20 results on '"Barbara, Loggini"'
Search Results
2. Atypical Ulcer Arising on Stasis Dermatitis: Achromic Melanoma
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Agata Janowska, Giulia Davini, Cristian Fidanzi, Valentina Dini, Barbara Loggini, Giovanni Bagnoni, Marco Romanelli, and Angelo D’Erme
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Diagnosis, Differential ,Medical–Surgical Nursing ,Skin Neoplasms ,Humans ,Dermatitis ,Dermoscopy ,Female ,Surgery ,Leg Dermatoses ,Melanoma ,Ulcer ,Aged - Abstract
Introduction. Due to venous insufficiency, a vascular ulcer frequently occurs with the progression of stasis dermatitis. Achromic melanoma, a rare form of pigmentless melanoma frequently located on the sole of the foot, is often and easily confused with a typical wound. Diagnosis of ulcerated achromic melanoma is thus often delayed and associated with a poor prognosis. Case Report. The authors report a very rare case of malignant melanoma in a 70-year-old female with stasis dermatitis. The painless ulcer was present for 1 year before the first visit. Upon clinical examination, a 2-cm diameter hypergranulating ulcer with irregular and pigmented borders was present. Dermoscopy revealed the presence of red globules, a gray-to-blue veil, irregular vessels, and the remains of a pigmented ridge pattern. Histological analysis showed infiltration of atypical melanocytes in the dermis, 2 mitoses, and ulceration. Diagnosis of melanoma was confirmed by positive MART-1 immunochemistry. After removal of the melanoma, the area was covered with an autologous skin graft excised from the inner thigh. In accordance with the guidelines, sentinel lymph node biopsy was performed, and the result was negative for lymph node involvement. A comprehensive clinical dermoscopic evaluation led to the correct diagnosis. Conclusions. The current case highlights the importance of evaluating a chronic, atypical, nonhealing ulcer clinically and dermoscopically as well as through a biopsy procedure.
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- 2022
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3. Neutrophil extracellular traps and Sweet syndrome
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Cristina, Croia, Valentina, Dini, Barbara, Loggini, Elisabetta, Manni, Angelo Giovanni, Bonadio, Marco, Romanelli, and Paola, Migliorini
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Infectious Diseases ,Neutrophils ,Humans ,Dermatology ,Extracellular Traps ,Sweet Syndrome - Published
- 2022
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4. Atypical Ulcers: Diagnosis and Management
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Barbara Loggini, Michela Iannone, Teresa Oranges, Valentina Dini, Marco Romanelli, and Agata Janowska
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Physical examination ,General Medicine ,Dermatology ,Systemic therapy ,03 medical and health sciences ,0302 clinical medicine ,Pain control ,Wound bed preparation ,Wound management ,Skin biopsy ,medicine ,030212 general & internal medicine ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery - Abstract
Atypical ulcers show atypical clinical features, histology, localization, and resistance to standard therapies. The persistence of a chronic ulcer despite treatment with standard therapies requires a more specific diagnostic investigation. Diagnosis involves obtaining the history and performing clinical examination and additional tests. A skin biopsy is frequently used to confirm unclear diagnosis. In difficult cases, microbiological and immunohistochemical examinations, laboratory blood tests, or instrumental tests should be evaluated. The treatment of atypical wounds is characterized by local systemic therapy and pain control. Our results highlight the need for early diagnosis, and standardized and targeted management by a multidisciplinary wound healing center.
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- 2019
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5. Unusual presentation of angiolymphoid hyperplasia with eosinophilia treated with intralesional and topic corticosteroid combination therapy
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Giammarco Granieri, Valentina Dini, Salvatore Panduri, Teresa Oranges, Marco Romanelli, Barbara Loggini, and Agata Janowska
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medicine.medical_specialty ,Combination therapy ,integumentary system ,medicine.drug_class ,business.industry ,corticosteroid therapy ,Case Report ,Nodule (medicine) ,Dermatology ,medicine.disease ,Infra-axilla ,body regions ,Angiolymphoid hyperplasia with eosinophilia ,Corticosteroid therapy ,RL1-803 ,Female patient ,medicine ,Corticosteroid ,medicine.symptom ,Presentation (obstetrics) ,business ,infraaxilla - Abstract
Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon angioproliferative benign disorder. A 24- year-old Caucasian female patient presented with multiple itchy reddish pearly nodule.
