225 results on '"Arcocha, A."'
Search Results
2. Rendimiento de la PET/TC con 11C-colina en el seguimiento del cáncer de próstata
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I. Martínez-Rodríguez, M. de Arcocha-Torres, F.J. Gómez-de la Fuente, J. Jiménez-Bonilla, A. Sánchez-Salmón, N. Martínez-Amador, V. Mendi-Barcina, J. Andrés-Pacheco, A. Gutiérrez-González, M. Pombo-López, A. Bota-Bota, M. Rodil-Gallego, A. García-Ruiz, and R. Quirce
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Radiology, Nuclear Medicine and imaging - Published
- 2023
3. Tratamiento a distancia de la insuficiencia cardiaca mediante el algoritmo HeartLogic. Registro RE-HEART
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Juan Gabriel Martínez, Rocío Cózar León, Nuria Rivas Gándara, Paula Sánchez-Aguilera, Nicasio Pérez Castellano, Ana B. Méndez Fernández, Olga Medina Moreno, Luis González Torres, Javier de Juan Bagudá, Óscar González Fernández, Pablo Ramos Ruiz, Carlos de Diego Rus, Virgilio Martínez Mateo, como representantes del grupo del registro Re-Heart, Juan F. Jimenez, Natalia Marrero Negrín, Josebe Goirigolzarri Artaza, Alfonso Macías Gallego, María F. Arcocha Torres, Gonzalo Luis Alonso Salinas, Juan José Gavira Gómez, Marta Pachón Iglesias, David Cordero Pereda, Manuel J. Fernández-Anguita, Inés Madrazo Delgado, Fernando Arribas Ynsaurriaga, Ignacio García Bolao, Rafael Salguero Bodes, Laura Peña Conde, Ernesto Díaz Infante, José Manuel López, Beatriz Díaz Molina, and Vanessa Escolar Pérez
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business.industry ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Humanities - Abstract
Resumen Introduccion y objetivos HeartLogic es un algoritmo multiparametrico incorporado a desfibriladores automaticos implantables (DAI). La alerta asociada predice descompensaciones de insuficiencia cardiaca (IC). Nuestro objetivo es analizar la asociacion entre alertas y eventos clinicos bajo un protocolo de seguimiento comun en un registro multicentrico. Metodos Se evaluaron la fase 1 (investigadores ciegos al estado de la alerta) y las fases 2 y 3 (tras la activacion de HeartLogic, segun practica local y un protocolo comun respectivamente). Resultados Se incluyo a 288 pacientes en 15 centros. En fase 1, tras una media de observacion de 10 meses, hubo 73 alertas (0,72 alertas/paciente-ano), con 8 hospitalizaciones y 2 visitas a urgencias por IC (0,10 eventos/ano-paciente). No hubo hospitalizaciones fuera del periodo de alerta. Las fases activas tuvieron una media de seguimiento de 16 (IC95%, 15-22) meses, con 277 alertas (0,89 alertas/ano-paciente); 33 se asociaron con hospitalizaciones o muerte por IC, 46 con descompensaciones menores y 78 con otros eventos. La tasa de alertas inexplicables fue 0,39/ano-paciente. Fuera del estado de alerta solo hubo una hospitalizacion y una descompensacion menor. La mayoria de las alertas (el 82% en fase 2 y el 81% en fase 3; p = 0,861) se gestionaron a distancia. La mediana de NT-proBNP fue superior en estado de alerta que fuera de el (7.378 frente a 1.210 pg/ml; p Conclusiones El indice HeartLogic se asocio con descompensaciones de IC y otros eventos relevantes, con baja tasa de alertas inexplicables. Un protocolo estandarizado permitio detectar y actuar a distancia con seguridad sobre las alertas.
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- 2022
4. Indios y negros en los documentos coloniales: género y relaciones interétnicas
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Rosa María Spinoso Arcocha
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General Medicine - Abstract
El propósito de este artículo es realizar una aproximación histórica con perspectiva de género a las relaciones interétnicas entre los indios y la población de origen africano en el México colonial, con base en la Historia Cultural y los enunciados teóricos del Dr. Patrick Carroll, así como de otros especialistas dedicados a los temas afroamericanos. Para Carroll (1995), los criterios hegemónicos usados durante la Colonia para la identificación de los indios y los negros fueron inoperantes, pero no fueron únicos: cada uno de estos grupos tenía sus propios criterios de identificación para sí y para los otros, y esto se reflejó en sus relaciones con los demás, en los índices y motivaciones de la endogamia y la exogamia de cada grupo, en las estrategias de género y de resistencia para hacer frente a las situaciones coyunturales de la vida cotidiana. Eso es lo que me propongo mostrar en los cuatro casos analizados, procedentes del acervo documental del Archivo General de la Nación (AGN), que fueron seleccionados por reunir las características más representativas de esos enunciados.
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- 2023
5. Clinical application of [18F]FDG PET/CT in follicular lymphoma
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A. Díaz-Silván, L.F. Otón-Sánchez, A.P. Caresia-Aróztegui, M. del Puig Cózar-Santiago, J. Orcajo-Rincón, M. de Arcocha-Torres, R.C. Delgado-Bolton, and D. Cabello-García
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General Engineering ,General Earth and Planetary Sciences ,General Environmental Science - Published
- 2022
6. Aplicación clínica de la [18F]FDG PET/TC en el linfoma folicular
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A. Díaz-Silván, L.F. Otón-Sánchez, A.P. Caresia-Aróztegui, M. del Puig Cózar-Santiago, J. Orcajo-Rincón, M. de Arcocha-Torres, R.C. Delgado-Bolton, and D. Cabello-García
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Radiology, Nuclear Medicine and imaging - Published
- 2022
7. Utilidad de los radioligandos PSMA en el diagnóstico y tratamiento del carcinoma de próstata
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M. Rodríguez-Fraile, P. Tamayo Alonso, Juan José Rosales Castillo, María de Arcocha-Torres, A.P. Caresia-Aróztegui, M. Puig Cózar-Santiago, Javier Orcajo-Rincon, Marc Simó Perdigó, Roberto Carlos Delgado Bolton, and C. Artigas Guix
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Radiology, Nuclear Medicine and imaging - Published
- 2022
8. EFFECT OF THREE GREEN MANURES ON THE AGRONOMIC CHARACTERISTICS OF NATIVE X’MEJEN NAAL MAIZE IN CAMPECHE, MEXICO
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MONICA BEATRIZ LOPEZ HERNANDEZ, GILBERTO MATOS PECH, ENRIQUE ARCOCHA GOMEZ, NOEL ANTONIO GONZALEZ VALDIVIA, PATRICIA MARGARITA GARMA QUEN, and ELIAS DE JESUS ECHAVARRIA GONGORA
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Animal Science and Zoology ,Plant Science ,Agronomy and Crop Science ,General Environmental Science - Abstract
In the agronomic management of maize (Zea mays L.), chemical fertilizers can be substituted for fertilizing techniques that reduce the pollutant effect of the excessive use of commercial fertilizers. The hypothesis was the green manure of legumes with or without the inoculation of microorganisms are capable of promoting agronomic characteristics of X’mejen Naal maize, comparable to conventional fertilization. In order to measure the effect in the agronomic characteristics of X´mejen Naal maize, an experiment was designed in complete randomized blocks in a bifactorial arrangement with four repetitions, in which three green manures were tested, with or without the inoculation of Fosfonat (endomycorrhizas, EM, plus nitrogen fixating bacteria, NFB). Treatments were Mucuna (Mucuna pruriens, T1=MUC), Xpelón (Vigna unguiculata, T2=PEL), Ibes (Phaseolus lunatus, T3=IBE), inoculated Mucuna (T4=MUCEM), inoculated Xpelón (T5=PELEM), inoculated Ibes (T6= IBEEM) and the control with the incorporated biomass of weeds plus the addition of 200 kg ha-1 of diammonium phosphate (T7=ARDAP). Results showed that there were only differences caused by the types of green manure and their interaction with the inoculated symbionts in the fresh weight or biomass in X´mejen Naal maize. IBE and ARDAP stood out in fresh weight (1162 and 1251 g), dry weight (168.6 and 163.6 g), 7.3 Mg ha-1 (Megagrams per hectare) in the dry aerial biomass in the maize plants, respectively. Despite the grain yield of maize was similar among treatments, it was noticeable that the higher average yields were also observed in IBE and ARDAP with 3.5 and 3.3 Mg ha-1 respectively. All yields (fodder and grain) managed to express the potential of the X´mejen Naal, which is relevant to recommend the use of green manures as an agro-environmental alternative to conventional fertilization in the Luvisol soils of Campeche.
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- 2022
9. Efecto de abonos verdes inoculados en las propiedades químicas de un luvisol férrico de Campeche, México
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Gilberto Matos-Pech, Enrique Arcocha-Gómez, Mónica Beatriz López-Hernández, Patricia Garma-Quen, Noel Antonio González-Valdivia, and Elías de Jesús Echavarría-Góngora
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Ecology ,Soil Science ,Pollution ,Biochemistry ,Ecology, Evolution, Behavior and Systematics - Abstract
Se realizó un experimento en campo con el objetivo de evaluar los efectos de la aplicación de tres abonos verdes de leguminosas sobre algunas propiedades químicas en un luvisol férrico (K´an kab en maya), representativo de las zonas agrícolas del estado de Campeche. Se utilizó un diseño de bloques completos al azar con siete tratamientos: Mucuna pruriens L., Vigna unguiculata L. y Phaseolus lunatus inoculados o no con endomicorrizas y bacterias benéf icas f ijadoras de nitrógeno, comparadas con el testigo constituido por la incorporación de arvenses más fosfato diamónico (DAP). Los resultados demuestran que todas las propiedades del suelo estudiadas: Materia orgánica (MOS), conductividad eléctrica (CE), características de pH, así como la determinación del contenido macronutrientes (N, P, K, Ca, Mg y Na), micronutrientes (B, Fe, Mn, Cu, Zn), suma bases intercambiables (meq/100 g) y la relación C/N, se comportaron de manera semejante en términos estadísticos (P < 0.05). Los abonos verdes lograron aportes de nutrientes equiparables a la fertilización que combinaba el DAP con la biomasa incorporada de arvenses, lo cual evidencia, que el uso de abonos verdes, incluso de especies leguminosas cultivadas como alimento en los agroecosistemas de la Península de Yucatán, pueden sustituir la fertilización convencional en luvisoles férricos de Campeche, México.
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- 2022
10. Effectiveness of
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I, Martínez-Rodríguez, M, de Arcocha-Torres, F J, Gómez-de la Fuente, J, Jiménez-Bonilla, A, Sánchez-Salmón, N, Martínez-Amador, V, Mendi-Barcina, J, Andrés-Pacheco, A, Gutiérrez-González, M, Pombo-López, A, Bota-Bota, M, Rodil-Gallego, A, García-Ruiz, and R, Quirce
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Our aim was to analyse the performance of [Three hundred and twenty-nine [Two hundred and nineteen (66.6%) out of the 329 PET/CT examinations were positive. The percentage of positive examinations was significantly higher in patients with other initial treatment than RP compared to patients with RP (85.6% vs. 43.6%, respectively). One hundred and thirty PET/CT (59.4%) showed local recurrence, 48 (21.9%) distant recurrence, and 41 (18.7%) local plus distant recurrence. Initial therapeutic approach was changed in 139 cases (63.5%). In the subgroup of 81 [[
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- 2022
11. Molecular characterization of advanced non-small cell lung cancer patients by cfDNA analysis: experience from routine laboratory practice
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Joan Antón Puig-Butillé, Iván Victoria, Roxana Reyes, Cristina Sánchez, Noemi Reguart, José Manuel González de Aledo-Castillo, Ana Isabel Martinez-Puchol, Nuria Viñolas, Pedro Jares, Ainara Arcocha, and Gabriel Felipe Rodríguez
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0301 basic medicine ,Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,non-small cell lung cancer (NSCLC) ,Cancer ,Gold standard (test) ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,Biopsy ,medicine ,Biomarker (medicine) ,Original Article ,Stage (cooking) ,business ,Prospective cohort study ,Lung cancer - Abstract
BACKGROUND: Analysis of circulating free DNA (cfDNA) by the real-time PCR cobas(®) EGFR Mutation Test v2 (cobas(®) EGFR Test) is a diagnostic approach used in clinical practice for the characterization of advanced non-small cell lung cancer (NSCLC) patients. The test additionally outputs a semiquantitative index (SQI) which reflects the proportion of mutated versus wild-type copies of the EGFR gene in cfDNA with potential use as a biomarker. CfDNA concentration and cfDNA fragmentation pattern have also shown potential utility as biomarkers for cancer patients. We evaluated the implementation of EGFR testing and cfDNA related parameters in NSCLC patients in routine clinical setting as biomarkers for disease stage and diagnosis. METHODS: A prospective cohort of 173 locally advanced or metastatic NSCLC TKI-naïve patients analyzed by the cobas(®) EGFR Test were included in the study. Reproducibility of the test was assessed in 56 patients. The concentration of cfDNA and fragment size pattern was measured using fluorometry and microchip electrophoresis respectively. RESULTS: The test showed high diagnostic accuracy when compared to the gold standard of biopsy tumor tissue testing. The SQI value showed a moderate reproducibility (r(2)=0.70) and did not correlate with cfDNA concentration (r(2)=0.17, P=0.28) or disease stage (stage III patients SQI =9.1±3.1 and stage IV patients SQI =11.5±4.8, P=0.41). We found differences in SQI values according to the type of EGFR mutation (Ex19Del mutations, SQI =13.6; p.L858R, SQI =8.88; P=0.001). Stage IV patients had higher concentrations of cfDNA (P
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- 2021
12. 152P Role of occupation in patients with non-small cell lung cancer (NSCLC) in Spain: Data from the SCAN study
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J.C. Laguna Montes, F. Turrisi, V. Albarran, L. Gonzalez-Aguado, T. Gorría Puga, I. Nalda Ariza, B. Pastor, M. Potrony, M. Garcia De Herreros, F.J. Muñoz i Carrillo, O. Castillo, P. Blasco, R. Reyes, N. Viñolas, S. Hijazo-Pechero, X. Sole, A. Arcocha, C. Teixido, N. Reguart, and L. Mezquita
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Pulmonary and Respiratory Medicine ,Oncology - Published
- 2023
13. OA13.04 Prevalence of Molecular Alterations in NSCLC and Estimated Indoor Radon in Europe: RADON EUROPE Study
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M. Garcia, M. Garcia de Herreros, E. Auclin, G. Caravaca, J. Sart, M. Riudavets, D. Vasseur, V. Albarran-Artahona, J.C. Laguna, T. Gorria, R. Lopez Castro, C. Teixido, G. Castellano, A. Bedmar Martinez, A. Arcocha, N. Vinolas, R. Reyes, A. Prat, N. Reguart, J. Elio, N. Leighl, B. Besse, and L. Mezquita
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Pulmonary and Respiratory Medicine ,Oncology - Published
- 2022
14. GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide
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Haas, S., Camm, J.A., Harald, D., Steffel, J., Virdone, S., Pieper, K., Brodmann, M., Schellong, S., Misselwitz, F., Kayani, G., Kakkar, A.K., Jean-Pierre, B., John Camm, A., Fitzmaurice, D.A., Fox, K.A.A., Gersh, B.J., Goldhaber, S.Z., Shinya, G., Sylvia, H., Werner, H., Mantovani, L.G., Frank, M., Pieper, K.S., Turpie, A.G.G., Martin van Eickels, Verheugt, F.W.A., Fox Bernard, K.A.A., Gersh, J., Hector, L., Luciardi Harry Gibbs, Marianne, B., Frank, C., Antonio Carlos Pereira Barretto, Connolly, S.J., John, E., Ramon, C., Zhi-Cheng, J., Petr, J., Jørn Dalsgaard Nielsen, Hany, R., Pekka, R., Jean-Yves Le Heuzey, Matyas, K., Jitendra Pal Singh Sawhney, Giancarlo, A., Giuseppe, A., Yukihiro, K., Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan, A., Janina, S., Elizaveta, P., Toon Wei Lim, Barry, J., Seil, O., Xavier, V., Marten, R., Jan, S., Pantep, A., Ali, O., Alex, P., Wael Al Mahmeed, David, F., Samuel, Z.G., Dayi Hu Kangning Chen, Yusheng, Z., Huaiqin, Z., Jiyan, C., Shiping, C., Daowen, W., Yuejin, Y., Weihua, L., Hui, L., Yuehui, Y., Guizhou, T., Ping, Y., Yingmin, C., Shenghu, H., Yong, W., Guosheng, F., Xin, L., Tongguo, W., Xiaoshu, C., Xiaowei, Y., Ruiping, Z., Moshui, C., Longgen, X., Ping, C., Yang, J., Ying, G., Xue, L., Zhiming, Y., Praveen Jadhavm Raghava Sarma, Govind, K., Prakash, C., Rasesh Atulbhai Pothiwala, Mohanan Padinhare Purayil, Kamaldeep, C., Veerappa Annasaheb Kothiwale, Bagirath, R., Vinod Madan Vijan, Jitendra, S., Ganapathi, B., Aziz, K., Ramdhan, M., Manojkumar, C., Sunitha, A., Vikas, B., Govindan, V., Debabrata, R., Rajashekhar, D., G Ravi Shankar, A., Sunil, K., Dinesh, J., Kartikeya, B., Vinay, K., Udigala Madappa Nagamalesh, Rajeeve Kumar Rajput, Yukihiro Koretsune Seishu