28 results on '"Armstrong, Richard"'
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2. ST-segment elevation in patients presenting with COVID-19: case series
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Saririan, Mehrdad, Armstrong, Richard, George, Jon C, Olechowski, Bartosz, O’Connor, Stephen, Byrd, James Brian, and Chapman, Andrew R
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Coronary angiography ,medicine.medical_specialty ,Histology ,Myocarditis ,Coronavirus disease 2019 (COVID-19) ,business.industry ,COVID-19 ,Disease ,medicine.disease ,medicine.disease_cause ,STEMI ,Coronary arteries ,medicine.anatomical_structure ,Internal medicine ,Case report ,medicine ,Cardiology ,ST segment ,Case Series ,AcademicSubjects/MED00200 ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business ,Coronavirus - Abstract
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the now pandemic disease, coronavirus disease (COVID-19). A number of reports have emerged suggesting these patients may present with signs and symptoms consistent with ST-segment elevation myocardial infarction without coronary artery occlusion. Case summary We report an international case series of patients with confirmed COVID-19 infection who presented with suspected ST-segment elevation myocardial infarction. Three patients with confirmed COVID-19 presented with electrocardiogram criteria for ST-segment elevation myocardial infarction. No patient had obstructive coronary disease at coronary angiography. Post-mortem histology in one case demonstrated myocardial ischaemia in the absence of coronary atherothrombosis or myocarditis. Discussion Patients with COVID-19 may present with features consistent with ST-segment elevation myocardial infarction and patent coronary arteries. The prevalence and clinical outcomes of this condition require systematic investigation in consecutive unselected patients.
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- 2021
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3. Rezension: Homer: The Odyssey. Translated by Emily Wilson (rezensiert von Richard H. Armstrong)
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Armstrong, Richard H.
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- 2019
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4. Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries The International Surgical Outcomes Study group
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Ahmad, T, Bouwman, RA, Grigoras, I, Aldecoa, C, Hofer, C, Hoeft, A, Holt, P, Fleisher, LA, Buhre, W, Pearse, RM, Ferguson, Marissa, MacMahon, Michael, Shulman, Mark, Cherian, Ritchie, Currow, Helen, Kanathiban, Kathirgamanathan, Gillespie, David, Pathmanathan, Edward, Phillips, Katherine, Reynolds, Jenifer, Rowley, Joanne, Douglas, Jeanene, Kerridge, Ross, Garg, Sameer, Bennett, Michael, Jain, Megha, Alcock, David, Terblanche, Nico, Cotter, Rochelle, Leslie, Kate, Stewart, Marcelle, Zingerle, Nicolette, Clyde, Antony, Hambidge, Oliver, Rehak, Adam, Cotterell, Sharon, Huynh, Wilson Binh Quan, McCulloch, Timothy, Ben-Menachem, Erez, Egan, Thomas, Cope, Jennifer, Halliwell, Richard, Fellinger, Paul, Haisjackl, Markus, Haselberger, Simone, Holaubek, Caroline, Lichtenegger, Paul, Scherz, Florian, Schmid, Werner, Hoffer, Franz, Cakova, Veronika, Eichwalder, Andreas, Fischbach, Norbert, Klug, Reinhold, Schneider, Elisabeth, Vesely, Martin, Wickenhauser, Reinhart, Grubmueller, Karl