1. Travel-related acquisition of diarrhoeagenic bacteria, enteral viruses and parasites in a prospective cohort of 98 Dutch travellers
- Author
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van Hattem, Jarne M, Arcilla, Maris S, Grobusch, Martin P, Bart, Aldert, Bootsma, Martin C., van Genderen, Perry J J, van Gool, Tom, Goorhuis, Abraham, van Hellemond, Jaap J., Molenkamp, Richard, Molhoek, Nicky, Oude Lashof, Astrid Ml, Stobberingh, Ellen E, de Wever, Bob, Verbrugh, Henri A, Melles, Damian C, Penders, John, Schultsz, Constance, de Jong, Menno D., Sub Mathematical Modeling, Mathematical Modeling, Medical Microbiology & Infectious Diseases, Public Health, Sub Mathematical Modeling, Mathematical Modeling, Medical Microbiology and Infection Prevention, AII - Infectious diseases, APH - Global Health, Infectious diseases, APH - Aging & Later Life, Global Health, Med Microbiol, Infect Dis & Infect Prev, RS: CAPHRI - R4 - Health Inequities and Societal Participation, RS: NUTRIM - R2 - Liver and digestive health, and RS: NUTRIM - R2 - Gut-liver homeostasis
- Subjects
0301 basic medicine ,Diarrhea ,030106 microbiology ,HEPATITIS-E ,medicine.disease_cause ,Microbiology ,Cohort Studies ,03 medical and health sciences ,Feces ,0302 clinical medicine ,Hepatitis E virus ,INFECTION ,medicine ,Enterovirus Infections ,Parasitic Diseases ,Prevalence ,Journal Article ,Humans ,Shigella ,Parasites ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,Dientamoeba fragilis ,Netherlands ,Blastocystis ,Travel ,biology ,Bacteria ,business.industry ,Environmental and Occupational Health ,Enterobacteriaceae Infections ,Public Health, Environmental and Occupational Health ,biology.organism_classification ,Hepatitis E ,medicine.disease ,Virology ,Diarrhoea ,Carriage ,Infectious Diseases ,Acquisition ,Plesiomonas shigelloides ,Viruses ,Public Health ,business ,Travel-Related Illness ,human activities - Abstract
Background: Limited prospective data are available on the acquisition of viral, bacterial and parasitic diarrhoeagenic agents by healthy individuals during travel.Methods: To determine the frequency of travel associated acquisition of 19 pathogens in 98 intercontinental travellers, qPCR was used to detect 8 viral pathogens, 6 bacterial enteric pathogens and 5 parasite species in faecal samples collected immediately before and after travel.Results: We found high pre-travel carriage rates of Blastocystis spp. and Dientamoeba fragilis of 32% and 19% respectively. Pre-travel prevalences of all other tested pathogens were below 3%. Blastocystis spp. (10%), Plesiomonas shigelloides (7%), D. fragilis (6%) and Shigella spp. (5%) were the most frequently acquired pathogens and acquisition of enteral viruses and hepatitis E virus in this relatively small group of travellers was rare or non-existent.Conclusions: Our findings suggest that the role of viruses as the cause of persisting traveller's diarrhoea is limited and bacterial pathogens are more likely as a cause of traveller's diarrhoea. The substantial proportion of travellers carrying Blastocystis spp. and D. fragilis before travel warrants cautious interpretation of positive samples in returning travellers with gastrointestinal complaints. (C) 2017 Elsevier Ltd. All rights reserved.
- Published
- 2017