Kanamori, Kenichi, Y., Koichiro, K., Yosuke, K., Keiki, Y., Fumitoshi, T., Yuji, M., Ikuo, M., Hiroo, N., Shinichi, A., Tetsuro, S., Masahiro, M., Hiroyuki, O., Susumu, A., Kei, C., Hiroaki, N., Makoto, T., Takeshi, K., Kunihiko, Y., Hiroshi, A., Takayuki, H., Megumi, O., Shiro, A., Shinichiro, K., Kenshi, K., Takashi, M., Jun, M., Yurika, O., Ryuji, S., Kazuo, G., Kotaro, M., Yoshikuni, H., Hisakazu, S., Hiroo, M., Hitoshi, K., Tsugihiro, N., Tadashi, N., Hidekazu, N., Ryuji, Z., Yoshihisa, F., Akira, Y., Hiroyuki, N., Jun, O., Yasuyuki, K., Kinshiro, M., Yutaka, W., Masanori, Y., Hiromitsu, M., Sumihisa, A., Hajime, K., Satoru, T., Katsumi, S., Hiroki, T., Ichiro, O., Takashi, K., Satoshi, H., Masamichi, G., Takuma, E., Hidetoshi, C., Kazuaki, F., Yuhei, S., Hirokuni, S., Toshihisa, N., Yoshihiko, A., Toshiro, N., Kazuhisa, S., Fumihiro, H., Naoto, Y., Masahiro, K., Toshifumi, T., Munesumi, I., Yoshitake, F., Daisuke, I., Taku, S., Tetsu, I., Norio, I., Koichi, O., Keizo, T., Yutaka, H., Motoshi, T., Hiroto, T., Shinjiro, N., Masaaki, I., Yuichiro, N., Naomasa, M., Ashida, K., Jun, A., Seishiro, M., Osamu, A., Shuji, F., Hirofumi, M., Kazuya, M., Yoshiki, H., Ichiro, S., Kotaro, O., Ichiro, T., Mitsuyuki, A., Toshihide, U., Yoshinori, G., Makoto, I., Shoji, M., Shigeru, M., Hideo, D., Mitsuru, T., Takaaki, K., Shigeo, K., Chiga, O., Masaki, S., Masami, N., Yutaka, K., Yoichi, N., Hiroshi, O., Rikimaru, O., Masato, A., Teruaki, M., Kazuhiko, N., Takafumi, M., Junichi, M., Mitsunori, A., Masako, F., Makoto, O., Tsuneo, F., Toshiya, T., Tenei, K., Hiroshi, K., Mizuho, I., Masahiro, A., Takashi, U., Hironori, O., Masahiko, I., Yoshiki, K., Atsuyuki, N., Shinobu, T., Mitsuhiro, S., Masayuki, N., Kenichiro, I., Motoyuki, I., Taro, M., Masamichi, W., Hiroaki, M., Masato, M., Fumio, O., Teruaki, K., Kuniaki, T., Masaaki, T., Morio, I., Hiroshi, W., Toshihiko, S., Shinya, H., Hiroaki, H., Mitsumoto, H., Michitaka, H., Koichi, M., Hideki, H., Nobuyoshi, S., Yukio, S., Akira, S., Kazuo, N., Tetsuro, Y., Kunio, A., Sen, A., Chiei, T., Saori, M., Hirofumi, K., Masanori, K., Shiro, N., Atsushi, T., Shuta, T., Kazuyuki, S., Akiko, M., Hiroki, S., Jin, N., Taketo, H., Takash, I., Kazuki, S., Kazuya, K., Tomobumi, K., Tsuyoshi, T., Hirosumi, S., Kiyoshi, N., Kenichi, I., Kazuo, M., Tomohiro, S., Takeshi, I., Koichi, K., Hiromichi, K., Tsutomu, T., Mamoru, H., Jisho, K., Akitoshi, S., Yoshihiro, T., Tetsuo, B., Koji, H., Masaaki, H., Koichi, H., Takao, B., Kazuaki, M., Toshihiko, K., Kunihiko, H., Toshihide, K., Akira, N., Eiji, O., Takashi, S., Hiroyoshi, H., Chikako, S., Takashi, Y., Ichiro, M., Kazunori, S., Isamu, N., Ken, T., Osamu, I., Koichi, T., Samu, U., Hirokazu, K., Takuya, O., Seizo, O., Junya, K., Toshihiko, N., Itaru, M., Yoshifusa, M., Yasuyuki, M., Kazuo, T., Hajime, H., Tetsutaro, K., Koji, M., Masaichi, N., Takashi, W., Tomoki, Y., Masato, S., Hidekazu, A., Hisanori, S., Hiroyuki, T., Nobufusa, F., Akira, O., Kentaro, Y., Kenji, A., Taku, Y., Takeaki, K., Shunji, S., Shu, S., Nitaro, S., Masayuki, W., Yosuke, N., Toru, A., Masaki, O., Tetsushi, W., Tomoko, K., Yasuo, S., Takeshi, T., Yoshihito, H., Shinichi, H., Yukihiko, A., Yoshihiro, S., Hirohide, U., Hiroshi, T., Shuichi, T., Naoto, H., Seiichi, M., Hisashi, S., Takuma, A., Yasunobu, S., Yawara, N., Osamu, M., Hideko, I., Katsumasa, N., Masatsugu, N., Kazuo, S., Toshiyuki, F., Nobuhisa, I., Shunichi, N., Kiyoharu, S., Yujin, S., Naoko, O., Teruhiko, K., Hideaki, O., Masato, E., Tsutomu, G., Makoto, H., Emiko, N., Noriyuki, N., Toshizumi, M., Shuichi, S., Katsuhiro, O., Yoko, E., Tsuyoshi, F., Haruhiko, D., Shuichi, K., Sho, N., Yuya, U., Tetsuro, F., Mitsuru, I., Takuo, O., Shunsuke, T., Hideo, I., Norihiko, S., Kiyomitsu, I., Nobuo, W., Masatake, A., Junji, D., Tetsuya, K., Masato, T., Naoya, M., Yasuaki, F., Wataru, F., Susumu, S., Akinori, F., Ryosai, N., Hiroyasu, K., Rei, F., Keijiro, N., Yoji, K., Junya, A., Kiyoshi, Y., Toshio, A., Yasuhiro, S., Tatsuo, H., Yuichiro, K., Yasuhide, S., Yukihiro, S., Shingo, M., Kojuro, M., Yasuko, S., Toyoshi, S., Fumiko, I., Toshiyuki, K., Jaeyoung, K., Hiroshi, Y., Yoichi, T., Yoko Onuki Pearce, Yasuyuki, S., Takayuki, F., Toru, N., Hideaki, K., Yoshiyuki, K., Tetsuji, I., Hironori, M., Yasufumi, M., Masahito, S., Shimato, O., Yutaka, O., Satoshi, U., Kojiro, K., Tatsuo, O., Naoki, M., Koichi, I., Atsushi, I., Tomohiro, Y., Toshihiro, G., Tsukasa, K., Atsushi, S., Etsuo, M., Toshio, T., Hiroshi, S., Shunichi, F., Tomohiro, K., Yoshiyuki, F., Hiroshi, H., Jun, N., Kiichiro, Y., Takuya, I., Takafumi, A., Chi Keong Ching Toon Wei Lim, Kelvin, W., Tan, Y., Seil Oh Hui Nam Park, Woo-Shik, K., Hyeyoung, L., Sung-Won, J., Dae Hyeok Kim, Jun, K., Dongryeol, R., Jaemin, S., Dae-Kyeong, K., Dong Ju Choi, Yong Seog Oh, Myeong-Chan, C., Hack-Lyoung, K., Hui-Kyung, J., Dong-Gu, S., Sang Weon Park, Hoon Ki Park, Sang-Jin, H., Jung Hoon Sung, Hyung-Wook, P., Gi-Byoung, N., Young Keun On, Hong Euy Lim, Jaejin, K., Tae-Joon, C., Taek Jong Hong, Seong Hoon Park, Jung Han Yoon, Nam-Ho, K., Kee-Sik, K., Byung Chun Jung, Gyo-Seung, H., Chong-Jin, K., Sakda Rungaramsin Peerapat Katekangplu, Porames, K., Thanita, B., Wanwarang, W., Pinij, K., Khanchai, S., Waraporn, T., Supalerk, P., Khanchit, L., Doungrat, C., Warangkana, B., Sirichai, C., Songkwan, S., Pisit, H., Seksan, C., Pairoj, C., Boonsert, C., Yingsak, S., Khompiya, K., Piya, M., Sasivimon, J., Ongkarn, K., Armagan Altun Ali Aydinlar, Ramazan, T., Zeki, O., Sadik, A., Durmus Yildiray Sahin, Ozcan, Y., Mehmet Birhan Yilmaz, Hasan, P., Mesut, D., Murat, S., Levent, S., Murat, E., Ertugrul, O., Dursun, A., Florencia Rolandi Adrian Cesar Ingaramo, Gustavo Alberto Sambadaro, Vanina Fernandez Caputi, Sofia Graciela Berman, Pablo, D., Andres Javier Kleiban, Nestor, C., Rodolfo Andres Ahuad Guerrero, Leonel Adalberto Di Paola, Ricardo Dario Dran, Javier, E., Matias Jose Fosco, Victor Alfredo Sinisi, Luis Rodolfo Cartasegna, Oscar Gomez Vilamajo, Jose Luis Ramos, Sonia, S., Gerardo, Z., Diego, C., Guillermo, G., Alberto Alfredo Fernandez, Mario Alberto Berli, Fabian, F., Dário Celestino Sobral Filho Jefferson Jaber, Luciana Vidal Armaganijan, Costantino Roberto Frack Costantini, André, S., Weimar Kunz 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- Subjects
Vitamin K antagonists ,Atrial fibrillation ,GARFIELD-AF ,Non-vitamin K antagonist oral anticoagulants ,Oral anticoagulation ,Phenprocoumon ,Settore MED/11 - Malattie dell'Apparato Cardiovascolare - Abstract
The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is a worldwide non-interventional study of stroke prevention in patients with non-valvular AF.52,080 patients with newly diagnosed AF were prospectively enrolled from 2010 to 2016. 4121 (7.9%) of these patients were recruited in DACH [Germany (n = 3567), Austria (n = 465) and Switzerland (n = 89) combined], and 47,959 patients were from 32 countries in other regions worldwide (ORW). Hypertension was most prevalent in DACH and ORW (85.3% and 75.6%, respectively). Diabetes, hypercholesterolaemia, carotid occlusive disease and vascular disease were more prevalent in DACH patients vs ORW (27.6%, 49.4%, 5.8% and 29.0% vs 21.7%, 40.9%, 2.8% and 24.5%). The use of non-vitamin K antagonist oral anticoagulants (NOACs) increased more in DACH over time. Management of vitamin K antagonists was suboptimal in DACH and ORW (time in therapeutic range of INR ≥ 65% in 44.6% and 44.4% of patients or ≥ 70% in 36.9% and 36.0% of patients, respectively). Adjusted rates of cardiovascular mortality and MI/ACS were higher in DACH while non-haemorrhagic stroke/systemic embolism was lower after 2-year follow-up.Similarities and dissimilarities in AF management and clinical outcomes are seen in DACH and ORW. The increased use of NOAC was associated with a mismatch of risk-adapted anticoagulation (over-and-undertreatment) in DACH. Suboptimal control of INR requires educational activities in both regional groups. Higher rates of cardiovascular death in DACH may reflect the higher risk profile of these patients and lower rates of non-haemorrhagic stroke could be associated with increased NOAC use.
- Published
- 2022
15. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
- Author
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Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. 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A., Andersson, A., Malmqvist, L., Martinsson, B., Bernsten, F., Engdahl, J., Thulin, J., Hot-Bjelac, A., Stalby, P., Aaröe, H., Ahbeck, E., Ahlmark, H., Al-Khalili, F., Bonkowski, G., Dzeletovic, S., Ekstrand, A. -B., Eriksson, G. -B., Floren, K., Grässjö, C., Hahn, S., Jaensson, P., Jansson, B., Jansson, J. -H., Kangert, R. -M., Koch, A., Kusiak, D., Lettenström, A., Lindberg, A., Lindholm, C. -J., Mannermyr, A., Mansson, K., Millborg, M., Nilsson, C., Ohlin, A. -M., Olofsson, A., Osberg, A., Pedersen, A., Risbecker, K., Rosenberg, K., Samuelsson, J., Shayesteh, M., Skoglund, K., Stjernberg, M., Thorsen, C., Steffel, J., Beer, J. H., Debrunner, J., Amstutz, D., Bruegger, J., Elise, G., Grau, A., Guinand, A., Henriette, I., Saga, E., Winnik, S., Parkhomenko, A., Rudyk, I., Tseluyko, V., Karpenko, O., Zhurba, S., Kraiz, I., Kupnovytska, I., Serediuk, N., Mostovoy, Y., Ushakov, O., Koval, O., Kovalskyi, I., Svyshchenko, Y., Sychov, O., Stanislavchuk, M., Kraydashenko, O., Yagensky, A., Tykhonova, S., Fushtey, I., Belegai, R., Berko, G., Burdeuna, L., Chabanna, O., Daniuk, I., Ivanov, A., Kamenska, E., Kaplan, P., Khyzhnyak, O., Kizim, S., Matova, O., Medentseva, O., Mochonyi, V., Mospan, M., Nemtsova, V., Ovdiienko, T., Palamarchuk, O., Pavelko, M., Petrovskyy, R., Plevak, D., Proshak, O., Pyvovar, S., Rasputina, L., Romanenko, O., Romanova, O., Sapatyi, A., Shumakov, O., Stets, R., Todoriuk, L., Varenov, V., Fitzmaurice, D., Chauhan, N., Goodwin, D., Saunders, P., Evans, R., Leese, J., Jhittay, P. S., Ross, A., Kainth, M. S., Pickavance, G., Mcdonnell, J., Williams, A., Gooding, T., Wagner, H., Suryani, S., Singal, A., Sircar, S., Bilas, R., Hutchinson, P., Wakeman, A., Stokes, M., Paul, N., Aziz, M., Ramesh, C., Wilson, P., Franklin, S., Fairhead, S., Thompson, J., St Joseph, V., Taylor, G., Tragen, D., Seamark, D., Paul, C., Richardson, M., Jefferies, A., Sharp, H., Jones, H., Giles, C., Page, M., Oginni, O., Aldegather, J., Wetherwell, S., Lumb, W., Evans, P., Scouller, F., Macey, N., Stipp, Y., West, R., Thurston, S., Wadeson, P., Matthews, J., Pandya, P., Gallagher, A., Railton, T., Sinha, B., Russell, D., Davies, J. A., Ainsworth, P., Jones, C. P., Weeks, P., Eden, J., Kernick, D., Murdoch, W., Lumley, L., Patel, R. P., Wong, S. W., Saigol, M., Ladha, K., Douglas, K., Cumberlidge, D. F., Bradshaw, C., Van Zon, G., Jones, K. P., Thomas, M. J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A. R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J. L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N. I., Thompson, R., Chigbo, C., Zaidi, S. M. A., Howard, M., Butter, K. C., Barrow, S., Little, H., Haq, I. U., Gibbons, L., Glencross, S., Mcleod, A. J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R. N., Lowe, S., Kamath, R., Dau, H. S., Webster, J., Hodgins, I., Vercoe, S., Roome, P. C., Pinnock, H., Patel, J. R. A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C. A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A. C., Sabir, A., Choudhary, F., Khalaque, S., Wilson, A., Peters, S., Coulson, W., Roberts, N., Heer, A., Coates, S., Ward, B., Jackson, D., Walton, S., Shepherd, D., Sterry, M., Wong, T., Boon, M., Bunney, R., Haria-Shah, R., Baron, R. T., Davies, S., Schatzberger, T., Hargreaves, N., Stephenson, T., Choi, H., Batson, R., Lucraft, L., Myhill, T., Estifano, S., Geatch, D., Wilkinson, J., Veale, R., Forshaw, K., Davies, T., Zaman, K., Vinson, P., Liley, C., Bandrapalli, M., Mcginty, P., Wastling, R., Mceleny, P., Beattie, A., Cooke, P., Wong, M., Gunasegaram, J., Pugsley, M., Ahmad, S., A'Court, C., Ayers, J., Bennett, J., Cartwright, S., Dobson, S., Dooldeniya, C., Flynn, A., Fox, R., Goram, J., Halpin, A., Hay, A., Jacobs, P., Jeffers, L., Lomax, L., Munro, I., Muvva, R., Nadaph, M., Powell, K., Randfield, S., Redpath, D., Reed, R., Rickenbach, M., Rogers, G., Saunders, P. B., Seamark, C., Shewring, J., Simmons, P., Simper, H., Stoddart, H., Sword, A., Thomas, N., Thomson, A., Gibbs, H., Blenkhorn, A., Singh, B., Van Gaal, W., Abhayaratna, W., Lehman, R., Roberts-Thomson, P., Kilian, J., Coulshed, D., Catanchin, A., Colquhoun, D., Kiat, H., Eccleston, D., French, J., Zimmett, L., Ayres, B., Phan, T., Blombery, P., Crimmins, D., O'Donnell, D., Choi, A., Astridge, P., Arstall, M., Jepson, N., Binnekamp, M., Lee, A., Rogers, J., Starmer, G., Carroll, P., Faunt, J., Aggarwala, A., Barry, L., Batta, C., Beveridge, R., Black, A., Bonner, M., Boys, J., Buckley, E., Campo, M., Carlton, L., Connelly, A., Conway, B., Cresp, D., Dimitri, H., Dixon, S., Dolman, M., Duroux, M., Eskandari, M., Eslick, R., Ferreira-Jardim, A., Fetahovic, T., Fitzpatrick, D., Geraghty, R., Gibbs, J., Grabek, T., Modi, M. H., Hayes, K., Hegde, M. P., Hesketh, L., Hoffmann, B., Jacobson, B., Johnson, K., Juergens, C., Kassam, I., Lawlor, V., Lehman, M., Lehman, S., Leung, D., Mackay, S., Mackenzie, M., Mccarthy, C., Mcintosh, C., Mckeon, L., Morrison, H., Mussap, C., Myers, J. -D., Nagalingam, V., Oldfield, G., O'May, V., Palmer, J., Parsons, L., Patching, K., Patching, T., Paul, V., Plotz, M., Preston, S., Rashad, H., Ratcliffe, M., Raynes, S., Rose, J., Sanders, L., Seremetkoska, M., Setio, H., Shone, S., Shrestha, P., Singh, C., Singleton, C., Stoyanov, N., Sutcliffe, S., Swaraj, K., Tarrant, J., Thompson, S., Tsay, I. M., Vorster, M., Waldman, A., Wallis, L., Wilford, E., Wong, K., Connolly, S. J., Spyropoulos, A., Eikelboom, J., Luton, R., Gupta, M., Pandey, A. S., Cheung, S., Leader, R., Beaudry, P., Ayala-Paredes, F., Berlingieri, J., Heath, J., Poirier, G., Du Preez, M., Nadeau, R., Dresser, G., Dhillon, R., Hruczkowski, T., Schweitzer, B., Coutu, B., Angaran, P., Macdonald, P., Vizel, S., Fikry, S., Parkash, R., Lavoie, A., Cha, J., Ramjattan, B., Bonet, J., Ahmad, K., Aro, L., Aves, T., Beaudry, K., Bergeron, C., Bigcanoe, J., Bignell, N., Breakwell, L., Burke, E., Carroll, L., Clarke, B., Cleveland, T., Daheb, S., Dehghani, P., Denis, I., Djaidani, Z., Dorian, P., Douglass, S., Dunnigan, J., Ewert, A., Farquhar, D., Fearon, A., Ferleyko, L., Fournier, D., Fox, B., Grenier, M. -C., Gulliver, W., Haveman, K., Hines, C., Hines, K., Jackson, A. M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., Ragy, H., Abd El-Aziz, A., Abou Seif, S. K., El Din, M. G., El Etriby, S., Elbahry, A., El-Etreby, A., Elkhadem, M., Katta, A., Khairy, T., Mowafy, A., Nawar, M., Ohanissian, A., Reda, A., Reda, M., Salem, H., Sami, N., Samir, S., Setiha, M., Sobhy, M., Soliman, A., Taha, N., Tawfik, M., Zaatout, E., Kettles, D., Bayat, J., Siebert, H., Horak, A., Kelfkens, Y., Garda, R., Pillay, T., Guerra, M., van Zyl, L., Theron, H., Murray, A., Louw, R., Greyling, D., Mntla, P., Ueckermann, V., Loghdey, R., Ismail, S., Ahmed, F., Engelbrecht, J., Ramdass, A., Maharajh, S., Oosthuysen, W., Angel, G., Bester, C., Booysen, M., Boshoff, C., Cannon, C., Cassimjee, S., Chami, C., Conway, G., Davids, A., de Meyer, L., Du Plessis, G., Ellis, T., Henley, L., Karsten, M., Loyd, E., Marks, J., Mavhusa, L., Mostert, M., Page, A., Rikhotso, L., Salie, M., Sasto, J., Shaik, F., Skein, A., Smith, L., Tarr, G., Tau, T., van Zyl, F., Al Mahmeed, W., Yousef, G., Agrawal, A., Nathani, M., Ibrahim, M., Esheiba, E. M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Goldhaber, S. Z., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W. M., Cox, M., Franco, M., Falkowski, S., Mendelson, R., Williams, M., Miller, S., Beach, S., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., Depauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J. A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
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Registrie ,Male ,Time Factors ,Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF ,030204 cardiovascular system & hematology ,Electrocardiography ,0302 clinical medicine ,Risk Factors ,Anticoagulant therapy ,Arrhythmia ,Atrial fibrillation ,GARFIELD-AF ,Aged ,Atrial Fibrillation ,Female ,Follow-Up Studies ,Humans ,Incidence ,India ,Prevalence ,Prognosis ,Prospective Studies ,Survival Rate ,Thromboembolism ,Registries ,Risk Assessment ,Medicine ,030212 general & internal medicine ,Prospective cohort study ,Incidence (epidemiology) ,cardiovascular system ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Risk assessment ,Human ,medicine.medical_specialty ,Time Factor ,RD1-811 ,Prognosi ,Follow-Up Studie ,03 medical and health sciences ,Internal medicine ,Diseases of the circulatory (Cardiovascular) system ,cardiovascular diseases ,Risk factor ,Survival rate ,Fibrillation ,business.industry ,Risk Factor ,ta3121 ,medicine.disease ,Clinical trial ,Prospective Studie ,RC666-701 ,Surgery ,Clinical and Preventive Cardiology ,business - Abstract
Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P
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- 2018
16. Preparación, radiomarcaje con 99mTc y 67Ga y estudios de biodistribución de nanopartículas de albúmina con recubrimientos poliméricos
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Margarita Ecay, Juan M. Irache, A. Erhard, G. Quincoces, Isabel Martínez-Rodríguez, Iván Peñuelas, Ignacio Banzo, María Collantes, Ana L. Martínez-López, and M. de Arcocha-Torres
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03 medical and health sciences ,0302 clinical medicine ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,business ,Humanities ,030218 nuclear medicine & medical imaging - Abstract
Resumen Objetivo Optimizar el radiomarcaje con 99mTc y 67Ga de nanoparticulas de albumina recubiertas con 4 polimeros sinteticos distintos y evaluar su estabilidad in vivo e in vitro, asi como su biodistribucion in vivo tras su administracion intravenosa. Material y metodos Las nanoparticulas se prepararon empleando albumina y albumina modificada con NOTA mediante el metodo de desolvatacion y se recubrieron con 4 polimeros distintos; HPMC, GMN2, GPM2 y GTM2. Se purificaron, liofilizaron y caracterizaron. El marcaje con 99mTc se realizo con 74 MBq de pertecnetato [99mTc] sodico previamente reducido con una disolucion acida de cloruro de estano a diferentes concentraciones (0,003; 0,005; 0,007; 0,01; 0,05 y 0,1 mg/ml), a distintos tiempos (5, 10, 15, 30 y 60 min) y temperaturas (temperatura ambiente, 40 °C y 60 °C). El marcaje con 67Ga se llevo a cabo mediante incubacion de las nanoparticulas con 37 MBq de cloruro de 67Ga (obtenido a partir de citrato de 67Ga comercial) a distintos tiempos (10 y 30 min) y temperaturas (temperatura ambiente, 30 °C y 60 °C) y posterior purificacion con microconcentradores. La pureza radioquimica de ambos marcajes se evaluo mediante TLC. Se llevaron a cabo estudios de estabilidad de las nanoparticulas marcadas en suero fisiologico y plasma sanguineo. Los estudios de biodistribucion de las nanoparticulas recubiertas con el polimero GPM2 se llevaron a cabo en ratas Wistar tras la administracion intravenosa de las nanoparticulas. Se realizaron animales control con pertecnetato [99mTc] sodico y cloruro de 67Ga. Posteriormente, los animales fueron sacrificados y se midio la actividad de los organos en un contador gamma. Resultados El marcaje con 99mTc se llevo a cabo de forma optima con una concentracion de estano de 0,007 mg/ml para las nanoparticulas GPM2 y de 0,005 mg/ml para el resto de formulaciones, con un tiempo de marcaje de 10 min y a temperatura ambiente. En el caso del 67Ga el marcaje se optimizo a 30 °C de temperatura y 30 min de incubacion. En ambos casos, la pureza radioquimica obtenida fue superior al 97%. Las nanoparticulas presentaron una elevada estabilidad in vitro pasadas las 48 h del marcaje (70% las nanoparticulas marcadas con 99mTc y 90% las marcadas con 67Ga). Los estudios de biodistribucion de las nanoparticulas [99mTc]-GPM2 y [67Ga]-NOTA-GPM2 mostraron una elevada acumulacion de actividad en el higado tanto a las 2 h como a las 24 h de la administracion intravenosa. Conclusion El procedimiento de marcaje con 99mTc y 67Ga de nanoparticulas de albumina y albumina modificada con NOTA permite la obtencion de nanoparticulas con elevados rendimientos de marcaje y una adecuada estabilidad in vitro, permitiendo su utilizacion para la realizacion de estudios in vivo.
