Search

Your search keyword '"Bandeira F"' showing total 5 results
Start Over Author "Bandeira F" Language undetermined
5 results on '"Bandeira F"'

5. Evaluation ofDEFB1polymorphisms in individuals with chronic periodontitis and diabetes mellitus type 2 in a population of northeastern Brazil

Author

Sergio Crovella, Francisco Bandeira, Ronaldo Celerino da Silva, Felipe Rodrigues de Almeida, Roberto Carlos Mourão Pinho, Bruna de Carvalho Farias Vajgel, Rayanne Soraia Aguiar de Melo Dias, Renata Cimões, Soraia Aguiar de Melo Dias, R., Carlos Mourao Pinho, R., Almeida, F. R. D., Alfredo Farias Bandeira, F., Celerino da Silva, R., Crovella, S., de Carvalho Farias Vajgel, B., and Cimoes, R.

Subjects
Male, 0301 basic medicine, beta-Defensins, Gastroenterology, 0302 clinical medicine, Genotype, 80 and over, Allele, Aged, 80 and over, education.field_of_study, diabetes mellitu, chronic periodontitis, Single Nucleotide, Middle Aged, β-defensin, beta-Defensin, diabetes mellitus, Female, Brazil, Type 2, Human, Adult, musculoskeletal diseases, medicine.medical_specialty, Population, Single-nucleotide polymorphism, Context (language use), Polymorphism, Single Nucleotide, 03 medical and health sciences, Aged, Alleles, Chronic Periodontitis, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Genetic Variation, Humans, Diabetes mellitus, Internal medicine, Genetic variation, medicine, Polymorphism, education, General Dentistry, business.industry, Haplotype, 030206 dentistry, medicine.disease, Chronic Periodontiti, 030104 developmental biology, business
Abstract

Aims: The role of genetic variations in genes related to innate response, as β-defensin-1 (DEFB1), in the context of chronic periodontitis (CP) and diabetes mellitus type 2 (DM2), is still not clear. The present study evaluates the distribution of DEFB1 single nucleotide polymorphisms (SNPs) 5′-untranslated (5′UTR) region and its relation with the CP in DM2 individuals in northeastern Brazilians. Methods: Two hundred and eighty individuals participated in the study, being 116 DM2+CP, 95 CP, and 69 healthy individuals. Three known DEFB1 functional SNPs [-52 G > A (rs1799946), -44 C > G (rs1800972), -20 G > A (rs11362)] were genotyped with allele-specific assays. Results: Association was found for the DEFB1 -20 G > A SNP. The G allele, the GA and GG genotypes were significantly (P

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results