Gernot, Leitgeb, Marion, Lang, Friedrich, Toro, Nancy, Bauer, Marlene, Laengle, Friedrich, Haberl, Claudia, Mayrhofer, Thomas, Trybus, Christoph, Buerkle, Christian, Forstner, Karin, Germann, Reinhard, Rinoesl, Harald, Schindler, Elke, Trampitsch, Ernst, Bogner, Gerhard, Dankl, Daniel, Duenser, Martin, Fritsch, Gerhard, Gradwohl-Matis, Ilse, Hartmann, Andreas, Hoelzenbein, Thomas, Jaeger, Tarkan, Landauer, Franz, Lindl, Gregor, Lux, Michael, Steindl, Johannes, Stundner, Ottokar, Szabo, Christian, Bidgoli, Jawad, Verdoodt, Hans, Forget, Patrice, Kahn, David, Lois, Fernande, Momeni, Mona, Pregardien, Caroline, Pospiech, Audrey, Steyaert, Arnaud, Veevaete, Laurent, De Kegel, Dirk, De Jongh, Karen, Foubert, Luc, Smitz, Carine, Vercauteren, Marcel, Poelaert, Jan, Van Mossevelde, Veerle, Abeloos, Jacques, Bouchez, Stefaan, Coppens, Marc, De Baerdemaeker, Luc, Deblaere, Isabel, De Bruyne, Ann, De Hert, Stefan, Fonck, Kristine, Heyse, Bjorn, Jacobs, Tom, Lapage, Koen, Moerman, Anneliese, Neckebroek, 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Lee, Hooi Sean, Sukawi, Ismawaty, Woon, Yuan Liang, Hadi, Husni Zaeem Abd, Azam, Ummi Azmira Ahmad, Alias, Abdul Hafiz, Kesut, Saiful Aizar, Lee, Jun May, Ooi, Dar Vin, Sulaiman, Hetty Ayuni, Lih, Tengku Alini Tengku, Mansor, Marzida, Veerakumaran, Jeyaganesh, Luna, Pastor, Rojas, Eder, Resendiz, Gerardo Esteban Alvarez, Zapata, Darcy Danitza Mari, Lopez, Julio Cesar Jesus Aguilar, Flores, Armando Adolfo Alvarez, Amador, Juan Carlos Bravo, Avila, Erendira Jocelin Dominguez, Aquino, Laura Patricia Gonzalez, Rodriguez, Ricardo Lopez, Landa, Mariana Torres, Urias, Emma, Hollmann, Markus, Hulst, Abraham, Preckel, Osne Kirzner Benedikt, Koopman-van Gemert, Ankie, Bouwman, Arthur, Buise, Marc, Tolenaar, Noortje, Weber, Eric, de Fretes, Jennifer, Houweling, Peter, Ormskerk, Patricia, Van Bommel, Jasper, Buhre, Wolfgang, Lance, Marcus, Smit-Fun, Valerie, van Zundert, Tom, Baas, Peter, de Boer, Hans Donald, Sprakel, Joost, Elferink-Vonk, Renske, Noordzij, Peter, van Zeggeren, Laura, Brand, 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Denham, Samuel, Griffiths, Ewen, Ip, Peter, Jeyanthan, Somasundaram, Joory, Kavita, Kaur, Satwant, Marriott, Paul, Mitchell, Natalie, Nagaiah, Sukumar, Nilsson, Annette, Parekh, Nilesh, Pope, Martin, Seager, Joseph, Serag, Hosam, Tameem, Alifia, Thomas, Anna, Thunder, Joanne, Torrance, Andrew, Vohra, Ravinder, whitehouse, Arlo, Wong, Tony, Blunt, Mark, Wong, Kate, Giles, Julian, Reed, Isabelle, Weller, Debbie, Bell, Gillian, Birch, Julie, Damant, Rose, Maiden, Jane, Mewies, Clare, Prince, Claire, Radford, Jane, Reynolds, Tim, Balain, Birender, Banerjee, Robin, Barnett, Andrew, Ben Burston, Ben Burston, Davies, Kirsty, Edwards, Jayne, Evans, Chris, Ford, David, Gallacher, Pete, Hill, Simon, Jaffray, David, Karlakki, Sudheer, Kelly, Cormac, Kennedy, Julia, Kiely, Nigel, Lewthwaite, Simon, Marquis, Chris, Ockendon, Matthew, Phillips, Stephen, Pickard, Simon, Richardson, James, Roach, Richard, Smith, Tony, Spencer-Jones, Richard, Steele, Niall, Steen, Julie, Van Liefland, Marck, White, Steve, Faulds, Matthew, Harris, Meredyth, Kelly, Carrie, Nicol, Scott, Pearson, Sally Anne, Chukkambotla, Srikanth, Andrew, Alyson, Attrill, Elizabeth, Campbell, Graham, Datson, Amanda, Fouracres, Anna, Graterol, Juan, Graves, Lynne, Hong, Bosun, Ishimaru, Alexander, Karthikeyan, Arvind, King, Helen, Lawson, Tom, Lee, Gregory, Lyons, Saoirse, Hall, Andrew