bilateral temporal epileptiform discharges or structural abnormalities are present. We aim to evaluate the lateralization value of beamformer analysis of magnetoencephalography (MEG) in TLE. Methods: MEG data from 14 TLE patients were analyzed through beamformer analysis. We measured the hemispherical power distribution of beamformer sources and calculated the lateralization index (LI). We calculated the LI at multiple frequencies to explore the frequency dependency and at the delta frequency to define laterality. LI values ranging from −1 to −0.05 indicated right hemispheric dominance. LI values ranging from 0.05 to 1 indicated left hemispheric dominance. LI values ranging from −0.05 to 0.05 defined bilaterality. We measured the power of beamformer sources with a 9-s duration to explore time dependency. Results: The beamformer analysis showed that 10/14 patients had power dominance ipsilateral to resection. The delta frequency band had a higher lateralization value than other frequency bands. A time-dependent power fluctuation was found in the delta frequency band. Conclusions: MEG beamformer analysis, especially in the delta band, might efficiently provide additional information regarding lateralization in TLE.

Background Point of care ultrasonography has been the focus of extensive research over the past few decades. Miniaturised, wireless systems have been envisaged for new application areas, such as capsule endoscopy, implantable ultrasound and wearable ultrasound. The hardware constraints of such small-scale systems are severe, and tradeoffs between power consumption, size, data bandwidth and cost must be carefully balanced. Methods In this work, two receiver architectures are proposed and compared to address these challenges. Both architectures uniquely combine low-rate sampling with synthetic aperture beamforming to reduce the data bandwidth and system complexity. The first architecture involves the use of quadrature sampling to minimise the signal bandwidth and computational load. Synthetic aperture beamforming (SAB) is carried out using a single-channel, pipelined protocol suitable for implementation on an FPGA/ASIC. The second architecture employs compressive sensing within the finite rate of innovation framework to further reduce the bandwidth. Low-rate signals are transmitted to a computational back-end (computer), which sequentially reconstructs each signal and carries out beamforming. Results Both architectures were tested using a custom hardware front-end and synthetic aperture database to yield B-mode images. The normalised root-mean-squared-error between the quadrature SAB image and the RF reference image was \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$13\%$$\end{document}13% while the compressive SAB error was \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$22\%$$\end{document}22% for the same degree of spatial compounding. The sampling rate is reduced by a factor of 2 (quadrature SAB) and 4.7 (compressive SAB), compared to the RF sampling rate. The quadrature method is implemented on FPGA, with a total power consumption of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$4.1 $$\end{document}4.1 mW, which is comparable to state-of-the-art hardware topologies, but with significantly reduced circuit area. Conclusions Through a novel combination of SAB and low-rate sampling techniques, the proposed architectures achieve a significant reduction in data transmission rate, system complexity and digital/analogue circuit area. This allows for aggressive miniaturisation of the imaging front-end in portable imaging applications.

Magnetoencephalography (MEG) captures the magnetic fields generated by neuronal current sources with sensors outside the head. In MEG analysis these current sources are estimated from the measured data to identify the locations and time courses of neural activity. Since there is no unique solution to this so-called inverse problem, multiple source estimation techniques have been developed. The nulling beamformer (NB), a modified form of the linearly constrained minimum variance (LCMV) beamformer, is specifically used in the process of inferring interregional interactions and is designed to eliminate shared signal contributions, or cross-talk, between regions of interest (ROIs) that would otherwise interfere with the connectivity analyses. The nulling beamformer applies the truncated singular value decomposition (TSVD) to remove small signal contributions from a ROI to the sensor signals. However, ROIs with strong crosstalk will have high separating power in the weaker components, which may be removed by the TSVD operation. To address this issue we propose a new method, the nulling beamformer with subspace suppression (NBSS). This method, controlled by a tuning parameter, reweights the singular values of the gain matrix mapping from source to sensor space such that components with high overlap are reduced. By doing so, we are able to measure signals between nearby source locations with limited cross-talk interference, allowing for reliable cortical connectivity analysis between them. In two simulations, we demonstrated that NBSS reduces cross-talk while retaining ROIs' signal power, and has higher separating power than both the minimum norm estimate (MNE) and the nulling beamformer without subspace suppression. We also showed that NBSS successfully localized the auditory M100 event-related field in primary auditory cortex, measured from a subject undergoing an auditory localizer task, and suppressed cross-talk in a nearby region in the superior temporal sulcus.

