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Networks of spiking neurons with adaption have been shown to be able to reproduce a wide range of neural activities, including the emergent population bursting and spike synchrony that underpin brain disorders and normal function. Exact mean-field models derived from spiking neural networks are extremely valuable, as such models can be used to determine how individual neuron and network parameters interact to produce macroscopic network behaviour. In the paper, we derive and analyze a set of exact mean-field equations for the neural network with spike frequency adaptation. Specifically, our model is a network of Izhikevich neurons, where each neuron is modeled by a two dimensional system consisting of a quadratic integrate and fire equation plus an equation which implements spike frequency adaptation. Previous work deriving a mean-field model for this type of network, relied on the assumption of sufficiently slow dynamics of the adaptation variable. However, this approximation did not succeeded in establishing an exact correspondence between the macroscopic description and the realistic neural network, especially when the adaptation time constant was not large. The challenge lies in how to achieve a closed set of mean-field equations with the inclusion of the mean-field expression of the adaptation variable. We address this challenge by using a Lorentzian ansatz combined with the moment closure approach to arrive at the mean-field system in the thermodynamic limit. The resulting macroscopic description is capable of qualitatively and quantitatively describing the collective dynamics of the neural network, including transition between tonic firing and bursting., Comment: 30 pages, 7 figures

The internationalization of Anglophone universities could allow English-dominant students to benefit from experience with English speakers from a wide variety of backgrounds, but US students have often complained of difficulty communicating with such instructors, especially International Teaching Assistants (ITAs). Research has largely focused on helping ITAs assimilate linguistically and culturally, although many applied linguists suggest that ITAs’ students would also benefit from training in skills for communication across linguistic difference, through attention to their language attitudes, familiarity with diverse Englishes, and communication strategies. We report on an intervention designed to address all three, here focusing on students’ willingness to engage in collaborative communication strategies. The intervention, conducted in a computer science department and reaching over 300 first-year students from varied linguistic backgrounds, included an online and an in-class component, each lasting about an hour. This brief intervention resulted in small but significant gains in domestic undergraduates’ (n = 174) stated intention to engage in collaborative behavior with their ITAs, although our detailed examination of qualitative responses suggests important areas for continued improvement of the intervention. We discuss the potential for such interventions to facilitate institutional and cultural change, encouraging the recognition of the shared responsibility for successful communication.