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- 2020
17. A snake that bites its own tail. Acquisition and loss of concepts in children and semantic dementia patients through the analysis of drawings
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Andrea Fernández-Rodríguez, Carmen Lage, Sara López-García, Julio Jiménez-Bonilla, María García-Martínez, Martha Kazimierczak, María De Arcocha-Torres, Andrea González-Suárez, Eloy Rodríguez-Rodríguez, Ángel Cano-Abascal, Javier Riancho, Ignacio Banzo, José Luis Vázquez-Higuera, María Bravo, Francisco Martínez-Dubarbie, Ana Pozueta, and Pascual Sánchez-Juan
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Adult ,medicine.medical_specialty ,Cognitive Neuroscience ,Semantic dementia ,Experimental and Cognitive Psychology ,Neuropsychological Tests ,Audiology ,050105 experimental psychology ,Semantic network ,Young Adult ,03 medical and health sciences ,Fluency ,0302 clinical medicine ,Memory ,Healthy volunteers ,medicine ,Animals ,Humans ,Semantic memory ,0501 psychology and cognitive sciences ,In patient ,Child ,Childhood development ,05 social sciences ,Snakes ,medicine.disease ,Semantics ,Neuropsychology and Physiological Psychology ,Age of Acquisition ,Child, Preschool ,Frontotemporal Dementia ,Frontotemporal Lobar Degeneration ,Psychology ,030217 neurology & neurosurgery - Abstract
Objective The structure of the semantic network is constructed and organized during childhood development. Previous publications have hypothesized that neurodegenerative diseases would lead to a disruption of this network reversing the steps acquired in childhood. Semantic Dementia (SD) is a subtype of frontotemporal lobe degeneration in which the main symptom is a specific loss of semantic memory. We aimed to describe the sequential acquisition of concepts in 3-8 years old children evaluated through the production of drawings and, in parallel, their progressive loss in SD patients. Methods 104 children between 40 and 96 months categorized into tertiles according to their age, 21 SD patients categorized into tertiles according to their score on a category fluency task and 34 healthy volunteers were asked to draw 12 items with, a priori, different age of acquisition and familiarity, belonging to four different semantic categories. We employed the drawings of the healthy volunteers to build a scoring scheme. We considered that a concept was acquired in children when 50% or more of its features were present in their drawings, and it was lost in patients when more than 50% were missing. Results Those concepts which the children were able to acquire earlier, according to our scoring scheme, tended to remain in patients with more advanced SD. While the items that children acquired later, were, in general, those that the SD patients lost at earlier disease stages. Conclusion The patterns of concept acquisition in children were the mirror image of the loss in patients with SD. Our study supports the hypothesis that the sequence of concept acquisition in childhood is reversed in SD patients.
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- 2020
18. FDG PET/TC en el cáncer colorrectal
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P. García-Talavera, María José García-Velloso, A. Sabaté-Llobera, M. de Arcocha-Torres, R.C. Delgado Bolton, J. Orcajo-Rincon, Macarena Rodríguez-Fraile, M.P. Cózar-Santiago, and A.P. Caresia-Aróztegui
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03 medical and health sciences ,0302 clinical medicine ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,business ,Humanities ,030218 nuclear medicine & medical imaging - Abstract
Resumen El cancer colorrectal es el tercer cancer en frecuencia a nivel mundial. Aunque su incidencia esta aumentando, fundamentalmente en menores de 50 anos, su mortalidad ha disminuido un 50% en los paises mas desarrollados, principalmente debido a la adopcion de nuevas practicas en la prevencion, diagnostico y tratamiento. En particular, las diversas modalidades de diagnostico por imagen permiten mejorar la toma de decisiones terapeuticas, la evaluacion de la respuesta y la eficacia de las nuevas terapias y la deteccion precoz de la recidiva. La finalidad del presente trabajo es hacer una revision de la evidencia cientifica disponible sobre el valor de la tomografia por emision de positrones con 18F-FDG (18F-FDG PET/TC) en el cancer colorrectal, haciendo especial hincapie en las indicaciones de las guias y recomendaciones de las principales asociaciones cientificas internacionales respecto a esta tecnica de imagen.
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- 2020
19. FDG PET/CT in colorectal cancer
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R.C. Delgado-Bolton, A. Sabaté-Llobera, J. Orcajo-Rincon, M. de Arcocha-Torres, P. García-Talavera, María José García-Velloso, A.P. Caresia-Aróztegui, M.P. Cózar-Santiago, and Macarena Rodríguez-Fraile
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medicine.medical_specialty ,PET-CT ,Modalities ,medicine.diagnostic_test ,business.industry ,Colorectal cancer ,Incidence (epidemiology) ,General Engineering ,Cancer ,medicine.disease ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Positron emission tomography ,Medical imaging ,medicine ,General Earth and Planetary Sciences ,Fdg pet ct ,Radiology ,business ,General Environmental Science - Abstract
Colorectal cancer is the third most frequent cancer worldwide. Although its incidence is increasing, mainly in those aged under50, mortality has decreased by 50% in the more developed countries, principally due to the adoption of new practices in prevention, diagnosis and treatment. In particular, the various diagnostic imaging modalities allow improved therapeutic decision-making, evaluation of the response and early detection of recurrence. The aim of this paper is to review the available scientific evidence on the value of positron emission tomography with 18F-FDG (18F-FDG PET/CT) in the colorectal cancer, with special emphasis on the indications of the guidelines and recommendations of the main international scientific associations regarding this imaging technique.
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- 2020
20. Clinical application of [
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A, Díaz-Silván, L F, Otón-Sánchez, A P, Caresia-Aróztegui, M, Del Puig Cózar-Santiago, J, Orcajo-Rincón, M, de Arcocha-Torres, R C, Delgado-Bolton, and D, Cabello-García
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Fluorodeoxyglucose F18 ,Positron Emission Tomography Computed Tomography ,Positron-Emission Tomography ,Humans ,Radiopharmaceuticals ,Lymphoma, Follicular - Abstract
The objective of the present paper was to review the clinical application of [
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- 2022
21. Remote heart failure management using the HeartLogic algorithm. RE-HEART Registry
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de Juan Bagudá J, Gavira Gómez JJ, Pachón Iglesias M, Cózar León R, Escolar Pérez V, González Fernández Ó, Rivas Gándara N, Goirigolzarri Artaza J, Díaz Molina B, Macías Gallego A, Martínez Mateo V, Martínez Martínez JG, Marrero Negrín N, Alonso Salinas GL, González Torres L, Delgado Jiménez JF, Sánchez-Aguilera P, Díaz Infante E, Arcocha Torres MF, Peña Conde L, Méndez Fernández AB, Pérez Castellano N, Rubín López JM, Madrazo Delgado I, Fernández-Anguita MJ, Ramos Ruiz P, Medina Moreno O, Cordero Pereda D, de Diego Rus C, Arribas Ynsaurriaga F, García Bolao I, Salguero Bodes R, and RE-HEART Registry group
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Cardiac resynchronization therapy ,Remote monitoring ,Terapia de resincronización cardiaca ,ICD ,Monitorización a distancia ,DAI ,Heart failure ,Estratificación de riesgo ,Risk stratification ,Insuficiencia cardiaca - Abstract
INTRODUCTION AND OBJECTIVES: HeartLogic is a multiparametric algorithm incorporated into implantable cardioverter-defibrillators (ICD). The associated alerts predict impending heart failure (HF) decompensations. Our objective was to analyze the association between alerts and clinical events and to describe the implementation of a protocol for remote management in a multicenter registry. METHODS: We evaluated study phase 1 (the investigators were blinded to the alert state) and phases 2 and 3 (after HeartLogic activation, managed as per local practice and with a standardized protocol, respectively). RESULTS: We included 288 patients from 15 centers. In phase 1, the median observation period was 10 months and there were 73 alerts (0.72 alerts/patient-y), with 8 hospitalizations and 2 emergency room admissions for HF (0.10 events/patient-y). There were no HF hospitalizations outside the alert period. In the active phases, the median follow-up was 16 (95%CI, 15-22) months and there were 277 alerts (0.89 alerts/patient-y); 33 were associated with HF hospitalizations or HF death (n=6), 46 with minor decompensations, and 78 with other events. The unexplained alert rate was 0.39 alerts/patient-y. Outside the alert state, there was only 1 HF hospitalization and 1 minor HF decompensation. Most alerts (82% in phase 2 and 81% in phase 3; P=.861) were remotely managed. The median NT-proBNP value was higher within than outside the alert state (7378 vs 1210 pg/mL; P
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- 2022
22. Cognitive and Behavioral Profiles of Left and Right Semantic Dementia: Differential Diagnosis with Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease
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José Berciano, Julio Jiménez-Bonilla, Eloy Rodríguez-Rodríguez, María García-Martínez, Ana Pozueta, Pascual Sánchez-Juan, Javier Riancho, María De Arcocha-Torres, Sara López-García, Ignacio Banzo, Martha Kazimierczak, Carmen Lage, José Luis Vázquez-Higuera, Andrea González-Suárez, and María Bravo
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Male ,0301 basic medicine ,medicine.medical_specialty ,Population ,Semantic dementia ,Neuropsychological Tests ,Audiology ,Diagnosis, Differential ,Executive Function ,03 medical and health sciences ,Cognition ,0302 clinical medicine ,Alzheimer Disease ,Memory ,medicine ,Humans ,Semantic memory ,education ,Episodic memory ,Aged ,Aged, 80 and over ,education.field_of_study ,business.industry ,General Neuroscience ,Neuropsychology ,Brain ,General Medicine ,Middle Aged ,medicine.disease ,Executive functions ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,Frontotemporal Dementia ,Positron-Emission Tomography ,Dementia ,Female ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,Frontotemporal dementia - Abstract
Background Semantic dementia (SD) is a subtype of frontotemporal dementia (FTD) characterized by semantic memory loss and preserved abilities of other cognitive functions. The clinical manifestations of SD require a differential diagnosis with Alzheimer's disease (AD), especially those with early onset, and behavioral variant FTD (bvFTD). Objective The present study aimed to compare cognitive performances and neuropsychiatric symptoms in a population of AD, bvFTD, and left and right SD defined with the support of molecular imaging (amyloid and 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography) and assessed the accuracy of different neuropsychological markers in distinguishing these neurodegenerative diseases. Methods Eighty-seven participants (32 AD, 20 bvFTD, and 35 SD (17 Left-SD and 18 Right-SD) completed a comprehensive neuropsychological battery that included memory, language, attention and executive functions, visuospatial function, visuoconstructional skills, and tasks designed specifically to evaluate prosopagnosia and facial emotions recognition. The Neuropsychiatric Inventory was administered to assess neuropsychiatric symptoms. Results An episodic memory test that included semantic cues, a visuospatial test (both impaired in AD), a naming test and a prosopagnosia task (both impaired in SD) were the four most valuable cognitive metrics for the differential diagnosis between groups. Several behavioral abnormalities were differentially present, of which aggression, self-care (both more frequent in bvFTD), and eating habits, specifically overeating and altered dietary preference (more frequent in SD), were the most valuable in group discrimination. Conclusion Our study highlights the value of a comprehensive neuropsychological and neuropsychiatric evaluation for the differential diagnosis between FTD syndromes and AD.
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- 2019
23. Spanish Catheter Ablation Registry. 18th Official Report of the Spanish Society of Cardiology Working Group on Electrophysiology and Arrhythmias (2018)
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José Luis Ibáñez Criado, Aurelio Quesada, Rocío Cózar, Jesús Almendral-Garrote, Pau Alonso-Fernández, Concepción Alonso-Martín, Nelson María Alvarenga-Recalde, Luis Álvarez-Acosta, Miguel Álvarez-López, Ignasi Anguera-Camos, Eduardo Arana-Rueda, María Fe Arcocha-Torres, Miguel Ángel Arias-Palomares, Antonio Asso-Abadía, Gabriel Alejandro Ballesteros-Derbenti, Alberto Barrera-Cordero, Juan Benezet-Mazuecos, Andrés I. Bodegas-Cañas, Josep Brugada-Terradellas, Claudia Cabadés-Rumbeu, María del Pilar Cabanas-Grandío, Sandra Cabrera-Gómez, Lucas R. Cano-Calabria, Silvia del Castillo-Arrojo, Víctor Castro-Urda, Rocío Cózar-León, Ernesto Díaz-Infante, Juan Manuel Durán-Guerrero, Juliana Elices-Teja, María del Carmen Expósito-Pineda, Juan Manuel Fernández-Gómez, Julio Jesús Ferrer-Hita, María Luisa Fidalgo-Andrés, Adolfo Fontenla-Cerezuela, Arcadio García-Alberola, J. Ignacio García-Bolao, Enrique García-Cuenca, Francisco Javier García-Fernández, Ignacio Gil-Ortega, Federico Gómez-Pulido, Juan Manuel Grande-Ingelmo, Eduard Guasch-i-Casany, José M. Guerra-Ramos, Santiago Heras-Herreros, Julio Hernández-Afonso, Benito Herreros-Guilarte, Víctor Manuel Hidalgo-Olivares, Alicia Ibáñez-Criado, José Luis Ibáñez-Criado, Sonia Ibars-Campaña, Miguel Eduardo Jáuregui-Abularach, F. Javier Jiménez-Candil, Javier Jiménez-Díaz, Jesús I. Jiménez-López, Carla Lázaro-Rivera, José Miguel Lozano-Herrera, Alfonso Macías-Gallego, Santiago Magnani-Ragamato, Javier Martínez-Basterra, Ángel Martínez-Brotons, José Luis Martínez-Sande, Gabriel Martín-Sánchez, Roberto Matías-Francés, José Luis Merino-Llorens, Josep Lluis Mont-Girbau, José Moreno-Arribas, Javier Moreno-Planas, Ángel Moya-i-Mitjans, Marta Ortega-Molina, Joaquín Osca-Asensi, Agustín Pastor-Fuentes, Ricardo Pavón-Jiménez, Rafael Peinado-Peinado, Luisa Pérez-Álvarez, Nicasio Pérez-Castellano, Rosa Porro-Fernández, Andreu Porta-Sánchez, Jordi Punti-Sala, Aurelio Quesada-Dorador, Nuria Rivas-Gándara, Gonzalo Rodrigo-Trallero, Felipe José Rodríguez-Entem, Juan Carlos Rodríguez-Pérez, Rafael Romero-Garrido, José Manuel Rubín-López, José Amador Rubio-Caballero, José Manuel Rubio-Campal, Jerónimo Rubio-Sanz, Pablo M. Ruiz-Hernández, Ricardo Salgado-Aranda, Juan Miguel Sánchez-Gómez, Georgia Sarquella-Brugada, Axel Sarrias-Mercé, Jose María Segura-Saint-Gerons, Federico Segura-Villalobos, and Irene Valverde-André
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Male ,Tachycardia ,medicine.medical_specialty ,Cavotricuspid isthmus ,medicine.medical_treatment ,Ablation of atrial fibrillation ,Cardiology ,Catheter ablation ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Registries ,Major complication ,Societies, Medical ,Retrospective Studies ,business.industry ,Data Collection ,Mortality rate ,Arrhythmias, Cardiac ,Atrial fibrillation ,General Medicine ,medicine.disease ,Ablation ,Surgery ,Spain ,Catheter Ablation ,Female ,medicine.symptom ,Electrophysiologic Techniques, Cardiac ,business - Abstract
Introduction and objectives: This report presents the findings of the 2018 Spanish Catheter Ablation Registry. Methods: Data collection was retrospective. A standardized questionnaire was completed by each of the participating centers. Results: Data sent by 100 centers were analyzed, with a total number of 16,566 ablation procedures performed (the highest historically reported in this registry) for a mean of 165.5 ± 127.9 and a median of 119 procedures per center. The ablation targets most frequently treated were atrial fibrillation (n = 4234; 25.6%), atrioventricular nodal re-entrant tachycardia (n = 3525; 21.3%) and cavotricuspid isthmus (n = 3425; 20.7%). A new peak was observed in the ablation of atrial fibrillation, increasing the distance from the other substrates. The overall success rate was 91%. The rate of major complications was 2.2%, and the mortality rate was 0.04%. A total of 2.1% of the ablations were performed in pediatric patients. Conclusions: The Spanish Catheter Ablation Registry systematically and continuously enrolls the ablation procedures performed in Spain, showing a progressive increase in the number of ablations over the years, with a high success rate and low percentage of complications.