International audience; This paper proposes a comparison between two optimization procedures for the design of continuous parallel plate waveguide multiple beam lens-like antennas. A phase-only approach is first considered and the design is analyzed in terms of angular scanning performances. A pattern-based optimization is then described, taking into account both phase and amplitude effects on the outer lens contour. Comparisons between the procedures are finally provided leading to conclusions on the potential of the proposed beamformer concept. © 2018 Institution of Engineering and Technology.All Rights Reserved.

Millimeter wave systems offer high date rate due to huge bandwidth but suffers from poor link budget. This is due to the blockage of the millimeter wave signal by the obstacles of size comparable to that of the wavelength of the signal. Various analysis in improving the signal strength is reported. One of them suggests use of directional antenna which guarantees signal delivery if line of sight communication between the transmitter and receiver exists. The other alternative scheme is Multi Input Multi Output (MIMO) beamforming that uses the channel statistics to steer the beam thereby improving the multiplexing gain and beamforming gain. In this paper, extensive research work carried out by us in MMW MIMO at 60 GHz covering aspects related to MIMO fixed-beam, adaptive beam and multibeam beamformers addressing line-of-sight and non-line-of-sight channel for MMW 60 GHz system is reviewed.

International audience; This paper presents the description and analysis of a continuous parallel plate waveguide (PPW) lens-like beamformer. The main design parameters of the continuous delay lens are defined starting from an ideal bifocal constrained lens. A dedicated ray tracing analysis tool is developed to better describe propagation effects in the delay lens and provide more insight on phase aberrations versus pointing angle. Numerical results of a specific design at Ku-band are reported by comparing radiation patterns obtained with the ray tracing tool and a full-wave method. These results are also compared to the ideal bifocal constrained lens design. © 2017 Euraap.

We propose source-space independent component analysis (ICA) for separation, tomography, and time-course reconstruction of EEG and MEG source signals. Source-space ICA is based on the application of singular value decomposition and ICA on the neuroelectrical signals from all brain voxels obtained post minimum-variance beamforming of sensor-space EEG or MEG. We describe the theoretical background and equations, then evaluate the performance of this technique in several different situations, including weak sources, bilateral correlated sources, multiple sources, and cluster sources. In this approach, tomographic maps of sources are obtained by back-projection of the ICA mixing coefficients into the source-space (3-D brain template). The advantages of source-space ICA over the popular alternative approaches of sensor-space ICA together with dipole fitting and power mapping via minimum-variance beamforming are demonstrated. Simulated EEG data were produced by forward head modeling to project the simulated sources onto scalp sensors, then superimposed on real EEG background. To illustrate the application of source-space ICA to real EEG source reconstruction, we show the localization and time-course reconstruction of visual evoked potentials. Source-space ICA is superior to the minimum-variance beamforming in the reconstruction of multiple weak and strong sources, as ICA allows weak sources to be identified and reconstructed in the presence of stronger sources. Source-space ICA is also superior to sensor-space ICA on accuracy of localization of sources, as source-space ICA applies ICA to the time-courses of voxels reconstructed from minimum-variance beamforming on a 3D scanning grid and these time-courses are optimally unmixed via the beamformer. Each component identified by source-space ICA has its own tomographic map which shows the extent to which each voxel has contributed to that component.

