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1. New approaches to determine negligible creep

Author

G. Baylac, C. Bullough, S. Holmström, W. Smith, A. Tonti, and C. Forot

Subjects
Mechanics of Materials, Mechanical Engineering, Materials Chemistry, Metals and Alloys, Ceramics and Composites, Condensed Matter Physics
Published
2022

2. Powder bed selective laser processing (sintering / melting) of Yttrium Stabilized Zirconia using carbon-based material (TiC) as absorbance enhancer

Author

Urruth, Giovanni, Maury, Delphine, Voisin, Christophe, Baylac, Vincent, Grossin, David, Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Marion Technologies, and European Project: 764935,DOC 3D Printing

Subjects
Yttrium stabilized zirconia, Selective laser sintering, Additive manufacturing, Powder bed fusion, Materials Chemistry, Ceramics and Composites, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, Titanium carbide
Abstract

International audience; This study aimed to process 8 mol.% yttrium stabilized zirconia by powder bed selective laser processing, as well known as selective laser sintering / melting. Titanium carbide was used as absorbance enhancer to a Nd:YAG laser. Titanium carbide was chosen for having the lowest weight / absorbance ratio among four additive options: silicon carbide, carbon black, graphite, and titanium carbide. Several trials were performed using 0,25 wt.% of titanium carbide as absorbance enhancer of 8 mol.% yttrium stabilized zirconia, testing different laser powers, laser speeds, laser strategies, hatch distances and designs. A window of optimized parameters was identified within the study conditions, capable of manufacturing parts with high relative density. In addition, challenges and technical aspects are discussed by analyzing the observed phenomena.

Published
2022

3. European Workshop on Photocathodes for Particle Accelerator Applications 2022: Summary Report

Author

Monaco, L., Sertore, D., Baylac, M., Jones, L. B., Noakes, T. C. Q., Kühn, J., and Xiang, R.

Subjects
Accelerator Physics (physics.acc-ph), FOS: Physical sciences, Physics - Accelerator Physics
Abstract

The European Workshop on Photocathodes for (particle) Accelerator Applications (EWPAA) brings together experts in the field of photocathode based electron sources for use in particle accelerators, with the aim of sharing their knowledge and latest research and development progress in this crucial field of particle accelerator science. The workshop is convened every other year, and is thus complementary to the P3 workshop (Photocathode Physics for Particle accelerators) run in the USA. Consequently, there is a workshop focusing on photocathodes for particle accelerator applications convened every year, either in Europe or the USA. The EWPAA 2022 is the 4th meeting in this workshop series. The event was hosted by the INFN LASA Institute in Milan in collaboration with University of Milano between September 20th and 22nd. The programme was organised with 7 working groups, with each oral contribution assigned to the most appropriate group. This report presents, summarised by the work group conveners, the innovative ideas, the challenges and the main points raised by each of the speakers., Comment: 11 pages, 1 figure Workshop website: https://agenda.infn.it/event/ewpaa2022

Published
2023
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4. Successful cefiderocol therapy of severe infections due to difficult-to-treat Pseudomonas aeruginosa in two allogeneic hematopoietic stem cell transplantation recipients

Author

Julien Gras, Sara Villar-Fernandez, Pierre Baylac, Aliénor Xhaard, Sandrine Valade, François Camelena, Béatrice Bercot, Sophie Touratier, Flore Sicre de Fontbrune, Jean-Michel Molina, and Matthieu Lafaurie

Subjects
Drug Resistance, Multiple, Bacterial, Pseudomonas aeruginosa, Hematopoietic Stem Cell Transplantation, Humans, Pseudomonas Infections, Hematology, General Medicine, Anti-Bacterial Agents, Cephalosporins
Published
2022

6. Book of epidemics

Author

Baptiste Baylac-Paouly

Subjects
History, Philosophy of science, 05 social sciences, General Social Sciences, 06 humanities and the arts, 050905 science studies, 0603 philosophy, ethics and religion, Epistemology, Philosophy of biology, History and Philosophy of Science, 060302 philosophy, 0509 other social sciences, History general, Philosophy of technology
Published
2021

9. Outline of the recent consolidated revision of EN13445-3, clause 18 and related annexes: detailed assessment of fatigue life

Author

Rüdiger Gawlick, Yves Simonet, Guy Baylac, Manuela Triay, Michael Krämer, Jürgen Rudolph, and Ralf Trieglaff

Subjects
Computer science, Assessment methods, Design methods, Construction engineering, Earth-Surface Processes
Abstract

The European Pressure Vessel Standard EN 13445 (harmonized Standard acc. to PED 2014/68/EU) provides in its Part 3 (Design) a simplified method for fatigue assessment (Clause 17) and a detailed method of fatigue assessment (Clause 18). While the new revision of Clause 17 has already been adopted, Clause 18 “Detailed Assessment of Fatigue Life” is now available as a consolidated revision in inquiry phase. This major and comprehensive revision has been developed within the framework of the European working group CEN/TC 54/WG 53 – Design methods and constitutes a crucial step towards a modern and user-friendly engineering fatigue assessment method. The overall structure and amendments of Clause 18 are to be presented. All these amendments aim at a significant increase in user friendliness and clear guidelines for application. The following items are to be mentioned in that context: • Fatigue assessment of welded components based on structural stress and structural hot-spot stress approaches, • Detailed guidelines for determining relevant stresses and stress ranges, • Cycle counting proposals in the context of the fatigue assessment method including a critical plane approach. The fatigue assessment of welded components is separated from the fatigue assessment of un-welded parts as it has already been done in previous versions with respective methodological differences. Stress analyses for clause 18 are usually based on detailed finite element analyses (FEA). As an essential amendment for the user, the determination of structural stress ranges for the fatigue assessment of welds is further detailed in a new appropriate annex. Different applicable methods for the determination of structural stresses are explained in connection with the requirements of the finite element models and analyses. The cycle counting issue is comprehensively treated in the context of different design and operation situations (design transients, operational stress-time-histories). The description is detailed towards a critical plane approach. Detailed proposals for implementation in an algorithmic programming framework are given making the described methods ready to use.

Published
2019

10. Prevalence of diabetic and impact on cardiovascular events and mortality in patients with chronic coronary syndromes, across multiple geographical regions and ethnicities