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- 2020
6. Cutaneous composite lymphoma consisting of chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma: a unique entity and a putative pathological mechanism for cutaneous composite lymphomas
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Eugenio Ciancia, Elena Sabattini, Claudio Agostinelli, Francesca Ambrosi, Alessandro Pileri, Costantino Ricci, and Barbara Loggini
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Lymphoma, B-Cell ,business.industry ,Mechanism (biology) ,Lymphoma, Non-Hodgkin ,Chronic lymphocytic leukemia ,Follicular lymphoma ,Dermatology ,medicine.disease ,Leukemia, Lymphocytic, Chronic, B-Cell ,Lymphocytic lymphoma ,Composite Lymphoma ,Infectious Diseases ,Composite lymphoma ,Cancer research ,medicine ,Humans ,business ,Lymphoma, Follicular ,Pathological - Published
- 2019
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7. Giant Schwannoma of the Saphenous Nerve in The Distal Thigh: A Case Report
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Giulia, Bugelli, Giacomo, Dell'Osso, Vanna, Bottai, Fabio, Celli, Barbara, Loggini, Giulio, Guido, and Stefano, Giannotti
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Diagnosis, Differential ,Treatment Outcome ,Thigh ,Peripheral Nervous System Neoplasms ,Humans ,Female ,Middle Aged ,Magnetic Resonance Imaging ,Neurilemmoma ,Neurosurgical Procedures - Abstract
Schwannomas are benign nerve myelin sheath tumors that can occur anywhere in the peripheral nervous system. It is very rare for Schwannomas to become malignant, but surgery is still the principal treatment to eliminate symptoms and to correctly diagnosis the tumor. We report an interesting case of a schwannoma of the saphenous nerve at the distal third of the posteromedial thigh: the patient complained of muscle weakness at left lower limb and vague anteromedial knee pain, mimicking a meniscal tear. Magnetic resonance images of the thigh showed a well-defined and oval mass lesion measuring 8.5 cm x 4.5 cm. Before investigating for a possible meniscal tear, we decided to remove the mass from the thigh, because we felt that it could itself be the cause of the mild pain complained about by the patient. Post-surgery, histological analysis conducted confirmed that this was a benign schwannoma.Schwannomas generally can be asymptomatic or present as a mass. The clinical presentation of this rare tumor makes the diagnosis difficult.This reported case is particularly interesting because of the rarity of the lesion localization along the course of the saphenous nerve. The combination of the location, and especially the large size of the tumor, led us to believe that there is a correlation with the particular clinical presentation.
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- 2016
8. Erratum: Dynamic markers based on blood perfusion fluctuations for selecting skin melanocytic lesions for biopsy
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Gemma Lancaster, Aneta Stefanovska, Margherita Pesce, Gian Marco Vezzoni, Barbara Loggini, Raffaele Pingitore, Fabrizio Ghiara, Paolo Barachini, Gregorio Cervadoro, Marco Romanelli, and Marco Rossi
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Diagnosis, Differential ,Genetic Heterogeneity ,Nevus, Pigmented ,Skin Neoplasms ,Multidisciplinary ,Biopsy ,Humans ,Erratum ,Prognosis ,Melanoma ,Biomarkers ,Blood Flow Velocity - Abstract
Skin malignant melanoma is a highly angiogenic cancer, necessitating early diagnosis for positive prognosis. The current diagnostic standard of biopsy and histological examination inevitably leads to many unnecessary invasive excisions. Here, we propose a non-invasive method of identification of melanoma based on blood flow dynamics. We consider a wide frequency range from 0.005–2 Hz associated with both local vascular regulation and effects of cardiac pulsation. Combining uniquely the power of oscillations associated with individual physiological processes we obtain a marker which distinguishes between melanoma and atypical nevi with sensitivity of 100% and specificity of 90.9%. The method reveals valuable functional information about the melanoma microenvironment. It also provides the means for simple, accurate, in vivo distinction between malignant melanoma and atypical nevi, and may lead to a substantial reduction in the number of biopsies currently undertaken.