Macalister, Mathoulin, Sophie, Mcintyre, Eilidh, Mclaughlin, Danny, Mulcahy, Kathleen, Paddle, Jonathan, Ratcliffe, Anna, Robbins, James, Sung, Weilin, Tayo, Adeoluwa, Trembath, Lisa, Venugopal, Suneetha, Walker, Robert, Wigmore, Geoffrey, Boereboom, Catherine, Downes, Charlotte, Humphries, Ryan, Melbourne, Susan, Smith, Coral, Tou, Samson, Ullah, Shafa, Batchelor, Nick, Boxall, Leigh, Broomby, Rupert, Deen, Tariq, Hellewell, Alistair, Helliwell, Laurence, Hutchings, Melanie, Hutchins, David, Keenan, Samantha, Mackie, Donna, Potter, Alison, Smith, Frances, Stone, Lucy, Thorpe, Kevin, Wassall, Richard, Woodgate, Andrew, Baillie, Shelley, Campbell, Tara, James, Sarah, King, Chris, de Araujo, Daniela Marques, Martin, Daniel, Morkane, Clare, Neely, Julia, Rajendram, Rajkumar, Burton, Megan, James, Kathryn, Keevil, Edward, Minik, Orsolya, Morgan, Jenna, Musgrave, Anna, Rajanna, Harish, Roberts, Tracey, Szakmany, Tamas, Adamson, Michael, Jumbe, Sandra, Kendall, Jennie, Muthuswamy, Mohan Babu, Anderson, Charlotte, Cruikshanks, Andrew, Wrench, Ian, Zeidan, Lisa, Ardern, Diane, Harris, Benjamin, Hellstrom, Johanna, Martin, Jane, Thomas, Richard, Varsani, Nimu, Brown, Caroline Wrey, Docherty, Philip, Gillies, Michael, McGregor, Euan, Usher, Helen, Craig, Jayne, Smith, Andrew, Ahmad, Tahania, Bodger, Phoebe, Creary, Thais, Everingham, Kirsty, Fowler, Alexander, Hewson, Russ, Ijuo, Eke, Januszewska, Marta, Jones, Timothy, Kantsedikas, Ilya, Lahiri, Sumitra, McLean, Aaron Lawson, Niebrzegowska, Edyta, Phull, Mandeep, Wang, Difei, Wickboldt, Nadine, Baldwin, Jacqueline, Doyle, Donna, Mcmullan, Sean, Oladapo, Michelle, Owen, Thomas, Williams, Alexandra, Daniel, Hull, Gregory, Peter, Husain, Tauqeer, Kirk-Bayley, Justin, Mathers, Edward, Montague, Laura, Harper, Mark, White, Stuart, Jack, James, Ridley, Carrie, Avis, Joanne, Cook, Tim, Dali-Kemmery, Lola, Kerslake, Ian, Lambourne, Victoria, Pearson, Annabel, Boyd, Christine, Callaghan, Mark, Lawson, Cathy, McCrossan, Roopa, Nesbitt, Vanessa, O'connor, Laura, Scott, Julia, Sinclair, Rhona, Farid, Nahla, Morgese, Ciro, Bhatia, Kailash, Karmarkar, Swati, Ahmed, Jamil, Branagan, Graham, Hutton, Monica, Swain, Andrew, Brookes, Jamie, Cornell, Jonathan, Dolan, Rachael, Hulme, Jonathan, van Vuuren, Amanda Jansen, Jowitt, Tom, Kalashetty, Gunasheela, Lloyd, Fran, Patel, Kiran, Sherwood, Nicholas, Brown, Lynne, Chandler, Ben, Deighton, Kerry, Emma, Temlett, Haunch, Kirsty, Cheeseman, Michelle, Dent, Kathy, Garg, Sanjeev, Gray, Carol, Hood, Marion, Jones, Dawn, Juj, Joanne, Rao, Roshan, Walker, Tara, Al Anizi, Mashel, Cheah, Clarissa, Cheing, Yushio, Coutinho, Francisco, Gondo, Prisca, Hadebe, Bernard, Hove, Mazvangu Onie, khader, Ahamed, Krishnachetty, Bobby, Rhodes, Karen, Sokhi, Jagdish, Baker, Katie-Anne, Bertram, Wendy, Looseley, Alex, Mouton, Ronelle, Hanna, George, Arnold, Glenn, Arya, Shobhit, Balfoussia, Danai, Baxter, Linden, Harris, James, Jones, Craig, Knaggs, Alison, Markar, Sheraz, Perera, Anisha, Scott, Alasdair, Shida, Asako, Sirha, Ravneet, Wright, Sally, Frost, Victoria, Gray, Catherine, Andrews, Emma, Arrandale, Lindsay, Barrett, Stephen, Cifra, Elna, Cooper, Mariese, Dragnea, Dragos, Elna, Cifra, Maclean, Jennifer, Meier, Sonja, Milliken, Donald, Munns, Christopher, Ratanshi, Nadir, Ramessur, Suneil, Salvana, Abegail, Watson, Anthony, Ali, Hani, Campbell, Gill, Critchley, Rebecca, Endersby, Simon, Hicks, Catherine, Liddle, Alison, Pass, Marc, Ritchie, Charlotte, Thomas, Charlotte, Too, Lingxi, Welsh, Sarah, Gill, Talvinder, Johnson, Joanne, Reed, Joanne, Davis, Edward, Papadopoullos, Sam, Attwood, Clare, Biffen, Andrew, Boulton, Kerenza, Gray, Sophie, Hay, David, Mills, Sarah, Montgomery, Jane, Riddell, Rory, Simpson, James, Bhardwaj, Neeraj, Paul, Elaine, Uwubamwen, Nosakhare, Alexander, Maini, Arrich, James, Arumugam, Swarna, Blackwood, Douglas, Boggiano, Victoria, Brown, Robyn, Chan, Yik