bBackground:/bThe situation in the world today, encompassing multiple armed conflicts, notably in Ukraine, the Coronavirus pandemic and the effects of climate change, increases the likelihood of childhood exposure to physical injury and pain. Other effects of these worldwide hardships include poverty, malnutrition and starvation, also bringing with them other forms of trauma, including emotional harm, neglect and deliberate maltreatment.bObjective:/bTo review the neurobiology of the systems in the developing brain that are most affected by physical and emotional trauma and neglect.bMethod:/bThe review begins with those that mature first, such as the somatosensory system, progressing to structures that have a more protracted development, including those involved in cognition and emotional regulation. Explored next are developing stress response systems, especially the hypothalamic-pituitary-adrenal axis and its central regulator, corticotropin-releasing hormone. Also examined are reward and anti-reward systems and genetic versus environmental influences. The behavioural consequences of interpersonal childhood trauma, focusing on self-harm and suicide, are also surveyed briefly. Finally, pointers to effective treatment are proffered.bResults:/bThe low-threshold nature of circuitry in the developing brain and lack of inhibitory connections therein result in heightened excitability, making the consequences of both physical and emotional trauma more intense. Sensitive and critical periods in the development of structures such as the amygdala render the nervous system more vulnerable to insults occurring at those points, increasing the likelihood of psychiatric disorders, culminating in self-harm and even suicide.bConclusion:/bIn view of the greater excitability of the developing nervous system, and its vulnerability to physical and psychological injuries, the review ends with an exhortation to consider the long-term consequences of childhood trauma, often underestimated or missed altogether when faced with adults suffering mental health problems.bAntecedentes:/bLa situación en el mundo actual, que abarca múltiples conflictos armados, mayormente en Ucrania, la pandemia del Coronavirus y los efectos del cambio climático, aumenta la probabilidad de exposición infantil a lesiones físicas y dolor. Otros efectos de estas dificultades mundiales incluyen pobreza, desnutrición y hambruna, también traen consigo otras formas de trauma, incluyendo daño emocional, negligencia y maltrato deliberado.bObjetivo:/bRevisar la neurobiología de los sistemas en el cerebro en desarrollo que se ven más afectados por el trauma físico y emocional y la negligencia.bMétodo:/bLa revisión comienza con aquellos que maduran primero, como el sistema somatosensorial, progresando hacia estructuras que tienen un desarrollo más prolongado, incluidas las involucradas en la cognición y regulación emocional. A continuación se exploraron los sistemas de respuesta al estrés en desarrollo, especialmente el eje hipotálamo-hipófisis-adrenal y su regulador central, la hormona liberadora de corticotrofina. También se examinaron los sistemas de recompensa y anti-recompensa e influencias genéticas versus ambientales. Tambien se investigaron brevemente, las consecuencias conductuales del trauma infantil interpersonal, centrándose en las autolesiones y suicidio. Finalmente, se ofrecieron indicaciones para un tratamiento eficaz.bResultados:/bLa naturaleza de bajo umbral de los circuitos en el cerebro en desarrollo y la falta de conexiones inhibitorias en ellos dan como resultado una mayor excitabilidad, lo que hace que las consecuencias del trauma físico y emocional sean más intensas. Los periodos críticos y sensibles en el desarrollo de estructuras como la amígdala hacen que el sistema nervioso sea más vulnerable a las agresiones que ocurren en esos puntos, lo que aumenta la probabilidad de trastornos psiquiátricos, culminando en autolesiones e incluso suicidio.bConclusión:/bEn vista de la mayor excitabilidad del sistema nervioso en desarrollo y su vulnerabilidad a las lesiones físicas y psicológicas, la revisión termina con una exhortación a considerar las consecuencias a largo plazo del trauma infantil, con frecuencia subestimado o ignorado totalmente cuando nos enfrentamos con adultos que sufren de problemas de salud mental.b背景：/b当今世界的局势，包括多种武装冲突，尤其在乌克兰，冠状病毒疫情和气候改变的影响，增加了童年期身体伤害和疼痛暴露的可能性。这些全球性困难的其他影响包括贫困、营养不良和饥饿，还带来其他形式的创伤，包括情感伤害、忽视和蓄意虐待。b目的：/b综述受身体和情感创伤和忽视影响最大的发育中大脑系统神经生物学。b方法：/b综述从先成熟的结构开始，例如体感系统，然后发展到发育更持久的结构，包括涉及认知和情绪调节的结构。接下来考查应激反应发育系统，尤其是下丘脑-垂体-肾上腺轴及其中枢调节剂促肾上腺皮质激素释放激素。还考查了奖赏和反奖赏系统以及遗传与环境的影响。还简单调查了童年期人际创伤的行为后果，重点是自伤和自杀。最后，提出了有效治疗的建议。b结果：/b发育中的大脑环路的低阈值性质和缺乏抑制性连接导致兴奋性增强，使身体和情感创伤的后果更加强烈。杏仁核等结构发育的敏感和关键阶段使神经系统对于这些部位的损伤更易感，从而增加了患上精神障碍的可能性，最终导致自残甚至自杀。b结论：/b鉴于发育中的神经系统具有更大的兴奋性，以及其对身体和心理伤害的易感性，本综述最终建议考虑童年期创伤的长期后果，当面对遭受心理健康问题的成年人时，这些创伤常常被低估或完全被忽略。.

First responders (e.g. police, firefighters, paramedics) experience significant and varied stressors in their personal and professional lives (Carleton et al. 2018a, Carleton et al. 2018b) and may be more vulnerable to psychological problems as a result (Komarovskaya et al. 2011). The use of support canines aids in mitigating psychological distress (Krause-Parello and Morales 2018); however, scant research exists on the effect of this support resource among first responders. The current study aimed to (1) assess first responders’ general endorsement of having support canines in their workplace and identify first responder characteristics that predict endorsement and (2) determine whether first responders from sites with (vs. without) support canines demonstrate better psychological wellness and psychological help-seeking. Participants included 140 first responders (64.3% males, 45.0% police officers) who completed measures of mental health (DASS-21; Lovibond and Lovibond 1995), psychological help-seeking (IASMHS; Mackenzie et al. 2004), and canine attitudes and experience with support canines (author developed). Results identified low levels of mental health symptoms overall, which did not significantly differ between participants from organizations with and without canine support. Participants were more receptive to having support canines when they had more positive attitudes towards canines in general. Although access to canine support animals did not appear to influence the overall psychological wellness of first responders on quantitative measures, qualitative data suggests that these animals may provide temporary stress relief benefits that require further empirical investigation.