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- 2016
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9. Long-Term Followup After Elective Testis Sparing Surgery for Leydig Cell Tumors: A Single Center Experience
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Maurizio De Maria, Gianluca Giannarini, Raffaele Pingitore, Girolamo Morelli, Filippo Menchini Fabris, Francesca Manassero, Andrea Mogorovich, Barbara Loggini, Andrea Cavazzana, and Cesare Selli
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Adult ,Male ,Nephrology ,endocrine system ,medicine.medical_specialty ,Urology ,Physical examination ,Single Center ,Spermatic cord ,Testicular Neoplasms ,Internal medicine ,medicine ,Humans ,Frozen section procedure ,Leydig cell ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Leydig Cell Tumor ,Germ cell tumors ,business ,Follow-Up Studies - Abstract
Although most Leydig cell tumors are benign, radical orchiectomy is currently considered the standard therapy. We retrospectively analyzed the long-term followup of a series of patients with Leydig cell tumors electively treated with testis sparing surgery.Between November 1990 and December 2005, 17 consecutive patients with Leydig cell tumors underwent testis sparing surgery on an elective basis. Preoperative evaluation included physical examination, serum markers for germ cell tumors, scrotal ultrasound, abdominal computerized tomography, chest x-ray and hormonal profile if clinically required. Testis sparing surgery was performed via an inguinal approach with spermatic cord clamping. Frozen section examination was performed in all cases, revealing Leydig cell tumors. Followup consisted of physical examination, scrotal ultrasound, abdominal computerized tomography and chest x-ray every 6 months for the first 2 years, then annually. Tumor recurrence and survival were evaluated.Mean patient age was 41.6 years (range 28 to 55). Medical referral was prompted by symptoms/signs such as infertility, gynecomastia or self-palpation of scrotal mass in 11 patients (64.7%), while in the remaining 6 (35.3%) the lesions were incidentally diagnosed. Hormonal profile was performed in 9 patients, showing abnormalities in all. Mean tumor diameter was 13.4 mm (range 5 to 31). Definitive pathological examination confirmed benign Leydig cell tumor in all cases. After a mean followup of 91 months (range 12 to 192), neither local recurrence nor distant metastases have been detected and all patients are alive without evidence of disease.In patients with Leydig cell tumors testis sparing surgery with frozen section examination provides an excellent long-term oncological outcome.
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- 2007
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10. Type 2 diabetic patient with a foot ulcer as initial manifestation of diffuse large B-cell lymphoma: A case report
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Elisabetta Iacopi, Barbara Loggini, Chiara Goretti, Alberto Piaggesi, and Alberto Coppelli
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Male ,medicine.medical_specialty ,Lymphoma, B-Cell ,Endocrinology, Diabetes and Metabolism ,Foot lesions ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Amputation, Surgical ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Bone Marrow ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Foot ulcers ,Aged ,business.industry ,General Medicine ,medicine.disease ,Antigens, CD20 ,Diabetic foot ,Dermatology ,Combined Modality Therapy ,Immunohistochemistry ,Diabetic Foot ,Lymphoma ,Surgery ,Amputation ,Diabetes Mellitus, Type 2 ,030220 oncology & carcinogenesis ,Diabetic patient ,business ,Tomography, X-Ray Computed ,Diffuse large B-cell lymphoma - Abstract
Diabetic foot ulcerations (DFU) represent a major cause of hospitalization and amputation. In people with diabetes it's not uncommon to find chronic wounds due to pathogenic mechanisms different from diabetes. Here we report the case of a foot lesion misdiagnosed as DFU but actually caused by diffuse large B-cell lymphoma.