Author

H Appeltants, C Boesch, I Cromarty, D Carretta, S Romanov, U Windstetter, F Mibach, Jens Refsgaard, S Lebedev, F Proietti, M Y Tamimi, M C Gamboa, M Novikova, E Prada, K H Sim, E Messas, E Zherlitsyna, A Kalampalikis, N Nevolina, N Trocan, J Cohen, G Szto, R Gilabert Gómez, M Omelchenko, A Pinzani, D Goodwin, J Umaran Sánchez, Kim Fox, S H Dong, K Kronberg, E Castillo Lueña, T Ignatieva, S Joubert, C Macchi, S Lee, S Eidelman, F Alizon, S Chandra, M Akbar, D M Colquhoun, G Yanes Bowden, J de Juan Baguda, M Sebastian, C Wernham, K Miedema, R La Greca, C Morton, B S Jheeta, A C Tran, T Q Do, O Rodrigues, J Yan, S H Kim, R Jurgaitienė, Jean-Claude Tardif, R Baleón, D Hay, V Hennebelle, F Fazekas, R Davies, P Gratia, L Sorodoc, S Y Wu, C Martínez Sánchez, L Lopes Antunes, T H T Pham, I Suliman, M J Gómez Martinez, A Pernat, S H Hur, M Alanazy, L Zhabina, M Stanley, J Rogers, Y J Kim, S Geffroy, L K Andersen, S Coman, V Pedrosa del Moral, Y Garaud, J Krupicka, O Dzhkha, C Paul, M Jeżewska, B Mahler Mioto, V Abduvalieva, P Morra, L Kucheryava, C La Rosa, B Chan, M Wrębiak-Trznadel, A Kozlowski, M Sharif, L López Barreiro, V Kolesnikov, M Lawrence, A Tucker, C Okawabata, B La Hay, E Sadauskienė, B K Nguyen, L Bui, A Said, M E Ruíz Esparza, R K Saran, M S C Ho, E Homs Espinach, J R Romo Santana, J Forte De Carvalho, I Pattison, H H Phan, L Baleeva, L Kisiel, A López Granados, C Raters, F Paganelli, R Haberl, A P T Wong, D Xu, R Jagathesan, L Grekhova, H Stursova, Q B Truong, P Raymond, Y Sosnova, N H Khong, J Zarauza Navarro, C Florescu, L Gorshkova, N Saaidin, E Gordillo Higuero, L Davin, I Budanova, C Lavicka, L Gruznykh, P Bogdański, A Dufka, I Arroja, H A R Tahir, G Wilson, G Kolios, S J Yoon, Simon Cattan, K Berdnik, A Serrano, B Sievers, A Rodríguez Almodóvar, L A Holden, F O'Reilly, D Verleyen, H Hafez, K Nehrig, S M Kang, S Berrisch-Rahmel, E Meyer-Michael, P Samama, L Soares, A K Nguyen, F Tuktarova, C Weytjens, E Sandoval Rodriguez, J Cheng, F M Villasenor, João Morais, B Sullivan, R Zimoląg, Albert V. Smith, S F Ding, J C Louchart, G Guardigli, R Furtak, P Azzolini, S Chushak, J L Delgado Prieto, S Kornienko, K K Sia, J H Shin, F Baylac Domengetroy, P Błaszczak, M Saade, N Černič-Šuligoj, K Coetzee, A Kadleckova, V Scollo, O Larina, R Pal, M M Singh, N Nosova, R Burns, B S Yoo, O Gukov, F Massari, V Antia, A Brattström, G Holt, M Scherbak, V Firastrau, Y J Li, E Mikhailova, L Machado Cesar, C García García, J Pjontek, C Everton Biglow, G Pes, C Brown, A Bumbu, S Felis, R Bosch, M Lazaro, Luigi Tavazzi, R Engel, I Romeo Castillejo, Y S Byun, F Matias, I Grushetskaya, C Mestre-Fernandes, T Kheliya, S Schlesingerova, G Theodorakis, I Tsamopoulos, R Pedretti, A Puente Barragán, M P Vo, B Lammens, T Carruthers, J S Bhatt, A Khodanov, N Pasechnaya, I Petrova, G Boutros, I A Khan, E Le Moal, D Garofalo, H R Malaterre, A Bahal, J F Martínez González, H N Dinh, N V Pham, C Barjhoux, I Gilmour, C Soriano Navarro, O D Chioncel, K Tóth, N Borodina, P Khanoyan, B Sevilla Toral, H H Kim, C M A Bui, C Dernedde, N Eliseeva, M Galinier, E Kosachek, M M Doohan, L Potapska, M Tennekoon, R Nourallah, L Perez De Isla, K H Chee, E Panova, D M Walker, G Glanowska, G Hua, A Silvestre, W Wang, Matthew A. Brown, B Luke, G Jarosiński, R Davis, S Cleron, C Liatas, I Orestis, M Dereń, J Sudnik, S X Zhou, J Fuertes Alonso, O Baranova, S Mingalaeva, T N Vo, K A Ngo, J A Rodríguez Fernández, R Ishmael, G Bode, K K Chan, G Al Radaideh, S Ramphall, H D Theron, V Montagud Saavedra, A Yusuf, G F Mazzanti Mignaqui, L Evtukhova, J Lorenc, D Beacock, O B Šlapikienė, F Alitto, J N Poujois, B Berzal Martín, M Felbermayer, V Mallamaci, T Spitsina, R Ramachandran, A Jánosi, V Dženkevičiūtė, S Gillam, V Joulie, G Esna Ashari, R Henry, E Durand, A Alam, V Fourchard, H Dreycopp, R Fressonnet, C Camossa, O Jerzykowska, M Castrucci, G Sinicropi, B K Goyal, V Vasylenko, R Grogono, M Partington, B Vaquette, R Blindt, Mª T Moreno Casquete, V Kukaleva, W Streb, P F Clavette, M Pérez Paredes, V Hadjiivanov, C Bundy, D E Manyari, A Wassef, J Kuchar, W Nisker, P S Bath, S Panpunnung, G H Choo, Datshana P Naidoo, Y Pavlova, R McManus, N Brand, E Davies, L Prunier, A Schenowitz, P Sternthal, T Sinotova, J Martínez Florez, R Sykulski, J Pinar Sopena, M Balbi, Y Pesant, D A Playford, C Villar Mariscal, F Redding Escalante, W Wongcharoen, O Grechishkina, A Girão, M Speth-Nitschke, K A Mahendran, A Bianco, A Vadavi, G Singh, L Petoin Peuch, L Sukhanova, A Y Y Fong, J L Vega Barbado, A Dzien, S Honorat, G Ansalone, G Kamensky, G McLaren, T B Kim, I Bratu, R Fillet, V Rogozhyna, L Nagy, M Malgina, M A Sheikh Abdul Kader, Z C Li, L Rotaru H Rus, D Adamczyk-Kot, J Estrella, S Serrano García, P Farto E Abreu, D Mescharekova, Su Thillai Vallal, P Seal, S Möller, A Cziráki, T T H Ta, S Davies, H Ge, M Arafah, M Ovize, A Olszewski, V Aboyans, C Roche, F Al Tamimi, L Popova, V Kazachkova, R Rennert, J Aubry, G Bourgeois, J Mackrell, F Al Kandari, N Reifart, J Bérubé, W H J Hutse, O Lysunets, I Butkuvienė, J Cotroneo, J Gdalia, J Dalle Mule, R Santos, B Singh, H Mohammed, A Birkenhagen, T Chiscaneanu, H Sullivan, Jacob A. Udell, N Bolotova, A Jankowska, M Skonieczny, B S K Ch'ng, O Aiyegbayo, S Ciaroni, N Lago, S R Coimbra, R Ellis, B K Koo, S Rostik, P Jacquier, A Conradie, N Biryukova, M Ayche, A Khripun, B Peperstraete, E Velasco Espejo-Saavedra, G Cunliffe, G Grollier, C Ceraulo, T L To, Q H Tran, M Anscombe, R Jordan, I Czuriga, P Haimes, R Ancín Viguiristi, H Q Zhang, C A Chételat, A Rafter, E Rinkūnienė, K Yang, W Gao, J Pearce, L C Fernández Léoz, L Gareeva, R Fernández Alvarez, G Verret, P Astrakhantseva, C M Chu, L Murphy, P A Do, J L Liu, A Clifford, K Woollard, N Dmitrieva, N Lousada, R Díaz Juárez, N Semenova, T Fesenko, F Henschel, R Amini, G Matuszewska, R Christodorescu, J Varaldi, S Varughese, V Lafarenko, A Ashford, J L Colomer Martín, S Assouline, H Noor Hasni, A Weatherup, T Forster, R Kaserbacher, I Caldwell, N Arabadzhi, Emmanuel Sorbets, A Rink, E C Rueda Calle, J M Stordeur, P West, V C Do, Béla Merkely, J Antunes, U Altmann, S Magheru, B Bachmann, W Parkar, M de los Reyes López, M Wazana, A Frattola, M Mospan, V Koval, E Giusti Rossi, J Vasconcelos, K B Do, A Ogorodnichuk, D Lighezan, G Mentz, J M Cherry, P Pouderou, M Moretti, C M Spinu, Emmanuelle Vidal-Petiot, N Kupstytė, P Jourdain, V Voronina, O Varezhnikova, S Williams, H AlFaleh, R Lew, P Hildebrant, J Drozd, G Muscio, T H Ashton, A Achilli, J Harinasuta, T Ghose, G Walawski, Y Arkhipova, M Alves Costa, B Day, A Suntinger, A Singh, P Sheringham, A Vázquez García, J Taggeselle, J T Dong, T H Goh, G Rojas, R Schultz, A Ballet, O Likhobabina, Z M Qian, S Sandoval Navarrete, D Manzi, S Langridge, W Haerer, C K Abdullah, L Hay, Á Herdade, A Gałuszka-Bilińska, F Biausque, V M Lai, D S Eccleston, L Nikolaeva, P Kalaras, J Martínez Redding, N P H Tran, B Wauer, Philippe Gabriel Steg, B Etcheverry, J Navarro Manchón, R Augarde, C Dixon, M Y Chen, J L Gleizes, S Pustovit, J L Farges, S Cox, G Manchet, K Shein, L Parker, C C Ang, O Sinyukova, V Veth, A Kurekhyan, N Cindea Nica, N Wittlich, J Al Yazeedi, A Pucheu, V Elliott, J Bories, K Alford, M F Ferrão E Vasconcelos, A Adamkiewicz-Piejko, R Cervenak, J F Beltrame, A Castro, L Safonova, G Koutsimpanis, C de Brito Vianna, R Wysocki, V Ginzburg, J Hernández Afonso, A Ihonor, O Golubeva, M Karachaliou, S Kleta, D d'Este, Gustavs Latkovskis, F Jäger, E Gamzatov, Y Kozhelenko, J Lippai, T T L Ong, S J Ge, A Hersi, K Kyd, S Mingam, V Yordanova, L Bardachenko, E Mozerova, S W Liu, J Zdrojewska, E Chung, M Leclair, M Nazir, S Zarechnova, A Rahman, M Sołtysiak, B Maguire, F Moreira Pinto, R Fathi, E Prieto Moriche, C Priftis, P Heno, N Sytilina, A Pladys, S Shimonenko, P Keller, J F Junior, G Amiel Oster Sauvinet, J P Kanner, L Tkachenko, J Dalal, A Liston, D Herrera Fernández, J L Bonnet, A Chirivella González, R P Shah, F A Reyes Cisneros, C Avgerinos, P Ravoala, V Albero Martínez, G Suarez, V Jouve, A Frankiewicz, A Lindsay, A De Meester, H Dau, M Pornin, J Álvarez Gil, J Murin, T Hodac, J J Gómez Barrado, Y J Wu, S Jean, P Hilti, A Dayani, R Steponėnienė, G A Somsen, H Zhang, J Moore, P Tarenidis, T H Nguyen, M Maliszewski, L Voloshyna, S Novo, A Phrommintikul, I Shanina, Roberto Ferrari, P Franklin, C Turner, W Boonyapisit, F Sepulcri, P Vandergoten, J Carvalho, J Halcox, V Rotenberger, J F Baril, M Turiel, P Shiels, P Painsipp, S Reis Monteiro, T Honsig, V Vivekaphirat, J Ardill, P Brodzicki, A Khalifa, H Audibert, T Wettstein, F Auhser, D Ezekiel, D Pella, E Simarro Martín-Ambrioso, H S Seo, J A Núñez Gamero, Gabriel Steg, M Orbán, S Bykovskaya, W Gadziński, N Rozkova, G H M Vawda, R A Motyer, B Limeres González, E Fernandez Valadez, Riyaz S. Patel, I Shaikh, E Ziak, A Estriga, P Dodemant, Dragos Vinereanu, W Miao, L Marullo, F MacNamara, S K Tan, N Giacomantonio, A Leherissier, H W Li, Arpana Agrawal, Y Moreau, F David, S K Ma, A N Jamaluddin, E Alegría Ezquerra, Scalzo, M C Ta, T T Nguyen, A Sudre, R Gupta, H Lagioia, M Haiba, P Kohan, M Szentivanyi, T Dmitrieva, N Vechtomova, C Vuille, R G Schena, P Navratil, O Tsygankov, L Saaby, P Lefebvre, S King Wong, S Maheas Morlet, N H Pham, P Bonnet, S Modi, L Gaspar, M Karlicek, S Pallie, H T Pham, S Abele, N Bizyaeva, L Facila Rubio, N Meneveau, G Poluyanova, J Calaça, S Orazi, M Emonts, A Yusufali, V Sprott, Z Vazhdaeva, M R Conte, E Bulakhova, K Giokoglu, E Page, E Kotova, G Maragoni, C Jerjes Sánchez, T Kiver, M Brunehaut Petaut, A Nagy, P Singer, Zs Sziegl, B Fontanet, S Strange, A Watson, J Föchterle, Janet A. Dunn, R Šlapikas, M Stikhurova, S Salimova, J Volmar, E Otero Chulian, S Hutchinson, R Koller, X Bonnaud, E Peris Domingo, F Marín