To purpose of the current study was to inform system level decision-making about the value of integrating clinically relevant personality information with criminogenic need risk appraisal in justic...

Neural firing in many inhibitory networks displays synchronous assembly or clustered firing, in which subsets of neurons fire synchronously, and these subsets may vary with different inputs to, or states of, the network. Most prior analytical and computational modeling of such networks has focused on 1D networks or 2D networks with symmetry (often circular symmetry). Here, we consider a 2D discrete network model on a general torus, where neurons are coupled to two or more nearest neighbors in three directions (horizontal, vertical, and diagonal), and allow different coupling strengths in all directions. Using phase model analysis, we establish conditions for the stability of different patterns of clustered firing behavior in the network. We then apply our results to study how variation of network connectivity and the presence of heterogeneous coupling strengths influence which patterns are stable. We confirm and supplement our results with numerical simulations of biophysical inhibitory neural network models. Our work shows that 2D networks may exhibit clustered firing behavior that cannot be predicted as a simple generalization of a 1D network, and that heterogeneity of coupling can be an important factor in determining which patterns are stable.

First responders experience substantial stress due to the nature of their work (Carleton et al. 2017). Occupational stress (OS) results from a myriad of employment conditions (e.g., ambiguous work expectations, unreasonable workload; Osipow 1998). OS can lead to maladaptive anger, which negatively impacts personal well-being and work performance (Velichkovsky 2009). In contrast, resilience to demanding working conditions is associated with lower state and trait anger (Wilson et al. 2001); thus, resilience may serve a protective ‘buffer’ role against anger in the face of stress. Thus, we hypothesized that resiliency would mediate relations between dimensions of OS and anger. The current study included 201 first responders (male = 77.6%; Mage = 43.73 years (SD = 10.97); police officers = 64.2%) who completed measures of OS (OSI-R; Osipow 1998), Anger (DSM-5 CC Anger; APA 2013), and Resiliency (CD-RISC; Connor and Davidson 2003). Results indicated that resiliency mediated relations between five components of OS and anger: Role Overload (p

The synchronization of different brain regions is widely observed under both normal and pathological conditions such as epilepsy. However, the relationship between the dynamics of these brain regions, the connectivity between them, and the ability to synchronize remains an open question. We investigated the problem of inter-region synchronization in networks of Wilson-Cowan/Neural field equations with homeostatic plasticity, each of which acts as a model for an isolated brain region. We considered arbitrary connection profiles with only one constraint: the rows of the connection matrices are all identically normalized. We found that these systems often synchronize to the solution obtained from a single, self-coupled neural region. We analyze the stability of this solution through a straightforward modification of the Master Stability Function (MSF) approach and found that synchronized solutions lose stability for connectivity matrices when the second largest positive eigenvalue is sufficiently large, for values of the global coupling parameter that are not too large. This result was numerically confirmed for ring systems and lattices and was also robust to small amounts of heterogeneity in the homeostatic set points in each node. Finally, we tested this result on connectomes obtained from 196 subjects over a broad age range (4-85 years) from the Human Connectome Project. We found that the second largest eigenvalue tended to decrease with age, indicating an increase in synchronizability that may be related to the increased prevalence of epilepsy with old age., Comment: 24 pages, 5 figures

We study a diffusive nutrient-phytoplankton-zooplankton (NPZ) model with spatio-temporal delay. The closed nature of the system allows the formulation of a conservation law of biomass that governs ...

Despite research demonstrating the validity of the Ontario Domestic Assault Risk Assessment (ODARA) for appraising risk of subsequent intimate partner violence, gaps remain with regard to its actual use by police officers in the field. The primary goals of the current study were to assess the rate at which the ODARA was used by police officers for intimate partner violence (IPV) in the Canadian context and to identify factors associated with its use. The current study used 142 randomly selected police files meeting criteria for IPV from three police agencies in an Atlantic Canadian province, following province-wide training on domestic violence and the ODARA. The ODARA was used by police in 60.3% of cases, though more commonly when physical Violence was present at index (70%). Significant ODARA use variation was noted across the three police gencies. ODARAs were more likely administered when the suspect was using drugs/alcohol (76.4%), the incident was between parties in a current intimate relationship (67.0%), when physical violence occurred in the index event (70.6%), and when a weapon was used (84.2%). Decisions to arrest and recommend charges to the prosecutor were predicted by higher ODARA total scores, above and beyond the influence of the police organization, suspect/victim characteristics, and incident context variables. Results are discussed in the context of police discretion/decision-making and the need for stronger implementation and policy use guidelines for risk appraisal by police officers, which includes a better understanding of IPV and the ODARA.