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- 2015
11. Mutations of Fas (APO-1/CD95) and p53 Genes in Nonmelanoma Skin Cancer
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Y. Zucconi, Paolo Simi, G. Cervadoro, Barbara Loggini, Fulvia Baldinotti, Fulvio Basolo, P. Barachini, Laura Boldrini, Silvia Gisfredi, Gabriella Fontanini, Raffaele Pingitore, and Antonella Fogli
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Skin Neoplasms ,Tumor suppressor gene ,Dermatology ,Fas apo 1 ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,fas Receptor ,Gene ,Polymorphism, Single-Stranded Conformational ,Reverse Transcriptase Polymerase Chain Reaction ,business.industry ,Proteins ,Genes, p53 ,Fas receptor ,medicine.disease ,Molecular biology ,Carcinoma, Basal Cell ,030220 oncology & carcinogenesis ,Mutation ,Carcinoma, Squamous Cell ,Surgery ,Skin cancer ,Apoptosis Regulatory Proteins ,business - Abstract
Background:There is considerable evidence that apoptosis plays an important role in the pathogenesis of a wide variety of skin diseases. Apoptosis failure may ensure the survival of transformed cells prone to sustain further genetic damage and it plays an important part in the development of tumors. Genetic alterations of Fas and p53, with consequent inactivation of gene protein products, may be involved in transcriptional downregulation of Fas.Objective:We investigated Fas and its ligand expression in 30 cases of nonmelanoma skin cancer, 19 basal cell and 11 squamous cell carcinomas, and we also analyzed Fas and p53 status, in an attempt to detect putative alterations.Method:Fas and its ligand expression were evaluated by RT-PCR; the promoter and the entire coding region of Fas, and the coding exons 4–9 of p53 were investigated by polymerase chain reaction, single strand conformation polymorphism, and DNA sequencing.Results:Fas alterations were found in 3/19 (15.8%) basal cell and in 4/11 (36.4%) squamous cell carcinomas. Five out of 25 cases (3/19 basal cell and 2/11 squamous cell carcinomas) were p53-mutated, and in the majority of these cases there were concomitant mutations of the Fas gene (χ2test; p = 0.035).Conclusion:Taken together, our findings highlight an involvement of the Fas/Fas-ligand system in the development of skin cancer, suggesting that the loss of its apoptotic function, in some cases linked to p53 alterations, may contribute to the self-maintenance of cancer cells.
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- 2003
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12. Immunohistochemical Study of 49 Cutaneous Melanomas: P53, PCNA, Bcl-2 Expression and Multidrug Resistance
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Raffaele Pingitore, Isabella Rinaldi, Renza Cristofani, Barbara Loggini, P. Barachini, and Maura Castagna
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Adult ,Male ,0301 basic medicine ,Cancer Research ,Skin Neoplasms ,Statistics, Nonparametric ,03 medical and health sciences ,Predictive Value of Tests ,Proliferating Cell Nuclear Antigen ,Biomarkers, Tumor ,medicine ,Humans ,Neoplasm ,Neoplasm Invasiveness ,ATP Binding Cassette Transporter, Subfamily B, Member 1 ,Melanoma ,Survival analysis ,Aged ,Aged, 80 and over ,Regulation of gene expression ,030102 biochemistry & molecular biology ,biology ,business.industry ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Immunohistochemistry ,Survival Analysis ,Proliferating cell nuclear antigen ,Gene Expression Regulation, Neoplastic ,Multiple drug resistance ,030104 developmental biology ,Proto-Oncogene Proteins c-bcl-2 ,Oncology ,Drug Resistance, Neoplasm ,Predictive value of tests ,Cancer research ,biology.protein ,Female ,Tumor Suppressor Protein p53 ,business - Abstract
Aims and Background Thickness and level of invasion are the main morphological elements for an approximate but not sufficiently sensitive prognostic evaluation of cutaneous melanomas. By using immunohistochemical methods it is possible to detect biological markers related to prognosis. We have studied p53, PCNA, Bcl-2 and P-gp expression in 49 primary cutaneous melanomas. Materials We used the immunophosphatase APAAP immunohistochemical method. The percentage of labeled cells (according to four classes of positivity: 50%) and the localization of immunoreactivity were expressed for each marker. Statistical analysis was performed to determine the correlations between markers and level or thickness of melanomas. Results We found a good correlation between p53 expression and melanoma thickness (P Conclusions Our data seem to indicate an unfavorable prognostic role of higher nuclear p53 expression. However, we believe that our results need to be integrated with patients’ clinical follow-up and with the study of the expression of these markers in benign melanocytic lesions to gain more accurate information about their prognostic significance.