Ortuño, E Galve Basilio, S Bongo, L Payot, C Miller, A Samothrakitis, L Silva Melchor, K Orzechowski, W Hofer, L V Nguyen, R Oliver, K T Jung, J Robb, D Sobczyk, J Muller, A Tomatti, M Gruchała, C Bradshaw, D Richmond, E Mineeva, E Smirnova, A Idrissi-Sbai, H Vial, R Balai, I Kiseleva, H Jones, M Gibbs, D Ohlmeyer, Y Al Wahshi, V d’Alessandro, S Pérez Ibiricu, V Zachos, A Chernozemova, D R Spink, J Schneider, A M Peset Cubero, M Irurita Latasa, M Migliore, G Perna, E Daniels, M H Tay, N Z Khiew, I Soin, F Bernasconi, T Garban, F Omardeen, O Rodina, L Kanagaratnam, I Blum-Decary, A Jaussi, D Romero Alvira, D Vermander, N Kanumilli, M A Romero Maldonado, M Fernández-Valls Gómez, H Tran, T P Nguyen, H Omar, R S Collette, B Kisjós, H Krause-Allmendinger, J Silva E Sá, H Topf, F Panetta, T C Do, G Roul, J Leso, A Lacroix, M Fic, C Hart, R Chan, L Lema, Y Polyanskaya, R Howlett, Lesley J. Burgess, X P Chen, Hywel C Williams, V T Le, N Gurianova, R Duchowska, V P Nair, D Mitropoulos, A Allcock, T T H Bui, M Golub, E Yakovenko, M Perry, F Belcastro, K Svolis, B H R Forge, F Fernández de la Cigoña, N Murga Eizagaechevarría, G Mariano Pêgo, V Mincheva, T N Nguyen, J Moyal, M Wei, H Vinhas, A Batalla Celorio, C Romero Menor, S Rahman, N Hassler jun, F Duclos, K Ladha, A Ordóñez España, B C Chang, R Cortés Sánchez, G Lafrance, I Mihailova, Y Riou, I Pashentseva, S Tantillo, U Casas Juarezy, Ian B. Wilkinson, MJuneja, Q L Liu, M Baquero Alonso, P Kirmond, A Stevens, T Bouvy, P Casas Giménez, G Kassianos, P Kohler, T Rundell, J A Romero Hinojosa, T Sagastagoitia Gorostiza, M A Bennouna, A Hourany, F Thoin, G Steurer, V Batushkin, L Kolevatova, A Földi, G Sabe-Affaki, J T M Geraedts, I Illushechkin, T Korotich, W Manlay, B Merian, G Morrison, Y Wang, G Solache, P Magnus, A Lugin, S Tereshko, Jorge Escobedo, D Sharp, A Thelemann, J Gold, M Catarino Carvalho, P Lang, B Hermellin, B Doucet, A Martín Santana, E Foltzer, J Mora Robles, A I Bakbak, G Stanciulescu, L Baurenski, O Demina, G Lalljie, N Shmakova, R Vicente Amato, N Q Nguyen, S Kimmel, J-M Grégoire, F Tumarov, R Cue Carpio, S Nikishina, A Mukhtar, J Rueda Soriano, M Gnädinger, Michal Tendera, P Raska, S Cicek-Hartvig, E Potapova, A Melero Pita, P Ormiston, L Pastor Torres, R Shaw, M S Chenniappan, T Guo, L Zharikova, R Amoretti, J Janssen, G Kositsina, S Rajendran, N Atamanchuk, V Plastiras, T Kiernan, M H Pham, V M J Jelinek, J Dalrymple, S Van de Walle, M Goethals, I Stelmakh, S Cantabrana Miguel, L Hurlock-Clarke, C Ferreyra Solorio, J Alcaravela, H H Chuang, C Statescu, T Ługowski, B G Vanhauwaert, E London, G Z Pan, Z Özkan-Rashed, F Fellous, O Fillipova, K Ashmak, L Sargento, N Starostina, J A Ortiz de Murua López, H Thomas, T Gerasimova, L H Gowdak, S Perings, E Gaxiola, K Walcher, O Pogrebna, T Stasiuk, J Bell P McNaught, J Upton, G Scott, P Rossi Sevillano, A Gillet, T K L Nguyen, L E Manautou, L Kardashevskaya, A B Syed, F Brumelot, E Il'ina, V Alekseenko, G Wehr, G Gerges, B Fitzgerald, M Castellari, I Bratishko, M Dorobantu, I O'Connor, M V Ivan, A Esenokova, M Z Abdul Wahab, S Sylivris, S S S Quek, P Buffet, L Thomas, S Darnes Soler, N Pelicano, B Truong, N Vyshnevaya, M Habab, J Moreira, S Z Lv, D Shukla, P Eavis, E Kryvenkova, S Hansone, S Tabet, M Adda, R Trambitas, L A Fernández Lázaro, M Basara, R Mažutavičius, B Roy, X Dreyfus, T Karaseva, R Tilluckdharry, K Królicka, A Rogowsky, A Rodríguez Fernández, S Junejo, H Ancliff, W K Son, G Bodur, G Pournaras, N Sharapova, J Egido, S Kuanprasert, E Alexanderson, L Vanneste, L Singh, N Bokuchava, D K Jin, E H M Tan, A Bernard, F Baslaib, M A Fazil, M Deissner, F Narro García, R Bonhomme, A Dan, V S Hoang, R Snikytė, O Ratovskaya, T T N Pham, M I Mendonça, F Bates, N Karnaukhova, P Nazeyrollas, L A Elizondo Sifuentes, D Onger, S Yakovova, R Sadłowski, B Doronzo, J Carda, A Taylor, A Albuquerque, V López Mouriño, I Segura Laborda, D O'Donnell, R K Pandey, M Asplanato, M A Paz Bermejo, E Rodríguez, L C Iosipescu, K Fikker, Y Porras Ramos, M Escande, D Binet, J Mantoux, P Barahona Pérez, V Zakirova, A Rocha de Lorenzo, I Konstantinidis, H-H Breuer, B Hockings, A Muthu, Koon-Hou Mak, A Soward, D D Ionescu, P Talbot, F Patriarchi, A Meinel, S Abdel Malak, E Craiu, N Ranjith, B A Lim, R Rosado Soares, G Barauskienė, J Vercammen, N Shelomova, S Govender, S González Romero, K S Ng, D M'Bey, B Al-Khalidi, J Berlingieri, J B Fournier, J Tan, P Mochkina, S Pouwels, G Caridi, D P Phan, P Soskin, D Farcas, C Constance, D Rouse, A Tudose, J M Yu, T T C Nguyen, R Brownlie, J Giordano, A Gigantino, T Yip, A I Noury, R Baroudi, E Pinch, I Landragin, T Cahill, N H Mohd Amin, S Baptista, V Lavicka, P Rodenas, M Jeserich, K F Alhabib, U Teleky, M Ege, D Bierge Valero, D Kozlov, M Vallis, A Rahali, F Maes, E Guiu, P Hutayanon, C Escobar Cervantes, H D Luong, T Salah, J C Ford, C Travill, G Barron, L Rebelo, A S Abdullah, K-H Schermaul, Z Lorenc, F Perreault, O Shamsutdinova, A Fernandes, H Rickli, E Usoltseva, C Cazenave, N Baboshina, P Matthews, N Schön, W Matta, J H Zo, N Pontaga, E Novo García, G R Searles, J A Wang, M S Grocutt, A Kondratovica, P Povolna, J Arnedillo Pardo, J L Prevot, J A Rodríguez Hernández, H Killat, M Hinrichsen, S Santaolalla Rodríguez, F Calvo Iglesias, P Mpompoth, M Claus, K Kunhali, K Panisois, A Lourenço, D Iovescu, I Simkova, C González Juanatey, A Vicentini, C Baranes, J Hilario 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M Baar, P Lafontaine, C O'Dong, I Petropoulos, B-M Altevogt, D Warden, T De Backer, G Miñana Escrivá, T L Mai, U Schlesinger-Irsch, M M Gomaa, E Moksyuta, M Drexler, P Monteiro, P Grooterhorst, J Moolman, P McAlavey, J O'Shea, L P Quinn, F Crespo, K Srinivasa Reddy, T Shokina, Ellen M. Schmidt, M H Jeong, K Denef, A Pleskof, I Takács, Y Tikhonov, O Ushakov, L Stevens, J Ezcurdia Sasieta, L Nkombua, O Henne Otero, J Y Fraboulet, D S Kim, G Hoh, A Tamm, M Sardon, G Chatzioakim, M A Ulecia Martínez, S Reymond, M Myint, G Proença, R Massabie, E Foster, H Dougall, Anjan Kumar Roy, C Franco Aranda, M Getman, E Filippova, C Aguiar, X D Pu, N Voronina, L L Chen, M Szulc, L Bayakhchan, M J Pinto Vaz, C Niederberger, N Vites, I Sen, Paul R. Kalra, J A Castillo Moreno, W K Ng, C Brunschwig, D Morgan, A Concepción Clemente, N Yakimova, J M Guy, A H Jaafar, J Badarienė, N Taylor, L Compson, R Amor, A Maximovitch, J L Bardají Mayor, E Marín Araez, N H Chau, N Srtumilenko, K Kelly, A Papathanasioy, S Erofeev, B Mamez, A Ribeiro, M Micko, N Alvarenga Recalde, K Atueva, Z Sebõk, P Kycina, A K Gupta, A Laucevičius, R Ahuja, A Prokop, P Stadler, S De Ridder, L Zhang, F B Ramadan, L Kapustina, V Fedoskin, A Bateman, C A Nacht, R Musetescu, M Aparici Feal, A Büttl, S Ross, M Rau, P Federico Zaragoza, G Brisson, M Zagreanu, T T H Pham, F Dominé, N Davydova, N Petrochenko, N Paul, P H Truong, S Frickel, W Bryl, G Brouillette, A Stumpp, M Barrera Bustillos, C Ziccarelli, O Zalyzniak, M eatherhead, N Watkins, G Riccioni, l Kudryavtsev, R Carvalho, J P S Sawhney, V González Toda, P Matos Dias, M Giorgadze, I Rodriguez Marrero, W Gritsch, K Lee, G W Kellam, I Parker, V Ecina, Mª I Soto Ruiz, C Delhomme, T Ivaschenko, Y W Cheah, I Grudtsina, R Chehayeb, T Dookie, O Krasnoslobodskaya, P Jarmużek, F Van den Branden, A M F Vandeplas, A Rocha De Almeida, M Espiga De Macedo, E Łotocka, K Nagy, R Paliulionienė, J L Leyva Pons, N Fedorova, Y Yanina, O Stasuk, Z Vlasuk, P Lim, P Egloff, T Berezhna, A Faria, J Cerda Rojas, E Moser, H G Jin, S J Oh, G Arquero García, K H Karner, I Leontaridis, A Banikova, J Fridrich, H Lesseliers, I Pokrovskaya, P Astridge, H Abdul Manap, R Daniel, C A Almeida Fernández, A Nowowiejska-Wiewióra, B Carvalho De Moura, M Malden, H Rosenstein, S Dixon, G Balogh, M Adam-Blanpain, A Sandalian, H Gervas Pavón, G A Antoniadis, N Naberezhnova, A Amlaiky, P Terrosu, K K H Lau, B Chartier, X Su, O Kovyrshyna, G Beale, P Primot, M H Chen, S S Ramesh, R Chyrek, E Gómez Álvarez, J Rodríguez Collado, G Sibilio, R Jeremiasz, R Colin, C Lalla, G M Fullerton, M P Samal, H Thümmel, R P Patel, J Takhar, H M Kwon, T A Cieza Lara, F Magliari, J Morrell, M Rayo Gutiérrez, T L Orenstein-Lyall, H Choi, S Kulinich, A Aftab, A Wallace, B B Abdul Kareem, S Kwok, A Królak, A Grover, Laurent Fauchier, Mª J Pinilla Lozano, G Sengupta, D Paris, M Al Dhanki, J Milewski, F Petersen Aranguren, H Brufau Redondo, H Mayr, A Arias Mendoza, M Ducoudre, A Correia, J S Awtar Singh, P Aylward, E Brscic, J Du Plooy, J L Arenas León, G Silva Alves, L Sreenivasa Murthy, P Dendale, F La Varra, S Minkin, T Eggeling, A Jamiel, G Lebischak, E Andreev, T V A Tuong, V Chaithiraphan, O Duprez, S Higgins, F Chometon, Y Cottin, A Bonny, C Guyetand, J Matos, F Henpin Yue Cesena, L Polyaeva, M Drijfhout, J Toplak, G E Vertes, N F Wang, J Doucet, A K Trivedi, P Turek, G Chouinard, A Al Lawati, W Filip, F Kovar, T J Cha, A Belanger, H L Cong, J F Robert, D López Gómez, J L Sanz Rodríguez, H Simper, P Shetty, A Chukwu, E Bukanina, C Amoros Galito, H MacCowan, T T T Tran, A Singal, K C Vu, O Ismail, A Ardiaca Capell, P Bousquet, F Goss, Z Galeeva, Maxime Guenoun, B Rijavec, Z Lazerevic, A McCracken, A C Motoc, Y Sharapova, S Wright, A J Paule Sánchez, L Mainar Latorre, I Sirazov, X L Yang, S E Paget, G Berkenboom, J Markenvard, I Surovtseva, S K George, Matthias Simon, M L Fuantos Delgado, C Christoforidis, M Lagares Carballo, P Alvarez García, J Könemann, L Crawford, I Gonos, D Saulnier, E Szabó, L Ardouin, J Bhayat, F J Abardía Oliva, X Bernard, O Sirbu, P Boutsikos, N Khmelevskikh, E Tavlueva, P LeBouthillier, I Bourazanis, A Sequeira, M López Martínez, C P Paulus, R K M Bhaskaran, F Pellerin, B Brown, B Saleh, A Lacchè, R Sola Casado, E Kaźmierczak, M Weingrod, and G Vijayaraghavan