A sample of Asian participants was assessed using the Brunel Mood Scale and the Positive & Negative Affect Scale before and after music mood induction procedures to which each participant was randomly assigned. A series of mixed analyses of variance with the type of music (happy/positive vs. sad/negative) as the between-subject factor and pre–post music exposure as the within-subject factor revealed that the sad music induction attenuated the positive moods Vigor and Happiness, as well as the negative moods Anger, Tension, Fatigue, and Confusion but had no significant impact on Depression or Calmness, casting doubt on the robustness of Thayer’s circumplex model of mood formation. The happy music induction increased Vigor and decreased Fatigue and Confusion, suggesting that positive music has the potential to lift energy levels. The happy music induction led to increases in Positive Affect only, whereas the sad music condition attenuated both Positive Affect and Negative affect, casting doubt on Watson and Tellegen’s contention that the Affect systems are independent and suggesting that the bipolarity hypothesis may not provide a comprehensive explanation of mood formation. The mechanisms by which music may impact mood and potential differences in the expression of affect between Asian and Western participants are discussed.

In this paper, we develop a population equation based on the Ricker model with periodic carrying capacity and embedded mechanisms of both weak and strong types of Allee effect: x ( n + 1 ) = x ( n ...

Robert William Fogel and G. R. Elton. Which Road to the Past? Two Views of History. New Haven and London: Yale University Press, 1983. Pp. vii, 136. Cloth, $14.95. Review by Stephen Kneeshaw of The School of the Ozarks. Emmanuel LeRoy Ladurie. The Mind and Method of the Historian. Translated by Sian Reynolds and Ben Reynolds. Chicago: University of Chicago Press, 1981. Pp. v, 310. Paper, $9.95. Review by Richard Harvey of Ohio University. John E. O'Connor, ed. American History/ American Television: Interpreting the Video Past. New York: Frederick Ungar Publishing Company, 1983. Pp. 463. Cloth, $17.50; Paper, $8.95. Review by D' Ann Campbell of Indiana University. Foster Rhea Dulles & Melvyn Dubofsky. Labor in America: A History. Arlington Heights, Illinois: Harlan Davidson, Inc., 1984. 4th edition. Pp. ix, 425. Cloth, $25.95. Paper, $15.95. Review by Robert W. Dubay of Bainbridge Junior College. Karen Ordahl Kupperman. Roanoke: The Abandoned Colony. Totowa, New Jersey: Rowman & Allanheld, 1984. Pp. viii, 182. Cloth, $24.95; Paper, $12.50. Review by John T. Reilly of Mount Saint Mary College. Kevin O'Reilly. Critical Thinking in American History: Exploration to Constitution. South Hamilton, Massachusetts: Hamilton-Wenham Regional High School, 1983. Pp. 86. Paper, $2.95. Teacher's Guides: Pp. 180. Paper, $12.95; Kevin O'Reilly. Critical Thinking in American History: New Republic to Civil War. South Hamilton, Massachusetts: Hamilton-Wenham Regional High School, 1984. Pp. 106. Paper, $2.95. Teacher's Guide: Pp. 190. Paper, $12.95. Review by James F. Marran of New Trier Township High School, Winnetka, Illinois. Michael J. Cassity, ed. Chains of Fear: American Race Relations Since Reconstruction. Westport, Connecticut: Greenwood Press, 1984. Pp. xxxv, 253. Cloth, $35.00. Review by Ann W. Ellis of Kennesaw College. L. P. Morris. Eastern Europe Since 1945. London and Exeter, New Hampshire: Heinemann Educational Books, 1984. Pp. 211. Paper, $10.00. Review by Thomas T. Lewis, Mount Senario College. John Marks. Science and the Making of the Modern World. Portsmouth, New Hampshire: Heinemann Educational Books, Inc., 1983. Pp. xii, 507. Paper, $25.00. Review by Howard A. Barnes of Winston-Salem State University. Kenneth G. Alfers, Cecil Larry Pool, William F. Mugleston, eds. American's Second Century: Topical Readings, 1865-Present. Dubuque, Iowa: Kendall/ Hunt Publishing Co., 1984. Pp. viii, 381. Paper, $8.95. Review by Richard D. Schubart of Phillips Exeter Academy. Sam C. Sarkesian. America's Forgotten Wars: The Counterrevoltuionary Past and Lessons for the Future. Westport, Connecticut: Greenwood Press, 1984. Pp. xiv, 265. Cloth, $29.95. Review by Richard Selcer of Mountain View College. Edward Wagenknecht. Daughters of the Covenant: Portraits of Six Jewish Women. Amherst: University of Massachusetts, 1983. Pp. viii, 192. Cloth, $17.50. Review by Abraham D. Kriegel of Memphis State University. Morton Borden. Jews, Turks, and Infidels. Chapel Hill and London: University of North Carolina Press, 1984. Pp. x, 163. Cloth, $17.95. Review by Raymond J. Jirran of Thomas Nelson Community College. Richard Schlatter, ed. Recent Views on British History: Essays on Historical Writing Since 1966. New Brunswick: Rutgers University Press, 1984. Pp. xiii, 524. Cloth, $50.00. Review by Fred R. van Hartesveldt of Fort Valley State College. Simon Hornblower. The Greek World, 479-323 B.C. London and New York: Methuen, 1983. Pp. xi, 354. Cloth, $24.00; Paper, $11.95. Review by Dan Levinson of Thayer Academy, Braintree, Massachusetts. H. R. Kedward. Resistance in Vichy France. New York: Oxford University Press, 1978. Paper edition 1983. Pp. ix, 311. Paper, $13.95. Review by Sanford J. Gutman of the State University of New York at Cortland.