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- 2019
24. CONOCIMIENTOS Y (DES)INFORMACIÓN DEL ALUMNADO DE SECUNDARIA SOBRE EL PERIODO HISTÓRICO DE LA TRANSICIÓN ESPAÑOLA
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Mikel Bueno Urritzelki and Elorri Arcocha Mendinueta
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- 2021
25. Time to –30°C as a predictor of acute success during cryoablation in patients with atrial fibrillation
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César Solórzano-Guillén, María Fe Arcocha, Jorge Toquero-Ramos, José Segura, Cózar Rocío, Jesús Martínez-Alday, Ángel Ferrero-de-Loma-Osorio, Alberto Barrera, Rafael Peinado, Roger Villuendas, Arcadio García-Alberola, Alicia Ibañez, Carlos Antonio Álvarez-Ortega, Carlos Grande, Miguel A. Ruiz, and Pablo Moriña-Vázquez
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Cryoablation ,Atrial fibrillation ,General Medicine ,Odds ratio ,Ablation ,medicine.disease ,Confidence interval ,Pulmonary vein ,medicine.anatomical_structure ,Internal medicine ,medicine ,Cardiology ,In patient ,Cardiology and Cardiovascular Medicine ,business ,Vein - Abstract
Background: Freezing rate of second-generation cryoballoon (CB) is a biophysical parameter that could assist pulmonary vein isolation. The aim of this study is to assess freezing rate (time to reach –30°C ([TT-30C]) as an early predictor of acute pulmonary vein isolation using the CB. Methods: Biophysical data from CB freeze applications within a multicenter, nation-wide CB ablation registry were gathered. Successful application (SA), was defined as achieving durable intraprocedural vein isolation with time to isolation in under 60 s (SA-TTI
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- 2021
26. The role of PSMA radioligands in the diagnosis and treatment of prostate carcinoma
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M. Rodríguez-Fraile, P. Tamayo Alonso, J.J. Rosales, María de Arcocha-Torres, A.P. Caresia-Aróztegui, María Puig Cózar-Santiago, Javier Orcajo-Rincon, Marc Simó Perdigó, R.C. Delgado Bolton, and C. Artigas Guix
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Male ,Heterocyclic Compounds, 1-Ring ,Prostatic Neoplasms, Castration-Resistant ,Carcinoma ,General Engineering ,Prostate ,General Earth and Planetary Sciences ,Humans ,Dipeptides ,General Environmental Science - Abstract
Prostate cancer (PC) is the most common tumor in men in the West and the fifth leading cause of cancer-related death. The use of PSMA radioligands has represented an important advance both in its diagnosis, through PET molecular imaging, and in its treatment in advanced stages of the disease. This article reviews the contribution of PET studies with PSMA radioligands in initial staging, in tumor detection in biochemical recurrence (elevation of PSA) after treatment with curative intent, and in the more advanced stages of the disease (castration resistant PC or CRPC). The contribution of PSMA radioligand therapy (PSMA-RLT) in CRPC patients who progress to standard therapy is also analyzed.
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- 2021
27. EP03.01-012 Characterization of Lung Cancer in Patients With High Familial Aggregation of Cancer: Preliminary Data From the SCAN Study
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J.C. Laguna, J. Torres-Jiménez, E. Auclin, L. Gonzalez-Aguado, V. Albarrán-Artahona, B. Pastor, T. Gorría, L. Moreno, M. Potrony, R. Reyes, P. Blasco, D. Martínez, N. Viñolas, L. Gaba, B. Adamo, A. Arcocha, J.A. Puig-Butillé, A. Prat, C. Teixidó, N. Reguart, and L. Mezquita
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Pulmonary and Respiratory Medicine ,Oncology - Published
- 2022
28. MA07.07 Clinical/Molecular Profile of Patients with Non-small Cell Lung Cancer (NSCLC) with Incidental Pathogenic Germline Variants Detected in cfDNA
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L. Mezquita, L. Bucheit, J.C. Laguna, B. Pastor, C. Teixido, T. Gorria, V. Albarran-Artahona, M. Garcia de Herreros, R. Reyes, N. Reguart, N. Viñolas, A. Arcocha, J.A. Puig-Butille, L.M. Drusbosky, I. Faull, E. Auclin, E. Castro, J.D. Patel, A. Prat, and B. Besse
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Pulmonary and Respiratory Medicine ,Oncology - Published
- 2022
29. P1.07-02 Personal and Family HiStory of CANcer in Patients with Non-small Cell Lung Cancer: Preliminary Data of the SCAN Study
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J.C. Laguna, L. Gonzalez-Aguado, E. Auclin, J. Torres-Jiménez, V. Albarrán-Artahona, B. Pastor, T. Gorría, L. Moreno, M. Potrony, R. Reyes, D. Martínez, O. Castillo, N. Viñolas, L. Gaba, B. Adamo, A. Arcocha, J.A. Puig-Butillé, A. Prat, C. Teixidó, N. Reguart, and L. Mezquita
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Pulmonary and Respiratory Medicine ,Oncology - Published
- 2022
30. P1.16-02 Clinical Utility of ctDNA in Advanced NSCLC at Diagnosis or Where Insufficient Tissue Was Available, Based on the ESMO ESCAT Scale
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L. Mezquita, M. Riudavets, M. Garcia de Herreros, E. Auclin, M. Dorta, V. Albarran, M. Aldea, C. Naltet, M. Grecea, P. Martin-Romano, L.L. Lacroix, C. Nicotra, A. Arcocha, A. Gazzah, C. Pipinikas, C. Morris, K. Howarth, C. Teixidó, R. Reyes, N. Viñolas, C. Massard, F. Barlesi, D. Planchard, and B. Besse
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Pulmonary and Respiratory Medicine ,Oncology - Published
- 2022
31. EP08.02-102 Feasibility and Clinical Utility of ctDNA for Detection of Sensitizing and Resistance EGFR Mutations in Patients with Non-small Cell Lung Cancer
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M. Garcia de Herreros, C. Teixido, V. Diez, A. Arcocha, R. Reyes, V. Albarran-Artahona, E. Marin, P. Galvan, D. Martinez, J. Padrosa, L. Vegas, O. Castillo, A. Prat, N. Viñolas, N. Reguart, and L. Mezquita
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Pulmonary and Respiratory Medicine ,Oncology - Published
- 2022
32. PROTEIN STUDY FROM A BIOKINEMATIC PERSPECTIVE: LITERATURE REVIEW
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Alfonso Hernandez Frias, Mikel Diez Sanchez, Victor Petuya Arcocha, and Monica Urizar Arana
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General Engineering - Abstract
Las proteinas son las macromoleculas encargadas de llevar a cabo la gran mayoria de las funciones vitales que los seres vivos requieren para su existencia. Estas macromoleculas, las cuales se asemejan a pequenos mecanismos o robots, fueron descubiertas hace 200 anos y observadas en su forma funcional hace menos de 60, y suponen uno de los campos de estudio mas prometedores del momento. El ambito de estudio de las proteinas es increiblemente rico y multidisciplinar, no pudiendose abordar completamente si no es desde una combinacion de la biologia y la ingenieria. La investigacion actual presenta grandes retos: la complejidad de las fuerzas que gobiernan las uniones atomicas, las cuales todavia estamos comenzando a comprender, y las limitaciones tecnologicas actuales que presentan serios obstaculos a la hora de tratar de comprender mejor el funcionamiento de estos robots de la naturaleza. En este trabajo, se presenta un breve estado del arte de los metodos desarrollados para resolver problemas como el plegado de proteinas o la simulacion del mecanismo molecular. El articulo se centra especialmente en aquellos que estan mas estrechamente relacionados con la ingenieria, pero sin olvidar los metodos clasicos para tratar de comprender un poco mejor el estado actual de la tecnica. Palabras clave: proteinas, estructura, biocinematica, mecanismos
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- 2019
33. Early Risks of Death, Stroke/Systemic Embolism, and Major Bleeding in Patients With Newly Diagnosed Atrial Fibrillation
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Voelkel-Babyesiza, R., Chen, D. D., Jaufeerally, F. R., Lee, Y. M., Lim, G., Lim, W. T., Thng, S., Yap, S. Y., Yeo, C., Oh, S., Pak, H. N., Kim, J-B, Kim, J. H., Jang, S-W, Kim, D. H., Ryu, D. R., Park, S. W., Kim, D-K, Choi, D. J., Oh, Y. S., Cho, M-C, Kim, S-H, Jeon, H-K, Shin, D-G, Park, J. S., Park, H. K., Han, S-J, Sung, J. H., Nam, G-B, On, Y. K., Lim, H. E., Kwak, J. J., Cha, T-J, Hong, T. J., Park, S. H., Yoon, J. H., Kim, N-H, Kim, K-S, Jung, B. C., Hwang, G-S, Kim, C-J, Worthy, V, Verdi, C., Tripti, T., Treasure, L., Thompson, N., Theobald, H., Thatcher, A., Stephanie, B., Smith, K., Shoemaker, J., Shaw, P., Sanghera, T., Sage, A., Robertson, C., Richardson, T., Richard, C., Raziano, S., Raynor, J., Purcell, T., Pickelsimer, N., Peterson, J., Pearl, G., Paserchia, S., Parrott, T., Parker, M., Palumbo, V, Orosco, C., Mooso, B., Minardo, J., Merritt, D., Malone, E., Lincoln, T., Lee, J. A., Lay, M., Langdon, J., Knowles, P., Kerr, J., Keeling, M., Karl, S., Jones, P., Jones, L., Jones, A., Jasinski, S., Hicks, T., Herrick, C., Henson, L., Headlee, M., Hawkins, B., Hartranft, E., Harbour, T., Hakimi, F., Haideri, A., Gentry, P., Fielder, D., Ferdinand, K., Felpel, S., Evans, L., Eley, M., Dickerson, A., DePauw, J., Congal, S., Cervellione, K., Cassidy, D., Canova, M., Cameron-Watts, J., Browne, A., Brown, A., Bowers, S., Bentley, M., Bartlett, M., Asafu-Adjaye, N., Treasure, C., Nishijima, D., Pitta, S., Duffy, P., Noveck, H., Ison, R., Alberts, M., Remmel, K., Theodoro, D., Diercks, D., Delafontaine, P., Ahmed, W., Reddy, R., Haque, I, Gutowski, T., Alfieri, A., Beach, S., Miller, S., Williams, M., Mendelson, R., Falkowski, S., Franco, M., Cox, M., Kutayli, W. M., Ferrick, K., Quick, A., Wilson, V, Mullen, P., Garcia, J., Blumberg, E., Rama, P., Canosa, R., Goldhaber, S. Z., Thanzeel, M., Sharma, R., Sharma, N., Mohamed, R., Maqsood, I, Makdad, M., Magdaluyo, K., Jadhav, S., Haridas, P., El Bardisy, S., Al Mulla, A., Abdul, A., Subbaraman, B., Khan, M., Gupta, R., Wassef, A., Bazargani, N., Maruthanayagam, R., Al Naeemi, A., Al Omairi, M., Abu-Mahfouz, M., Naguib, A., Singh, R., Esheiba, E. M., Ibrahim, M., Nathani, M., Agrawal, A., Yousef, G., Al Mahmeed, W., van Zyl, F., Tau, T., Tarr, G., Smith, L., Skein, A., Shaik, F., Sasto, J., Salie, M., Rikhotso, L., Page, A., Mostert, M., Mavhusa, L., Marks, J., Loyd, E., Karsten, M., Henley, L., Ellis, T., Du Plessis, G., de Meyer, L., Davids, A., Conway, G., Chami, C., Cassimjee, S., Cannon, C., Boshoff, C., Booysen, M., Bester, C., Angel, G., Oosthuysen, W., Maharajh, S., Ramdass, A., Engelbrecht, J., Ahmed, F., Ismail, S., Loghdey, R., Ueckermann, V, Mntla, P., Greyling, D., Louw, R., Murray, A., Theron, H., van Zyl, L., Guerra, M., Pillay, T., Garda, R., Kelfkens, Y., Horak, A., Siebert, H., Bayat, J., Kettles, D., Zaatout, E., Tawfik, M., Taha, N., Soliman, A., Sobhy, M., Setiha, M., Samir, S., Sami, N., Salem, H., Reda, M., Reda, A., Ohanissian, A., Nawar, M., Mowafy, A., Khairy, T., Katta, A., Elkhadem, M., El-Etreby, A., Elbahry, A., El Etriby, S., El Din, M. G., Abou Seif, S. K., Abd El-Aziz, A., Ragy, H., Wright, D., Wong, S., Trahey, T., Stevenson, J., Spearson, S., Snell, L., Schulman, S., Sas, G., Robinson, M., Roberts, P., Raines, M., Pinter, A., Petrie, F., Pandey, M., Otis, R., Otis, J., Neas, I, Navratil, J., Moor, R., Mangat, I, Lewis, S., Lewis, C., Largy, J., Kwan, L., Kornder, J., Korley, V, Kim, R., Kelly, S., Kahlon, R., Jethoo, G., Jean, C., Jackson, A. M., Hines, K., Hines, C., Haveman, K., Gulliver, W., Grenier, M-C, Fox, B., Fournier, D., Ferleyko, L., Fearon, A., Farquhar, D., Ewert, A., Dunnigan, J., Douglass, S., Dorian, P., Djaidani, Z., Denis, I, Dehghani, P., Daheb, S., Cleveland, T., Clarke, B., Carroll, L., Burke, E., Breakwell, L., Bignell, N., Bigcanoe, J., Bergeron, C., Beaudry, K., Aves, T., Aro, L., Ahmad, K., Bonet, J., Ramjattan, B., Cha, J., Lavoie, A., Parkash, R., Fikry, S., Vizel, S., MacDonald, P., Angaran, P., Coutu, B., Schweitzer, B., Hruczkowski, T., Dhillon, R., Dresser, G., Nadeau, R., Du Preez, M., Poirier, G., Heath, J., Berlingieri, J., Ayala-Paredes, F., Beaudry, P., Leader, R., Cheung, S., Pandey, A. S., Gupta, M., Luton, R., Eikelboom, J., Spyropoulos, A., Connolly, S. J., Wong, K., Wilford, E., Wallis, L., Waldman, A., Vorster, M., Tsay, I. M., Thompson, S., Tarrant, J., Swaraj, K., Sutcliffe, S., Stoyanov, N., Singleton, C., Singh, C., Shrestha, P., Shone, S., Setio, H., Seremetkoska, M., Sanders, L., Rose, J., Raynes, S., Ratcliffe, M., Rashad, H., Preston, S., Plotz, M., Paul, V, Patching, T., Patching, K., Parsons, L., Palmer, J., O'May, V, Oldfield, G., Nagalingam, V, Myers, J-D, Mussap, C., Morrison, H., McKeon, L., McIntosh, C., McCarthy, C., MacKenzie, M., Mackay, S., Leung, D., Lehman, S., Lehman, M., Lawlor, V, Kassam, I, Juergens, C., Johnson, K., Jacobson, B., Hoffmann, B., Hesketh, L., Hegde, M. P., Hayes, K., Modi, M. H., Grabek, T., Gibbs, J., Geraghty, R., Fitzpatrick, D., Fetahovic, T., Ferreira-Jardim, A., Eslick, R., Eskandari, M., Duroux, M., Dolman, M., Dixon, S., Dimitri, H., Cresp, D., Conway, B., Connelly, A., Carlton, L., Campo, M., Buckley, E., Boys, J., Bonner, M., Black, A., Beveridge, R., Batta, C., Barry, L., Aggarwala, A., Faunt, J., Carroll, P., Starmer, G., Rogers, J., Lee, A., Binnekamp, M., Jepson, N., Arstall, M., Astridge, P., Choi, A., O'Donnell, D., Crimmins, D., Blombery, P., Phan, T., Ayres, B., Zimmett, L., French, J., Eccleston, D., Kiat, H., Colquhoun, D., Catanchin, A., Coulshed, D., Kilian, J., Roberts-Thomson, P., Lehman, R., Abhayaratna, W., Van Gaal, W., Singh, B., Blenkhorn, A., Gibbs, H., Thomson, A., Thomas, N., Sword, A., Stoddart, H., Simper, H., Simmons, P., Shewring, J., Seamark, C., Saunders, P. B., Rogers, G., Rickenbach, M., Reed, R., Redpath, D., Randfield, S., Powell, K., Nadaph, M., Muvva, R., Munro, I, Lomax, L., Jeffers, L., Jacobs, P., Hay, A., Halpin, A., Goram, J., Fox, R., Flynn, A., Dooldeniya, C., Dobson, S., Cartwright, S., Bennett, J., Ayers, J., A'Court, C., Ahmad, S., Pugsley, M., Gunasegaram, J., Wong, M., Cooke, P., Beattie, A., McEleny, P., Wastling, R., McGinty, P., Bandrapalli, M., Liley, C., Vinson, P., Zaman, K., Davies, T., Forshaw, K., Veale, R., Wilkinson, J., Geatch, D., Estifano, S., Myhill, T., Lucraft, L., Batson, R., Choi, H., Stephenson, T., Hargreaves, N., Schatzberger, T., Davies, S., Baron, R. T., Haria-Shah, R., Bunney, R., Boon, M., Wong, T., Sterry, M., Shepherd, D., Walton, S., Jackson, D., Ward, B., Coates, S., Heer, A., Roberts, N., Coulson, W., Peters, S., Wilson, A., Khalaque, S., Choudhary, F., Sabir, A., Rothwell, A. C., Kim, D. B., Edwards, D., Braddick, M., Mannion, S., Aylward, M., Oliver, R., Hawkins, C., Galloway, S., Sharma, P., Heath, R., Danielsen, M., Neden, C. A., Stuart, E., Davies, R., Hart, N., Ali, A., Patel, J. R. A., Pinnock, H., Roome, P. C., Vercoe, S., Hodgins, I, Webster, J., Dau, H. S., Kamath, R., Lowe, S., Smith, R. N., Burns, G., Conn, P., Warke, A., Mulholland, C., Poland, K., McLeod, A. J., Glencross, S., Gibbons, L., Haq, I. U., Little, H., Barrow, S., Butter, K. C., Howard, M., Zaidi, S. M. A., Chigbo, C., Thompson, R., Walls, N., Hutton, C., Jacobs, M., Abushal, S., Davies, E., Oliver, J. L., Priyadharshan, R., Rogers, S., Milne, K., Parfitt, M., Wakeling, J., Alborough, E., Kelsall, A. R., Fooks, T., Fisher, E., Litchfield, J., Bisatt, J., Clark, M., Gray, D., Bird, N., Vishwanathan, B., Howitt, A., Strieder, E., Gilliland, A., de Kare-Silver, N., Sathananthan, S., Cairns, J., Willcock, W., Ahmad, N., Sarai, B., Watson, E., Thomas, M. J., Jones, K. P., Van Zon, G., Bradshaw, C., Cumberlidge, D. F., Douglas, K., Ladha, K., Saigol, M., Wong, S. W., Patel, R. P., Lumley, L., Murdoch, W., Kernick, D., Eden, J., Weeks, P., Jones, C. P., Ainsworth, P., Davies, J. A., Russell, D., Sinha, B., Railton, T., Gallagher, A., Pandya, P., Matthews, J., Wadeson, P., Thurston, S., West, R., Stipp, Y., Macey, N., Scouller, F., Evans, P., Lumb, W., Wetherwell, S., Aldegather, J., Oginni, O., Giles, C., Jones, H., Sharp, H., Jefferies, A., Richardson, M., Paul, C., Seamark, D., Tragen, D., Taylor, G., St Joseph, V, Thompson, J., Fairhead, S., Franklin, S., Wilson, P., Ramesh, C., Aziz, M., Paul, N., Stokes, M., Wakeman, A., Hutchinson, P., Bilas, R., Sircar, S., Singal, A., Suryani, S., Wagner, H., Gooding, T., Williams, A., McDonnell, J., Pickavance, G., Kainth, M. S., Ross, A., Jhittay, P. 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M., Martini, G., Tessitori, M., Cappelli, R., Poli, D., Quintavalla, R., Melone, F., Cosmi, F., Pizzini, A., Piseddu, G., Fanelli, R., Latella, C., Santi, R., Pancaldi, L., De Cristofaro, R., Palareti, G., De Blasio, A., Zrazhevskiy, K., Novikova, T., Kostenko, V, Moiseeva, Y., Polkanova, E., Uriarte, J. Salerno, Minetti, F., Pogliani, E. M., Lonati, L. M., Accogli, M., Ciampani, N., Malengo, S., Feola, M., Raisaro, A., Fattore, L., Grilli, P., Germini, F., Settimi, M., Alunni, M., Sobolev, K., Rossovskaya, M., Duranti, G., Tedeschi, L., Zubeeva, G., Shapovalova, Y., Baglioni, G., Avanzino, G., Berardi, M., Pannacci, V, Giombolini, A., Nicoli, S., Scarponi, T., Allasia, B., Ricciarini, P., Nasorri, R., Argena, A., Bossolasco, P., Ronchini, P., Filippi, A., Tradati, F., Bulla, C., Donzelli, L., Foppa, L., Bottarelli, M. L., Tomasello, A., Mauric, A., Femiano, C., Reggio, R., Lillo, F., Mariani, A., Forcignano, F., Volpe, M., D'Avino, M., Yildirim, E., Yildirim, R., Bongiorni, M. G., Severi, S., Capucci, A., Lodigiani, C., Salomone, E., Serviddio, G., Tondo, C., Golino, P., Mazzone, C., Iacopino, S., Pengo, V, Galvani, M., Moretti, L., Ambrosino, P., Banfi, E., Biagioli, V, Bianchi, A., Boggian, G., Breschi, M., Brusorio, S., Ball, K., Calcagnoli, F., Campagna, G., Page, M., Renom, R., Jimeno Besa, B., Carpenedo, M., Ciabatta, C., Ciliberti, G., Kis, E., Cimmino, G., Ramos Gonzalez, M., Vieira Torres, L. G., Sucu, M., Chattranukulchai, P., Cho, J-G, D'Arienzo, C., Di Gennaro, L., Fedele, M., Ferrini, P. M., Jerzewski, A., Gorrebeeck, K., Geerlings, F., Dols, S., Debordes, M., de Graauw, J., De Graaf, J., Granzow, K., Danse, I, Bruin, S., Bosschaert, M., Bosman, F., Boersma-Slootweg, M., Boersma, L. V. A., Buiks, C., Terpstra, W., Groenemeijer, B. E., Nagibovich, O., Hermans, W., Guazzaloca, G., Hoogslag, P. A. M., Nierop, P. R., Guerra, F., The, S. H. K., Adriaansen, H., Lucassen, A., Lochorn, G., Herrman, J-P, Guldener, C., Pieterse, M. G. C., Bongaerts, M., Klomps, H., Ruiter, J. H., ten Cate, H., Zecca, C., Villani, R., Sottilota, G., Segreti, L., Scarone, C., Scaccianoce, A., Salomone, L., Rangel, G., Oriana, V, Occhilupo, P., Poeta, E. Mollica, Mesolella, E., Macellari, F., Longo, S., Lo Buglio, A., Tao, G. Z., Rosenqvist, Marten, Kasala, L., Oto, Ali, He, X. A., Zhou, B., Vinolas, Xavier, Kakkar, Ajay K., Fitzmaurice, David A., Fox, Keith A. A., Kayani, Gloria, Virdone, Saverio, Camm, A. John, and Pieper, Karen S.