Subjects
medicine.medical_specialty, Cardiac & Cardiovascular Systems, Epidemiology, LONG-TERM, medicine.medical_treatment, Chronic coronary syndromes, Coronary Artery Disease, Revascularization, Ventricular Function, Left, GLUCOSE, MELLITUS, Risk Factors, Internal medicine, Diabetes mellitus, Diabetes Mellitus, Ethnicity, Prevalence, medicine, Humans, ARTERY-DISEASE, Myocardial infarction, Stroke, RISK, OUTCOMES, Ejection fraction, Science & Technology, business.industry, Proportional hazards model, CLARIFY Investigators, Hazard ratio, Diabetes, Stroke Volume, Geographical disparities, Syndrome, medicine.disease, MIDDLE-EAST, EUROPEAN-SOCIETY, Treatment Outcome, MYOCARDIAL-INFARCTION, Heart failure, CLARIFY registry, Cardiovascular System & Cardiology, HEART-FAILURE, Cardiology and Cardiovascular Medicine, business, Life Sciences & Biomedicine
Abstract

BackgroundIn contrast with the setting of acute myocardial infarction, there are limited data regarding the impact of diabetes mellitus on clinical outcomes in contemporary cohorts of patients with chronic coronary syndromes. We aimed to investigate the prevalence and prognostic impact of diabetes according to geographical regions and ethnicity.Methods and resultsCLARIFY is an observational registry of patients with chronic coronary syndromes, enrolled across 45 countries in Europe, Asia, America, Middle East, Australia, and Africa in 2009–2010, and followed up yearly for 5 years. Chronic coronary syndromes were defined by ≥1 of the following criteria: prior myocardial infarction, evidence of coronary stenosis >50%, proven symptomatic myocardial ischaemia, or prior revascularization procedure.Among 32 694 patients, 9502 (29%) had diabetes, with a regional prevalence ranging from below 20% in Northern Europe to ∼60% in the Gulf countries. In a multivariable-adjusted Cox proportional hazards model, diabetes was associated with increased risks for the primary outcome (cardiovascular death, myocardial infarction, or stroke) with an adjusted hazard ratio of 1.28 (95% confidence interval 1.18, 1.39) and for all secondary outcomes (all-cause and cardiovascular mortality, myocardial infarction, stroke, heart failure, and coronary revascularization). Differences on outcomes according to geography and ethnicity were modest.ConclusionIn patients with chronic coronary syndromes, diabetes is independently associated with mortality and cardiovascular events, including heart failure, which is not accounted by demographics, prior medical history, left ventricular ejection fraction, or use of secondary prevention medication. This is observed across multiple geographic regions and ethnicities, despite marked disparities in the prevalence of diabetes.ClinicalTrials identifierISRCTN43070564

Published
2021

14. Deformation behavior of crystallized mannitol during compression using a rotary tablet press simulator

Author

Nicolas Tarlier, Tahmer Sharkawi, Bernard Bataille, Philippe Lefevre, Noelia M. Sanchez-Ballester, Gilles Baylac, Ian Soulairol, Adrien Aubert, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Tablet press simulator, Materials science, Compressive Strength, Scanning electron microscope, Pharmaceutical Science, Lactose, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 02 engineering and technology, 030226 pharmacology & pharmacy, Dosage form, 03 medical and health sciences, Tableting, chemistry.chemical_compound, 0302 clinical medicine, Brittleness, Lubrication, Pressure, medicine, Technology, Pharmaceutical, [CHIM]Chemical Sciences, Mannitol, Particle Size, Composite material, Cellulose, Pharmaceutical Excipient, Mannitol crystal, Models, Theoretical, 021001 nanoscience & nanotechnology, Deformation, Microcrystalline cellulose, chemistry, Deformation mechanism, Crystallization, 0210 nano-technology, Stearic Acids, Tablets, medicine.drug
Abstract

International audience; Mannitol is commonly used as a pharmaceutical excipient for tablets; the most widely used oral dosage form for drug delivery. For tableting, mannitol is provided in two different forms: native crystals and textured particles. In order to optimize its formulation, a good understanding of the mechanical behavior mechanism of mannitol is necessary. Thus, the aim of this study is to evaluate the deformation mechanism of native mannitol crystals presenting different particle sizes. Pharmaco-technical and compression studies were performed using mannitol with different mean diameters (160 µm, 50 µm and 25 µm). Lactose (monohydrate) and microcrystalline cellulose were used as brittle and plastic reference materials, respectively. Tableting tests and mathematical models, HECKEL and WALKER, were used to study the deformation mechanism of mannitol (β). Mean Yield Pressure (Py) and WALKER coefficient (W) values showed that the studied crystalline mannitol presents a deformation mechanism close to brittle material. A particle-size analyzer was used at different pulverization pressures to show the high sensibility of the mannitol particles to fragmentation when exposed to high pressures, especially for particles presenting 160 µm size. Scanning Electron Microscopy (SEM) was used to show the fragmentation after high-pressure measurements.

Published
2018

15. Characterization and modelling of layout effects in SiGe channel pMOSFETs from 14nm UTBB FDSOI technology

Author

Didier Dutartre, Sylvie Ortolland, Michel Haond, Emmanuel Josse, Francois Andrieu, R. Nicolas, Alain Claverie, Thierry Poiroux, E. Baylac, R. Berthelon, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), STMicroelectronics [Crolles] (ST-CROLLES), STMicroelectronics, Centre d'élaboration de matériaux et d'études structurales (CEMES), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)

Subjects
Electron mobility, Insulator (electricity), 02 engineering and technology, 01 natural sciences, law.invention, PMOS logic, law, 0103 physical sciences, Materials Chemistry, Electronic engineering, Stress profile, Electrical and Electronic Engineering, ComputingMilieux_MISCELLANEOUS, [PHYS]Physics [physics], 010302 applied physics, business.industry, Transistor, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Threshold voltage, CMOS, Optoelectronics, Relaxation length, 0210 nano-technology, business
Abstract

The introduction of strained channel is mandatory to achieve high performance in Ultra-Thin-Body and Buried-Oxide Fully-Depleted-Silicon-On-Insulator (UTBB FDSOI) technology. Especially, compressive SiGe channel has been demonstrated to enhance hole mobility and therefore pMOSFETs drive currents. At the same time, the performance gain induced by this mechanical stressor comes along with layouts effects. In this study, we characterize experimentally the impact of the active region dimensions and shape on the threshold voltage and linear drain current of SiGe channel pMOSFETs directly on insulator fabricated for the 14 nm technology node. The pMOS threshold voltage increases by 105 mV for a gate-to-STI distance of 80 nm compared to 980 nm while IODLIN decreases by 51%. An analytical model is proposed to reproduce the layout dependences. The model is based on the stress profile, taking into account both the stress from the SiGe channel and from SiGe source/drain. It reproduces the experimental data with a good accuracy in the cases of symmetric and asymmetric layouts, provided a typical relaxation length of 112 nm is used. Finally, a special attention is paid on multifinger transistors, since they are widely used in standard cells designs.