A Connected Autonomous Vehicle Network (CAVN) is an emerging paradigm that can reduce traffic congestion by allowing vehicles to cooperatively behave according to information out of the line of sight and improve traffic flow by decreasing inter-vehicular gaps on roadways. In this paper, the stability of CAVN with constant and time-varying communication delays is studied. When the time delay depends on time, the semi-discretization method is used to study the plant stability of the flow equilibrium of CAVN and construct approximate stability regions charts over control gain space. To study the influence of time-varying delay, a constant delay is considred as the average value of the time delay function. Then, explicit sufficient conditions are provided for the stability of the flow equilibrium and study the string stability of the CAVN. The proposed controller is validated using simulations and experimentally with a platoon of four autonomous robots under time-varying delays.

The human brain constitutes one of the most advanced networks produced by nature, consisting of billions of neurons communicating with each other. However, this communication is not in real-time, with different communication or time-delays occurring between neurons in different brain areas. Here, we investigate the impacts of these delays by modeling large interacting neural circuits as neural-field systems which model the bulk activity of populations of neurons. By using a Master Stability Function analysis combined with numerical simulations, we find that delays (1) may actually stabilize brain dynamics by temporarily preventing the onset to oscillatory and pathologically synchronized dynamics and (2) may enhance or diminish synchronization depending on the underlying eigenvalue spectrum of the connectivity matrix. Real eigenvalues with large magnitudes result in increased synchronizability while complex eigenvalues with large magnitudes and positive real parts yield a decrease in synchronizability in the delay vs. instantaneously coupled case. This result applies to networks with fixed, constant delays, and was robust to networks with heterogeneous delays. In the case of real brain networks, where the eigenvalues are predominantly real, owing to the nearly symmetric nature of these weight matrices, biologically plausible, small delays, are likely to increase synchronization, rather than decreasing it.

Police agencies have an important role to play in responding to intimate partner violence (IPV) situations. The objective of our study was to examine how police officers define IPV and to circumscribe police officers’ attitudes about the issue. This study examined results from a survey conducted with police officers ( N = 169) in the province of New Brunswick. A major implication of our study points toward education and training as a necessary passage to more efficient intervention as perceptions are not enough to make an informed decision about IPV situations.

Written submissions are traditionally used in the assessment of applications for Fellowship of the Higher Education Academy, with dialogue offering an alternative approach. Quite why individuals el...

This paper extends the results in [1] considering time delays in Standard Car Following models (CFMs). In [1], connected vehicles are characterized with CFMs models and controlled using linear string analysis to stabilize single-lane car following of human-driven vehicles (HDVs). In this paper, we revisit stability and safety conditions for traffic considering time delays due to lags in the input signals. We perform plant stability and string stability analysis to derive these conditions. Then we obtain the optimal number of HDVs that can be stabilized using one autonomous vehicle. Numerical simulations are provided to implement a case study on Intelligent Driver Model to discuss the influence of time delays that arise on HDVs and the autonomous vehicle on optimal number of HDVs that can be stabilized using one autonomous vehicle.

