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Objectives To evaluate the outcomes of delayed intravitreal injections (IVIs) caused by the outbreak of coronavirus disease 2019 (COVID-19), in patients with neovascular age-related macular degeneration (nAMD). Methods nAMD patients with scheduled IVIs between March 1st and April 30th, 2020 were stratified through a risk-based selection into a non-adherent group (NA-group) if they skipped at least one IVI and an adherent group (A-group) if they followed their treatment schedule. During the pandemic visit (v0), if a significant worsening of the disease was detected, a rescue therapy of three-monthly IVIs was performed. Multimodal imaging and best-corrected visual acuity (BCVA) findings were evaluated after 6 months (v6), compared between groups and with the visit prior the lockdown (v−1). Results Two hundred fifteen patients (132 females, mean age: 81.89 ± 5.98 years) delayed their scheduled IVI while 83 (53 females, mean age: 77.92 ± 6.06 years) adhered to their protocol. For both groups, BCVA at v0 was significantly worse than v−1 (mean 4.15 ± 7.24 ETDRS letters reduction for the NA-group and 3 ± 7.96 for the A-group) but remained stable at v6. The two groups did not significantly differ in BCVA trends after 6 months and neither for development of atrophy nor fibrosis. Conclusions A risk-based selection strategy and a rescue therapy may limit the long-term outcomes of an interruption of the treatment protocol in patients with nAMD.

Petra, famous for its monumental archaeology, is in danger: it is ‘crumbling’. This fragile sandstone wonder has fallen victim to degradation. This research sheds light on the deterioration of valuable archaeology in the Petra Archaeological Park. It is aimed to clarify the factors contributing to this decay and the need for active and continuous protection. Additionally, it highlights specific monuments and natural features within the archaeological park which require a ention regarding their deterioration and safety-risks. Protecting Petra equally means the safeguarding of perishable data. Through reviewing Petra’s geo-archaeological data, applying safety regulations, and conducting extensive risk- and damage-assessments, its archaeology and safety can be maintained.