Published
2017

16. Correlative Light and Electron Microscopy of Autophagosomes

Author

Sigurdur, Gudmundsson, Jenny, Kahlhofer, Nastassia, Baylac, Katri, Kallio, and Eeva-Liisa, Eskelinen

Subjects
Microscopy, Electron, Microscopy, Confocal, Cell Survival, Optical Imaging, Autophagosomes, Image Processing, Computer-Assisted, Humans, Microtomy, Microtubule-Associated Proteins, Software, HeLa Cells
Abstract

Live-cell imaging has been widely used to study autophagosome biogenesis and maturation. When combined with correlative electron microscopy, this approach can be extended to reveal ultrastructural details in three dimensions. The resolution of electron microscopy is needed when membrane contact sites and tubular connections between organelles are studied.

Published
2019

17. Correlative Light and Electron Microscopy of Autophagosomes

Author

Eeva-Liisa Eskelinen, Jenny Kahlhofer, Nastassia Baylac, Katri Kallio, and Sigurdur Runar Gudmundsson

Subjects
Autophagosome, Correlative, 0303 health sciences, Materials science, Resolution (electron density), 02 engineering and technology, 021001 nanoscience & nanotechnology, law.invention, 03 medical and health sciences, Electron tomography, Live cell imaging, law, Organelle, Ultrastructure, Biophysics, Electron microscope, 0210 nano-technology, 030304 developmental biology
Abstract

Live-cell imaging has been widely used to study autophagosome biogenesis and maturation. When combined with correlative electron microscopy, this approach can be extended to reveal ultrastructural details in three dimensions. The resolution of electron microscopy is needed when membrane contact sites and tubular connections between organelles are studied.

Published
2019

19. Stone Tool Forms and Functions: A Morphometric Analysis of Modern Humans' Stone Tools From Song Terus Cave (Java, Indonesia)

Author

Raphaël Cornette, Michel Baylac, and Antony Borel

Subjects
Morphometrics, Stone tool, 010506 paleontology, Archeology, History, geography.geographical_feature_category, 060102 archaeology, Java, Specific function, 06 humanities and the arts, engineering.material, 01 natural sciences, Archaeology, Geography, Morphometric analysis, Cave, engineering, 0601 history and archaeology, computer, 0105 earth and related environmental sciences, computer.programming_language
Abstract

Stone industries from the beginning of the Holocene of South-East Asia are difficult to characterize typo-technologically. We apply modern morphometrics to informal pieces to complement usewear analysis and gain a better understanding of the relation between forms and functions. Both the log shape ratio (LSR) based on linear measurements and elliptical Fourier analysis (EFA) based on 2D outlines are used to analyse a sample of 2372 stone artefacts from Song Terus cave (Java, Indonesia). The results show that no specific form corresponds to a specific function or vice versa. Nevertheless, among used artefacts, EFA highlighted several shape tendencies.

Published
2016

20. (Invited) UTBB FDSOI PMOSFETs Including Strained SiGe Channels at the 14nm Technology Node and Beyond

Author

Simeon Morvan, E. Baylac, Emmanuel Josse, Michel Haond, Cyrille Le Royer, Olivier Gourhant, Didier Dutartre, Remy Berthelon, and Francois Andrieu

Subjects
business.industry, Computer science, Node (networking), Electrical engineering, business
Abstract

We have physically and electrically characterized pMOSFETs of compressively strained SiGe channel built on Ultra-Thin-Body and Buried-Oxide Fully-Depleted-Silicon-On-Insulator (UTBB FDSOI). Such a channel greatly contributes to the FDSOI CMOS high-performance at the 14nm node. At the same time, it induces strong layout effects, which are reported and explained in this paper. They can be reproduced by an accurate physics-based electrical model, which enables us to predict the device and design performance for various technological configurations: germanium concentration in the channel, isolation and channel process integration. In order to mitigate the impacts of the SiGe channel relaxation, we have studied two kinds of solutions. First, technological solutions are possible, leading experimentally to a -15 percent delay reduction for a ring-oscillator of 1-gate finger inverters at 0.8V supply voltage. Secondly, we demonstrate the benefits induced by smart design layouts, enabled by process integration goodies and some layout constructs. Namely, a continuous-RX design, which consists in a long active line configuration, optimizes the stress configuration, maintaining a high level of longitudinal compressive stress, while relaxing the transverse one. A 28 percent ring oscillator delay improvement is experimentally demonstrated at a given leakage for 1-finger inverter at 0.8V supply voltage. This demonstrates the interest of process/design co-optimization of strain-induced layout effects. Finally, we discuss the technological knobs and especially the strain boosters that can furthers the scaling of FDSOI below the 14nm node: SiGe channel and source/drain of high-Ge content, influence of the surface orientation and channel direction, as well as the gate last integration.

Published
2016

22. MOESM1 of Engineering of Escherichia coli for Krebs cycle-dependent production of malic acid

Author

Trichez, Debora, Auriol, Clément, Baylac, Audrey, Irague, Romain, Dressaire, Clémentine, Carnicer-Heras, Marc, Heux, Stéphanie, François, Jean, and Walther, Thomas

Abstract

Additional file 1: Table S1. Fermentation products of E. coli MG1655 mutants in mineral medium with glucose as the carbon source. Table S2. Comparison of carbon fluxes given in mol% relative to glucose uptake measured in different studies for wild-type and mutant E. coli strains.

Published
2018
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23. Origin, evolution and conservation of the honey bees from La Palma Island (Canary Islands): molecular and morphological data

Author

Mikel Iriondo, Andone Estonba, Michel Baylac, Lionel Garnery, C. Manzano, W Steve Sheppard, and Irati Miguel

Subjects
0106 biological sciences, Conservation genetics, education.field_of_study, Genetic diversity, Lineage (genetic), Ecotype, Population, Zoology, Honey bee, Biology, 010603 evolutionary biology, 01 natural sciences, 010602 entomology, Phylogeography, Insect Science, behavior and behavior mechanisms, Microsatellite, education
Abstract

Genetic studies have shown a significant hybridization of local populations of Apis mellifera in the Canary Islands, as a consequence of queen importation. Since La Palma Island was a probable exception to this hybridization rule, a local honey bee Conservation Project was developed. As a first step, the genetic characterization of the population was performed with the scope of generating fundamental knowledge to correctly manage honey bee genetic resources. In this sense, the origin of the Canarian honey bee is at issue, since diverse morphological and genetic studies have shown it to be either African or European. In our study, 499 colonies from La Palma were analyzed using mitochondrial DNA, microsatellites and wing geometric morphometric data. Hybridization from the C evolutionary lineage was observed mainly at mitochondrial level, but this hybridization was focused on a restricted area and hybrid colonies were detected for replacement. All genetic and geometric morphometric results showed the Canaria...

Published
2015

24. Challenges in Silicon Photonics Process Technology

Author

Charles Baudot, E. Baylac, Nathalie Vulliet, Sebastien Cremer, Frederic Boeuf, and S. Messaoudene

Subjects
010302 applied physics, Engineering, Silicon photonics, Silicon, business.industry, Process (engineering), chemistry.chemical_element, Hardware_PERFORMANCEANDRELIABILITY, 01 natural sciences, Engineering physics, 010309 optics, chemistry, Etching (microfabrication), 0103 physical sciences, Process integration, Hardware_INTEGRATEDCIRCUITS, Photonics, business, Lithography
Abstract

In this paper we discuss the specific challenges of process integration of Si-Photonics for the current and future applications, including lithography, etching and heterogeneous materials integration.

Published
2017

25. Sensitivity Characterization of a COTS 90-nm SRAM at Ultra Low Bias Voltage

Author

Guillaume Hubert, Raoul Velazco, Francisco J. Franco, Juan Antonio Clemente, Francesca Villa, Maud Baylac, Helmut Puchner, Hortensia Mecha, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), ONERA / DPHY, Université de Toulouse [Toulouse], PRES Université de Toulouse-ONERA, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Cypress Semiconductor [San Jose], Techniques de l'Informatique et de la Microélectronique pour l'Architecture des systèmes intégrés (TIMA), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Universidad Complutense de Madrid [Madrid] (UCM), ONERA-PRES Université de Toulouse, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Cypress Semiconductor, Techniques of Informatics and Microelectronics for integrated systems Architecture (TIMA), and Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)

Subjects
Nuclear and High Energy Physics, Engineering, COTS, 01 natural sciences, Electronic mail, Reliability (semiconductor), RADIATION HARDNESS, Hardware, 0103 physical sciences, Static random-access memory, Electrical and Electronic Engineering, Circuitos integrados, Radiation hardening, 010302 applied physics, 010308 nuclear & particles physics, business.industry, LOW-BIAS VOLTAGE, Electrical engineering, Biasing, STATIC RANDOM ACCESS MEMORY (SRAM), NEUTRON TESTS, SOFT ERROR, [SPI.TRON]Engineering Sciences [physics]/Electronics, Soft error, Nuclear Energy and Engineering, 13. Climate action, RELIABILITY, Optoelectronics, Electrónica, Física nuclear, business, Sensitivity (electronics), Voltage
Abstract

This paper presents the characterization of the sensitivity to 14-MeV neutrons of a Commercial Off-The-Shelf (COTS) 90-nm Static Random Access Memories (SRAMs) manufactured by Cypress Semiconductor, when biased at ultra low voltage. Firstly, experiments exposing this memory at 14-MeV neutrons, when powering it up at bias voltages ranging from 0.5V to 3.3V, are presented and discussed. These results are in good concordance with theoretical predictions issued by the modeling tool MUSCA-SEP 3 (MUlti-SCAles Single Event Phenomena Predictive Platform). Then, this tool has been used to obtain Soft Error Rate (SER) predictions at different altitudes above the Earth’s surface of this device vs. its bias voltage. Finally, the effect of contamination by α articles has also been estimated at said range of bias Voltages.