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- 2001
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13. The role of the glutathione system during dehydration of Boea hygroscopica
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Cristina Sgherri, Concetta Vazzana, S. Meneguzzo, Barbara Loggini, and Flavia Navari-Izzo
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chemistry.chemical_classification ,Antioxidant ,biology ,Physiology ,Chemistry ,Glutathione peroxidase ,medicine.medical_treatment ,Glutathione reductase ,Dehydrogenase ,Cell Biology ,Plant Science ,General Medicine ,Glutathione ,medicine.disease ,Desiccation tolerance ,chemistry.chemical_compound ,Biochemistry ,Genetics ,biology.protein ,medicine ,Dehydration ,Peroxidase - Abstract
Plants of Boea hygroscopica F. Muell were subjected to dehydration for 25 days until the relative water content was 23%. The rate of water loss was very slow during the first 12 days of dehydration while it dramatically increased during the last 3 days of the treatment. On day 12 of dehydration total glutathione content was reduced to 24% of the control level and was mainly present in the oxidized form. At that time an oxidation of the sulfhydryl groups of soluble proteins was observed. A protection of glutathione against oxidation of the sulfhydryl groups of soluble proteins was established only after 22 days of desiccation, at the same time as glutathione began to accumulate. During the whole desiccation period enzyme activities related to glutathione utilization and regeneration and the activity of NADP + -dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12), which contains essential sulfhydryl groups, were maintained. The results of the present experiment suggest that during dehydration of Boea hygroscopica glutathione has, above all, a primary role in the protection of the sulfhydryl groups of the thylakoid proteins, which were maintained in the reduced form during the whole dehvdration period.
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- 1997
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14. Antioxidant system in Boea hygroscopica: Changes in response to desiccation and rehydration
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Adriana Bochicchio, Flavia Navari-Izzo, Barbara Loggini, and Cristina Sgherri
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Boea hygroscopica, Gesneriaceae, desiccation tolerance, resurrection, ascorbate/glutathione cycle, soluble proteins ,Antioxidant ,Ascorbate glutathione cycle ,desiccation tolerance ,ascorbate/glutathione cycle ,medicine.medical_treatment ,Glutathione reductase ,ved/biology.organism_classification_rank.species ,Resurrection plant ,Plant Science ,Horticulture ,Biology ,Biochemistry ,Desiccation tolerance ,chemistry.chemical_compound ,medicine ,Dehydration ,Food science ,Molecular Biology ,soluble proteins ,Chromatography ,ved/biology ,General Medicine ,Glutathione ,Gesneriaceae ,resurrection ,medicine.disease ,chemistry ,biology.protein ,Boea hygroscopica ,Peroxidase - Abstract
In leaves of Boea hygroscopica subjected to either rapid or slow dehydration and rehydration, the response to H 2 O 2 production was studied by monitoring the changes in the amounts of ascorbic and dehydroascorbic acids as well as the amounts of reduced and oxidized glutathione and related enzyme activities. Boea hygroscopica is a resurrection plant in which drought tolerance depends on the rate of desiccation. For this reason, excised leaves of B. hygroscopica were subjected either to rapid or slow dehydration, by a 144-hr exposure to 0% or 80% relative humidity, respectively. Slowly dried leaves, rehydrated for 36 hr, were able to resume their activities completely, while rapidly dried leaves were not able to revive. After dehydration, H 2 O 2 production decreased both in slowly and in rapidly dried leaves, whereas the levels of total ascorbate and glutathione became two and 50 times as high, respectively, as in the control. During slow drying, reduced glutathione was oxidized, since its content in slowly dried leaves was 50% lower than in rapidly dried leaves. The levels of soluble proteins were found to be, respectively, five and six times as high in rapidly and slowly dried leaves as in the control and rehydrated leaves. The electrophoretic patterns of soluble proteins were similar in both dehydrated leaves, but different from control and rehydrated leaves, which also presented similar patterns. The specific activities of dehydroascorbate reductase (EC 1.8.5.1), glutathione reductase (EC 1.6.4.2) and ascorbate peroxidase (EC 1.11.1.11) also had the same values in both slowly and rapidly dried leaves. Following rehydration, oxidative processes were intensified: H 2 O 2 levels and the oxidation of ascorbate and glutathione mostly increased during this period in which the functioning of the ascorbate/glutathione cycle was induced.
