6 results on '"Annen, Jitka"'
Search Results
2. Brain, Behavior, and Cognitive Interplay in Disorders of Consciousness: A Multiple Case Study
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Aubinet, Charlène, Murphy, Lesley, Bahri, Mohamed A., Larroque, Stephen K., Cassol, Helena, Annen, Jitka, Carrière, Manon, Wannez, Sarah, Thibaut, Aurore, Laureys, Steven, and Gosseries, Olivia
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neuropsychological assessment ,positron emission tomography ,Neurology ,cognitive functions ,behavior ,neural correlates ,(emergence from) minimally conscious state ,structural magnetic resonance imaging ,lcsh:Neurology. Diseases of the nervous system ,lcsh:RC346-429 ,Original Research - Abstract
Patients with prolonged disorders of consciousness (DoC) after severe brain injury may present residual behavioral and cognitive functions. Yet the bedside assessment of these functions is compromised by patients' multiple impairments. Standardized behavioral scales such as the Coma Recovery Scale-Revised (CRS-R) have been developed to diagnose DoC, but there is also a need for neuropsychological measurement in these patients. The Cognitive Assessment by Visual Election (CAVE) was therefore recently created. In this study, we describe five patients in minimally conscious state (MCS) or emerging from the MCS (EMCS). Their cognitive profiles, derived from the CRS-R and CAVE, are presented alongside their neuroimaging results using structural magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET). Scores on the CAVE decreased along with the CRS-R total score, establishing a consistent behavioral/cognitive profile for each patient. Out of these five cases, the one with highest CRS-R and CAVE performance had the least extended cerebral hypometabolism. All patients showed structural and functional brain impairments that were consistent with their behavioral/cognitive profile as based on previous literature. For instance, the presence of visual and motor residual functions was respectively associated with a relative preservation of occipital and motor cortex/cerebellum metabolism. Moreover, residual language comprehension skills were found in the presence of preserved temporal and angular cortex metabolism. Some patients also presented structural impairment of hippocampus, suggesting the presence of memory impairments. Our results suggest that brain-behavior relationships might be observed even in severely brain-injured patients and they highlight the importance of developing new tools to assess residual cognition and language in MCS and EMCS patients. Indeed, a better characterization of their cognitive profile will be helpful in preparation of rehabilitation programs and daily routines.
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- 2018
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3. Multifaceted brain networks reconfiguration in disorders of consciousness uncovered by co-activation patterns
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Di Perri, Carol, Amico, Enrico, Heine, Lizette, Annen, Jitka, Martial, Charlotte, Larroque, Stephen Karl, Soddu, Andrea, Marinazzo, Daniele, and Laureys, Steven
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Adult ,Male ,unresponsive wakefulness syndrome ,fMRI ,Brain ,coma ,dynamic network interactions ,consciousness ,Magnetic Resonance Imaging ,Oxygen ,Cross-Sectional Studies ,Cerebrovascular Circulation ,Neural Pathways ,Medicine and Health Sciences ,Consciousness Disorders ,Humans ,Female ,signal processing ,pathological hyperconnectivity ,Research Articles ,co-activation patterns - Abstract
Introduction: Given that recent research has shown that functional connectivity is not a static phenomenon, we aim to investigate the dynamic properties of the default mode network's (DMN) connectivity in patients with disorders of consciousness. Methods: Resting-state fMRI volumes of a convenience sample of 17 patients in unresponsive wakefulness syndrome (UWS) and controls were reduced to a spatiotemporal point process by selecting critical time points in the posterior cingulate cortex (PCC). Spatial clustering was performed on the extracted PCC time frames to obtain 8 different co-activation patterns (CAPs). We investigated spatial connectivity patterns positively and negatively correlated with PCC using both CAPs and standard stationary method. We calculated CAPs occurrences and the total number of frames. Results: Compared to controls, patients showed (i) decreased within-network positive correlations and between-network negative correlations, (ii) emergence of “pathological” within-network negative correlations and between-network positive correlations (better defined with CAPs), and (iii) “pathological” increases in within-network positive correlations and between-network negative correlations (only detectable using CAPs). Patients showed decreased occurrence of DMN-like CAPs (1–2) compared to controls. No between-group differences were observed in the total number of frames. Conclusion: CAPs reveal at a more fine-grained level the multifaceted spatial connectivity reconfiguration following the DMN disruption in UWS patients, which is more complex than previously thought and suggests alternative anatomical substrates for consciousness. BOLD fluctuations do not seem to differ between patients and controls, suggesting that BOLD response represents an intrinsic feature of the signal, and therefore that spatial configuration is more important for consciousness than BOLD activation itself. Hum Brain Mapp 39:89–103, 2018. © 2017 Wiley Periodicals, Inc.