The study of functional connectivity using magnetoencephalography (MEG) is an expanding area of neuroimaging, and adds an extra dimension to the more common assessments made using fMRI. The importance of such metrics is growing, with recent demonstrations of their utility in clinical research, however previous reports suggest that whilst group level resting state connectivity is robust, single session recordings lack repeatability. Such robustness is critical if MEG measures in individual subjects are to prove clinically valuable. In the present paper, we test how practical aspects of experimental design affect the intra-subject repeatability of MEG findings; specifically we assess the effect of co-registration method and data recording duration. We show that the use of a foam head-cast, which is known to improve co-registration accuracy, increased significantly the between session repeatability of both beamformer reconstruction and connectivity estimation. We also show that recording duration is a critical parameter, with large improvements in repeatability apparent when using ten minute, compared to five minute recordings. Further analyses suggest that the origin of this latter effect is not underpinned by technical aspects of source reconstruction, but rather by a genuine effect of brain state; short recordings are simply inefficient at capturing the canonical MEG network in a single subject. Our results provide important insights on experimental design and will prove valuable for future MEG connectivity studies.

Background Simultaneous bilateral cochlear implantation promotes symmetric development of bilateral auditory pathways but binaural hearing remains abnormal. To evaluate whether bilateral cortical processing remains impaired in such children, cortical activity to unilateral and bilateral stimuli was assessed in a unique cohort of 16 children who received bilateral cochlear implants (CIs) simultaneously at 1.97 ± 0.86 years of age and had ~4 years of CI experience, providing the first opportunity to assess electrically driven cortical development in the absence of reorganized asymmetries from sequential implantation. Methods Cortical activity to unilateral and bilateral stimuli was measured using multichannel electro‐encephalography. Cortical processing in children with bilateral CIs was compared with click‐elicited activity in 13 normal hearing children matched for time‐in‐sound. Source activity was localized using the Time Restricted, Artefact and Coherence source Suppression (TRACS) beamformer method. Results Consistent with dominant crossed auditory pathways, normal P1 activity (~100 ms) was weaker to ipsilateral stimuli relative to contralateral and bilateral stimuli and both auditory cortices preferentially responded to the contralateral ear. Right hemisphere dominance was evident overall. Children with bilateral CIs maintained the expected right dominance but differences from normal included: (i) minimal changes between ipsilateral, contralateral and bilateral stimuli, (ii) weaker than normal contralateral stimulus preference, (iii) symmetric activity to bilateral stimuli, and (iv) increased occipital lobe recruitment during bilateral relative to unilateral stimulation. Between‐group contrasts demonstrated lower than normal activity in the inferior parieto‐occipital lobe (suggesting deficits in sensory integration) and greater than normal left frontal lobe activity (suggesting increased attention), even during passive listening. Conclusions Together, findings suggest that early simultaneous bilateral cochlear implantation promotes normal‐like auditory symmetry but that abnormalities in cortical processing consequent to deafness and/or electrical stimulation through two independent speech processors persist.

The processing required for the global maximization of the intelligibility of speech acquired by multiple microphones and rendered by a single loudspeaker, is considered in this paper. The intelligibility is quantized, based on the mutual information rate between the message spoken by the talker and the message as interpreted by the listener. We prove that then, in each of a set of narrow-band channels, the processing can be decomposed into a minimum variance distortionless response (MVDR) beamforming operation that reduces the noise in the talker environment, followed by a gain operation that, given the far-end noise and beamforming operation, accounts for the noise at the listener end. Our experiments confirm that both processing steps are necessary for the effective conveyance ofa message and, importantly, that the second step must be aware of the first step.