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medicine.medical_specialty ,business.industry ,Systemic embolism ,Atrial fibrillation ,Newly diagnosed ,Meth ,ta3121 ,medicine.disease ,chemistry.chemical_compound ,chemistry ,Physiology (medical) ,Internal medicine ,Antithrombotic ,Cardiology ,Medicine ,In patient ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,Stroke ,Major bleeding - Abstract
Background: Atrial fibrillation is associated with increased risks of death, stroke/systemic embolism, and bleeding (incurred by antithrombotic therapy), which may occur early after diagnosis. Methods: We assessed the risk of early events (death, stroke/systemic embolism, and major bleeding) over 12 months and their relation to the time after diagnosis of atrial fibrillation in 52 014 patients prospectively enrolled in the GARFIELD-AF registry (Global Anticoagulant Registry in the FIELD–Atrial Fibrillation) between March 2010 and August 2016. Results: Over 12 months, 2140 patients died (mortality rate, 4.3; 95% CI, 4.2–4.5 per 100 person-years), of whom 288 (13.5%) died in the first month (6.8; 95% CI, 6.1–7.6). Over 12 months, 657 patients had a stroke/systemic embolism (1.3; 95% CI, 1.2–1.4) and 411 had a major bleeding (0.8; 95% CI, 0.8–0.9). During the first month, the rates (per 100 person-years) of stroke/systemic embolism and major bleed were 2.3 (95% CI, 1.9–2.8) and 1.5 (95% CI, 1.2–1.9), respectively. The elevated 1-month mortality rate was mostly attributable to cardiovascular mortality (3.5; 95% CI, 3.0–4.1), in particular, heart failure, sudden death, and acute coronary syndromes (1.0 [95% CI, 0.8–1.4], 0.6 [95% CI, 0.4–0.8], and 0.5 [95% CI, 0.3–0.8], respectively). Age, heart failure, prior stroke, history of cirrhosis, vascular disease, moderate-to-severe kidney disease, diabetes mellitus, and living in North or Latin America were independent predictors of a higher risk of early death, whereas anticoagulation and living in Europe or Asia were independent predictors of a lower risk of early death. A predictive model developed for the 1-month risk of death had a C-statistic of 0.81 (95% CI, 0.78–0.83). Conclusions: The increased hazard of early events, in particular, cardiovascular mortality, in newly diagnosed atrial fibrillation points to the importance of comprehensive care for such patients and should alert clinicians to detect warning signs of possible early mortality. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01090362.
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- 2019
34. Impact of body mass index on the outcome of catheter ablation of atrial fibrillation
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Glover, B. M., Hong, K. L., Dagres, Arbelo, Laroche, Riahi, Bertini, Mikhaylov, E. N., Galvin, Kiliszek, Pokushalov, Kautzner, Calvo, Blomström-Lundqvist, Brugada, ESC-EHRA Atrial Fibrillation Ablation Long-Term Registry investigators, Committees and Investigators Executive Committee: Nikolaos Dagres, Josep, Brugada, Elena, Arbelo, Luigi, Tavazzi, Carina Blomström Lundqvist, Evgeny, Pokushalov, Josef, Kautzner, Steering Committee (National Coordinators): Clemens Steinwender, Aldo P. Maggioni., Alexandr, Chasnoits, Georges, Mairesse, Tosho, Balabanski, Sam, Riahi, Mostafa, Nawar, Mervat Abul El Maaty, Pekka, Raatikainen, Frederic, Anselme, Thorsten, Lewalter, Turgut, Brodherr, Michalis, Efremidis, Laszlo, Geller, Ben, Glover, Roy, Beinart, Michael, Glikson, Fiorenzo, Gaita, Roin, Rekvava, Oskars, Kalejs, Sergetrines, Zbigniew, Kalarus, Mario Martins Oliveira, Pedro, Adragao, Radu, Ciudin, Evgeny, Mikhaylov, Matjaz, Sinkovec, Julian Perez Villacastin, Carina, Blomström-Lundqvist, Oleg, Sychov, Investigators: Austria, Paul Roberts., Graz, D Daniel Scherr, Martin, Manninger, Bernadette, Mastnak, Innsbruck Otamr Pachinger, Florian, Hintringer, Markus, Stühlinger, Linz Clemens Steinwender, Belgium, Yvoir Olivier Xhaet, Bulgaria, Sofia Tchavdar Shalganov, Milko, Stoyanov, Mihail, Protich, Sofia Vassil Traykov, Daniel, Marchov, Genadi, Kaninski, BELARUS Minsk Alexandr Chasnoits, Czech, Republic, Prague Robert Cihak, Hradec Kralove Ludek Haman, Germany, Frankfurt Boris Schmidt, Julian Chun, K. R., Laura, Perrotta, Stefano, Bordignon, Hamburg Roland Tilz, Hamburg Stephan Willems, Leipzig Gerhard Hindricks, München Turgut Brodherr, Koutsouraki, Ilia S., Denmark, Aalborg Sam Riahi, Bodil Ginnerup Sørensen, Egypt, Cairo Wagdi Galal, Cairo Amir Abdel Wahab, Cairo, S Sherif Mokhtar, Spain, Alicante Ignacio Gil Ortega, Juan Gabriel Martinez Martinez, Badajoz Manuel Doblado Calatrava, Barcelona Roger Villuendas Sabate, Barcelona Lluis Mont Girbau, Bilbao Maria Fe Arcocha, Larraitz, Gaztañaga, Estibaliz, Zamarreño, Granada Miguel Álvarez, Rosa, Macías, LasPalmas de Gran Canaria Federico Segura Villalobos, Juan Carlos Rodríguez Pérez, Madrid Nicasio Perez Castellano, Victoria, Cañadas, Juan, J Gonzalez Ferrer, David, Filgueiras, Madrid Jose Manuel Rubio Campal, Pepa, Sánchez-Borque, Juan, Benezet-Mazuecos, Madrid Jorge Toquero Ramos, Fernandezlozano, Victor Castro Urda, Malaga Alberto Barrera Cordero, Carmen Medina Palomo, Amalio, Ruiz-Salas, Javier, Alzueta, Madrid Rafael Peinado, David, Filqueiras-Rama, Alfonso Gómez Gallanti, Daniel, Garófalo, Pamplona Naiara Calvo, Santander JuanJ ose Olalla Antolin, Sevilla Alonso Pedrote, Eduardo, Arana-Rueda, Lorena, García-Riesco, Finland, Turku Juha Lund, Tampere Pekka Raatikainen, France, Grenoble Pascal Defaye, Peggy, Jacon, Sandrine, Venier, Florian, Dugenet, SaintDenis Olivier Piot, Xavier, Copie, Olivier, Paziaud, Antoine, Lepillier, Saint Etienne Antoine Da Costa, Cécile, Romeyer-Bouchard, Toulouse Serge Boveda, Jean-Paul, Albenque, Nicolas, Combes, Stéphane Combes Marseille AngeFerracci, André, Pisapia, Greece, Athens Demosthenes Katritsis, Athens Konstantinos Letsas, Kostas, Vlachos, Louiza, Lioni, Vassilikos, Thessaloniki Vassilios P., Hungary, Budapest Laszlo Geller, Nándor, Szegedi, Gábor, Széplaki, Tamás, Tahin, Debrecen Zoltan Csanadi, Gabor, Sandorfi, Alexandra, Kiss, Edina, Nagy-Balo, Szeged Laszlo Saghy, Ireland, Glover, Dublin Benedict M., Joseph, Galvin, Edward, Keelan, Israel, Ramat Roy Beinart, Eyal, Nof, Italy, Acquaviva delle Fonti Massimo Grimaldi, Federico, Quadrini, Antonio Di Monaco, Federica, Troisi, Castellanza Massimo Tritto, Elvira, Renzullo, Antonio, Sanzo, Domenico, Zagari, Cotignola Carlo Pappone, Crema Pietro Maria Giovanni Agricola, Milano Paolo Della Bella, Napoli Giuseppe Stabile, Assunta, Iuliano, Pisa Maria Grazia Bongiorni, Roma Leonardo Calo, Ermenegildo de Ruvo, Sciarra, L, Torino Matteo Anselmino, Federico, Ferraris, Varese Roberto De Ponti, Raffaella, Marazzi, Doni, Lorenzo A., Kazakhstan, Almaty Roin Rekvava, Anna, Kim, Latvia, Riga Oskars Kalejs, Netherlands, Breda Sander Molhoek, Groningen Isabelle Van Gelder, Michiel, Rienstra, Leiden Serge Trines, Compier, Marieke G., Maastricht Laurent Pison, Crijns, Harry J., Kevin, Vernooy, Justin, Luermans, Rotterdam, Lucjordaens, Natasja de Groot, Tamas, Szili-Torok, Rohit, Bhagwandien, Zwolle Arif Elvan, Thomas, Buist, Pim, Gal, Poland, Lodz Andrzej Lubinski, Gdansk Tomasz Krolak, Katowice Seweryn Nowak, Katarzyna, Mizia-Stec, Anna Maria Wnuk-Wojnar, Krakow Jacek Lelakowski, Szczecin Jaroslaw Kazmierczak, Warszawa Piotr Kulakowski, Jakub, Baran, Warszawa Grzegorz Opolski, Marek, Kiliszek, Piotr, Lodziński, Sonia, Borodzicz, Paweł, Balsam, Poznan Krzysztof Blaszyk, Warszawa Mariusz Pytkowski, Rafal, Kuteszko, Jan, Ciszewski, Wroclaw Artur Fuglewicz, Zabrze Zbigniew Kalarus, Aleksandra, Woźniak, Karolina, Adamczyk, Portugal, Carnaxide Lisboa Pedro Adragao, Lisboa Pedro Cunha, Romania, Iasi Mihaela Grecu, Grigore, Tinica, Cluj-Napoca Lucian Muresan, Radu, Rosu, Russian, Federation, Kemerovo Egor Khomenko, Khanty-Mansiysk Nikita Scharikov, Krasnoyarsk Dmitry Zamanov, Krasnoyarsk Evgenii Kropotkin, Novosibirsk Evgeny Pokushalov, Alexander, Romanov, Sevda, Bayramova, Mikhaylov, Saint-Petersburg Evgeny N., Lebedev, Dmitry S., Patsouk, Anna V., Saint-Petersburg Sergey Yashin, Saint-Petersburg Dmitry Kryzhanovskiy, Saransk Vyacheslav Bazayev, Surgut Denis Morgunov, Ilya, Silin, Tomsk Sergey Popov, Tyumen Vadim Kuznetsov, Swedon, Linköping Anders Jönsson, Lund Pyotr Platonov, Fredrik, Holmqvist, Ole, Kongstad, Shiwenyuan, Umeå Niklas Höglund, Uppsala Helena Malmborg, David, Mörtsell, Slovenia, Ljubljana Matjaz Sinkovec, Andrej, Pernat, United, Kingdom, Southampton John Morgan, Paul, Roberts, Greenwood, Elizabeth F., Fletcher, Lisa L., Ukraine, Donetsk Tetiana Kravchenko, Kiev Alexander Doronin, Maryna, Meshkova, Odessa Iurii Karpenko, Alex, Goryatchiy, Anna, Abramova., UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service de cardiologie
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Male ,obesity ,Fluoroscopy/methods ,medicine.medical_treatment ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,Comorbidity ,030204 cardiovascular system & hematology ,Overweight ,Body Mass Index ,0302 clinical medicine ,Recurrence ,Risk Factors ,catheter ablation ,Atrial Fibrillation ,030212 general & internal medicine ,Registries ,Correlation of Data ,Registries/statistics & numerical data ,Atrial fibrillation ,Middle Aged ,Overweight/diagnosis ,Europe ,Cardiology ,Catheter Ablation ,Female ,atrial fibrillation, catheter ablation, obesity, Body Mass Index, Aged, Comorbidity, Correlation of Data, Europe, Radiation Dosage, Risk Assessment, Risk Factors, Overweight, Obesity, Recurrence, Risk Reduction Behavior, Atrial Fibrillation, Catheter Ablation, Fluoroscopy ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,Catheter Ablation/adverse effects ,Catheter ablation ,Radiation Dosage ,Risk Assessment ,NO ,Europe/epidemiology ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Obesity ,Aged ,business.industry ,Radiation dose ,nutritional and metabolic diseases ,Obesity/diagnosis ,medicine.disease ,Obstructive sleep apnea ,Fluoroscopy ,Atrial Fibrillation/epidemiology ,business ,Body mass index ,Risk Reduction Behavior ,Follow-Up Studies - Abstract
ObjectivesThe association between obesity and atrial fibrillation (AF) is well-established. We aimed to evaluate the impact of index body mass index (BMI) on AF recurrence at 12 months following catheter ablation using propensity-weighted analysis. In addition, periprocedural complications and fluoroscopy details were examined to assess overall safety in relationship to increasing BMI ranges.MethodsBaseline, periprocedural and follow-up data were collected on consecutive patients scheduled for AF ablation. There were no specific exclusion criteria. Patients were categorised according to baseline BMI in order to assess the outcomes for each category.ResultsAmong 3333 patients, 728 (21.8%) were classified as normal (BMI 2), 1537 (46.1%) as overweight (BMI 25.5–29.0 kg/m2) and 1068 (32.0%) as obese (BMI ≥30.0 kg/m2). Procedural duration and radiation dose were higher for overweight and obese patients compared with those with a normal BMI (p=0.002 and p2led to a 1.2-fold increased likelihood of experiencing recurrent AF at 12-months follow-up as compared with overweight patients (HR 1.223; 95% CI 1.047 to 1.429; p=0.011), while no significant correlation was found between overweight and normal BMI groups (HR 0.954; 95% CI 0.798 to 1.140; p=0.605) and obese versus normal BMI (HR 1.16; 95% CI 0.965 to 1.412; p=0.112).ConclusionsPatients with a baseline BMI ≥30 kg/m2have a higher recurrence rate of AF following catheter ablation and therefore lifestyle modification to target obesity preprocedure should be considered in these patients.
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- 2019
35. 18F-FDG PET/CT in locally advanced cervical cancer: A review
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R.C. Delgado-Bolton, J. Orcajo-Rincon, María José García-Velloso, M. del Puig Cózar-Santiago, A.P. Caresia-Aróztegui, M. de Arcocha-Torres, and S. Alvarez-Ruiz
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Cervical cancer ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,General Engineering ,Locally advanced ,medicine.disease ,Gynecological cancer ,030218 nuclear medicine & medical imaging ,Acquisition Protocol ,Response assessment ,Radiation therapy ,03 medical and health sciences ,0302 clinical medicine ,Radiological weapon ,medicine ,General Earth and Planetary Sciences ,Fdg pet ct ,Radiology ,business ,General Environmental Science - Abstract
Cervical cancer is the second most common gynecological cancer worldwide. In locally advanced cervical cancer, 18F-FDG PET/CT has become important in the initial staging, particularly in the detection of nodal and distant metastasis, aspects with treatment implications and prognostic value. The aims of this study were to review the role of 18F-FDG PET/CT in uterine cervical cancer, according to the guidelines of the main scientific institutions (FIGO, NCCN, SEGO, SEOM, ESGO, and ESMO) and its diagnostic accuracy compared to conventional radiological techniques, as well as to review the acquisition protocol and its utility in radiotherapy planning, response assessment and detection of recurrence.
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- 2019
36. Effect of positive carbon-11-choline PET/CT results in the therapeutic management of prostate cancer biochemical relapse
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Julio Jiménez-Bonilla, N. Martínez-Amador, Francisco J. Gómez-de la Fuente, Blanca Lucas-Velázquez, Oriana Cuenca-Vera, Aida Sánchez-Salmón, Ignacio Banzo, María De Arcocha-Torres, Isabel Martínez-Rodríguez, and Remedios Quirce
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Male ,medicine.medical_specialty ,PET/CT ,medicine.medical_treatment ,Computed tomography ,carbon-11-choline ,Choline ,030218 nuclear medicine & medical imaging ,Management of prostate cancer ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Recurrence ,Positron Emission Tomography Computed Tomography ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Carbon Radioisotopes ,External beam radiotherapy ,Aged ,Retrospective Studies ,Aged, 80 and over ,Chemotherapy ,medicine.diagnostic_test ,business.industry ,clinical effect ,Prostatic Neoplasms ,Original Articles ,General Medicine ,Middle Aged ,Choline pet ct ,prostate cancer ,medicine.disease ,therapeutic management ,030220 oncology & carcinogenesis ,Second Malignancy ,biochemical relapse ,Biochemical relapse ,Radiology ,business - Abstract
Objective Carbon-11-(11C)-choline PET/computed tomography (CT) has shown good results in re-staging of prostate cancer (PCa) with raised serum levels of prostate-specific antigen. Our aim was to evaluate the effect of positive 11C-choline PET/CT results in the therapeutic management of patients with PCa with biochemical relapse (BR) after curative intention treatment. Patients and methods A total of 112 patients with PCa BR and positive 11C-choline PET/CT were retrospectively evaluated. PET/CT was acquired 20 min after intravenous administration of 555–740 MBq of 11C-choline. The therapeutic management after 11C-choline PET/CT was obtained from the clinical records. The minimum follow-up time was 18 months. Results In 80 (71.4%) of 112 patients, 11C-choline PET/CT showed local recurrence of PCa; in 17 (15.2%) patients, distant recurrence; and in 15 (13.4%) patients, local plus distant recurrence. A second malignancy was detected in five (4.5%) patients. The planned therapeutic management was changed as per positive 11C-choline PET/CT result in 74 (66.1%) patients and were treated as follows: 31 (27.7%) patients with HT, combined with other treatments in eight (7.1%), 17 (15.2%) with BT, 13 (11.6%) with external beam radiotherapy, one (0.9%) with RP, and four (3.6%) with chemotherapy. Treatment approach was not modified in 37 (33%) patients. No data was available from one (0.9%) patient. Conclusion Positive 11C-choline PET/CT result had an important effect in the therapeutic management of patients with PCa and BR, leading to a change in the planned approach in two (66.1%) out of three patients. In addition, in 4.5% of the patients, the 11C-choline PET/CT allowed the detection of a second malignancy.