Lam, Chatterjee, Devnandan, Chhabra, Ashok, Christian, Rachel, Costelloe, Hannah, Matthewman, Madeline Coxwell, Dalton, Emma, Darko, Julia, Davari, Maria, Dave, Tejal, Deacon, Matthew, Deepak, Shantal, Edmond, Holly, Ellis, Jessica, El-Sayed, Ahmed, Eneje, Philip, English, Rose, Ewe, Renee, Foers, William, Franklin, John, Gallego, Laura, Garrett, Emily, Goldberg, Olivia, Goss, Harry, Greaves, Rosanna, Harris, Rudy, Hennings, Charles, Jones, Eleanor, Kamali, Nelson, Kokkinos, Naomi, Lewis, Carys, Lignos, Leda, Malgapo, Evaleen Victoria, Malik, Rizwana, Milne, Andrew, Mulligan, John-Patrick, Nicklin, Philippa, Palipane, Natasha, Parsons, Thomas, Piper, Rebecca, Prakash, Rohan, Ramesh, Byron, Rasip, Sarah, Reading, Jacob, Rela, Mariam, Reyes, Anna, Stephens, Robert, Rooms, Martin, Shah, Karishma, Simons, Henry, Solanki, Shalil, Spowart, Emma, Stevens, Amy, Thomas, Christopher, Waggett, Helena, Yassaee, Arrash, Kennedy, Anthony, Scott, Sara, Somanath, Sameer, Berg, Andrew, Hernandez, Miguel, Nanda, Rajesh, Tank, Ghanshyambhai, Wilson, Natalie, Wilson, Debbie, Al-Soudaine, Yassr, Baldwin, Matthew, Cornish, Julie, Davies, Zoe, Davies, Leigh, Edwards, Marc, Frewer, Natasha, Gallard, Sian, Glasbey, James, Harries, Rhiannon, Hopkins, Luke, Kim, Taeyang, Koompirochana, Vilavan, Lawson, Simon, Lewis, Megan, Makzal, Zaid, Scourfield, Sarah, Ahmad, Yousra, Bates, Sarah, Blackwell, Clare, Bryant, Helen, Collins, Hannah, Coulter, Suzanne, Cruickshank, Ross, Daniel, Sonya, Daubeny, Thomas, Edwards, Mark, Golder, Kim, Hawkins, Lesley, Helen, Bryant, Hinxman, Honor, Levett, Denny, Salmon, Karen, Seaward, Leanne, Skinner, Ben, Tyrell, Bryony, Wadams, Beverley, Walsgrove, Joseph, Dickson, Jane, Constantin, Kathryn, Karen, Markwell, O'Brien, Peter, O'Donohoe, Lynn, Payne, Hannah, Sundayi, Saul, Walker, Elaine, Brooke, Jenny, Cardy, Jon, Humphreys, Sally, Kessack, Laura, Kubitzek, Christiane, Kumar, Suhas, Cotterill, Donna, Hodzovic, Emil, Hosdurga, Gurunath, Miles, Edward, Saunders, Glenn, Campbell, Marta, Chan, Peter, Jemmett, Kim, Raj, Ashok, Naik, Aditi, Oshowo, Ayo, Ramamoorthy, Rajarajan, Shah, Nimesh, Sylvan, Axel, Blyth, Katharine, Burtenshaw, Andrew, Freeman, David, Johnson, Emily, Lo, Philip, Martin, Terry, Plunkett, Emma, Wollaston, Julie, Allison, Joanna, Carroll, Christine, Craw, Nicholas, Craw, Sarah, Pitt-Kerby, Tressy, Rowland-Axe, Rebecca, Spurdle, Katie, McDonald, Andrew, Simon, Davies, Sinha, Vivek, Smith, Thomas, Banner-Goodspeed, Valerie, Boone, Myles, Campbell, Kathleen, Lu, Fengxin, Scannell, Joseph, Sobol, Julia, Balajonda, Naraida, Clemmons, Karen, Conde, Carlos, Elgasim, Magdi, Funk, Bonita, Hall, Roger, Hopkins, Thomas, Olaleye, Omowunmi, Omer, Omer, Pender, Michelle, Porto, Angelo, Stevens, Alice, Waweru, Peter, Yeh, Erlinda, Bodansky, Daniella, Evans, Adam, Kleopoulos, Steven, Maril, Robert, Mathney, Edward, Sanchez, Angela, Tinuoye, Elizabeth, Bateman, Brian, Eng, Kristen, Jiang, Ning, Ladha, Karim, Needleman, Joseph, Chen, Lee-lynn, Lane, Rondall, Robinowitz, David, Ghushe, Neil, Irshad, Mariam, O'Connor, John, Patel, Samir, Takemoto, Steven, Wallace, Art, Mazzeffi, Michael, Rock, Peter, Wallace, Karin, Zhu, Xiaomao, Chua, Pandora, Fleisher, Lee, Mattera, Matthew, Sharar, Rebecca, Thilen, Stephan, Treggiari, Miriam, Morgan, Angela, Sofjan, Iwan, Subramaniam, Kathirvel, Avidan, Michael, Maybrier, Hannah, Muench, Maxwell, and Wildes, Troy