Recent modelling studies (Hadjipapas et al. [2009]: Neuroimage 44:1290-1303) have shown that it may be possible to distinguish between different neuronal populations on the basis of their macroscopically measured (EEG/MEG) mean field. We set out to test whether the different orientation columns contributing to a signal at a specific cortical location could be identified based on the measured MEG signal. We used 1.5deg square, static, obliquely oriented grating stimuli to generate sustained gamma oscillations in a focal region of primary visual cortex. We then used multivariate classifier methods to predict the orientation (left or right oblique) of the stimuli based purely on the time-series data from this one location. Both the single trial evoked response (0–300 ms) and induced post-transient power spectra (300–2,300 ms, 20–70 Hz band) due to the different stimuli were classifiable significantly above chance in 11/12 and 10/12 datasets respectively. Interestingly, stimulus-specific information is preserved in the sustained part of the gamma oscillation, long after perception has occurred and all neuronal transients have decayed. Importantly, the classification of this induced oscillation was still possible even when the power spectra were rank-transformed showing that the different underlying networks give rise to different characteristic temporal signatures. Hum Brain Mapp, 2010. © 2009 Wiley-Liss, Inc.

International audience; The relationship between neural oscillations recorded at various spatial scales remains poorly understood partly due to an overall dearth of studies utilizing simultaneous measurements. In an effort to study quantitative markers of attention during reading, we performed simultaneous magnetoencephalography (MEG) and intracranial electroencephalography (iEEG) recordings in four epileptic patients. Patients were asked to attend to a specific color when presented with an intermixed series of red words and green words, with words of a given color forming a cohesive story. We analyzed alpha, beta, and gamma band oscillatory responses to the word presentation and compared the strength and spatial organization of those responses in both electrophysiological recordings. Time-frequency analysis of iEEG revealed a network of clear attention-modulated high gamma band (50-150 Hz) power increases and alpha/beta (9-25 Hz) suppressions in response to the words. In addition to analyses at the sensor level, MEG time-frequency analysis was performed at the source level using a sliding window beamformer technique. Strong alpha/beta suppressions were observed in MEG reconstructions, in tandem with iEEG effects. While the MEG counterpart of high gamma band enhancement was difficult to interpret at the sensor level in two patients, MEG time-frequency source reconstruction revealed additional activation patterns in accordance with iEEG results. Importantly, iEEG allowed us to confirm that several sources of gamma band modulation observed with MEG were indeed of cortical origin rather than EMG muscular or ocular artifact.

Objective. In epilepsy, high-frequency oscillations (HFOs) are expressively linked to the seizure onset zone (SOZ). The detection of HFOs in the noninvasive signals from scalp electroencephalography (EEG) and magnetoencephalography (MEG) is still a challenging task. The aim of this study was to automate the detection of ripples in MEG signals by reducing the high-frequency noise using beamformer-based virtual sensors (VSs) and applying an automatic procedure for exploring the time-frequency content of the detected events. Approach. Two-hundred seconds of MEG signal and simultaneous iEEG were selected from nine patients with refractory epilepsy. A two-stage algorithm was implemented. Firstly, beamforming was applied to the whole head to delimitate the region of interest (ROI) within a coarse grid of MEG-VS. Secondly, a beamformer using a finer grid in the ROI was computed. The automatic detection of ripples was performed using the time-frequency response provided by the Stockwell transform. Performance was evaluated through comparisons with simultaneous iEEG signals. Main results. ROIs were located within the seizure-generating lobes in the nine subjects. Precision and sensitivity values were 79.18% and 68.88%, respectively, by considering iEEG-detected events as benchmarks. A higher number of ripples were detected inside the ROI compared to the same region in the contralateral lobe. Significance. The evaluation of interictal ripples using non-invasive techniques can help in the delimitation of the epileptogenic zone and guide placement of intracranial electrodes. This is the first study that automatically detects ripples in MEG in the time domain located within the clinically expected epileptic area taking into account the time-frequency characteristics of the events through the whole signal spectrum. The algorithm was tested against intracranial recordings, the current gold standard. Further studies should explore this approach to enable the localization of noninvasively recorded HFOs to help during pre-surgical planning and to reduce the need for invasive diagnostics.