In this paper, we study the stability of Connected Autonomous Vehicle Networks (CAVN) with commensurate time delays under the assumption that communication time delays increase as the distance between the vehicles increases. Two delays are said to be commensurate if their ratio is a rational number. We characterize the maximum range of delay where the system becomes plant stable and carry out string stability analysis. We provide numerical simulation and observe that the stability region in the control gains plane decreases as when commensurate time delays increase.

BACKGROUND Juvenile idiopathic arthritis (JIA) is a heterogeneous group of 7 chronic arthritides categories that affects children younger than 16 years. This case series elucidates the characteristics of patients from a single center diagnosed with JIA at younger than 12 months. METHODS We included patients who presented to the rheumatology clinic for JIA with symptom onset at younger than 1 year. Chart review was conducted to complete case report forms that included demographics, historical features, examination features, laboratory results, imaging results, and treatment courses. RESULTS We identified 12 patients who met our inclusion criteria. Eight of our patients were diagnosed with oligoarticular JIA, 3 had polyarticular JIA, and 1 was diagnosed with systemic JIA. Overall, 58% (7/12) of patients had joint contractures at their initial visit. Of the patients with oligoarticular JIA, 50% (4/8) required a disease-modifying antirheumatic drug to achieve disease remission; 12.5% (1/8) required biologic therapy. All of the polyarticular JIA patients had highly positive antinuclear antibodies, as well as elevated inflammatory markers. CONCLUSIONS Children with infantile JIA are overall similar to the larger population of patients with JIA. Disease severity may not be different compared with that of older children with JIA; however, there is likely a larger delay in diagnosis and the presence of contractures, which occurred in more than half of our patients.

To address the need for simple, safe, sensitive, and scalable SARS-CoV-2 tests, we validated and implemented a PCR test that uses a saliva collection kit use at home. Individuals self-collected 300 µl saliva in vials containing Darnell Rockefeller University Laboratory (DRUL) buffer and extracted RNA was assayed by RT-PCR (the DRUL saliva assay). The limit of detection was confirmed to be 1 viral copy/µl in 20 of 20 replicate extractions. Viral RNA was stable in DRUL buffer at room temperature up to seven days after sample collection, and safety studies demonstrated that DRUL buffer immediately inactivated virus at concentrations up to 2.75×106 PFU/ml. Results from SARS-CoV-2 positive nasopharyngeal (NP) swab samples collected in viral transport media and assayed with a standard FDA Emergency Use Authorization (EUA) test were highly correlated with samples placed in DRUL buffer. Direct comparison of results from 162 individuals tested by FDA EUA oropharyngeal (OP) or NP swabs with co-collected saliva samples identified four otherwise unidentified positive cases in DRUL buffer. Over six months, we collected 3,724 samples from individuals ranging from 3 months to 92 years of age. This included collecting weekly samples over 10 weeks from teachers, children, and parents from a pre-school program, which allowed its safe reopening while at-risk pods were quarantined. In sum, we validated a simple, sensitive, stable, and safe PCR-based test using a self-collected saliva sample as a valuable tool for clinical diagnosis and screening at workplaces and schools.

We describe the presentation and diagnosis of a child with newly diagnosed antineutrophil cytoplasmic antibody–associated vasculitis and associated diffuse alveolar hemorrhage who was positive for coronavirus disease 2019 immunoglobulin G antibodies, indicative of a previous asymptomatic infection. Results of multiple polymerase chain reaction tests coinciding with the start of symptoms were negative, indicating that acute infection was not the cause of the patient’s symptoms. Coronavirus disease 2019–induced autoimmune diseases have been described in adults, but this case report represents the first case described in a pediatric patient.

We study a model for a network of synaptically coupled, excitable neurons to identify the role of coupling delays in generating different network behaviors. The network consists of two distinct populations, each of which contains one excitatory-inhibitory neuron pair. The two pairs are coupled via delayed synaptic coupling between the excitatory neurons, while each inhibitory neuron is connected only to the corresponding excitatory neuron in the same population. We show that multiple equilibria can exist depending on the strength of the excitatory coupling between the populations. We conduct linear stability analysis of the equilibria and derive necessary conditions for delay-induced Hopf bifurcation. We show that these can induce two qualitatively different phase-locked behaviors, with the type of behavior determined by the sizes of the coupling delays. Numerical bifurcation analysis and simulations supplement and confirm our analytical results. Our work shows that the resting equilibrium point is unaffected by the coupling, thus the network exhibits bistability between a rest state and an oscillatory state. This may help understand how rhythms spontaneously arise in neuronal networks.