Published
2017

26. Statistical Deviations from the Theoretical only-SBU Model to Estimate MCU rates in SRAMs

Author

Solenne Rey, Guillaume Hubert, Juan Antonio Clemente, Maud Baylac, Raoul Velazco, Francisco J. Franco, Hortensia Mecha, Helmut Puchner, Juan A. de Agapito, Francesca Villa, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), ONERA - The French Aerospace Lab [Toulouse], ONERA, Techniques de l'Informatique et de la Microélectronique pour l'Architecture des systèmes intégrés (TIMA), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Techniques of Informatics and Microelectronics for integrated systems Architecture (TIMA), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)

Subjects
010302 applied physics, Nuclear and High Energy Physics, Random access memory, Engineering, 010308 nuclear & particles physics, business.industry, Voltage control, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], Monte Carlo method, Electrical engineering, 01 natural sciences, Ordenadores, Electronic mail, Set (abstract data type), Microcontroller, Nuclear Energy and Engineering, 0103 physical sciences, Electrónica, Física nuclear, Electrical and Electronic Engineering, business, Circuitos integrados, Algorithm, Event (probability theory)
Abstract

International audience; This paper addresses a well-known problem that occurs when memories are exposed to radiation: the determination if a bit flip is isolated or if it belongs to a multiple event. As it is unusual to know the physical layout of the memory, this paper proposes to evaluate the statistical properties of the sets of corrupted addresses and to compare the results with a mathematical prediction model where all of the events are single bit upsets. A set of rules easy to implement in common programming languages can be iteratively applied if anomalies are observed, thus yielding a classification of errors quite closer to reality (more than 80% accuracy in our experiments).

Published
2017

27. Evolution of wing shape in hornets: why is the wing venation efficient for species identification?

Author

Michel Baylac, James M. Carpenter, Claire Villemant, and Adrien Perrard

Subjects
Morphometrics, animal structures, Wing, Ecology, Climate, Wasps, Biology, Biological Evolution, Models, Biological, Insect flight, Species Specificity, Evolutionary biology, Mimicry, Animals, Wings, Animal, Species identification, High dimensionality, Phylogeny, Ecology, Evolution, Behavior and Systematics, Identification criteria, Insect wing
Abstract

Wing venation has long been used for insect identification. Lately, the characterization of venation shape using geometric morphometrics has further improved the potential of using the wing for insect identification. However, external factors inducing variation in wing shape could obscure specific differences, preventing accurate discrimination of species in heterogeneous samples. Here, we show that interspecific difference is the main source of wing shape variation within social wasps. We found that a naive clustering of wing shape data from taxonomically and geographically heterogeneous samples of workers returned groups congruent with species. We also confirmed that individuals can be reliably attributed to their genus, species and populations on the basis of their wing shape. Our results suggested that the shape variation reflects the evolutionary history with a potential influence of other factors such as body shape, climate and mimicry selective pressures. However, the high dimensionality of wing shape variation may have prevented absolute convergences between the different species. Wing venation shape is thus a taxonomically relevant marker combining the accuracy of quantitative characters with the specificity required for identification criteria. This marker may also highlight adaptive processes that could help understand the wing's influence on insect flight.

Published
2014

28. Ge Condensation Using Rapid Thermal Oxidation for SGOI Substrate Preparation

Author

F. Abbate, E Baylac, Clement Pribat, D. Barge, Marc Juhel, C. Gaumer, A. Pofelski, Vincent Mazzocchi, Germain Serventon, Olivier Gourhant, Francois Andrieu, and Maud Bidaud

Subjects
Thermal oxidation, Materials science, Chemical engineering, business.industry, Condensation, Substrate (printing), Structural engineering, business
Abstract

High mobility channels are considered as an interesting path to increase PMOS performances for advanced CMOS technology. Silicon-Germanium On Insulator (SGOI) benefits from both the advantage of the SiGe material (hole mobility booster) and the On Insulator structure (better electrostatic control of the channel by the gate) [1]. The co-integration of NMOS and PMOS, respectively on Silicon On Insulator (SOI) and SGOI zones, can be enabled easily by the Ge condensation technique [1,2]. This technique is based on the competition between Ge diffusion and Si oxidation which are both driven by temperature. For this purpose, mainly furnace oxidation is reported in the literature [1-3]. In this work, we propose to study Ge condensation using Rapid Thermal Oxidation (RTO) as an alternative process. SGOI structures were fabricated on 300mm SOI wafers, with 11nm thick top silicon. First, epitaxy layers of SiGe were grown with varying thickness (from 3 to 10nm) and Ge concentration (from 10 to 40%). The SiGe film was grown by Rapid Thermal Chemical Vapor Deposition at temperature between 600°C and 650°C. Then, Ge condensation was performed by RTO in O2 ambient at temperatures between 950°C and 1150°C. Both aspects of Ge condensation were studied: Ge diffusion then Si oxidation. The RTO temperature effect on Ge diffusion was analysed by ToF-SIMS (Figure 1). In the case of short oxidation duration (below 2 minutes), as typically used in RTO compared to furnace (several hours), almost no diffusion is observed at 950°C. This leads to Ge enrichment of the initial SiGe layer with Ge concentration gradient. For longer oxidation, this might result in very high Ge concentration generating strain relaxation via stacking fault creation [4]. Therefore, temperatures above 950°C are prefered to avoid defects creation. TEM and STEM-EDX of the structure after condensation (Figure 2) shows that Ge concentration is still not totally homogeneous at 1100°C. Oxidation kinetics is shown on Figure 3, comparing the effect of substrate: SiGe/Si/BOX vs Si. SiGe is oxidized faster than Si, as already reported [5,6]. Moreover, SiGe oxidation is enhanced with increasing Ge concentration. Same trend is observed concerning SiGe thickness, indicating the effect of Ge diffusion in the underneath Si layer. A compositional analysis of the oxide grown by condensation was performed by XPS, monitoring the Ge3d peak (Figure 4). Starting from the same SiGe/Si/BOX structure, the oxide thickness was kept the same using different RTO temperatures but tuning the O2 pressure and the RTO duration. The effect of Ge diffusion is clearly observed by the intensity of the Ge-Si contribution. Higher temperature leads to lower Ge concentration due to a more homogeneous Ge distribution. Surprisingly, Ge-O bounds are also observed, whereas SixGe1-xalloy oxidation is thermodynamically considered to be Si selective [7]. Moreover, the amount of Ge-O bounds increases when the RTO temperature decreases. As shown previously, low temperature oxidation leads to high Ge concentration at the SiO2/SiGe interface, which may enable the formation of Ge-O bounds [8]. As a consequence, oxidation kinetics plays an important role in this phenomenon. This study reveals the significant role of temperature in Ge condensation by RTO. Due to kinetics effect, Ge-O bounds are formed which is not predicted by thermodynamics. Finally, the role of temperature will be investigated through electrical characterization of the SixGeyO properties. [1] B. Vincent at al, Mat. Sc. Semicond. Proc. 11, 2008 [2] T. Tezuka et al., Jpn. J. Appl. Phys. 40, 2886, 2001. [3] Z. Di et al., J. Crystal Growth 281, 2005 [4] B. Vincent, Appl. Phys. Lett. 90, 2007 [5] O. W. Holland et al., Appl. Phys. Lett. 51, 7, 1987 [6] S. J. Kilpatrick et al., J. Appl. Phys. 81, 12, 1997 [7] D. C. Paine et al, J. Appl. Phys. 70, 5076, 1991 [8] J. Eugene, Appl. Phys. Lett. 59, 78, 1991

Published
2014

29. Ultrathin (5nm) SiGe-On-Insulator with high compressive strain (−2GPa): From fabrication (Ge enrichment process) to in-depth characterizations

Author

D. Barge, Thibaud Denneulin, C. Le Royer, David Cooper, Jean-Paul Barnes, P. Nguyen, O. Bonnin, J. M. Pedini, Olivier Gourhant, E. Baylac, Walter Schwarzenbach, Yves Campidelli, F. Glowacki, Y. Morand, Jean-Michel Hartmann, and Denis Rouchon

Subjects
Fabrication, Materials science, business.industry, Silicon on insulator, Insulator (electricity), Condensed Matter Physics, Dark field microscopy, Electronic, Optical and Magnetic Materials, symbols.namesake, Scanning transmission electron microscopy, Materials Chemistry, Electronic engineering, symbols, Optoelectronics, Wafer, Field-effect transistor, Electrical and Electronic Engineering, business, Raman spectroscopy
Abstract

300 mm ultrathin Silicon-On-Insulator (SOI) wafers with SiGe/Si stacks on top were used as pre-structures for the fabrication of 5 nm thick SiGe-On-Insulator (SGOI) substrates obtained by the Ge enrichment technique. Those substrates will be used as the channel of advanced Fully Depleted (FD) p-type Metal Oxide Semiconductor Field Effect Transistors (pMOSFET). We present in the first part the successful fabrication of 5 nm SGOI wafers. Various characterization techniques are used to investigate the Ge profile and the final strain in the fabricated 5 nm Si 0.7 Ge 0.3 film. Secondary Ions Mass Spectrometry (SIMS) and Scanning Transmission Electron Microscopy (STEM) clearly show that the Ge content is very homogeneous ( x Ge = 30 ± 1%) in the SiGe layer. Raman spectroscopy and High Angle Annular Dark Field (HAADF) STEM both confirm that the 5 nm thick SiGe film is compressively strained (−2 GPa). The second part is dedicated to the sensitivity of the Ge enrichment process (based on numerical modelling). We investigate the impact of single and combined fluctuations of the pre-structure parameters ( T Si , T SiGe,0 , x Ge,0 ) on the final SiGe layer ( T SiGe , x Ge ).