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surgery ,postoperative care/methods ,cohort studies ,operative/mortality ,data ,postoperative care/statistics and numerical ,Medicine and Health Sciences ,critical care/utilisation ,surgical procedures - Abstract
Background: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. Methods: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. Results: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with amedian hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. Conclusions: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care.
- Published
- 2016
5. Timing of tectonism: SHRIMP dates on Damara granites, Namibia
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Gerrit.S. De Kock and Armstrong, Richard
- Published
- 2014
- Full Text
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6. SHRIMP dating on magmatic rocks from the Karibib-Otjimbingwe region, Namibia
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Gerrit.S. De Kock and Armstrong, Richard
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- 2014
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7. Akanyaru-Ankole Supergroup of Rwanda:Strata, structures and ages
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Gerrit.S. De Kock, Taufeeq Dhansay, and Armstrong, Richard
- Published
- 2014
- Full Text
- View/download PDF
8. CONSTITUTIVE MODELING OF LIQUEFACTION EFFECTS IN SLOPING GROUND
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Ziotopoulou, Katerina, Maharjan, Manika, Boulanger, Ross, Beaty, Michael, Armstrong, Richard, and Takahashi, Akihiro
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Condensed Matter::Soft Condensed Matter ,Physics::Geophysics - Abstract
Experimental studies on the deformation of clean sands under undrained cyclic direct simple shear loading show a progressive accumulation of shear strains both under a zero and a non-zero static shear stress ratio which represent level and sloping ground conditions, respectively. Single element numerical simulations of undrained cyclic loading using a number of constitutive models show that they all have certain limitations and that the effect of sloping ground conditions is particularly difficult to simulate for many of the models. Accurate prediction of the cyclic mobility behavior associated with the undrained cyclic loading of sand under a nonzero static shear stress ratio can be important for numerically simulating earthquake-induced deformations of slopes. This paper presents results from undrained cyclic direct simple shear tests on clean sands under static shear stress conditions, reviews findings from past experimental studies for these types of loading conditions, and presents examples of the performance of selected constitutive models in modeling the observed experimental results.
- Published
- 2014
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- View/download PDF
9. Radiocarbon Dates from Jar and Coffin Burials of the Cardamom Mountains Reveal a Previously Unrecorded Mortuary Ritual in Cambodia's Late- to Post-Angkor Period (15th-17th Centuries AD)
- Author
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Beavan, Nancy, Halcrow, Sian, McFadgen, Bruce, Hamilton, Derek, Buckley, Brendan M., Shewan, Louise, Sokha, Ouk, Fallon, Stewart, Miksic, John, Armstrong, Richard, O'Reilly, Dougald, Domett, Kate, and Chhem, K. R.