The present study developed a fast MEG source imaging technique based on Fast Vector-based Spatio-Temporal Analysis using a L1-minimum-norm (Fast-VESTAL) and then used the method to obtain the source amplitude images of resting-state magnetoencephalography (MEG) signals for different frequency bands. The Fast-VESTAL technique consists of two steps. First, L1-minimum-norm MEG source images were obtained for the dominant spatial modes of sensor-waveform covariance matrix. Next, accurate source time-courses with millisecond temporal resolution were obtained using an inverse operator constructed from the spatial source images of Step 1. Using simulations, Fast-VESTAL's performance was assessed for its 1) ability to localize multiple correlated sources; 2) ability to faithfully recover source time-courses; 3) robustness to different SNR conditions including SNR with negative dB levels; 4) capability to handle correlated brain noise; and 5) statistical maps of MEG source images. An objective pre-whitening method was also developed and integrated with Fast-VESTAL to remove correlated brain noise. Fast-VESTAL's performance was then examined in the analysis of human median-nerve MEG responses. The results demonstrated that this method easily distinguished sources in the entire somatosensory network. Next, Fast-VESTAL was applied to obtain the first whole-head MEG source-amplitude images from resting-state signals in 41 healthy control subjects, for all standard frequency bands. Comparisons between resting-state MEG sources images and known neurophysiology were provided. Additionally, in simulations and cases with MEG human responses, the results obtained from using conventional beamformer technique were compared with those from Fast-VESTAL, which highlighted the beamformer's problems of signal leaking and distorted source time-courses. © 2013.

In electroencephalography (EEG) and magnetoencephalography signal processing, scalar beamformers are a popular technique for reconstruction of the time-course of a brain source in a single time-series. A prerequisite for scalar beamformers, however, is that the orientation of the source must be known or estimated, whereas in reality the orientation of a brain source is often not known in advance and current techniques for estimation of brain source orientation are effective only for high signal-to-noise ratio (SNR) brain sources. As a result, vector beamformers are applied which do not need the orientation of the source and reconstruct the source time-course in three orthogonal (x, y, and z) directions. To obtain a single time-course, the vector magnitude of the three orthogonal outputs of the beamformer can be calculated at each time point (often called neural activity index, NAI). The NAI, however, is different from the actual time-course of a source since it contains only positive values. Moreover, in estimating the magnitude of the desired source, the background activity (undesired signals) in the beamformer outputs also become all positive values, which, when added to each other, leads to a drop in the SNR. This becomes a serious problem when the desired source is weak. We propose applying independent component analysis (ICA) to the orthogonal time-courses of a brain voxel, as reconstructed by a vector beamformer, to reconstruct the time-course of a desired source in a single time-series. This approach also provides a good estimation of dipole orientation. Simulated and real EEG data were used to demonstrate the performance of voxel-ICA and were compared with a scalar beamformer and the magnitude time-series of a vector beamformer. This approach is especially helpful when the desired source is weak and the orientation of the source cannot be estimated by other means.

We have explored both the benefits and detriments of providing electrical input through a cochlear implant in one ear to the auditory system of young children. A cochlear implant delivers electrical pulses to stimulate the auditory nerve, providing children who are deaf with access to sound. The goals of implantation are to restrict reorganization of the deprived immature auditory brain and promote development of hearing and spoken language. It is clear that limiting the duration of deprivation is a key factor. Additional considerations are the onset, etiology, and use of residual hearing as each of these can have unique effects on auditory development in the pre-implant period. New findings show that many children receiving unilateral cochlear implants are developing mature-like brainstem and thalamo-cortical responses to sound with long term use despite these sources of variability; however, there remain considerable abnormalities in cortical function. The most apparent, determined by implanting the other ear and measuring responses to acute stimulation, is a loss of normal cortical response from the deprived ear. Recent data reveal that this can be avoided in children by early implantation of both ears simultaneously or with limited delay. We conclude that auditory development requires input early in development and from both ears.