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- 2019
37. Prevalence of incidental pathogenic germline variants detected in cfDNA in patients with oncogene-driven non-small cell lung cancer
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Laura Mezquita, Leslie A. Bucheit, Juan Carlos Laguna, Belen Pastor, Cristina Teixido, Teresa Gorria, Victor Albarran-Artahona, Marta Garcia de Herreros, Roxana Reyes, Noemi Reguart, Nuria Vinolas, Ainara Arcocha, Joan Anton Puig-Butillé, Leylah Drusbosky, Iris Faull, Elena Castro, Jyoti D. Patel, Aleix Prat, and Benjamin Besse
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Cancer Research ,Oncology - Abstract
10569 Background: Preliminary data has highlighted inherited predisposition to lung cancer (LC) related to certain pathogenic germline variant (PGV) in cancer predisposing genes, including patients (pts) with tumors harboring somatic driver oncogene alterations (alt); however, the frequency of PGV in LC is unknown. Liquid biopsy assays may be able to identify incidental PGV (iPGV) in pts with solid tumors at scale. Here, we report the prevalence of iPGV in genes predisposing to cancer in pts with advanced non-small cell LC (aNSCLC) relative to driver alt status. Methods: Genomic results were retrospectively queried from 31126 pts with aNSCLC who had Guardant360 testing as part of routine clinical care from 10/2020-12/2021. iPGVs were defined as being non-synonymous, non-VUS alt in selected genes known to increase lifetime cancer risk (Table) with variant allele frequency (VAF) >30% and pathogenicity defined by a proprietary bioinformatics pipeline. Clinical factors such as age, gender, histology, and diagnosis status (new/progressing) were extracted from test requisition forms. The driver group included guideline-recommended and emerging somatic mutations (m) in EGFR/KRAS/BRAF/MET/HER2, fusions (f) in ALK/ROS1/RET/NTRK1-3 and amplifications (a) in HER2/MET. Results: Out of 31126, 720 (2.3%) of pts had predicted iPGV, of whom 54% were female, with a median age of 64 (22-100); most pts were newly diagnosed (66%). Among them, 92% of pts had iPGVs identified in the homologous recombination and repair (HRR) pathway, 3% in mismatch repair (MMR) pathway and 5% EGFR iPGVs. A total of 335 (47%) pts with iPGVs had somatic driver alt (Table): 20% of pts with iPGV had KRASm (n=144/720; 67 G12C), 12% EGFRm (n=87; 28 ex19del, 35 ex21(L858R)), 2.5% BRAFm (n=18), 2.5% METm ex14 skip (n=18), 0.1% HER2m (n=1), 0.8% ALKf (n=6), 0.1% ROS1f (n=1), 0.1% RETf (n=1), 0.1% HER2a (n=1), and 0.4% METa (n=3). ATM iPGVs were enriched in pts with driver alt. (45% driver vs 27% non-driver, p
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- 2022
38. Risk Profile and 1-Year Outcome of Newly Diagnosed Atrial Fibrillation in Japan ― Insights From GARFIELD-AF ―
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Kolesova, T., Yilmaz, MEHMET BİRHAN, Kakkar, Ajay K., Allu, Jagan, Worthy, V., Verdi, C., Tripti, T., Treasure, L., Thompson, N., Theobald, H., Thatcher, A., Stephanie, B., Smith, K., Shoemaker, J., Shaw, P., Sanghera, T., Sage, A., Robertson, C., Richardson, T., Richard, C., Raziano, S., Raynor, J., Minardo, J., Merritt, D., Merliss, A., Malone, E., Lincoln, T., Lee, J. A., Lay, M., Langdon, J., Knowles, P., Kerr, J., Keeling, M., Karl, S., Jones, P., Jones, L., Jones, A., Johnson, K., Jasinski, S., Hicks, T., Herrick, C., Henson, L., Headlee, M., Hawkins, B., Hartranft, E., Harbour, T., Hakimi, F., Haideri, A., Gentry, P., Fielder, D., Ferdinand, K., Felpel, S., Evans, L., Eley, M., Dickerson, A., DePauw, J., Congal, S., Cervellione, K., Cassidy, D., Canova, M., Browne, A., Brown, A., Bowers, S., Bentley, M., Bartlett, M., Ball, K., Asafu-Adjaye, N., Treasure, C., Nishijima, D., Pitta, S., Duffy, P., Noveck, H., Ison, R., Alberts, M., Remmel, K., Theodoro, D., Diercks, D., Delafontaine, P., Ahmed, W., Reddy, R., Haque, I., Gutowski, T., Alfieri, A., Sharma, N., Beach, S., Miller, S., Williams, M., Mendelson, R., Falkowski, S., Franco, M., Cox, M., Kutayli, W. M., Ferrick, K., Quick, A., Wilson, V., Mullen, P., Garcia, J., Blumberg, E., Rama, P., Canosa, R., Goldhaber, S. Z., Thanzeel, M., Sharma, R., Mohamed, R., Maqsood, I., Makdad, M., Magdaluyo, K., Jadhav, S., Haridas, P., El Bardisy, S., Al Mulla, A., Abdul, A., Subbaraman, B., Khan, M., Gupta, R., Wassef, A., Bazargani, N., Maruthanayagam, R., Al Naeemi, A., Al Omairi, M., Naguib, A., Singh, R., Esheiba, E. M., Ibrahim, M., Nathani, M., Agrawal, A., Yousef, G., Al Mahmeed, W., van Zyl, F., Tau, T., Tarr, G., Smith, L., Skein, A., Shaik, F., Sasto, J., Salie, M., Rikhotso, L., Page, A., Mostert, M., Mavhusa, L., Marks, J., Loyd, E., Karsten, M., Henley, L., Ellis, T., Du Plessis, G., de Meyer, L., Davids, A., Conway, G., Chami, C., Cassimjee, S., Cannon, C., Boshoff, C., Booysen, M., Bester, C., Angel, G., Oosthuysen, W., Maharajh, S., Ramdass, A., Engelbrecht, J., Ahmed, F., Ismail, S., Loghdey, R., Ueckermann, V., Mntla, P., Greyling, D., Louw, R., Murray, A., Theron, H., van Zyl, L., Guerra, M., Pillay, T., Garda, R., Kelfkens, Y., Horak, A., Hines, C., Haveman, K., Gulliver, W., Grenier, M. -C., Fox, B., Fournier, D., Ferleyko, L., Fearon, A., Farquhar, D., Ewert, A., Dunnigan, J., Douglass, S., Djaidani, Z., Denis, I., Dehghani, P., Daheb, S., Cleveland, T., Clarke, B., Carroll, L., Burke, E., Breakwell, L., Bignell, N., Bigcanoe, J., Bergeron, C., Beaudry, K., Aves, T., Aro, L., Angaran, P., Ahmad, K., Bonet, J., Ramjattan, B., Cha, J., Lavoie, A., Parkash, R., Fikry, S., Vizel, S., MacDonald, P., Coutu, B., Schweitzer, B., Hruczkowski, T., Dhillon, R., Dresser, G., Nadeau, R., Du Preez, M., Poirier, G., Heath, J., Purcell, T., Pickelsimer, N., Peterson, J., Pearl, G., Paserchia, S., Parrott, T., Parker, M., Palumbo, V., Orosco, C., Mooso, B., Berlingieri, J., Ayala-Paredes, F., Beaudry, P., Leader, R., Cheung, S., Pandey, A. 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(Masahiko), Okawa, M., Fujii, M., Nakamura, Y. (Yuichiro), Iwaki, M., Miyamoto, N., Nagano, S., Takezawa, H., Oshiro, K., Nii, K., Kameko, M., Tabuchi, T., Seto, T., Nagoshi, T., Atsuchi, Y., Fujisawa, K., Sanno, K., Nagatomo, T., Sumi, H., Shiga, Y. (Yuhei), Morii, S., Unoki, T., Mishima, K., Go, Y., Oda, H. (Hiroyuki), Ageta, M., Oyama, R., Nakamura, Y. (Yoichi), Kitami, Y., Hatori, Y., Takeuchi, M., Tsuchida, K., Iwao, T., Yokota, N., Hoshino, F., Takamura, I., Akutsu, M., Shimoyama, M., Ogurusu, C., Murata, K., Nakatsuka, M., Ishizawa, M., Fujiura, Y. (Yoshitake), Ikeda, D., Yoshida, H., Eto, T., Gushiken, M., Higa, S., Kuwahata, T., Oba, I., Tachibana, H., Obunai, K., Fudo, T., Saito, K. ( Kazuyuki), Saito, K. (Katsumi), Tsunoda, S., Kihara, H., Abe, S., Maekawa, H., Yamasawa, M., Wakasa, Y., Murakami, K., Kamogawa, Y., Tatematsu, H., Ogawa, J., Numata, H., Yoshimura, A., Fujiura, Y. (Yoshihisa), Zaitsu, R., Nandate, H., Nakamura, T. (Tsugihiro), Nakamura, T. (Tadashi), Kato, H., Miyagi, H., Suefuji, H., Haraguchi, Y., Minoda, K., Goto, K., Sonoda, R., Oba, Y., Matsumura, J., Murayama, T., Kumeda, K., Komaki, S., Azakami, S., Okada, K., Higashi, T., Ando, H., Yamamoto, K., Koyanagi, T., Tsuruta, M., Norita, H., Chiba, K., Adachi, S., Shiraishi, K., Oda, H. (Hiroshi), Minamoto, M., Suetsugu, T., Ando, S., Gersh, Bernard J., Kayani, Gloria, Verheugt, Freek W. A., van Eickels, Martin, Turpie, Alexander G. G., Pieper, Karen S., Misselwitz, Frank, Mantovani, Lorenzo G., Hacke, Werner, Haas, Sylvia, Goto, Shinya, Goldhaber, Samuel Z., Fitzmaurice, David A., Camm, A. John, Bassand, Jean-Pierre, Chibana, H., Oba, I, Arai, H., Arima, S., Nagai, S., Date, H., Nomura, K., Fujiki, R., Inakura, T., Barretto, A. C. P., Zurbrigk, F. J., Zillo, M., Yunis, M. E., Vallejo, M., Tufare, A. L., Tonelli, L., Tinto, J. F., Sossich, A., Schygiel, P. O., Sanziani, L. S., Salinger, M., Said Palladino, M. E., Rolandi, F., Rodriguez, M. A., Ricotti, C., Potito, R. N., Pontoriero, J., Perez Prados, G., Novas, V., Navarro, A., Munguia, R., Meirino, A., Mautner, B., Matkovich, J., Martinelli, C., Martinelli, A., Maffei, L., Maehara, G., Lopez, A., Ingratta, M., Hrabar, A. D., Hansen, V., Tsuji, T., Tsuchiya, Y., Toru, S., Tohyo, S., Teragawa, H., Taya, K., Tanabe, G., Tana, T., Takenaka, K., Takei, K., Takeda, H., Take, S., Takanaka, C., Takai, H., Takahashi, S., Takahashi, K., Takagi, Y., Takagi, T., Taguchi, A., Tada, M., Ogawa, T., Nozoe, M., Nomura, S., Niwa, I., Nishizawa, K., Nishioka, H., Nishino, K., Nishihata, Y., Nishida, Y., Niinuma, H., Niijima, Y., Nariyama, J., Nanke, T., Nakazato, R., Nakayama, T., Nakanishi, N., Nakamura, R., Nakamura, M., Nakahara, S., Nakagomi, A., Nagata, H., Nagata, E., Nagai, S. (Shunichi), Nagai, S. (Sho), Murai, O., Morishita, K., Moriai, O., Mori, T., Mizuno, A., Mizuguchi, I., Miyata, S., Miyashita, A., Miyamoto, H., Miyajima, S., Miyaguchi, S., Miura, N., Mitsuhashi, H., Mineoi, K., Matsuura, Y., Matsushita, K., Matsui, S., Maruyama, Y., Maeda, K., Maeda, I., Kumazaki, T., Kumai, Y., Kozuka, T., Kotani, T., Koshibu, Y., Komatsu, I., Komatsu, H., Kojima, J., Koeda, T., Kobayashi, T., Kito, T., Kitazumi, H., Kitazawa, H., Kira, T., Kawano, S., Kawamoto, T., Kawakami, S., Kawakami, K., Kawai, K., Kawada, Y., Kato, Y., Kato, T., Kasai, T., Kano, H., Kaneko, M., Kanda, H., Kanai, H., Kamata, J., Kakuda, H., Iwase, T., Ito, N., Inoue, T., Inaba, H., Imaizumi, M., Ikeoka, K., Ikeda, K., Ikeda, H., Iiji, O., Ido, T., Horie, H. (Hideki), Honda, M., Hirota, S., Hirose, M., Hirayama, H., Hirasawa, K., Higuchi, K., Hayashi, Y., Hatsuno, T., Hasegawa, K., Hanazono, N., Hamaoka, M., Goto, T., Furumoto, W., Furukawa, T., Furukawa, N., Fukui, T., Fukuda, T., Fujisawa, Y., Fujisawa, A., Fujii, Y., Endo, M., Emura, Y., Doiuchi, J., Betsuyaku, T., Baba, T., Azuma, J., Asano, T., Asano, H., Arino, T., Aoyama, T., Aoki, K., Amano, T., Akahane, K., Adachi, T., Adachi, S. (Susumu), Adachi, S. (Sen), Abe, Y., Nagasaka, S., Okuda, F., Mukawa, H., Wada, M., Minagawa, T., Ishiguro, M., Mizuguchi, M., Yoshida, T. (Tomoki), Fujiura, Y., Kawano, Y., Abe, M., Mizuno, Y., Kanamori, S., Mori, E., Shirakawa, K., Ishioka, N., Noguchi, H., Nobuhito, Y., Shiga, Y., Toyota, F., Nakamura, T., Nakamura, Y., Okamoto, Y., Miyoshi, H., Shinohara, H., Shigekiyo, M., Miyamoto, Y., Ota, A., Okada, M., Yoshida, T., Iseki, F., Katsuya, T., Shindo, T., Suzuki, S., Shiraiwa, T., Ono, T., Otaki, E., Sato, K., Saito, K., Suzuki, K., Kodera, K., Pearce, Onuki Y., Sezaki, K., Ubukata, S., Honzawa, T., Sasaki, T., Seta, Y., Saito, Y., Oriuchi, T., Suzuki, Y., Suzuki, S. (Susumu), Suzuki, S. (Shunji), Suzuki, S. (Shu), Suzuki, K. (Keita), Suzuki, K. (Kazuo), Sugimoto, C., Suga, T., Shozawa, Y., Shirai, T., Shinozuka, T., Shinohe, R., Shimoyama, Y., Shimono, H., Shiina, Y., Shibata, N., Sekine, Y., Seki, S., Sawano, M., Sato, K. (Kiyoharu), Sato, K. (Kazuki), Sasaki, A., Sasaguri, H., Sasagawa, Y., Samejima, Y., Sakamoto, Y., Sakamoto, N., Sakai, H., Oriso, S., Pearce, Y. Onuki, Ono, H., Okuyama, M., Okita, H., Okamoto, K., Ohara, N., Misumi, I., Shah, S., Purayil, M. Padinhare, Pothiwala, R. A., Chandwani, P., Kulkarni, G., Kishore, R., Chopda, M., Roy, D., Srinivas, A., Sarma, R., Bhargava, K., Rajput, R. K., Shankar, A. G. Ravi, Durgaprasad, R., Jadhav, P., Sawhney, J. P. S., Kakkar, S., Zhu, X. Y., Zhou, Z. H., Zhou, B., Zheng, W. Y., Zhang, Y., Zhang, R., Zhang, Q., Zhang, G. S., Zhan, Q., Zhai, H., Yu, T., Yu, J. H., Yu, H. Y., Ye, Y., Yang, Y. J., Yang, Q., Yang, L. L., Yang, J. S., Xu, R. Y., Xie, Q., Wu, R. N., Wang, L., Wang, K., Tian, G., Sun, Y. H., Shi, X. J., Sheng, X., Peng, J. Q., Ma, T. Y., Luo, X. L., Lu, Z. C., Liu, Y. Y., Liu, W. L., Liu, T. T., Li, Y. H., Li, L., Li, J., Li, B., Huang, X. F., Hu, X. S., He, X. A., He, R. H., Guo, W. N., Gao, X. J., Fu, Q. H., Feng, S., Chen, X., Chen, J. Y., Chen, J., Bai, C. L., Yang, Z. M., Wang, F. Z., Xue, L., Guo, Y., Jiao, Y., Chen, P., Xiong, L. G., Chen, M. S., Zhao, R. P., Yan, X. W., Cheng, X. S., Wu, T. G., Li, X., Wang, Y. ( Yong), Wang, Y. (Ying), He, S. H., Chen, Y. M., Yang, P., Tao, G. Z., Yin, Y. H., Li, W. H., Wang, D. W., Cao, S. P., Chen, J. Z., Zhang, H. Q., Zhao, Y. S., Chen, K. N., Hu, D. Y., Fitzmaurice, David, Al Mahmeed, Wael, Parkhomenko, Alex, Oto, Ali, Angchaisuksiri, Pantep, Steffel, Jan, Rosenqvist, Marten, Vinolas, Xavier, Oh, Seil, Jacobson, Barry, Lim, Toon Wei, Panchenko, Elizaveta, Stepinska, Janina, Atar, Dan, Ten Cate, Hugo, Sanchez Diaz, Carlos Jerjes, Koretsune, Yukihiro, Ambrosio, Giuseppe, Agnelli, Giancarlo, Sawhney, Jitendra Pal Singh, Kakkar, Sanjay, Keltai, Matyas, Darius, Harald, Le Heuzey, Jean-Yves, Raatikainen, Pekka, Ragy, Hany, Nielsen, Jorn Dalsgaard, Jansky, Petr, Hu, Dayi, Corbalan, Ramon, Eikelboom, John, Spyropoulos, Alex, Connolly, Stuart J., Pereira Barretto, Antonio Carlos, Cools, Frank, Brodmann, Marianne, Gibbs, Harry, Lucas Luciardi, Hector, Oda, H., Sato, A., Fujimoto, S., Tsubokura, T., Goda, T., Maeda, I, Takamura, I, Agata, J., Yokota, Naoto, Ando, Shin-ichi, Shibuya, Mitsuhiro, Eshima, Kenichi, Sakuma, Ichiro, Kumeda, Kenshi, Suetsugu, Tetsuro, Katsuda, Yousuke, Etoh, Takuma, Abu-Mahfouz, M., Sadamatsu, K., Katsuda, Y., Kumagai, K., Koretsune, Y., Panse, S. G., Vanajakshamma, V., Suresh, S., Singhal, S., Shiva, P., Sharma, M., Sadhu, N., Rao, N. M., Rao, M., Prashanth, K., Naik, D., More, P., Meena, R., Madarkar, N., Lokesh, B., Lawande, A., Krishnappa, S., Kaur, S., Kasala, L., Karthikeyan, R., Jain, V., Giradkar, S., Ganatra, A., Earath, M., Duhan, S., Dhyani, V., Dhakrao, P., Deshpande, B., Davies, D., Dargude, M., Bhattacharjee, P., Begum, H., Barai, A., Adak, D., Abraham, S., Jain, D., Kumar, S., Gupta, J. B., Khan, A., Bisne, V., Bantwal, G., Vijan, V. M., Vijayaraghavan, G., Raghuraman, B., Kothiwale, V. A., Chawla, K., Inagaki, K., Anno, T., Iseki, A., Horie, H., Narumi, J., Owari, M., Mizuguchi, I, Furukawa, Y., Matsumoto, N., Dorian, P., Tarrant, J., Cameron-Watts, J., Hegde, M. P., Dumikyan, A., Figura-Chmielewska, M., Alborough, E., Sabir, A., Reimer, D., Hergdt, G., Nierop, P. R., Baglioni, G., Viana, T., Vargas, T., Ely Pizzato, P., Drummond Wainstein, A. P., Ikitimur, B., Genc, D., Yoshida, T. (Tetsuro), Nagamalesh, U. M., Ishihara, A., Fu, G. S., Fox, Keith A. A., Flint, K., and Roesch, H.
