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4 results on '"Banat, Ibrahim"'

1. MOESM1 of Biosynthesis of rhamnolipid by a Marinobacter species expands the paradigm of biosurfactant synthesis to a new genus of the marine microflora

Author

Tripathi, Lakshmi, Twigg, Matthew, Zompra, Aikaterini, Salek, Karina, Irorere, Victor, Gutierrez, Tony, Spyroulias, Georgios, Marchant, Roger, and Banat, Ibrahim

Abstract

Additional file 1: Fig. S1. Effect of various sea salt concentrations, pH, temperature and nitrogen source on the growth of Marinobacter sp. MCTG107b over a period of 96 h. Growth curves show the OD600 of strain MCTG107b during growth at different (A) salinities (5.0 to 40 g L−1), (B) pH values (4.0 to 8.5), or (C) temperatures (25 °C, 28 °C, 30 °C, 37 °C). Fig. S2. HPLC–MS chromatogram for rhamnolipids produced by Marinobacter sp. MCTG107b. The MS was operated in the negative mode. Main intensities in the chromatogram were Rha-Rha-C10-C10 and Rha-Rha-C10-C10-CH3. Table S1. Full 22 factorial design with pH and salt as independent variables using surface tension and biosurfactant yield as response variables. Surface tension and biosurfactant yield according to full factorial design after 96 h of shake-flask study of Marinobacter sp. MCTG107b. Table S2. Analysis of variance (ANOVA) for response variables surface tension and biosurfactant yield by Marinobacter sp. MCTG107b.

Published
2019
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2. Development of a Cradle-to-Grave Approach for Acetylated Acidic Sophorolipid Biosurfactants

Author

Baccile, Niki, Babonneau, Florence, Banat, Ibrahim M, Ciesielska, Katarzyna, Cuvier, Anne-Sophie, Devreese, Bart, Everaert, Bernd, Lydon, Helen, Marchant, Roger, Mitchell, Christopher A, Roelants, Sophie, Six, Lasse, Theeuwes, Elke, Tsatsos, Georgios, Tsotsou, Georgia Eleni, Vanlerberghe, Brecht, Van Bogaert, Inge NA, and Soetaert, Wim

Subjects
6. Clean water

4. Lactonic Sophorolipids Increase Tumor Burden in Apcmin+/- Mice

Author

Helen Lydon, Inge N. A. Van Bogaert, Sophie Roelants, Breedge Callaghan, Ibrahim M. Banat, Christopher A. Mitchell, Roger Marchant, Banat, Ibrahim M [0000-0001-8964-2840], Mitchell, Christopher A [0000-0002-4422-7499], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Cell Extracts, Male, APC GENE, Physiology, Cancer Treatment, lcsh:Medicine, Apoptosis, Pharmacology, MOUSE, chemistry.chemical_compound, Mice, 0302 clinical medicine, BIOSURFACTANTS, Oral administration, Immune Physiology, Medicine and Health Sciences, lcsh:Science, chemistry.chemical_classification, Multidisciplinary, Cell Death, Sophorolipid, Biological activity, Animal Models, APOPTOSIS, Tumor Burden, Up-Regulation, Oncology, Biochemistry, Cell Processes, 030220 oncology & carcinogenesis, Cell lines, Female, Anatomy, Biological cultures, Colorectal Neoplasms, HT29 Cells, MICROBIAL-PRODUCTION, Research Article, Genes, APC, Sophorose, Mouse Models, Mice, Transgenic, Biology, 03 medical and health sciences, Model Organisms, Glycolipid, Ascomycota, In vivo, Cell Line, Tumor, Animals, Humans, IGE PRODUCTION, CANCER CELLS, Cell Proliferation, Colorectal Cancer, SEPSIS, lcsh:R, Biology and Life Sciences, Cancers and Neoplasms, Fatty acid, Cell Biology, HCT116 Cells, In vitro, MODEL, Research and analysis methods, Gastrointestinal Tract, 030104 developmental biology, chemistry, lcsh:Q, Caco-2 Cells, Glycolipids, Digestive System, Spleen, FOOD-INDUSTRY
Abstract

Sophorolipids (SL) are amphiphilic biosurfactant molecules consisting of a disaccharide sophorose with one fatty acid at the C1 position and optional acetylation at the C6' and C6 '' positions. They exist in a closed ring lactonic (LSL) or open acidic (ASL) structure Sophorolipids are produced in crude mixtures in economically viable amounts by the yeast Starmerella bombicola and used in a variety of consumer products. Varying levels of antiproliferative and anti-cancer activity of crude sophorolipid mixtures are described in a number of tumor cell lines in vitro. However, significant inter-study variation exists in the composition of sophorolipid species as well as other biologically active compounds in these mixtures, which makes interpretation of in vitro and in vivo studies difficult. We produced a 96% pure C18:1 lactonic sophorolipid that dose-dependently reduces the viability of colorectal cancer, as well as normal human colonic and lung cell lines in vitro. Oral administration of vehicle-only; or lactonic sophorolipids (50 mg/kg for 70 days), to Apcmin(+/-) mice resulted in an increase in the number (55.5 +/- 3.3 vs 70.50 +/- 7.8: p < 0.05) and size (modal size 2mm vs 4mm) of intestinal polyps. Lactonic administration resulted in a systematic effect via reduced hematocrit (49.5 +/- 1.0 vs 28.2 +/- 2.0 vs: p

Published
2018
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