The perception-action account of empathy states that observation of another person's state automatically activates a similar state in the observer. It is still unclear in what way ongoing sensorimotor alpha oscillations are involved in this process. Although they have been repeatedly been implicated in (biological) action observation and understanding communicative gestures, less is known about their role in vicarious pain observation. Their role is understood as providing a graded inhibition through functional inhibition, thereby streamlining information flow through the cortex. Although alpha oscillations have been shown to have at least visual and sensorimotor origins, only the latter are expected to be involved in the empathetic response. Here, we used magnetoencephalography (MEG), allowing us to spatially distinguish and localize oscillatory components using beamformer source reconstruction. Subjects observed realistic pictures of limbs in painful and no-pain (control) conditions. As predicted, time-frequency analysis indeed showed increased alpha suppression in the pain condition compared to the no-pain (control) condition. Although both pain and non-pain conditions suppressed alpha and beta band activity at both posterior and central sensors, the pain condition suppressed alpha more only at central sensors. Source reconstruction localized these differences along the central sulcus. Our results could not be accounted by differences in the evoked fields, suggesting a unique role of oscillatory activity in empathetic responses. We argue that alpha oscillations provide a unique measure of the underlying functional architecture of the brain, suggesting an automatic disinhibition of the sensorimotor cortices in response to the observation of pain in others.

Processing of broadband signals induced on an antenna array using a tapped delay line filter and a set of steering delays has two problems. Firstly one needs to manipulate large matrices to estimate the filter coefficients. Secondly the use of steering delays is not only cumbersome but implementation errors cause loss of system performance. This thesis looks at both of these problems and presents elegant solutions by developing and studying a design method referred to as the DFT method, which does not require steering delays and is computationally less demanding compared to existing methods. Specifically the thesis studies and compares the performance of a time domain element space beamformer using the proposed method and that using an existing method, and develops the DFT method when the processor is implemented in partitioned form. The study presented in the thesis shows that the processors using the DFT method are robust to look direction errors and require less computation than that using the existing method for comparable performance. The thesis further introduces a broadband beamformer design which does not require any steering delays between the sensors and the tapped delay line section as is presently the case. It has the capability of steering the array in an arbitrary direction with a specified frequency response in the look direction while canceling unwanted uncorrelated interferences. The thesis presents and compares the performance of a number of techniques to synthesize an antenna pattern of a broadband array. These techniques are designed to produce isolated point nulls as well as broad sector nulls and to eliminate the need for the steering delays. Two of the pattern synthesis techniques presented in the thesis allow optimization against unwanted interferences in unknown directions. The techniques allow formulation of a beamforming problem such that the processor is not only able to place nulls in specified directions but also able to cancel directional interferences in unknown directions along with a specified frequency response in the look direction over a band of interest. The thesis also presents a set of directional constraints such that one does not need steering delays and an array can be constrained in an arbitrary direction with a specified frequency response. The constraints presented in the thesis are simple to implement. Based on these constraints a pattern synthesis technique for broadband antenna array is also presented.

A number of beamformers have been introduced to localize neuronal activity using magnetoencephalography (MEG) and electroencephalography (EEG). However, currently available information about the major aspects of existing beamformers is incomplete. In the present study, detailed analyses are performed to study the commonalities and differences among vectorized versions of existing beamformers in both theory and practice. In addition, a novel beamformer based on higher-order covariance analysis is introduced. Theoretical formulas are provided on all major aspects of each beamformer; to examine their performance, computer simulations with different levels of correlation and signal-to-noise ratio are studied. Then, an empirical data set of human MEG median-nerve responses with a large number of neuronal generators is analyzed using the different beamformers. The results show substantial differences among existing MEG/EEG beamformers in their ways of describing the spatial map of neuronal activity. Differences in performance are observed among existing beamformers in terms of their spatial resolution, false-positive background activity, and robustness to highly correlated signals. Superior performance is obtained using our novel beamformer with higher-order covariance analysis in simulated data. Excellent agreement is also found between the results of our beamformer and the known neurophysiology of the median-nerve MEG response.