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Archaeology ,Funeral rites and ceremonies - Abstract
We present the first radiocarbon dates from previously unrecorded, secondary burials in the Cardamom Mountains, Cambodia. The mortuary ritual incorporates nautical tradeware ceramic jars and log coffins fashioned from locally harvested trees as burial containers, which were set out on exposed rock ledges at 10 sites in the eastern Cardamom Massif. The suite of 28 14C ages from 4 of these sites (Khnorng Sroal, Phnom Pel, Damnak Samdech, and Khnang Tathan) provides the first estimation of the overall time depth of the practice. The most reliable calendar date ranges from the 4 sites reveals a highland burial ritual unrelated to lowland Khmer culture that was practiced from cal AD 1395 to 1650. The time period is concurrent with the 15th century decline of Angkor as the capital of the Khmer kingdom and its demise about AD 1432, and the subsequent shift of power to new Mekong trade ports such as Phnom Penh, Udong, and Lovek. We discuss the Cardamom ritual relative to known funerary rituals of the pre- to post-Angkorian periods, and to similar exposed jar and coffin burial rituals in Mainland and Island Southeast Asia.
- Published
- 2012
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10. Kunstblasen und Kulturimperialismus
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Wiederstein, Michael and Armstrong, Richard
- Published
- 2011
- Full Text
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11. Geochronology and trace element chemistry of zircon and garnet from granulite xenoliths: Constraints on the tectonothermal evolution of the lower crust under central Spain
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Orejana García, David, Villaseca González, Carlos, Armstrong, Richard A., and Jeffries, Teresa E.
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Petrología - Abstract
The nature of the lower crust under central Spain can be constrained from the study of deep-seated xenoliths entrapped within ultrabasic alkaline dykes of upper Permian age. These xenoliths are predominantly metaigneous peraluminous felsic granulites. Cathodoluminescence (CL) imaging of zircons from these rocks reveals a complex internal structure with magmatic inherited cores (sometimes showing convoluted or blurred oscillatory zoning) and metamorphic homogeneous domains. U–Pb SHRIMP dating shows that zircon core formation took place in several stages, mainly during the Upper Proterozoic (674–542 Ma). These ages are likely related to a pre-Variscan (Cadomian) tectono-magmatic episode. Most of the geochronological data correspond to metamorphic unzoned grains and rims formed during the Variscan orogeny (274–320 Ma). This time period greatly overlaps the intrusion ages of the granitic batholith in central Spain, reinforcing the hypothesis that the granulites from the lower crust might be genetically related to the extraction of the felsic magmas. Trace element concentrations in zircon and accompanying garnets, determined by Laser Ablation ICP-MS, suggest that both phases were in equilibrium in the studied granulites. HREE partition coefficients estimated in one sample are very close to 1, resembling results from previous studies in similar granulitefacies rocks. The composition of the HREE-rich magmatic zircon cores contrast markedly with metamorphic grains equilibrated with garnet (GdN/YbNN0.37). It is also possible to distinguish several types of metamorphic zircon rims on the basis of Th, U and REE composition. Temperatures estimated on these latter domains using the Ti-in zircon thermometer indicate that they formed during granulite-facies metamorphism. Zircons with high Th/U ratios (2.7–3.3) yield high-T estimates (~1000 °C) and older ages (283–320 Ma), whereas zircons with low Th/U ratios (0.04–0.38) give lower temperatures (900–950 °C) and ages (274–283 Ma). The variation in Th/U values and Ce and Eu anomalies in zircons seems to be highly influenced by element availability during metamorphic reactions and partitioning with co-existing minerals, such as monazite and feldspar. The modification of zircon geochemistry and the relationship between the temperature of crystallization and age implies a significant variation of the metamorphic conditions associated with the cooling stage at the end of the Variscan orogeny.
- Published
- 2011
12. A morphometric study of the spatial patterns of TDP-43 immunoreactive neuronal inclusions in frontotemporal lobar degeneration (FTLD) with progranulin (GRN) mutation
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Armstrong, Richard A. and Cairns, Nigel J.