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- 1994
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15. Different estrogen receptor beta expression in distinct histologic subtypes of lung adenocarcinoma
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Adele Servadio, Franca Melfi, Matteo Dell'Omodarme, Valentina Donati, Maria Cristina Prati, Tiziano Camacci, Barbara Loggini, Marco Lucchi, Gabriella Fontanini, Greta Alì, and Alfredo Mussi
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Adult ,Male ,medicine.medical_specialty ,Pathology ,Lung Neoplasms ,Estrogen receptor ,Biology ,Adenocarcinoma ,Pathology and Forensic Medicine ,Pathogenesis ,Immunoenzyme Techniques ,medicine ,Biomarkers, Tumor ,Estrogen Receptor beta ,Humans ,Lung cancer ,Estrogen receptor beta ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Cell Nucleus ,Cancer ,Anatomical pathology ,Cell Dedifferentiation ,Middle Aged ,medicine.disease ,Fluorescent Antibody Technique, Direct ,Lymphatic Metastasis ,Immunohistochemistry ,Female ,Lymph Nodes - Abstract
Adenocarcinoma is becoming the most common histologic type of lung cancer in both sex. Although most cases are seen in smokers, it develops more frequently than other histologic types in individuals who have never smoked. This evidence suggests that other putative etiologic factors, such as sex hormones, need to be investigated. Several subtypes of lung adenocarcinoma have been recently described with distinct clinicopathologic features and prognostic implications. The purpose of this study is to investigate the role of estrogen receptor beta in lung adenocarcinoma, with particular attention paid to its different histologic subtypes. Nuclear estrogen receptor beta expression was evaluated by immunohistochemistry in 112 lung adenocarcinomas, including both "single subtype" and "mixed subtype" samples. Using a 2-level (high/low) score system, estrogen receptor beta expression was high in most (75%) adenocarcinomas and turned out to be strongly related to the histologic subtypes. In fact, estrogen receptor beta expression was low or negative in 68.2% of solid subtypes, whereas it was high in 76.5% of nonmucinous bronchioloalveolar, in 69.4% of acinar, and in 61.2% of papillary patterns (P = .00004). Furthermore, a strong association between estrogen receptor beta expression and tumor histologic grade was observed: estrogen receptor beta was highly expressed predominantly in well- and moderately differentiated tumors (P = .0014). In conclusion, estrogen receptor beta expression has distinct patterns in lung adenocarcinoma, suggesting a specific role for estrogen receptor beta in the pathogenesis of different histologic subtypes of this type of cancer. Moreover, loss of estrogen receptor beta expression in poorly differentiated (G3) tumors could represent a crucial step in the dedifferentiation process of lung adenocarcinoma.
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- 2008
16. Lichen myxedematosus with systemic involvement: clinical and autopsy findings
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P. Barachini, Alessandro Avvenente, Barbara Loggini, Raffaele Pingitore, and Giuseppina Giuliano
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Pathology ,medicine.medical_specialty ,Mucinoses ,business.industry ,Skin Diseases, Papulosquamous ,Ascites ,Autopsy ,Dermatology ,medicine.disease ,stomatognathic diseases ,Lichen myxedematosus ,medicine.anatomical_structure ,Dermis ,Medicine ,Humans ,Female ,business ,Digestive System ,Papular mucinosis ,Rare disease ,Aged - Abstract
Lichen myxedematosus is a rare disease that is characterized by the formation of lichenoid papules and plaques. Histologic examination shows deposition of mucinous material in the dermis. We report the case of a patient with cutaneous and systemic involvement and examine the clinical and postmortem data.