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- 2018
4. BCI Performance and Brain Metabolism Profile in Severely Brain-Injured Patients Without Response to Command at Bedside
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Annen, Jitka, Blandiaux, Séverine, Lejeune, Nicolas, Bahri, Mohamed A., Thibaut, Aurore, Cho, Woosang, Guger, Christoph, Chatelle, Camille, Laureys, Steven, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - (SLuc) Service de neurologie, and UCL - (SLuc) Centre neurologique William Lennox
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Brain metabolism ,body regions ,Disorders of consciousness ,Cognitive ERP ,PET ,genetic structures ,Consciousness ,Brain Computer Interface ,P3 ,BCI ,FDG-PET ,Brain computer interface ,Covert command following - Abstract
Detection and interpretation of signs of “covert command following” in patients with disorders of consciousness (DOC) remains a challenge for clinicians. In this study, we used a tactile P3-based BCI in 12 patients without behavioral command following, attempting to establish “covert command following.” These results were then confronted to cerebral metabolism preservation as measured with glucose PET (FDG-PET). One patient showed “covert command following” (i.e., above-threshold BCI performance) during the active tactile paradigm. This patient also showed a higher cerebral glucose metabolism within the language network (presumably required for command following) when compared with the other patients without “covert command-following” but having a cerebral glucose metabolism indicative of minimally conscious state. Our results suggest that the P3-based BCI might probe “covert command following” in patients without behavioral response to command and therefore could be a valuable addition in the clinical assessment of patients with DOC.
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- 2018
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5. MindBEAGLE: An EEG-based BCI developed for patients with disorders of consciousness
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Allison, Brendan, Guger, Christoph, Annen, Jitka, Ortner, Rupert, Wannez, Sarah, Piarulli, Andrea, and Laureys, Steven
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Proceedings Of The 6Th International Bci Meeting: Bci Past, Present, And Future
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- 2016
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6. Theta network centrality correlates with tDCS response in disorders of consciousness
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Aurore Thibaut, Srivas Chennu, Géraldine Martens, Jitka Annen, Camille Chatelle, Steven Laureys, Helena Cassol, Chatelle, Camille [0000-0002-7526-2107], Martens, Géraldine [0000-0001-7038-7165], Annen, Jitka [0000-0002-7459-4345], Laureys, Steven [0000-0002-3096-3807], and Apollo - University of Cambridge Repository
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Biophysics ,Disorders of consciousness ,050105 experimental psychology ,lcsh:RC321-571 ,03 medical and health sciences ,0302 clinical medicine ,medicine ,0501 psychology and cognitive sciences ,Coma ,Electroencephalography (EEG) ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Connectivity ,business.industry ,General Neuroscience ,05 social sciences ,medicine.disease ,Transcranial direct current stimulation (tDCS) ,Neurology (clinical) ,medicine.symptom ,Centrality ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Transcranial direct current stimulation (tDCS) applied over the dorsolateral prefrontal cortex (DLPFC) has induced promising behavioral improvement, both in acute and chronic minimally conscious state (MCS - [ 1 ]) patients [ 2 , 3 ]. We previously defined a tDCS-responder as a patient who demonstrates a new sign of consciousness following stimulation, which was neither present beforehand, nor before or after the sham stimulation [ 2 ]. In a study investigating the metabolic and structural differences between DLPFC-tDCS-responders and non-responders, we have identified that tDCS-responders presented a preservation of brain metabolism and grey matter integrity under the stimulated area, but also in the thalamus and the precuneus, areas involved in consciousness recovery [ 4 ]. Even if these results provided relevant insights into potential biomarkers of responsiveness, the access to such neuroimaging techniques (positron emission tomography - PET - and magnetic resonance imaging - MRI) remains limited. Recently, it has been demonstrated that high-density electroencephalography (hdEEG) network metrics in the alpha band correlates with the level of consciousness [ 5 ]. In addition, a strong correlation between brain metabolism and hdEEG network metrics was reported, making this bedside assessment a robust way to evaluate patients’ brain function.
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- 2018
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