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Male ,Intranuclear Inclusion Bodies ,Frontotemporal lobar degeneration ,Article ,Progranulins ,mental disorders ,Humans ,Protein Precursors ,Aged ,Aged, 80 and over ,Inclusion Bodies ,Neurons ,616.8 - Neurología. Neuropatología. Sistema nervioso ,Brain ,nutritional and metabolic diseases ,Neurofibrillary Tangles ,Organ Size ,Middle Aged ,nervous system diseases ,DNA-Binding Proteins ,nervous system ,TDP-43 Proteinopathies ,Mutation ,Intercellular Signaling Peptides and Proteins ,Female ,Frontotemporal Lobar Degeneration - Abstract
Mutations of the progranulin (GRN) gene are a major cause of familial frontotemporal lobar degeneration with transactive response (TAR) DNAbinding protein of 43kDa (TDP-43) proteinopathy (FTLD-TDP). We studied the spatial patterns of TDP-43 immunoreactive neuronal cytoplasmic inclusions (NCI) and neuronal intranuclear inclusions (NII) in histological sections of the frontal and temporal lobe in eight cases of FTLD-TDP with GRN mutation using morphometric methods and spatial pattern analysis. In neocortical regions, the NCI were clustered and the clusters were regularly distributed parallel to the pia mater; 58% of regions analysed exhibiting this pattern. The NII were present in regularly distributed clusters in 35% of regions but also randomly distributed in many areas. In neocortical regions, the sizes of the regular clusters of NCI and NII were 400-800 µm, approximating to the size of the modular columns of the cortico-cortical projections, in 31% and 36% of regions respectively. The NCI and NII also exhibited regularly spaced clustering in sectors CA1/2 of the hippocampus and in the dentate gyrus. The clusters of NCI and NII were not spatially correlated. The data suggest degeneration of the cortico-cortical and cortico-hippocampal pathways in FTLD-TDP with GRN mutation, the NCI and NII affecting different clusters of neurons.
- Published
- 2011
13. Triassic metamorphism in the northern part of the Central cordillera of Colombia
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Ordóñez-Carmona, Oswaldo, Restrepo, Jorge Julian, and Armstrong, Richard
- Published
- 2010
- Full Text
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14. U-Pb SHRIMP AND Rb-Sr AGES OF THE SONSÓN BATHOLITH
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Ordóñez-Carmona, Oswaldo, Pimentel, Marcio, Armstrong, Richard, Gioia, Simone, and Junges, Sergio
- Published
- 2001
- Full Text
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15. Richard Artschwager : lucid opacity = Erhellung durch Verhüllung
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Armstrong, Richard and Nansen
- Published
- 1996
- Full Text
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16. Characterization of FITC-Conjugated Lectin Binding to Candida albicans
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Smith, Stephen N., Armstrong, Richard A., Bird, Roger A., Rita Chohan, Hartell, Nick A., and David R Poyner
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Physiology ,Genetics ,Cell Biology ,General Medicine ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics - Published
- 2001
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17. 7. RAA thesis: Chapter 6: The radial growth of lichen thalli at different locations on a rock surface
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Armstrong, Richard A.
- Published
- 1974
- Full Text
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18. Cumulus ... from America : fil-o-fax
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Armstrong, Richard and Brockmann, Elisabeth
- Published
- 1986
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19. 6. RAA Thesis Chapter 5: Small-scale pattern in lichen thalli on rock surfaces
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Armstrong, Richard A.
- Published
- 1974
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20. 4. RAA Thesis Chapter 3: The effect on growth of transplanting four saxicolous lichens to rock surfaces of different aspect
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Armstrong, Richard A.
- Published
- 1974
- Full Text
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21. 10. RAA thesis: Chapter 9: An application of life tables to the age structure of lichen populations
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Armstrong, Richard A.
- Published
- 1974
- Full Text
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22. 11. RAA Thesis: References and Appendices
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Armstrong, Richard A.
- Published
- 1974
- Full Text
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23. 8. RAA thesis: Conclusion to section B and chapter 7: The succession of lichen communities on rock surfaces in an area of south Merionethshire, Wales
- Author
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Armstrong, Richard A.
- Published
- 1974
- Full Text
- View/download PDF
24. 9. RAA thesis. Chapter 8: A method of estimating the age of a lichen thallus and the age structure of a lichen population on a substratum of unknown age
- Author
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Armstrong, Richard A.