Time delay estimation (TDE)-based algorithms for estimation of direction of arrival (DOA) have been most popular for use with speech signals. This is due to their simplicity and low computational requirements. Though other algorithms, like the steered response power with phase transform (SRP-PHAT), are available that perform better than TDE based algorithms, the huge computational load required for this algorithm makes it unsuitable for applications that require fast refresh rates using short frames. In addition, the estimation errors that do occur with SRP-PHAT tend to be large. This kind of performance is unsuitable for an application such as video camera steering, which is much less tolerant to large errors than it is to small errors. We propose an improved TDE-based DOA estimation algorithm called time delay selection (TIDES) based on either minimizing the weighted least squares error (MWLSE) or minimizing the time delay separation (MWTDS). In the TIDES algorithm, we consider not only the maximum likelihood (ML) TDEs for each pair of microphones, but also other secondary delays corresponding to smaller peaks in the generalized cross-correlation (GCC). From these multiple candidate delays for each microphone pair, we form all possible combinations of time delay sets. From among these we pick one set based on one of the two criteria mentioned above and perform least squares DOA estimation using the selected set of time delays. The MWLSE criterion selects that set of time delays that minimizes the least squares error. The MWTDS criterion selects that set of time delays that has minimum distance from a statistically averaged set of time delays from previously selected time delays. Both TIDES algorithms are shown to out-perform the ML-TDE algorithm in moderate signal to reverberation ratios. In fact, TIDES-MWTDS gives fewer large errors than even the SRP-PHAT algorithm, which makes it very suitable for video camera steering applications. Under small signal to reverberation ratio environments, TIDES-MWTDS breaks down, but TIDES-MWLSE is still shown to out-perform the algorithm based on ML-TDE. Master of Science

This paper considers optimization problems over networks where agents have individual objectives to meet, or individual parameter vectors to estimate, subject to subspace constraints that require the objectives across the network to lie in low-dimensional subspaces. This constrained formulation includes consensus optimization as a special case, and allows for more general task relatedness models such as smoothness. While such formulations can be solved via projected gradient descent, the resulting algorithm is not distributed. Starting from the centralized solution, we propose an iterative and distributed implementation of the projection step, which runs in parallel with the stochastic gradient descent update. We establish in this Part I of the work that, for small step-sizes $\mu$, the proposed distributed adaptive strategy leads to small estimation errors on the order of $\mu$. We examine in the accompanying Part II (R. Nassif, S. Vlaski, and A. H. Sayed, 2019) the steady-state performance. The results will reveal explicitly the influence of the gradient noise, data characteristics, and subspace constraints, on the network performance. The results will also show that in the small step-size regime, the iterates generated by the distributed algorithm achieve the centralized steady-state performance.

This paper presents a dual-band feed network for K-/Ka-Band phased array transceiver modules. It is intended to interface receive and transmit beamformer chips and the antenna elements with the remaining front-end circuitry. The whole arrangement consists of two printed circuit boards (PCBs) which are mounted on both sides of an aluminum 1:4 rectangular waveguide (RWG) power divider/combiner. It includes transitions from grounded coplanar waveguide (GCPW) to RWG. These are self-diplexing and thus an integral part of the whole feed network. Due to the RWG aluminum body, this integration approach offers adequate heat transfer capabilities and increased space for surface mount devices (SMDs). Because of its high frequency selectivity, image reject filters in the Rx-path can be dispensed with. The manufactured passive demonstrator exhibits reflection coefficients below -10 dB from 18.7 GHz to 20.5 GHz (Rx-band) and from 29.2 GHz to 30.5 GHz (Tx-band) and an insertion loss of $3.9\ \text{dB} < \text{IL} < 4.8\ \text{dB}$ and $2.8\ \text{dB} < \text{IL} < 3.6\ \text{dB}$ at these frequencies. Although the Rx- and the Tx-paths share the same RWG divider/combiner, they are diplexed with an isolation of more than 30 dB in both bands.