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2. Serum lipoprotein pattern as modified in G6PD-deficient children during haemolytic anaemia induced by fava bean ingestion

Author

Dessi, S., Batetta, B., Spano, O., Pulisci, D., Mulas, M. F., Muntoni, S., Armeni, M., Sanna, C., Roberto ANTONUCCI, and Pani, P.

Subjects
Male, Anemia, Hemolytic, Hyperplasia, Lipoproteins, Cholesterol, HDL, Favism, Cholesterol, LDL, Glucosephosphate Dehydrogenase Deficiency, Bone Marrow, Child, Preschool, Humans, lipids (amino acids, peptides, and proteins), Female, Child, Research Article
Abstract

In the present study, plasma lipid concentrations were determined at different times after admission in sera from G6PD-deficient children during haemolytic crisis induced by fava bean ingestion. Reductions in total, LDL and HDL cholesterol were found in association with the maximum of bone marrow hyperplasia. A return towards normal values occurred with regression of the disease. No changes in other lipid parameters were observed. These data suggest that alterations of lipoprotein pattern, other than in experimental animals, are also present in humans with non-malignant proliferative processes. These changes appear to be a consequence of the disease, probably due to an increased utilization of cholesterol by proliferating cells.

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