- Published
- 1974
- Full Text
- View/download PDF
25. Allen County Data Bank
- Author
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Armstrong, Richard E.
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LOGIC ,local government information control ,real estate data - Published
- 1967
26. A triassic time scale dilemma : K-Ar dating of Upper Triassic mafic igneous rocks, Eastern U.S.A. and Canada and Post-Upper Triassic plutons, Western Idaho, U.S.A
- Author
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Armstrong, Richard Lee and Besancon, James
- Published
- 1970
- Full Text
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27. The multistage crystallization of zircon in calc-alkaline
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Pereira, M. Francisco, Chichorro, Martim, Patrícia Moita, Santos, J. Francisco, Sola, A. M. Rita, Williams, Ian S., Silva, Jose B., and Armstrong, Richard A.
28. Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations
- Author
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Jacqueline Boultwood, Emmanouela Repapi, Christopher J. Smith, Richard N. Armstrong, Eva Hellström-Lindberg, Thomas Luft, Sally Killick, Stephen S. Taylor, Marco L. Hennrich, Anne-Claude Gavin, Eshita Sharma, Helen Lockstone, Luca Malcovati, Andrea Sanchi, Angela Hamblin, Paresh Vyas, Andrea Pellagatti, Anna Schuh, Hamid Dolatshad, Stephen Smith, Violetta Steeples, Aleksandar Radujkovic, Patrick Horn, Mario Cazzola, John Broxholme, Swagata Roy, Anthony D. Ho, Elli Papaemmanuil, Shalini Singh, Aristoteles Giagounidis, Pellagatti, Andrea [0000-0002-6122-0221], Armstrong, Richard N [0000-0001-7744-5890], Boultwood, Jacqueline [0000-0002-4330-2928], and Apollo - University of Cambridge Repository
- Subjects
0301 basic medicine ,Spliceosome ,Splicing Factor U2AF/genetics ,DNA Repair ,RNA Splicing ,Immunology ,Serine-Arginine Splicing Factors/genetics ,Biology ,medicine.disease_cause ,Biochemistry ,Cohort Studies ,03 medical and health sciences ,Splicing factor ,Phosphoproteins/genetics ,hemic and lymphatic diseases ,medicine ,Humans ,RNA Splicing Factors/genetics ,Spliceosomes/genetics ,Gene ,Myelodysplastic Syndromes/epidemiology/genetics ,Regulation of gene expression ,Gene knockdown ,Mutation ,Serine-Arginine Splicing Factors ,Cell Biology ,Hematology ,Phosphoproteins ,Splicing Factor U2AF ,Survival Analysis ,Phenotype ,030104 developmental biology ,Gene Expression Regulation ,Myelodysplastic Syndromes ,RNA splicing ,Spliceosomes ,Cancer research ,RNA Splicing Factors - Abstract
SF3B1, SRSF2, and U2AF1 are the most frequently mutated splicing factor genes in the myelodysplastic syndromes (MDS). We have performed a comprehensive and systematic analysis to determine the effect of these commonly mutated splicing factors on pre-mRNA splicing in the bone marrow stem/progenitor cells and in the erythroid and myeloid precursors in splicing factor mutant MDS. Using RNA-seq, we determined the aberrantly spliced genes and dysregulated pathways in CD34+ cells of 84 patients with MDS. Splicing factor mutations result in different alterations in splicing and largely affect different genes, but these converge in common dysregulated pathways and cellular processes, focused on RNA splicing, protein synthesis, and mitochondrial dysfunction, suggesting common mechanisms of action in MDS. Many of these dysregulated pathways and cellular processes can be linked to the known disease pathophysiology associated with splicing factor mutations in MDS, whereas several others have not been previously associated with MDS, such as sirtuin signaling. We identified aberrantly spliced events associated with clinical variables, and isoforms that independently predict survival in MDS and implicate dysregulation of focal adhesion and extracellular exosomes as drivers of poor survival. Aberrantly spliced genes and dysregulated pathways were identified in the MDS-affected lineages in splicing factor mutant MDS. Functional studies demonstrated that knockdown of the mitosis regulators SEPT2 and AKAP8, aberrantly spliced target genes of SF3B1 and SRSF2 mutations, respectively, led to impaired erythroid cell growth and differentiation. This study illuminates the effect of the common spliceosome mutations on the MDS phenotype and provides novel insights into disease pathophysiology.
- Published
- 2018
- Full Text
- View/download PDF
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