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- 2001
17. Multiple pyogenic granuloma of the penis in a four-year-old child: a case report
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Martina Di Giacomo, Claudio Spinelli, Barbara Loggini, Raffaele Pingitore, and A Bertocchini
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Medicine(all) ,Anamnesis ,Pathology ,medicine.medical_specialty ,business.industry ,Pyogenic granuloma ,General Medicine ,Penis foreskin ,medicine.disease ,medicine.anatomical_structure ,Case report ,medicine ,Multiple Pyogenic Granulomas ,business ,Penis - Abstract
Pyogenic granulomas are common, acquired, benign vascular lesions of the skin and mucous membranes that can develop both spontaneously and traumatically. We present a unique case of a four-year healthy, uncircumcised boy with multiple pyogenic granuloma on the mucous face of the penis foreskin. Although penile multiple pyogenic granulomas have previously been described in adults, there are no reports of similar problems in children. In this patient, the pathogenesis of the lesions is probably trauma related as reported in the anamnesis. Therapeutic options are discussed.
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- 2009
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18. The Response of the Glutathione System to Drought in <u>Boea Hygroscopica</u>: Protection Against Oxidation of -SH Groups of Proteins
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Adriana Bochicchio, Cristina Sgherri, Flavia Navari-Izzo, Barbara Loggini, and S. Meneguzzo
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chemistry.chemical_compound ,Sh groups ,Biochemistry ,Boea hygroscopica ,Chemistry ,Plant Science ,Glutathione ,Ecology, Evolution, Behavior and Systematics - Abstract
(1995). The Response of the Glutathione System to Drought in Boea Hygroscopica: Protection Against Oxidation of -SH Groups of Proteins. Giornale botanico italiano: Vol. 129, No. 4, pp. 1128-1129.
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- 1995
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19. Micropropagated vines and vines from cutting of kiwifruit cv llayward subjected to water deficit
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Flavia Navari-Izzo, Riccardo Izzo, Barbara Loggini, and Maria Teresa Antonietta Milone
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Horticulture ,Botany ,Plant Science ,Biology ,Ecology, Evolution, Behavior and Systematics ,Water deficit - Published
- 1995
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20. Evaluation of telomerase in non-melanoma skin cancer
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D. Di Quirico, P. Barachini, R. Biondi, Raffaele Pingitore, Laura Boldrini, Barbara Loggini, Silvia Gisfredi, Gabriella Fontanini, G. Cervadoro, Fulvio Basolo, and Y. Zucconi
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Adult ,Male ,Telomerase ,Skin Neoplasms ,Protein subunit ,Biology ,medicine.disease_cause ,Telomerase RNA component ,Genetics ,medicine ,Humans ,Telomerase reverse transcriptase ,Aged ,Ribonucleoprotein ,Aged, 80 and over ,General Medicine ,Middle Aged ,Molecular biology ,Reverse transcriptase ,Telomere ,DNA-Binding Proteins ,Carcinoma, Basal Cell ,Carcinoma, Squamous Cell ,Female ,Carcinogenesis - Abstract
Telomerase, a ribonucleoprotein, is capable of adding telomeric sequences (TTAGGG hexameric repeats) to the ends of chromosomes and, thereby, halting the erosion of chromosome at each cell division. Whereas most normal somatic cells contain minimal or no detectable telomerase activity, most immortal and tumour cells exhibit significant levels of telomerase activity and show no net loss of telomere length during proliferation. The evaluation of telomerase has been proposed for diagnostic and therapeutic purposes in human cancer. Skin cancer is the most common cancer in humans; the precise molecular events in skin carcinogenesis are numerous and complicated and not yet completely clarified. In this study, we evaluated telomerase in 35 basal cell carcinomas and in 14 squamous cell carcinomas in order to determine if activation of the telomerase enzyme was a pivotal step in the development of skin cancer and whether telomerase activity levels were different between the two histotypes. A higher enzymatic level was shown to be associated with squamous cell carcinomas, while low levels were mainly detected in the basal cell histotype (chi2 test; p=0.02). Telomerase complex activity is dependent on its catalytic subunit, telomerase reverse transcriptase hTERT. By reverse transcription-PCR, using primers within the reverse transcriptase domain of hTERT, we observed a significant correlation between hTERT expression and telomerase activity in our skin tumour samples (p=0.0003). We detected the presence of multiple, alternately spliced transcripts, corresponding to full-length messages as well as spliced messages with critical reverse transcriptase motifs deleted. A higher telomerase messenger level was shown to be associated with squamous cell carcinomas (chi2 test; p
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