Author: "Anne Miersch" / Language: undetermined - Searchworks@Jio Institute Digital Library Search Results

Author: Gerhard Hilt, Anne Miersch, and Corinna Kohlmeyer
Subjects: inorganic chemicals, chemistry.chemical_classification, In situ, Double bond, Vinyl bromide, Organic Chemistry, Alkyne, chemistry.chemical_element, Zinc, Catalysis, Coupling reaction, chemistry.chemical_compound, chemistry, Bromide, Polymer chemistry, Palladium
Abstract: The synthesis of vinyl bromide derivatives was realised by a zinc-mediated addition of a benzylic bromide to a terminal alkyne. The geometry of the C=C bond is dependent on the amount of zinc powder applied. When 5 mol% of Zn is used, the Z-configured vinyl bromide is generated while with 150 mol% the E-geometry is obtained predominantly. In a three-component one-pot reaction, the in situ generated vinyl bromides were reacted further in a palladium-catalysed Suzuki cross-coupling reaction utilizing aromatic boronic acids to obtain trisubstituted double bonds in good overall yields. The reactions were conducted on a 5–20 mmol scale to visualise that the reactions are also capable of generating larger amounts of products.
Published: 2013

Author: Anne Miersch, Corinna Kohlmeyer, and Gerhard Hilt
Subjects: In situ, chemistry.chemical_compound, Hydrogen bond catalysis, Chemistry, Vinyl bromide, chemistry.chemical_element, Organic chemistry, General Medicine, Zinc, Coupling reaction, Catalysis, Palladium
Published: 2014

Author: Gerhard Hilt, Anne Miersch, and Klaus Harms
Subjects: chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Double bond, Cascade reaction, Product (mathematics), Aryl, chemistry.chemical_element, Knoevenagel condensation, General Medicine, Zinc, Medicinal chemistry
Abstract: In case of the aryl substituted products (IVb) and (IVc) partial migration of the double bond towards the Knoevenagel product occurs.
Published: 2014

Author: Anne Miersch, Klaus Harms, and Gerhard Hilt
Subjects: Addition reaction, Metals and Alloys, chemistry.chemical_element, Regioselectivity, General Chemistry, Zinc, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, chemistry, Oxalyl chloride, Cascade reaction, Reaction sequence, Materials Chemistry, Ceramics and Composites, Organic chemistry, Amine gas treating
Abstract: The zinc-mediated regioselective addition reactions of diethyl bromomalonate and aromatic and aliphatic alkynes were investigated for the synthesis of vinyl malonates. When the vinyl organo-zinc intermediates were reacted with acid chlorides 2H-pyran-2-ones were obtained while the application of oxalyl chloride and an amine led to tetracarbonyl derivatives in a one-pot multi-step reaction sequence.
Published: 2013

Author: Anne Miersch and Gerhard Hilt
Subjects: inorganic chemicals, Component (thermodynamics), organic chemicals, chemistry.chemical_element, General Medicine, Zinc, urologic and male genital diseases, Medicinal chemistry, chemistry.chemical_compound, chemistry, Benzyl bromide, polycyclic compounds, heterocyclic compounds, Stereoselectivity
Abstract: The addition of benzyl bromide (II) to alkynes proceeds in a stereoselective manner, depending on the amount of zinc.
Published: 2013

Author: Anne Miersch and Gerhard Hilt
Subjects: inorganic chemicals, Component (thermodynamics), organic chemicals, Organic Chemistry, chemistry.chemical_element, General Chemistry, Zinc, urologic and male genital diseases, Catalysis, chemistry.chemical_compound, Benzyl bromide, chemistry, polycyclic compounds, Organic chemistry, heterocyclic compounds, Stereoselectivity, Palladium
Abstract: The addition of benzyl bromide (II) to alkynes proceeds in a stereoselective manner, depending on the amount of zinc.
Published: 2012

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