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According to the World Health Organization, the most common (up to 90% of cases) hematological pathology is anemia, a condition characterized by a decrease in the level of hemoglobin in the blood due to a decrease in the total number of red blood cells or a violation of hemoglobin synthesis, which can have serious consequences for the body, such as decreased immunity, impaired respiratory and metabolic processes. Currently, it is necessary to improve the methods of prevention and treatment of anemia. To test new drugs for these purposes, it is necessary to create new models, including on laboratory animals. The aim of the study was to develop experimental models of iron deficiency (IDA) and hemolytic anemia (HA) on laboratory animals. The objects of the study were sexually mature male laboratory rats of the Wistar breed, aged 7 months and weighing 260 ± 20 g. 38 animals were involved in the experiment (for IDA n= 24, for HA n= 14). Laboratory animals were kept in the same external conditions for 3-4 individuals in a cage. To simulate IDA, rats were subcutaneously injected with the drug “Desferal”. To simulate GA, rats were intraperitoneally injected with the drug “Hydrochloric acid phenylhydrozine”. At each stage, blood was taken by cutting off the tip of the tail. A detailed blood test was performed on a hematological analyzer “Heska Element HT5”. As a result, it was found that when the drug “Desferal” was administered at concentrations of 125 and 250 mg / 100g per animal weight, hematological changes were observed in rats, such as an increase in red blood cells, platelets, leukocytes by stage 2 and a decrease to control values by stage 4. When the drug “Hydrochloric acid phenylhydrozine” was administered, hematological changes were detected in rats only within the experimental group. There was an increase in the indicators of erythrocytes, platelets, leukocytes by stages 2 and 3 and a decrease to control values by stage 4. Thus, when the studied drugs were administered in the presented dosages in vivo, a change in the hematological parameters of the blood was detected in the direction of an increase in their number due to adaptation to the effects of substances.

The article deals with the issues of individual prevention of offenses in the system of activities of prevention subjects, determining the place of the Internal Affairs bodies of the Russian Federation in this process and describing the methods of their activities in this area. It is established that the system of crime prevention includes a set of measures aimed, first of all, at ensuring the appropriate moral formation of the individual, identifying and eliminating adverse effects on it that can lead to illegal behavior. The main methods of activity of Internal Affairs bodies in individual prevention of offenses — persuasion and coercion-are considered. The article uses a number of methods of scientific research, in particular, analysis, synthesis, classification, formal-logical, comparative-legal, historical-legal, etc.

The article focuses on the theoretical and practical explanations of political and economic processes in the “post-Western” international reality. Proceeding from the assumptions of the complex system theory, the authors prove the necessity to use already established analytical approaches in combination with the newly developed ones to be able to understand and forecast the spatial-temporal evolution of the international system as a complex system. International political economy and world regional studies now investigate the empirical aspects of working out the most competitive and simultaneously most stable socio-political and politicaleconomic model of development. These studies also search for the ways national versions of development can become closer to this model and analyze to what extent regional/national models may differ from it without losing their international competitiveness. Exploring the evolution of the international system and political and economic transformations in the world leading states the authors conclude that a polycentric world cannot sustain a growing geopolitical confrontation and struggle for the geopolitical infl uence over the buffer areas. The polycentric international system requires a consensual elaboration of mutually benefi cial regional policies aimed at building transregional links between various regional areas. Reducing the instability in its regional and national segments the international system will move towards its overall greater stability. The authors further support this assumption analyzing transregional projects in Eurasia and the AsiaPacific region.

A Series of Publications in Japanese Studies: History, Politics, Foreign Policy, International Relations, Russia-Japan Relations and Japanese Studies in Russia.