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Male ,medicine.medical_specialty ,medicine.drug_class ,Embolism ,Administration, Oral ,Hemorrhage ,Newly diagnosed ,030204 cardiovascular system & hematology ,Risk Assessment ,Risk profile ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Registries ,Stroke ,Aged ,Aged, 80 and over ,Fibrillation ,business.industry ,Anticoagulant ,Anticoagulants ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,Stroke prevention ,Cohort ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Platelet Aggregation Inhibitors ,030217 neurology & neurosurgery - Abstract
Background Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective non-interventional study of stroke prevention in patients with newly diagnosed non-valvular AF (NAVF) that is being conducted in 35 countries. Methods and Results: A total of 52,081 patients with a new diagnosis of NVAF were enrolled prospectively in GARFIELD-AF. Of these, 4859 (9.3%) were recruited in Japan (2010-2016). In cohort 1 (2010-2011), few patients were on non-vitamin K antagonist oral anticoagulants (NOAC) globally. From cohort 2 onwards (2011-2016), however, there was a rapid increase in NOAC use around the globe, especially in Japan. By the last year of enrolment (2015-2016), 67.9% of patients in Japan and 43.1% of patients globally were on NOAC±antiplatelet therapy (AP). In Japan and globally, 17.0% and 12.2% of patients, respectively, did not receive stroke prevention treatment. Few patients in Japan (5.7%) received AP only. Compared with the other countries, the unadjusted rates of all-cause mortality and major bleeding were low, while rates of stroke/systemic embolism were similar after 1 year of follow-up. Conclusions GARFIELD-AF continues to provide important information on the homogeneity and heterogeneity of baseline characteristics and treatment patterns in patients with newly diagnosed NVAF. This diversity reflects the differences in outcomes in Japan compared with the rest of the world.
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- 2018
39. Remote heart failure management using the HeartLogic algorithm. RE-HEART registry
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Javier de Juan Bagudá, Juan J. Gavira Gómez, Marta Pachón Iglesias, Rocío Cózar León, Vanessa Escolar Pérez, Óscar González Fernández, Nuria Rivas Gándara, Josebe Goirigolzarri Artaza, Beatriz Díaz Molina, Alfonso Macías Gallego, Virgilio Martínez Mateo, Juan G. Martínez Martínez, Natalia Marrero Negrín, Gonzalo L. Alonso Salinas, Luis González Torres, Juan F. Delgado Jiménez, Paula Sánchez-Aguilera, Ernesto Díaz Infante, María F. Arcocha Torres, Laura Peña Conde, Ana B. Méndez Fernández, Nicasio Pérez Castellano, José M. Rubín López, Inés Madrazo Delgado, Manuel J. Fernández-Anguita, Pablo Ramos Ruiz, Olga Medina Moreno, David Cordero Pereda, Carlos de Diego Rus, Fernando Arribas Ynsaurriaga, Ignacio García Bolao, and Rafael Salguero Bodes
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Heart Failure ,Hospitalization ,Humans ,General Medicine ,Registries ,Algorithms ,Defibrillators, Implantable - Abstract
HeartLogic is a multiparametric algorithm incorporated into implantable cardioverter-defibrillators (ICD). The associated alerts predict impending heart failure (HF) decompensations. Our objective was to analyze the association between alerts and clinical events and to describe the implementation of a protocol for remote management in a multicenter registry.We evaluated study phase 1 (the investigators were blinded to the alert state) and phases 2 and 3 (after HeartLogic activation, managed as per local practice and with a standardized protocol, respectively).We included 288 patients from 15 centers. In phase 1, the median observation period was 10 months and there were 73 alerts (0.72 alerts/patient-y), with 8 hospitalizations and 2 emergency room admissions for HF (0.10 events/patient-y). There were no HF hospitalizations outside the alert period. In the active phases, the median follow-up was 16 (95%CI, 15-22) months and there were 277 alerts (0.89 alerts/patient-y); 33 were associated with HF hospitalizations or HF death (n=6), 46 with minor decompensations, and 78 with other events. The unexplained alert rate was 0.39 alerts/patient-y. Outside the alert state, there was only 1 HF hospitalization and 1 minor HF decompensation. Most alerts (82% in phase 2 and 81% in phase 3; P=.861) were remotely managed. The median NT-proBNP value was higher within than outside the alert state (7378 vs 1210 pg/mL; P.001).The HeartLogic index was frequently associated with HF-related events and other clinically relevant situations, with a low rate of unexplained events. A standardized protocol allowed alerts to be safely and remotely detected and appropriate action to be taken on them.
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- 2021
40. 'The gap is still open': Soledad de Orozco Ávila and the feminist vote in Mexico
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Rosa María Spinoso Arcocha
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Mujeres mexicanas ,Revolución ,Political science ,Mujeres - Voto - México ,Sindicalismo ,Voto femenino ,Periodismo ,General Medicine ,Humanities ,Social activism - Abstract
espanol?Como una sociedad conservadora y religiosa de la region de Los Altos, escenario privilegiado de la Cristiada en el estado mexicano de Jalisco, vio nacer y produjo una mujer revolucionaria, anticlerical, anarcosindicalista y libre pensadora?, segun ella se autodefinia mientras ayudaba a crear una de las secciones de la Casa del Obrero Mundial, en 1924. La Cristiada fue un movimiento armado en los anos 20, entre el gobierno y las milicias de catolicos que resistian a la legislacion y politicas publicas. Partiendo de esa problematica propongo una aproximacion, desde la Historia Cultural, a la vida y activismo politico y social de Soledad de Avila Orozco, tambien pionera del sufragio femenino en Mexico, cuando se postulo en 1937 como candidata independiente para diputada local, en el estado de Guanajuato. Gano, con un amplio margen de votos, pero como habia previsto, no le permitieron desempenar el cargo. Tampoco era eso lo importante, segun decia, y si “abrir brecha y sentar un precedente”. ?Sus electores? Eran de las mas diferentes filiaciones e ideologias, desde catolicos, anticlericales y anarquistas, pero, principalmente, miembros del Frente Unico Pro-Derechos de la Mujer, del que Soledad Avila Orozco sera una de las fundadoras. Siguio luchando hasta los 84 anos, cuando murio en 1985. EnglishHow did a conservative and religious society in Los Altos region, a privileged place of the “Cristeada” in the Mexican state of Jalisco, saw the birth and production of a revolutionary, anti-clerical, anarcho-syndicalist and free-thinking woman? She defined herself with all this caracteristics while she helped to create one of the sections of the “Casa del Obrero Mundial”, in 1924. But what is “La Cristiada? It was an armed movement in the 20s, between the government and militias of Catholics who rejected the legislation and public policies of the moment. Based on this problem, I propose an approach, using the methods from Cultural History, to the life and the political and social activism of Soledad de Avila Orozco. She is also a pioneer of women's suffrage in Mexico, in 1937, as an independent candidate for local deputation, in the neighboring state of Guanajuato. He won, with a wide margin of votes, but as he had anticipated, he was not allowed to hold the position. But as she said, that was not the important thing, what mattered was "open the gap and set a precedent." And what about her constituents? They belogned at different affiliations and ideologies, they were Catholics, anticlericals, and anarchists; but mainly of them were part of the United Front for Women's Rights, grup of which she was a founding member. He continued fighting for the women’s rights until the age 84, she died in 1985.
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- 2021
41. Improving Skills in Mechanism and Machine Science Using GIM Software
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Alfonso Hernandez Frias, Monica Urizar Arana, Erik Macho Mier, and Victor Petuya Arcocha
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Technology ,QH301-705.5 ,QC1-999 ,Teaching method ,Library science ,computer.software_genre ,mechanism science ,Software ,learning tools ,Political science ,General Materials Science ,Biology (General) ,problem-based learning ,QD1-999 ,Instrumentation ,educational software ,Educational software ,Fluid Flow and Transfer Processes ,Government ,teaching methodology ,business.industry ,Physics ,Process Chemistry and Technology ,General Engineering ,Engineering (General). Civil engineering (General) ,Computer Science Applications ,Chemistry ,Problem-based learning ,TA1-2040 ,business ,computer ,Mechanism (sociology) - Abstract
The field of education has evolved significantly in recent years as it has incorporated new pedagogical methodologies. Many of these methodologies are designed to encourage students’ participation in the learning process. The traditional role of the student as a passive receiver of content is no longer considered valid. Teaching in mechanical engineering is no stranger to these changes either, where new learning activities have been designed to complement theory-heavy lectures. These activities take place in both physical and virtual laboratories. In case of the latter, the use of the GIM software (developed at the Department of Mechanical Engineering of the University of the Basque Country UPV/EHU, Spain) is a promising option. In this paper, features of the GIM that are most frequently used to support and exemplify the theoretical concepts taught in lectures are described using a case study. In addition, GIM is integrated into different learning activities to show its potential as a tool for learning and self-evaluation. This research was funded by Ministerio de Economía y Competitividad, Spanish Government Project, MINECO/FEDER, UE (grant number DPI2015-67626-P), Departamento de Educación, Política Lingüística y Cultura, Regional Government of the Basque Country (grant number IT949-16) and University of the Basque Country UPV/EHU (grant number PIE2012/14).
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- 2021
42. Business model and family company : practical application through canvas model
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Alonso Arcocha, Desirée, Pérez Pérez, Marta, Serrano Bedia, Ana María, and Universidad de Cantabria
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Modelo de Negocio de Canvas ,Sector Pesquero ,Empresas Familiares - Abstract
Resumen. El objetivo de este trabajo fin de grado es analizar el modelo de negocio de una empresa familiar dedicada a la venta de pescado fresco, que paso de ser líder de mercado durante veinte años a perder cuota de mercado, para ello se utilizará el Modelo de negocio de Canvas. Se va a poner en contexto al lector informando sobre la situación actual del sector pesquero tanto a nivel nacional, regional y local analizando diferentes variables (consumo per cápita, consumo en los hogares, consumo de pescado fresco, distribución por canales…) para conocer la evolución del consumo y precio de este tipo de producto fresco, para así poder analizar a la empresa. Abstract: The aim of this final degree project is to analyse the business model of a family business devoted to the sale of fresh fish, which went from being market leader for twenty years to losing market share, using the Canvas business model. The reader will be put in context by informing about the current situation of the fishing sector at national, regional, and local level, analysing different variables (per capita consumption, household consumption, consumption of fresh fish, distribution by channels...) to find out the evolution of consumption and price of this type of fresh product, to be able to analyse the company. Grado en Administración y Dirección de Empresas
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- 2021
43. Long-Term Outcomes Among a Nationwide Cohort of Patients Using an Implantable Cardioverter-Defibrillator: UMBRELLA Study Final Results
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Sem Briongos‐Figuero, Arcadio García‐Alberola, Jerónimo Rubio, José María Segura, Aníbal Rodríguez, Rafael Peinado, Javier Alzueta, José B. Martínez‐Ferrer, Xavier Viñolas, Joaquín Fernández de la Concha, Ignasi Anguera, María Martín, Laia Cerdá, Luisa Pérez, Ricardo Pavón, José María Arizón, Miguel Álvarez López, Ernesto Díaz Infante, David Calvo, Juan Carlos Rodríguez, Luis Álvarez, Juanjo Olalla, Javier Jiménez Díaz, Javier Balaguer, Miguel Ángel Arias, Marisa Fidalgo, Francisco‐Javier García, Josep Brugada, Roger Villuendas, Rosa Porro, Enrique García Campo, Ignacio Fernández Lozano, Julián Villacastín, Ángel Arenal, Roberto Muñoz Aguilera, Antonio Hernández, Arcadio García Alberola, Fernando Pérez Lorente, Nuria Basterra, María Fe Arcocha, Andrés Bodegas, Francisco Zumalde, José B Martínez Ferrer, José María Porres, José Moreno Arribas, Ricardo Ruiz, Aurelio Quesada, Juan Gabriel Martínez, and María José Sancho‐Tello
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Male ,medicine.medical_treatment ,Psychological intervention ,030204 cardiovascular system & hematology ,Sudden Cardiac Death ,Cohort Studies ,0302 clinical medicine ,Preventive Health Services ,Long term outcomes ,Arrhythmia and Electrophysiology ,030212 general & internal medicine ,Inappropriate shock ,Original Research ,Incidence (epidemiology) ,Middle Aged ,Implantable cardioverter-defibrillator ,appropriate implantable cardioverter‐defibrillator therapy ,Defibrillators, Implantable ,inappropriate shock ,Cohort ,Female ,Cardiology and Cardiovascular Medicine ,Needs Assessment ,medicine.medical_specialty ,All-cause death ,Heart Diseases ,Electric Countershock ,implantable cardioverter‐defibrillator ,Risk Assessment ,Appropriate implantable cardioverter-defibrillator therapy ,03 medical and health sciences ,medicine ,Humans ,Mortality ,Heart Failure ,all‐cause death ,business.industry ,sustained ventricular arrhythmia ,Survival Analysis ,Equipment Failure Analysis ,Spain ,Emergency medicine ,Tachycardia, Ventricular ,business ,Sustained ventricular arrhythmia ,Catheter Ablation and Implantable Cardioverter-Defibrillator ,All cause mortality - Abstract
Background Large‐scale studies describing modern populations using an implantable cardioverter‐defibrillator (ICD) are lacking. We aimed to analyze the incidence of arrhythmia, device interventions, and mortality in a broad spectrum of real‐world ICD patients with different heart disorders. Methods and Results The UMBRELLA study is a prospective, multicenter, nationwide study of contemporary patients using an ICD followed up by remote monitoring, with a blinded review of arrhythmic episodes. From November 2005 to November 2017, 4296 patients were followed up. After 46.6±27.3 months, 16 067 episodes of sustained ventricular arrhythmia occurred in 1344 patients (31.3%). Appropriate ICD therapy occurred in 27.3% of study population. Patients with ischemic cardiomyopathy (hazard ratio [HR], 1.51; 95% CI, 1.29–1.78), dilated cardiomyopathy (HR, 1.28; 95% CI, 1.07–1.53), and valvular heart disease (HR, 1.94; 95% CI, 1.43–2.62) exhibited a higher risk of appropriate ICD therapies, whereas patients with hypertrophic cardiomyopathy (HR, 0.72; 95% CI, 0.54–0.96) and Brugada syndrome (HR, 0.25; 95% CI, 0.14–0.45) showed a lower risk. All‐cause death was 13.4% at follow‐up. Ischemic cardiomyopathy (HR, 3.09; 95% CI, 2.58–5.90), dilated cardiomyopathy (HR, 3.33; 95% CI, 2.18–5.10), and valvular heart disease (HR, 3.97; 95% CI, 2.25–6.99) had the worst prognoses. Delayed high‐rate detection was enabled in 39.7% of patients, and single‐zone programming occurred in 52.6% of primary prevention patients. Both parameters correlated with lower risk of first appropriate ICD therapy, with no excess risk of mortality. The rate of inappropriate shocks at follow‐up was low (6%) and did not differ among type of ICD but was lower in SmartShock‐capable devices. Conclusions Irrespective of the cause, contemporary ICD patients with heart failure–related disorders had a similar risk of ICD life‐saving interventions and death. Current ICD programming recommendations still need to be implemented. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NTC01561144.
- Published
- 2020
44. Remote heart failure management using a multiparameter implantable cardioverter-defibrillator alert: the multicentric RE-HEART registry
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C De Diego Rus, R Salguero Bodes, G.L. Alonso Salinas, J.G Martinez Martinez, C Briz De Felipe, R Cozar Leon, J. de Juan Baguda, J.J. Gavira Gómez, J.M Rubin Lopez, J. Goirigolzarri Artaza, M Pachon Iglesias, M.F Arcocha Torres, L Pena Conde, J M Medina Gil, and V Martinez Mateo
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Heart failure ,Emergency medicine ,medicine ,Cardiology and Cardiovascular Medicine ,Implantable cardioverter-defibrillator ,business ,medicine.disease - Abstract
Background The HeartLogic algorithm combines multiple implantable cardioverter-defibrillator (ICD)-based sensors into an index for prediction of impending heart failure (HF) decompensation. In patients with ICD and cardiac resynchronization therapy ICD remotely monitored at 13 Spanish centers, we analyzed the association between clinical events and HeartLogic alerts and we described the use of the algorithm for the remote management of HF. Methods The association between clinical events and HeartLogic alerts was studied in the blinded phase (from ICD implantation to alert activation – no clinical actions taken in response to alerts) and in the following active phase (after alert activation – clinicians automatically notified in case of alert). Results We enrolled a total of 215 patients (67±13 years old, 77% male, 53% with ischemic cardiomyopathy) with ICD (19%) or CRT-D (81%). The median duration of the blinded phase was 8 [3–12] months. In this phase, the HeartLogic index crossed the threshold value (set by default to 16) 34 times in 20 patients. HeartLogic alerts were associated with 6 HF hospitalizations and 5 unplanned in-office visits for HF. Five additional HeartLogic threshold crossings were not associated with overt HF events, but occurred at the time of changes in drug therapy or of other clinical events. The rate of unexplained alerts was 0.25 alert-patient/year. The median time spent in alert was longer in the case of HF hospitalizations than of in-office visits (75 [min-max: 30–155] days versus 39 [min-max: 5–105] days). The maximum HeartLogic index value was 38±15 in the case of hospitalizations and 24±7 in that of minor HF events. The median duration of the following active phase was 5 [2–10] months. After HeartLogic activation, 40 alerts were reported in 26 patients. Twenty-seven (68%) alerts were associated with multiple HF- or non-HF related conditions or changes in prescribed HF therapy. Multiple actions were triggered by these alerts: HF hospitalization (4), unscheduled in-office visits (8), diuretics increase (8), change in other cardiovascular drugs (5), device reprogramming (2), atrial fibrillation ablation (1), patient education on therapy adherence (2). The rate of unexplained alerts not followed by any clinical action was 0.13 alert-patient/year. These alerts were managed remotely (device data review and phone contact), except for one alert that generated an unscheduled in-office visit. Conclusions HeartLogic index was frequently associated with HF-related clinical events. The activation of the associated alert allowed to remotely detect relevant clinical conditions and to implement clinical actions. The rate of unexplained alerts was low, and the work required in order to exclude any impending decompensation did not constitute a significant burden for the centers. Funding Acknowledgement Type of funding source: None
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- 2020
45. Author response for 'Multiplex RNA‐based detection of clinically relevant MET alterations in advanced non‐small cell lung cancer'
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Elba Marin, Laura López-Vilaró, Santiago Viteri, Sonia Rodríguez, Ana Giménez-Capitán, Ivana Sullivan, Sergi Castillo, Miguel Mesa-Guzman, Noemí Reguart, Rafael Rosell, Ruth Román, Elena Gonzalvo, Silvia Muñoz, Nuria Viñolas, Aleix Prat, Luis M. Montuenga, Cristina Aguado, Maria Gonzalez-Cao, Cristina Teixido, Irene Moya, María Dolores Lozano, Carlos Cabrera, Andrés Felipe Cardona, Ramon Palmero, Roxana Reyes, Miguel Angel Molina-Vila, Erika Aldeguer, Alejandro Martinez-Bueno, Cristina Sainz, Ainara Arcocha, William P.J. Leenders, and A. Aguilar-Hernández
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business.industry ,Cancer research ,RNA ,Medicine ,Multiplex ,Non small cell ,business ,Lung cancer ,medicine.disease - Published
- 2020
46. Usefulness of Two Independent DNA and RNA Tissue-Based Multiplex Assays for the Routine Care of Advanced NSCLC Patients
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Sergi Castillo, Nuria Viñolas, Miguel Angel Molina-Vila, MªCarmen Rodríguez-Mues, Pedro Jares, Elba Marin, Roxana Reyes, Mireia García, Carlos R. Cabrera, Noemi Reguart, Marcelo Sánchez, Ainara Arcocha, Silvia Muñoz, I. Sullivan, Antonio Martínez, Aleix Prat, Elena Carmona-Rocha, Ivan Vollmer, Adela Rodriguez, Silvia Alos, and Cristina Teixidó
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0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Gene mutation ,medicine.disease_cause ,oncogenic drivers ,lcsh:RC254-282 ,Article ,Targeted therapy ,molecular diagnostics ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Multiplex ,Lung cancer ,Genotyping ,advanced non-small cell lung cancer ,business.industry ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Molecular diagnostics ,mutations ,targeted therapies ,respiratory tract diseases ,030104 developmental biology ,030220 oncology & carcinogenesis ,KRAS ,Personalized medicine ,business - Abstract
Personalized medicine is nowadays a paradigm in lung cancer management, offering important benefits to patients. This study aimed to test the feasibility and utility of embedding two multiplexed genomic platforms as the routine workup of advanced non-squamous non-small cell lung cancer (NSCLC) patients. Two parallel multiplexed approaches were performed based on DNA sequencing and direct digital detection of RNA with nCounter®, technology to evaluate gene mutations and fusions. The results were used to guide genotype-directed therapies and patient outcomes were collected. A total of 224 advanced non-squamous NSCLC patients were prospectively included in the study. Overall, 85% of samples were successfully characterized at DNA and RNA levels and oncogenic drivers were found in 68% of patients, with KRAS, EGFR, MET&Delta, ex14, BRAF, and ALK being the most frequent (31%, 19%, 5%, 4%, and 4%, respectively). Among all patients with complete genotyping results and follow-up data (n = 156), the median overall survival (OS) was 1.90 years (confidence interval (CI) 95% 1.69&ndash, 2.10) for individuals harbouring an actionable driver treated with a matched therapy, compared with 0.59 years (CI 95% 0.39&ndash, 0.79) in those not eligible for any targeted therapy and 0.61 years (CI 95% 0.12&ndash, 1.10) in patients with no drivers identified (p <, 0.001). Integrating DNA and RNA multiplexing technologies into the routine molecular testing of advanced NSCLC patients is feasible and useful and highlights the necessity of widespread integrating comprehensive molecular diagnosis into lung cancer care.