Published
2014

30. Challenges and prospects of electron cyclotron resonance charge breeders applied to radioactive ion beam facilities

Author

T. Thuillier, J. Angot, M. Baylac, T. Lamy, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)

Subjects
010302 applied physics, Materials science, Ion beam, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], 0103 physical sciences, Charge (physics), Atomic physics, 7. Clean energy, 01 natural sciences, Instrumentation, Mathematical Physics, Electron cyclotron resonance, 010305 fluids & plasmas
Abstract

International audience; Electron cyclotron resonance charge breeder (ECR CB) is one of the instruments used to boost the radioactive ion beam (RIB) charge state (from 1+ to N+) in isotope separator on-line (ISOL) facilities. While existing ECR CB can manage intense incoming 1+ RIB without difficulty, significant amounts of background impurities are extracted with the N+ RIB signal. When the N+ RIB signal is very low, the dominant background can be detrimental to the study of the RIB in today facilities, if no downstream high mass resolution separation is available. This work investigates the improvements achievable with a new generation 18 GHz ECR CB applicable to future facility like EURISOL. The study shows that with a modified ion source geometry, an optimized magnetic confinement, a careful wall metal choice like beryllium, a UHV technology, the charge breeder performance will improve as follows: +20% higher capture efficiency, −40% charge breeding time, charge state ion production with mass over charge of 3 up to xenon and over 6 up to uranium, co-extracted contaminant density reduction by a factor 60 to 600. An 18 GHz ECR CB ion source layout is finally proposed for EURISOL.

Published
2019

31. COV ON, une solution pour initier autrement l’accompagnement social et médico-social

Author

Xavier Baylac and Laurent Pourtau

Abstract

Des situations singulieres questionnent le quotidien des professionnels medico-sociaux, sociaux ou educatifs, les laissant souvent demunis quant aux outils leur permettant de pallier ou d’attenuer la distance et l’incomprehension avec les personnes aupres desquelles ils interviennent.Pour tous ces acteurs du bien-etre et de la cohesion sociale, confrontes a la difference et au multiculturalisme, comment se porter pleinement a la rencontre de l’Autre pour appuyer sa reconnaissance, sa valorisation et sa mise en autonomie ? Le postulat de la solution cov on est le suivant : chacune des personnes accompagnees est riche d’un parcours, d’une trajectoire de vie parsemee de moments forts, d’un heritage familial, culturel, de ressources qui fondent son identite singuliere. Toutes ces histoires humaines peuvent se dessiner, s’illustrer… a partir des outils numeriques en se materialisant en une narration cartographique.

Published
2019

32. Does shape co-variation between the skull and the mandible have functional consequences? A 3D approach for a 3D problem

Author

Chazeau, C., Marchal, J., Hackert, R., Perret, M., Cornette, Raphaël, Baylac, Michel, Souter, Thibaud, Herrel, Anthony, Institut Jean Le Rond d'Alembert (DALEMBERT), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Origine, structure et évolution de la biodiversité (OSEB), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Plateforme de morphométrie, Muséum national d'Histoire naturelle (MNHN), Mécanismes adaptatifs : des organismes aux communautés, and Outils et Méthodes de la Systématique Intégrative (OMSI)

Subjects
Models, Anatomic, 0106 biological sciences, Histology, [SDV]Life Sciences [q-bio], Context (language use), Mandible, Biology, Models, Biological, 010603 evolutionary biology, 01 natural sciences, 03 medical and health sciences, Imaging, Three-Dimensional, medicine, Animals, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, 0303 health sciences, Shrews, [SDV.BA]Life Sciences [q-bio]/Animal biology, Skull, Original Articles, Cell Biology, Anatomy, Co variation, Surface shape, Biomechanical Phenomena, medicine.anatomical_structure, Biting, Mastication, Biomechanical model, Adductor muscles, Developmental Biology
Abstract

Morpho-functional patterns are important drivers of phenotypic diversity given their importance in a fitness-related context. Although modularity of the mandible and skull has been studied extensively in mammals, few studies have explored shape co-variation between these two structures. Despite being developmentally independent, the skull and mandible form a functionally integrated unit. In the present paper we use 3D surface geometric morphometric methods allowing us to explore the form of both skull and mandible in its 3D complexity using the greater white-toothed shrew as a model. This approach allows an accurate 3D description of zones devoid of anatomical landmarks that are functionally important. Two-block partial least-squares approaches were used to describe the co-variation of form between skull and mandible. Moreover, a 3D biomechanical model was used to explore the functional consequences of the observed patterns of co-variation. Our results show the efficiency of the method in investigations of complex morpho-functional patterns. Indeed, the description of shape co-variation between the skull and the mandible highlighted the location and the intensity of their functional relationships through the jaw adductor muscles linking these two structures. Our results also demonstrated that shape co-variation in form between the skull and mandible has direct functional consequences on the recruitment of muscles during biting.

Published
2013

33. Optimizing Radioactive Material Transport: Transport Risk Management

Author

Véronique Baylac-Domengetroy and Pascal Chollet

Subjects
Risk, Risk analysis, Engineering, Event (computing), business.industry, Process (engineering), Supply chain, Public Acceptance, Specific risk, Scheduling (production processes), Transport, Transport engineering, Emergency Response, Energy(all), Risk analysis (engineering), Strategic business unit, Supply Chain, Safety, business, Risk Analysis, Risk management
Abstract

The safety of nuclear transport is essential to the AREVA Group as it is to the nuclear industry at large. Because transport or radioactive materials is performed in the public domain, it is sensitive to the public and its environment. In order to optimize transport safety of the AREVA Group the Logistics Business Unit of AREVA has setup, since 2006, a specific organization with a dedicated team, specific IT tools and processes: the “Transport Risk Management”. “Transport Risk Management” covers all nuclear materials and contaminated equipment representing a specific risk to the group. Approximately 10 000 radioactive shipments per year are covered by this process. This paper will introduce the approach the AREVA Group has taken to develop and implement “Transport Risk Management” with its Logistics BU. The approach is composed of three steps: – Identification of transport flows and risk analysis, – Mitigation proposals often involving the supply chain, – Decisions on priorities for implementation, anticipation and preparation (such as for emergency response), and control. The risk analysis and risk management is evaluated for each transportation flow: the occurrence or probability of an event during transport and the consequence of any potential event provides a Risk Level which is evaluated against the current Level of Management for the same transport flow. Control and continuous improvement are key to the process. Decision making for implementing the proposed mitigation plans and scheduling is based on the above risk analysis and evaluation. “Transport Risk Management” provides for improved safety, image as well as performance.

Published
2013

34. Radioactive material transport risk management initiative: AREVA’s extensive approach to operations safety

Author

V Baylac-Domengetroy and M Lebrun

Subjects
Precautionary principle, Engineering, Guiding Principles, business.industry, Materials Science (miscellaneous), Physical protection, Radioactive waste, S+ extensive, Unit (housing), Risk analysis (engineering), Strategic business unit, Operations management, Safety, Risk, Reliability and Quality, business, Waste Management and Disposal, Risk management
Abstract

Since 2006, when AREVA mandated its Logistics Business Unit to handle ‘Transport Risk Management’, the Unit has executed or has, at least, ensured the proper management of shipments of radioactive material, which involve particular risks. This mission is fully complementary to the strict implementation of national and international regulations regarding the safety of radioactive material transport. Taking these regulations as a starting point, the AREVA Transport Risk Management Initiative develops general principles of risk management appropriate to operations that are sensitive by nature. By applying the Transport Risk Management Initiative to the shipment of radioactive materials, AREVA has widened the precautionary principle beyond the field of safety and radioprotection: accomplishing safe transport necessarily implies the identification and management of all risks inherent in these operations (safety, physical protection, media pressure, geopolitics, etc.). The guiding principles currently i...

Published
2012

35. Geometric morphometric discrimination of the three African honeybee subspecies Apis mellifera intermissa, A. m. sahariensis and A. m. capensis (Hymenoptera, Apidae): Fore wing and hind wing landmark configurations

Author

Michel Baylac and Choukri Barour

Subjects
0106 biological sciences, canonical variate analysis (CVA), Landmark, Wing, biology, Apidae, wing venation, Zoology, Hymenoptera, Subspecies, Bees, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, 010602 entomology, Insect Science, lcsh:Zoology, Botany, Africa, African honeybee, lcsh:QL1-991, Procrustes superimposition, Ecology, Evolution, Behavior and Systematics, morphometry, biodiversity
Abstract

In this study, a landmark-based geometric morphometric analysis was carried out on three honeybee subspecies: Apis m. intermissa and A. m. sahariensis collected from Algeria, and, as a reference, A. m. capensis collected from South Africa. The aim of this study was to discriminate honeybee subspecies by patterns of shape variation of fore and hind wings. A total of 540 wings from 270 honeybee workers were analyzed. Our results revealed very high cross-validation classification rates (96.7% based on fore wing shape and 99.6% based on the combination of fore and hind wing forms respectively). Discrimination was better using shape and form (shape + centroid size) of the fore wings than of the hind wings. The wing form parameters were found to differ significantly in shape and centroid size among the three analyzed subspecies. Finally, it may be concluded that landmark-based geometric morphometrics could be a powerful tool to characterize the Algerian honey bees.

Published
2016

36. Evaluation of the sensitivity of a COTS 90-nm SRAM memory at low bias voltage

Author

Raoul Velazco, Juan Antonio Clemente, Francisco J. Franco, Hortensia Mecha, Maud Baylac, Francesca Villa, and Guillaume Hubert

Subjects
Random access memory, Engineering, 010308 nuclear & particles physics, business.industry, Electrical engineering, Biasing, Ranging, 01 natural sciences, Power (physics), 03 medical and health sciences, 0302 clinical medicine, Aerospace electronics, 030220 oncology & carcinogenesis, 0103 physical sciences, Electronic engineering, Static random-access memory, Sensitivity (control systems), business
Abstract

This paper presents an experimental study of the sensitivity to 14-MeV neutrons to low bias voltage of a COTS 90-nm Cypress SRAM. Experiments involving power supplies ranging from 0.5V to 3.3V are presented and discussed. These results have also been compared with cross-section and SER theoretical predictions.