This chapter analyzes the changing policies of the Western militaries toward female, gay, and lesbian soldiers in the post-1945 era and the challenges these policies posed to dominant ideas of military masculinity. The focus will be on the NATO states of Britain, Canada, and the United States with different military traditions. The chapter discusses the main blocking, enabling and driving factors for policies of integrating women as well as gays and lesbians in these three countries. It argues that their integration was fostered, first, by the move to professional armies based on volunteers, which led to growing military manpower needs; second, by the expanding centrality of degendered technological sophistication, which allowed the integration of more and more women, because it required skills and knowledge and not mainly strength; third, by social movements that pushed for equal rights for women and queer people; and fourth, a change in public opinion.

We study a model for a network of synaptically coupled, excitable neurons to identify the role of coupling delays in generating different network behaviors. The network consists of two distinct populations, each of which contains one excitatory-inhibitory neuron pair. The two pairs are coupled via delayed synaptic coupling between the excitatory neurons, while each inhibitory neuron is connected only to the corresponding excitatory neuron in the same population. We show that multiple equilibria can exist depending on the strength of the excitatory coupling between the populations. We conduct linear stability analysis of the equilibria and derive necessary conditions for delay-induced Hopf bifurcation. We show that these can induce two qualitatively different phase-locked behaviors, with the type of behavior determined by the sizes of the coupling delays. Numerical bifurcation analysis and simulations supplement and confirm our analytical results. Our work shows that the resting equilibrium point is unaffected by the coupling, thus the network exhibits bistability between a rest state and an oscillatory state. This may help understand how rhythms spontaneously arise neuronal networks.

Transportation infrastructure plays an essential role in flood response and recovery. However, flooding may disturb road functionality and generate direct and indirect adverse impacts, including the loss of access to essential services. This paper presents a comprehensive analysis of flood impacts on road network topology and accessibility to amenities for major communities in the State of Iowa using graph-theoretic methods, including single-source shortest path analyses. We assessed the disruption of transportation networks on the accessibility to critical amenities (e.g., hospitals) under 100 and 500-year flood scenarios. Our analysis methodology leads toward the development of an integrated real-time decision support system that will allow decision-makers to explore “what if” flood scenarios to identify vulnerable areas and population in their authority. Due to locations and effects on road topology under flood events, the results show differential impacts in access to critical services.

In this work, we consider a general conductance-based neuron model with the inclusion of the acetycholine sensitive, M-current. We study bifurcations in the parameter space consisting of the applied current $I_{app}$ I a p p , the maximal conductance of the M-current $g_{M}$ g M and the conductance of the leak current $g_{L}$ g L . We give precise conditions for the model that ensure the existence of a Bogdanov–Takens (BT) point and show that such a point can occur by varying $I_{app}$ I a p p and $g_{M}$ g M . We discuss the case when the BT point becomes a Bogdanov–Takens–cusp (BTC) point and show that such a point can occur in the three-dimensional parameter space. The results of the bifurcation analysis are applied to different neuronal models and are verified and supplemented by numerical bifurcation diagrams generated using the package . We conclude that there is a transition in the neuronal excitability type organised by the BT point and the neuron switches from Class-I to Class-II as conductance of the M-current increases.

Small pulmonary nodules (≤1.5 cm) are frequently detected on routine chest imaging and lung cancer screening studies. Our goal was to determine the clinical value of CT-guided core needle biopsy (CNB) in the evaluation of such nodules. In this single-center study, we retrospectively analyzed patient data (n = 44) for CNBs on lung nodules (≤1.5 cm) performed at our biopsy center between May 2017 and March 2020. We analyzed for the rate of pathology diagnosis, molecular/biomarker analysis, complications, and change in clinical management and outcome over a period ranging up to 60 months after biopsy. A pathology diagnosis of malignancy or benign lesion was obtained in 97.9% of biopsies in this cohort. The rate of complications was low with only 6.8% of patients requiring the insertion of a temporary small profile interventional radiology (IR) pigtail chest tube for pneumothorax. Out of the subset of biopsy specimens that were sent for tissue molecular analysis, 90% had enough tissue preserved after initial pathological analysis to obtain at least one molecular marker. Our data show that CT-guided CNB is safe and reliable, and should be considered for the evaluation of small, suspicious lung nodules found on routine screenings for the early detection and evaluation of malignant lesions.