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- 2020
47. Aspectos de la gramatización antigua de la lengua vasca
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Aurélie Arcocha-Scarcia and Joseba Andoni Lakarra
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grammatisation ,translation ,Language and Literature ,gramatización ,humanismo ,traducción ,imprenta ,traduction ,lengua vasca ,humanisme ,humanism ,langue basque ,imprimerie ,grammatization ,Réforme ,Reforma ,Reformation ,basque language - Abstract
Following the state of affairs (§1.1) in studies on the LVP, we showcase two complementary points of view for their correct understanding, i.e., their “publication as a book” and the role played therein by Morpain and Lehet (§1.3) in Bordeaux, the humanist and reformist focus following the creation of the College of Guienne (§1.2) and in 1.4. we provide some notes on the initial stages of the Bordeaux printing press. In 1.5. We focus on the similarities of Etxepare with humanists and the Renaissance prior to Du Bellay like in Tory and Dolet and in §1.6 we present a lexical examination of the Epistola Dedicatoria, Contrapas and Sautrela that takes us in that same direction. In §1.7 and §1.8 we underscore the parallel between the "Debile principium" and Rabelais and the remembering the Basque fragments of Rabelais. In §2 we show the context of the book’s repression and the religious wars during which Leizarraga’s work (§2.1) emerged, emphasising the deep meaning that La Rochelle and Haultin contributed to L’s translation work (§2.2), and we analyse the problem of his original or “hypotext” (§2.3), an inescapable task in order to understand its praxis and objectives; in §2.4. We present a new approach in the search for the translated model from the analysis of loans words without same linguistic roots and in 2.5 we remember that grammarization does not imply standardised unification of the language. The sibilants In §2.6 and §2.7, certain Leizarraga graphic options are examined, related to the doctrines of French Protestant grammarians and printers: and biunivocity in sibilants with distinction of fricative and affricate sounds.. In §3 we address aspects of the grammatization of RS, contrasting it with Garibay and other old testimonies: in 3.1 we analyse the size of RS and the "direction" of the translation (Basque/Spanish); in 3.2 we examine certain very marked spellings of RS within the Basque text tradition ( and apical affricate sibilant), related more to the French than the Hispanic tradition; in 3.3 we demonstrate that Mares and not Porralis was the true publisher of the RS and in 3.4 that, in reality, this work was above all a teaching / learning instrument for languages (partic. Basque), a function demonstrated by its singular structure with numbers over each word (§3.5) and in §3.6 we include a coda about the origins of RS incuding the role of Mares is included. In §4 we include the principal conclusions, among which that publications in the vernacular language needed the establishment of linguistic tools, the development of grammatization and a cultural context that permitted the “enlightening” of the language; for that reason, both the LVP and the NT and the RS were born within a continuum, not ex-nihilo or on an island, which makes it essential to reread these works in relation to the printing workshops, scrutinising their ideological surroundings in the context of the extension of new ideas, in an interconnected geopolitical space which experienced major jumps and evolutions in this period. The cited bibliography is included in §5. Tras un estado de la cuestión (§1.1) de los estudios sobre el LVP, se presentan dos puntos de vista complementarios para su correcta comprensión, i.e., su “puesta en libro” y el papel que en ello juegan Morpain y Lehet (§1.3) en Burdeos, foco humanista y reformista tras la creación del Colegio de Guyena (§1.2) y en 1.4. unas notas sobre los inicios de la imprenta bordelesa. En 1.5. se incide en las similitudes de Etxepare con humanistas y renacentistas anteriores a Du Bellay como Tory y Dolet y en §1.6 presentamos un examen léxico de la Epístola-Dedicatoria, del Contrapás y del Sautrela que nos lleva en la misma dirección. En §1.7 y §1.8 se recuerda el paralelo del « Debile principium » compartido con Rabelais y los fragmentos vascos de Rabelais. Mostramos en §2 el contexto de la represión del libro y de las guerras religiosas en el que surge la obra de Leizarraga (§2.1), destacando la profunda significación que La Rochelle y Haultin aportan a la labor traductora de L (§2.2), y analizamos el problema de su original o “hypotexto” (§2.3), tarea insoslayable para entender su praxis y objetivos; en §2.4. presentamos un Nuevo acercarmiento en la búsqueda del modelo traducido a partir del análisis de préstamos sin arraigo y en 2.5 recordamos que la gramatización no implica unificación de la lengua. Las sibilantes En §2.6 y §2.7 se examinan ciertas opciones gráficas leizarraganas, relacionables con doctrinas de los gramáticos e impresores franceses protestantes: la y la biunivocidad en las sibilantes con distinción de fricativas y africadas. En §3 abordamos aspectos de la gramatización de RS, contraponiéndolo a Garibay y otros testimonios antiguos: en 3.1 analizamos el tamaño del RS y la dirección de la traducción (vasco/castellano); en 3.2 tratamos ciertas grafías muy marcadas de RS dentro de la tradición textual vasca ( y las de la sibilante africada apical), relacionadas más con la tradición francesa que con la hispana; en 3.3 mostramos que fue Mares y no Porralis el verdadero impresor de los RS y en 3.4 que, en realidad, esta obra era ante todo un instrumento de enseñanza / aprendizaje de lenguas (partic. la vasca), función demostrada por su singular estructura con números sobre cada palabra (§3.5) y en §3.6 se incluye una coda sobre los orígenes de RS y el papel de Mares. En §4 recogemos las principales conclusiones, entre ellas que las impresiones en lengua vernácula necesitan el establecimiento de un utillaje linguistico, el desarrollo de una gramatización y de un contexto cultural que permita la "ilustración" de la lengua; por ello, tanto el LVP como el NT y los RS nacen dentro de un continuum, no ex-nihilo ni en una isla, lo que hacía imprescindible una relectura de estas obras en relación con los talleres de impresión, ponderando el entorno ideológico de ellas en el contexto de extensión de las nuevas ideas, en un espacio geopolítico interconectado que conoce grandes sobresaltos y evoluciones en este período. En §5 se recoge la bibliografía citada. Les auteurs de l’article, contrairement au point de vue habituellement adopté par l’historiographie textuelle et littéraire du domaine basque, basent leurs réflexions sur les divers processus de grammatisation à l’oeuvre dans les premiers ouvrages et fragments en langue basque imprimés au XVIème siècle en décloisonnant et reliant, sur une même ligne diachronique, des mouvements habituellement séparés par la critique spécialisée. Il s’agit ici de tenir compte de la genèse ayant mené à l’acte d’impression du Linguae Vasconum Primitiae (LVP) (« Prémices de la langue des Basques »), « petit traité » (« petit tract ») imprimé en langue basque chez Morpain à Bordeaux en 1545 dédié par l’auteur Bernard Etxepare (Echepare ou Dechepare) originaire de la Navarre de Ultrapuertos à son ami Bernard de Lehet (ou Lahet) avocat du roi François Ier au Parlement de Bordeaux; du Iesvs Christ Gvre Iavnaren Testamentv Berria (« Le Nouveau Testament de Notre Seigneur Jésus Christ ») et des deux opuscules ABC et Kalendrera, traduits en basque par le pasteur Joanes Leizarraga (Liçarrague) et son équipe qui seront imprimés en 1571 chez Haultin à La Rochelle, bastion du protestantisme, selon les voeux de la souveraine du Béarn et reine de Navarre Jeanne d’Albret. S’ajoute également à cette réflexion l’opuscule anonyme Refranes y Sentencias (RS) imprimé à Pampelune en 1596. La question de la grammatisation est posée aussi pour les fragments en langue basque figurant dans le Pantagruel et le Gargantua de Rabelais dans les éditions imprimées par François Juste à Lyon en 1542. Les « illustrations » qui figurent dans l’article ont pour fonction d’enrichir la réflexion en convoquant « le regard graphique » apporté par l’imprimé (Tory etc.).L’article commence par dresser un état des lieux sur les travaux critiques qui se rapportent au LVP en offrant un nouveau point de vue centré sur la matérialité du livre, la péritextualité éditoriale, la grammatisation qui a pu être préalablement mise en place notamment au niveau de l’imprimerie dans le contexte humaniste bordelais dévoilé par « l’archéologie du livre ». En §1, l’orthotypographie et l’analyse lexicale de l’Épitre dédicatoire ainsi que des composition poétiques comme Contrapas (« Contrepas ») et Sautrela (« Sauterelle » ou « Saltarel ») dévoilent l’émergence d’un projet linguistique « d’illustration et de défense » de la langue basque, d’ailleurs bien mis en évidence dans la péritextualité éditoriale par le terme « tract » du Collophon en français, terme qu’il convient de mettre en relation avec les divers projets de grammatisation des langues vulgaires et plus particulièrement avec ceux du français, seule langue citée dans l’ouvrage (cf. l’emprunt du caractère typographique < ç >). Par ailleurs, la reliure du LVP portant les armes de Louis Ier de Bourbon Condé sur les deux à-plats ainsi que la « fermesse » de Jeanne d’Albret sur le dos, renvoient à un lien bibliographique avec la souveraineté du Béarn et le royaume de Navarre remontant au moins à 1564 date à laquelle apparaît le signe du « S fermé » (Chareyre). En §2 les auteurs évoquent le contexte politique (répression du livre, guerres de religion) au sein duquel intervient la traduction en basque du Nouveau Testament (NT) ou Testamentv Berria (TB). L’impression de la traduction en basque du NT se fait en effet après la fin de la troisième guerre de religion qui a vu l’assassinat en 1569 à Jarnac du calviniste et beau-frère de la reine Jeanne, Louis Ier de Bourbon Condé. Les interrogations au sujet de l’hypotexte du NT traduit en basque, sa praxis ainsi que ses objectifs sont mentionnés dans l’article. Il y est rappelé aussi que grammatisation ne signifie pas unification de la langue. Enfin, en §2.6 et §2.7 certaines options graphiques sont mises en relation avec les théories de grammairiens et imprimeurs protestants, choix typographique du < k > et biunivocité dans les sifflantes fricatives et affriquées, de même que l’accent en syllabe finale que Leizarraga a pris à Estienne ainsi qu’à d’autres auteurs protestants français (§2.8). En §3, les auteurs abordent certains aspects de la grammatisation de Refranes y Sentencias : parallèles établis avec l’historiographe Garibay et d’autres témoignages anciens ; matérialité ; direction de la traduction (basque→espagnol); graphies très marquées dans le cadre de la tradition textuelle basque (< hu- > ainsi que celles de la sifflante affriquée apicale) davantage en relation avec la tradition française ou flamande qu’avec l’hispanique ; visée didactique orientée sur l’apprentissage des langues (en particulier du basque) via une structure singulière « avec des nombres sur chaque mot ». L’identité de l’imprimeur de RS sera également questionnée et il apparaîtra que le véritable imprimeur de RS était en réalité Mathias Mares et non Pedro Porralis. La recherche de l’hypotexte de RS est l’occasion de présenter une nouvelle approche fondée sur l’analyse du dialecte basque de RS (zone de Bilbao) et de la marque typographique « A LA FONTAINE ET BOIRE » de Mares, qui renvoie aux Écritures et notamment à Apocalypse 21-6. En conclusion (§4), il apparaît que les impressions en langue vernaculaire (ici le basque) nécessitent au préalable l’établissement d’un outillage linguistique, d’une grammatisation qui rendent possible « l’illustration » d’une langue. Le LVP, le NT traduit en basque, les RS sont mis en livre dans des ateliers d’imprimeur dans un contexte historique et politique précis, au sein d’un continuum complexe en constante évolution et non ex-nihilo.
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- 2020
48. La transición española : ¿qué sabe el alumnado de 1º de bachillerato?
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Mikel Bueno Urritzelki, Elorri Arcocha Mendinueta, Universidad Pública de Navarra. Departamento de Ciencias Humanas y de la Educación, and Nafarroako Unibertsitate Publikoa. Giza eta Hezkuntza Zientziak Saila
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Encuesta ,Conocimientos ,Secondary education ,Quantitative methodology ,Top 100 historical figures of Wikipedia ,Geography ,Knowledge ,Transición española ,Alumnado ,Bachillerato ,Pedagogy ,Performance art ,High school ,PEDAGOGÍA [UNESCO] ,Students ,Survey ,Cartography ,UNESCO::PEDAGOGÍA ,Period (music) ,Spanish transition - Abstract
El presente artículo es el resultado del análisis de una encuesta realizada a 79 estudiantes de 1º de Bachillerato sobre la transición española. Mediante esta investigación se quiere acreditar, con metodología cuantitativa, los conocimientos e ideas que el alumnado encuestado tiene acerca de ese periodo histórico tras la realización de la Educación Secundaria. Para ello se ha realizado una encuesta con variedad de preguntas entre las cuales se han incluido algunas relacionadas entre sí para comprobar posibles contradicciones en las respuestas. La encuesta abarca diferentes cuestiones: desde personajes históricos hasta actores más globales como diferentes organizaciones o movilizaciones sociales. El estudio revela que para el alumnado encuestado la transición fue un periodo violento, aunque se comprueban también ciertas contradicciones en su conocimiento sobre este periodo. The present article is the result of the analysis of a survey conducted among 79 first-year High School students about the Spanish transition. Through this research, we want to assess, with a quantitative methodology, the knowledge and ideas that the surveyed students have about this historical period after the completion of Secondary Education. A survey was conducted with a variety of questions, among which are included some interrelated to check possible contradictions in the answers. The survey covers different issues: from historical figures to more global actors such as different organizations or social mobilizations. This study reveals that surveyed students think that the transition was a violent period, although there are also some contradictions in their knowledge of this period.
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- 2020
49. 1101 Multimodality imaging in the assessment of pericardial malign disease
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J.M. Ormaetxe Merodio, S Cisneros Carpio, M Castellanos Alcalde, E Galve Calvo, M Rodriguez Martinez, M.F. Arcocha Torres, A Manzanal Rey, L Sande Sardina, A Lambarri Izaguirre, K Ugedo Alzaga, R Candina Urizar, G Ramirez-Escudero Ugalde, L Ruiz Gomez, M Codina, and N Garcia Ibarrondo
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medicine.medical_specialty ,business.industry ,medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Disease ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Multimodality - Abstract
Metastases to the heart and pericardium are discovered at autopsy in 10%–12% of all patients with malignancies. The most common primary tumor involving the pericardium is lung cancer, followed by breast, melanoma, and lymphoma. Pericardial effusion may be the result of the tumor spreading to the visceral pericardium which increases production of fluid, or accumulation of the fluid due to the obstruction of venous and lymphatic outflow. A malignant pericardial effusion is associated with decreased survival rate. We present a 72 year-old woman, former smoker with dyslipidemia and psoriatic arthritis as well as previous bladder carcinoma that was healed in 1986. On august 2017 after an acute intestinal obstruction she was diagnosed with stage IV ileum adenocarcinoma treated initially with palliative chemotherapy (Capecitabine and oxaliplatin) that was suspended for poor tolerance and according to patient desire. Few months later the patient complained of rapidly progressive dyspnoea that prevented her normal life activity, arterial pressure and blood oxygen saturation was normal, but she was tachycardic. Echocardiogram was performed (see figure) which showed marked pericardial nodular thickening and severe pericardial effusion with echocardiographic signs of cardiac tamponade. Curiously, pericardial effusion was dense and markedly hyperechogenic. A computed tomography (CT) was performed to rule out pericardial carcinomatosis and find out the pericardial fluid composition and demostrated several pericardial nodular thickenings that suggested metastases. The pericardial fluid was dense (40 hounsfield units) and consistent with blood. After multidispiplinar consultation and in accordance with patients wishes a palliative pericardial window was performed and hematic pericardial fluid was obtained. Pericardial liquid citology demonstrates atipical cells compatible with carcinoma and pericardial biospy showed fibrinous pericarditis and reactive mesothelial hyperplasia. Pericardial carcinomatosis consists of macroscopic or microscopic affection of pericardial layers. Metastasis from colorectal cancer to the pericardium is uncommon, and usually indicates terminal stage with multiple metastases, only a few cases have been reported. Malignant Pericardial effusions in patients with cancer may also be triggered by other mechanism than cancer itself, including chemotherapy, radiation therapy, and, less commonly, an infectious disease. Whereas echocardiography is most frequently used to examine the heart and pericardium, multimodaliy imaging with magnetic resonance (MR) or/and CT offer advantages when dealing with metastatic disease. Abstract 1101 Figure. Echocardiogram and CT images
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- 2020
50. Radiomarcaje de nanopartículas de albúmina con radiometales (Tecnecio-99M, Galoo-67, Zirconio-89) y estudio de su biodistribución mediante imagen molecular
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de-Arcocha-Torres, M. (María), Peñuelas-Sanchez, I. (Ivan), and Quincoces, G. (Gemma)
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Radiofármacos ,Medicina nuclear ,Aplicaciones de isótopos ,Ciencias de la Salud [Materias Investigacion] - Abstract
Las nanopartículas de albúmina pueden utilizarse para la encapsulación de fármacos, permitiendo una liberación controlada y dirigida de los mismos. Además, su superficie puede modificarse mediante el recubrimiento con polímeros, mejorando sus propiedades físico-químicas. Sin embargo, resulta extremadamente difícil conocer el comportamiento in vivo de estas nanopartículas tras su administración, lo cual es esencial a la hora de determinar su efectividad o sus posibles efectos secundarios. El radiomarcaje de nanopartículas con isótopos emisores gamma o emisores de positrones y la adquisición de imágenes mediante técnicas de imagen molecular, puede proporcionar información relevante sobre el comportamiento de estas nanopartículas in vivo. En esta tesis doctoral, se han marcado radiactivamente con tecnecio-99m, galio-67 y zirconio-89 nanopartículas de albúmina recubiertas con los polímeros hidroxipropilmetilcelulosa (HPMC) y los polímeros conjugados de Gantrez-AN con la tiamina (GTM2), manosamina (GMN2) y polietilenglicol 2000 (GPM2). Las nanopartículas se prepararon empleando el método de desolvatación. Posteriormente las nanopartículas se marcaron mediante marcaje directo con pertecnetato sódico de tecnecio-99 y con cloruro de galio-67 mediante la formación de un complejo quelante-radiometal, empleando el quelante NOTA. Tras estudiar la estabilidad in vitro del marcaje en suero fisiológico 0,9% y plasma sanguíneo, las nanopartículas radiomarcadas se ensayaron in vivo tras su administración intravenosa en ratas Wistar mediante tomografía computerizada por emisión de fotón único (SPECT/CT). Finalmente los animales fueron sacrificados, se extrajeron los órganos y se cuantificó la radiactividad presente en los mismos empleando un contador gamma. Los resultados obtenidos muestran que las nanopartículas de albúmina recubiertas con diferentes polímeros pueden marcarse de forma efectiva con radiometales, obteniéndose elevados rendimientos de marcaje. Las nanopartículas radiomarcadas mostraron una elevada estabilidad in vitro pasadas las 48 horas del marcaje tanto en suero fisiológico como en plasma sanguíneo. Los estudios in vivo permitieron conocer la biodistribución de las nanopartículas durante periodos prolongados de tiempo y los resultados obtenidos se confirmaron con los hallazgos de estudios ex vivo.
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- 2020
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