Published
2016

38. Design / technology co-optimization of strain-induced layout effects in 14nm UTBB-FDSOI CMOS: Enablement and assessment of continuous-RX designs

Author

Michel Haond, Maud Vinet, Alain Aurand, V. Farys, E. Baylac, A. Claverie, E. Petitprez, Emmanuel Josse, Raphael Bingert, M-A. Jaud, T. Poiroux, E. Bechet, Jean-Claude Marin, Didier Dutartre, S. Delmedico, Olivier Weber, C. Bernicot, E. Bernard, P. Sardin, F Andrieu, S. Ortolland, Joris Lacord, E. Serret, R. Berthelon, Patrick Scheer, A. Pofelski, Pierre Perreau, Denis Rideau, STMicroelectronics [Crolles] (ST-CROLLES), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Matériaux et dispositifs pour l'Electronique et le Magnétisme (CEMES-MEM), Centre d'élaboration de matériaux et d'études structurales (CEMES), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), and Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Materials science, Delay improvements, Longitudinal stress, Nanobeam diffraction, Silicon on insulator, 02 engineering and technology, Ring oscillator, Integrated circuit design, VLSI circuits, 01 natural sciences, Integrated circuit layout, Integrated circuit testing, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Electronic engineering, Silicon on insulator technology, Leakage (electronics), Stress management, [PHYS]Physics [physics], 010302 applied physics, Fully depleted silicon-on-insulator, CMOS integrated circuits, Co-optimization, CMOS technology, 020202 computer hardware & architecture, CMOS, Inverter, Voltage
Abstract

cited By 4; International audience; We report on the main local layout effect in 14nm Ultra-Thin Buried oxide and Body Fully Depleted Silicon On Insulator (UTBB-FDSOI) CMOS technology [1]. This effect is demonstrated by Nano-Beam Diffraction to be directly induced by the strain in the SiGe channel and reproduced by an accurate electrical compact model. An original continuous-RX design optimizes the stress management, maintaining longitudinal stress component while relaxing the transverse one. A 28% ring oscillator delay improvement is experimentally demonstrated at same leakage for 1-finger inverter at VDD=0.8V supply voltage and a frequency gain up to 15% is simulated in a critical path of an A9 core. © 2016 IEEE.

Published
2016

41. Annexes

Author

Alà Baylac Ferrer

Published
2016

44. À suivre

Author

Alà Baylac Ferrer

Published
2016

46. ThePGM3gene encodes the major phosphoribomutase in the yeastSaccharomyces cerevisiae

Author

Audrey Baylac, Hélène Cordier, Amélie Vax, Jean Marie François, Thomas Walther, Ceren Alkim, Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés (LISBP), Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Recherche Agronomique (INRA), ANR Blanc [05-2-42128], Institut National de la Recherche Agronomique (INRA)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), and Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
EXTRACTION, Saccharomyces cerevisiae Proteins, [SDV]Life Sciences [q-bio], Mutant, Saccharomyces cerevisiae, Biophysics, METABOLITES, Biochemistry, Substrate Specificity, 03 medical and health sciences, Structural Biology, In vivo, REVEALS, PGM1, Genetics, Nucleotide, Phosphoribomutase, Molecular Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, STRAINS, 030302 biochemistry & molecular biology, Glucosephosphates, Cell Biology, biology.organism_classification, Yeast, Enzyme, PHOSPHOGLUCOMUTASE, chemistry, Phosphoglucomutase, Purine nucleotide metabolism
Abstract

The phosphoglucomutases (PGM) Pgm1, Pgm2, and Pgm3 of the yeast Saccharomyces cerevisiae were tested for their ability to interconvert ribose-1-phosphate and ribose-5-phosphate. The purified proteins were studied in vitro with regard to their kinetic properties on glucose-1-phosphate and ribose-1-phosphate. All tested enzymes were active on both substrates with Pgm1 exhibiting only residual activity on ribose-1-phosphate. The Pgm2 and Pgm3 proteins had almost equal kinetic properties on ribose-1-phosphate, but Pgm2 had a 2000 times higher preference for glucose-1-phosphate when compared to Pgm3. The in vivo function of the PGMs was characterized by monitoring ribose-1-phosphate kinetics following a perturbation of the purine nucleotide balance. Only mutants with a deletion of PGM3 hyper-accumulated ribose-1-phosphate. We conclude that Pgm3 functions as the major phosphoribomutase in vivo. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

Published
2012

47. Rapid morpho-functional changes among insular populations of the greater white-toothed shrew

Author

Françoise Poitevin, Anthony Herrel, Raphaël Cornette, Jean-François Cosson, and Michel Baylac

Subjects
0106 biological sciences, Morphometrics, 0303 health sciences, biology, Ecology, Crocidura russula, Shrew, Zoology, Morpho, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Predation, Russula, Mandible (arthropod mouthpart), 03 medical and health sciences, Atlantic Islands, biology.animal, 14. Life underwater, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology
Abstract

Islands are often considered to be natural laboratories where repeated ‘evolutionary experiments’ have taken place. Consequently, islands have been key model systems in our understanding of evolutionary theory. The greater white-toothed shrew (Crocidura russula) is of interest as it has invaded French Atlantic islands within the last few thousand years and is considered to be morphologically and genetically stable in this area. In this article, we study the shape of the mandible of the greater white-toothed shrew on four islands and compare it with that of individuals from populations on the mainland to quantify the effects of insularity. The degree of insularity (i.e. island size and distance to the continent) is thought to be linked to differences in ecological characteristics of islands compared with the mainland. We used geometric morphometric analyses to quantify differences in size and shape between populations and employed a simple biomechanical model to evaluate the potential effects of shape differences on bite force. Specimens from island populations are different from continental populations in shape and mechanical potential of the mandible. Among islands, the mandible shows various shapes that are correlated with both the distance from the coast and island area. The shape differences are located on different parts of the mandible, suggesting different ecological constraints on each island. Moreover, these shapes are linked to the ‘mechanical potential’, which is markedly different between islands. Mechanical potential has been suggested to evolve in response to prey size and or mechanical properties. In conclusion, our results show that, in spite of the relatively recent colonization of the Atlantic Islands, the mandible of C. russula possesses a distinct shape. Moreover, the shape differs among islands and is probably linked to the consumption of different prey. © 2012 The Linnean Society of London, Biological Journal of the Linnean Society, 2012, , –.

Published
2012

48. Differences in caste dimorphism among three hornet species (Hymenoptera: Vespidae): forewing size, shape and allometry

Author

James M. Carpenter, Adrien Perrard, Claire Villemant, and Michel Baylac

Subjects
Sexual dimorphism, Morphometrics, Imaginal disc, Wing, Vespidae, Evolutionary biology, Ecology, Caste, Allometry, Hymenoptera, Biology, biology.organism_classification, Ecology, Evolution, Behavior and Systematics
Abstract

Caste shape dimorphism (CShD) has previously been studied in wasps through comparison of different body parts, originating from different imaginal discs. Using geometric morphometrics with a new protocol for measuring wings of pinned specimens from natural history collections, we tested CShD of three hornet species in an organ developed from a single imaginal disc: the forewing. Gaussian mixture models retrieved most castes and species levels, confirming that caste is an important component of wing variations in females of these hornets. Size and allometry – the influence of size on shape – contribution to wing dimorphism between castes was major, but failed to explain the entire shape dimorphism. This deviation from simple allometric scaling was not similar in the three species: in Vespa tropica, allometric directions in the shape space differed between castes, whereas in V. crabro and V. velutina, they were similar but a significant part of CShD resulted from lateral transpositions. These results clearly indicate that queens are not just enlarged workers. They also support that the different patterns of CShD may result from different developmental mechanisms. Finally, they highlight that even in a highly social group like hornets, there is still variation in caste dimorphism among species.

Published
2012

49. Study of the three-dimensional orientation of the labrum: its relations with the osseous acetabular rim

Author

Michel Baylac, July Bouhallier, Olivier Gagey, Christine Tardieu, and Noémie Bonneau

Subjects
Hip surgery, Labrum, Histology, Plane (geometry), Biomechanics, Cell Biology, Anatomy, Acetabulum, Cadaver, Orientation (geometry), Perpendicular, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Geology, Developmental Biology
Abstract

Understanding the three-dimensional orientation of the coxo-femoral joint remains a challenge as an accurate three-dimensional orientation ensure an efficient bipedal gait and posture. The quantification of the orientation of the acetabulum can be performed using the three-dimensional axis perpendicular to the plane that passes along the edge of the acetabular rim. However, the acetabular rim is not regular as an important indentation in the anterior rim was observed. An innovative cadaver study of the labrum was developed to shed light on the proper quantification of the three-dimensional orientation of the acetabulum. Dissections on 17 non-embalmed corpses were performed. Our results suggest that the acetabular rim is better represented by an anterior plane and a posterior plane rather than a single plane along the entire rim as it is currently assumed. The development of the socket from the Y-shaped cartilage was suggested to explain the different orientations in these anterior and posterior planes. The labrum forms a plane that takes an orientation in between the anterior and posterior parts of the acetabular rim, filling up inequalities of the bony rim. The vectors VL, VA2 and VP, representing the three-dimensional orientation of the labrum, the anterior rim and the posterior rim, are situated in a unique plane that appears biomechanically dependent. The three-dimensional orientation of the acetabulum is a fundamental parameter to understand the hip joint mechanism. Important applications for hip surgery and rehabilitation, as well as for physical anthropology, were discussed.

Published
2012

50. Forewing Shape Variation in Algerian Honey Bee Populations ofApis mellifera intermissa(Buttel-Reepen, 1906) (Hymenoptera: Apidae): A Landmark-Based Geometric Morphometrics Analysis

Author

Choukri Barour, Ali Tahar, and Michel Baylac

Subjects
Morphometrics, Apiary, Apidae, Ecology, Biodiversity, Honey bee, Hymenoptera, Biology, biology.organism_classification, Gene flow, Worker bee, Insect Science, Agronomy and Crop Science, Ecology, Evolution, Behavior and Systematics
Abstract

The biodiversity of Apis mellifera intermissa in the northern parts of Algeria is analysed using geometric morphometric investigations of workers' forewing variability. A total of 3400 worker bees was collected from hived colonies throughout the northern parts of Algeria, between 35°19′N–37°01′N and 00°54′W–8°06′E. Results showed a clear differentiation between the main three northern ecological regions. Differences involve mostly shape, while size contribution is generally weak. Within regions, shape variability between apiaries and colonies does not appear related either to the geographic location or to altitude. The large variability observed at the colony and apiary levels can possibly be related to anthropogenic introductions or exchanges, and it is concluded that both drift and polyandry are the most probable explanations. Finally, phenotypic differences between ecological regions probably result from restrictions to gene flow between their respective populations. Nevertheless, the relative contribu...

Published
2011

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