The risk-need-responsivity model (RNR; Bonta & Andrews, 2017) has become a leading approach for effective offender case management, but field tests of this model are still required. The present study first assessed the predictive validity of the RNR-informed Level of Service/Case Management Inventory (LS/CMI; Andrews, Bonta, & Wormith, 2004) with a sample of Atlantic Canadian male and female community-supervised provincial offenders (N = 136). Next, the case management plans prepared from these LS/CMI results were analyzed for adherence to the principles of risk, need, and responsivity. As expected, the LS/CMI was a strong predictor of general recidivism for both males (area under the curve = .75, 95% confidence interval [.66, .85]), and especially females (area under the curve = .94, 95% confidence interval [.84, 1.00]), over an average 3.42-year follow-up period. The LS/CMI was predictive of time to recidivism, with lower risk cases taking longer to reoffend than higher risk cases. Despite the robust predictive validity of the LS/CMI, case management plans developed by probation officers generally reflected poor adherence to the RNR principles. These findings highlight the need for better training on how to transfer risk appraisal information from valid risk tools to case plans to better meet the best-practice principles of risk, need, and responsivity for criminal behavior risk reduction. (PsycINFO Database Record

Almost all population communities are strongly influenced by their seasonally varying living environments. We investigate the influence of seasons on populations via a periodically forced predator-prey system with a nonmonotonic functional response. We study four seasonality mechanisms via a continuation technique. When the natural death rate is periodically varied, we get six different bifurcation diagrams corresponding to different bifurcation cases of the unforced system. If the carrying capacity is periodic, two different bifurcation diagrams are obtained. Here we cannot get a "universal diagram" like the one in the periodically forced system with monotonic Holling type Ⅱ functional response; that is, the two elementary seasonality mechanisms have different effects on the population. When both the natural death rate and the carrying capacity are forced with two different seasonality mechanisms, the phenomena that arise are to some extent different. The bifurcation results also show that each seasonality mechanism can display complex dynamics such as multiple attractors including stable cycles of different periods, quasi-periodic solutions, chaos, switching between these attractors and catastrophic transitions. In addition, we give some orbits in phase space and corresponding Poincare sections to illustrate different attractors.

Substantial research has demonstrated the value of using risk assessment tools for the prediction and management of violence risk, including for intimate partner violence (IPV) (Mills, Kroner, and Morgan 2011). Such tools have been advocated for use by police officers (Hilton, Grant, and Rice 2010), but little is known about police officers’ perceptions of using these tools to inform their decision-making. Using a sample of 159 Canadian police officers (73% male, M age = 41.8 years, SD = 8.9), the current study examined police officer’s experiences with IPV risk tools, their attitudes about using such tools, and identified predictors of these attitudes using an online survey. Most of this sample had previously used an IPV risk tool, which was most commonly the Brief Spousal Assault Form for the Evaluation of Risk (64.1%). Most police officers rated use of risk tools as at least somewhat to extremely helpful (73.5%), and 67.4% indicated that they would use a risk tool with sufficient training on it. Regression analyses indicated that police officers’ perceived IPV risk tool usefulness was significantly predicted by older respondent age and greater perceived need for guidance in responding to IPV calls. In conclusion, most police officers view IPV risk screening as valuable for informing their responses to such calls for service and are likely to embrace such decision-aids with sufficient training on their potential impact for enhancing safety.

This paper explores how, and how effectively, two systems of international law have addressed exploitation, violence and abuse of people with mental disabilities. The two international systems reviewed were the Council of Europe's European Court of Human Rights and the United Nations Committee on the Rights of Persons with Disabilities. The two issues dealt with are (a) forced institutionalisation and denial of community-based services and (b) medically-sanctioned treatment as abuse or violence. The paper offers a comparative analysis of the way in which the two bodies have dealt with exploitation, violence and abuse of people with disabilities, and offers recommendations as to how the two bodies could adjust their approaches to come into closer alignment.

We compare family and parental effects on child verbal facility, verbal achievement and mathematics achievement in the United States and Great Britain. We study 3,438 5-13 year-old children from the 1994 NLSY Child-Mother Data Set and 1429 same-aged children from the National Child Development Study, also known as the British Child. Multivariate analyses suggest that the processes through which families invest in child cognition are similar across societies, with factors including low birth weight, child health, maternal cognition, family size and children's home environments being consequential. We conclude that parental investments are equally important across the two societies. The more developed welfare state in Great Britain does not notably compensate for parental investments in that society, although it may play a greater role when parental resources are absent or stretched thin.