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A woman in her mid-30s presented to the orthopaedic team, unable to mobilise, shortly after her caesarean section. On questioning, she reported 10 weeks of atraumatic right hip pain. A radiograph revealed a displaced right subcapital neck of femur fracture. An MRI confirmed this, as well as identifying a minimally displaced left subcapital neck of femur fracture. She underwent a right total hip replacement and internal fixation of the left hip. A dual energy X-ray absorptiometry (DEXA) scan showed severe osteoporosis, and a diagnosis of transient osteoporosis of the hip was made. She was seen by the bone metabolism team and given calcium and vitamin D medication. Although atraumatic hip fractures are rare in young patients, disproportionate or persisting hip pain in pregnant patients should raise the index of suspicion and prompt further investigation in the form of an MRI. This will allow timely management of hip fractures and improve patient outcomes.

Background: A routine ultrasound scan is used to assess a variety of renal pathological cases. Sonographers face a variety of challenges that may affect their interpretation. Understanding normal organ shapes, human anatomy, physical concepts, and artifacts is required for accurate diagnosis. Sonographers must understand how artifacts appear in ultrasound images in order to reduce errors and improve diagnosis. The purpose of this study is to assess sonographers' awareness and knowledge of artifacts in renal ultrasound scans. Methods: Participants in this cross-sectional study were asked to complete a survey containing different types of common artifacts in renal system ultrasound scans. An online questionnaire survey was used to collect the data. The questionnaire targeted radiologists, radiologic technologists, and intern students in Madinah hospitals in the ultrasound department. Results: The total number of participants was 99, with 9.1% being radiologists, 31.3% being radiology technologists, 6.1% being senior specialists, and 53.5% being intern students. There was a significant difference in the participants’ knowledge of ultrasound artifacts in the renal system with the total selection of the right artifact in senior specialists at 73% and intern students 45%. There was a direct relationship between age and years of experience in distinguishing artifacts in the renal system scan. A category of participants with the highest age and experience got 92% of the correct selection of artifacts. Conclusion: The study concluded that intern students and radiology technologists have limited knowledge of ultrasound scan artifacts, whereas senior specialists and radiologists have a high level of awareness of the artifacts.

Abstract: Cardiovascular disorders are among the critical side effects of cancer therapy. Damage to the function and normal structure of the heart can cause serious threats to patients that are being treated for cancer. Cardiovascular complications may be induced by various types of chemotherapy drugs and also radiation therapy. The severity of cardiovascular toxicity depends on several factors, such as types of drugs, tumor location for radiotherapy, the presence of cardiac disease history, the dose of drugs or ionizing radiation, etc. Radiotherapy and chemotherapy can cause heart diseases through various mechanisms, such as oxidative stress, inflammation, cell death, fibrosis, endothelial to mesenchymal transition (EndMT), etc. Chronic inflammation following damage to a huge number of cells can trigger more accumulation of inflammatory cells and chronic release of reactive oxygen species (ROS) and nitric oxide (NO). Oxidative stress can induce more cell death and cardiac remodeling through damage to vessels and valvular and disruption of the normal structure of the extracellular matrix. These changes may lead to cardiomyopathy, myocarditis, pericarditis, and vascular disorders that may lead to heart attack and death. This review provides basic information on cellular and molecular mechanisms of different types of cardiovascular disorders following cancer therapy by radiation or chemotherapy. We also recommend some adjuvants and targets to reduce the risk of heart toxicity by radiation/chemotherapy.

Abstract: Tuberculosis is a challenge in organ transplantation due to the interaction between Anti- Tuberculosis Treatment (ATT) and immunosuppressive drugs, such as Tacrolimus (TAC). This study aimed to assess this interaction and discuss the guidelines used in this specific case. Methods: A retrospective, observational, single-center analysis was performed at the Department of Clinical Pharmacology (National Centre of Pharmacovigilance, Tunisia). We analyzed the database of patients who received TAC from 2009 until 2018. We included samples provided from renal transplant patients infected by Mycobacterium tuberculosis after transplantation. Trough blood levels (C0) were determined using an immunoassay analyzer. The Therapeutic Range (TR) of TAC was considered between 5 and 10 ng/mL. Pharmacokinetic parameters were compared between the period of co-administration of TAC/ATT (period A) and the period during which patients received only TAC (period B). Results: Seven renal transplant patients treated by TAC were included. 41 samples were analyzed (16; period A, 25; period B). Only 6 % of C0 values were found within TR during period A, while this rate was 44% during period B. During period A, 88% of TAC C0 was under the lower limit of TR, indicating a high risk of transplant rejection. The mean C0 and C0/D were significantly lower during period A (3.11±1.53 ng/mL vs 7.11 ± 3.37 ng/mL; p = 0.001 and 33.06 ± 24.89 vs 83.14 ± 44.46; p = 0.0006, respectively), without difference in doses between periods. Conclusion: Considering the results of this study, clinicians are suggested to monitor TAC closely in this particular circumstance.

Abstract: Glioblastoma multiforme (GBM) is an aggressive form of adult brain tumor that can arise from a low-grade astrocytoma. In recent decades, several new conventional therapies have been developed that have significantly improved the prognosis of patients with GBM. Nevertheless, most patients have a limited long-term response to these treatments and survive < 1 year. Therefore, innovative anti-cancer drugs that can be rapidly approved for patient use are urgently needed. One way to achieve accelerated approval is drug repositioning, extending the use of existing drugs for new therapeutic purposes, as it takes less time to validate their biological activity as well as their safety in preclinical models. In this review, a comprehensive analysis of the literature search was performed to list drugs with antiviral, antiparasitic, and antidepressant properties that may be effective in GBM and their putative anti-tumor mechanisms in GBM cells.

Background: The indole backbone is encountered in a class of N-heterocyclic compounds with physiological and pharmacological effects such as anti-cancer, anti-diabetic, and anti-HIV. These compounds are becoming increasingly popular in organic, medicinal, and pharmaceutical research. Nitrogen compounds' hydrogen bonding, dipole- dipole interactions, hydrophobic effects, Van der Waals forces, and stacking interactions have increased their relevance in pharmaceutical chemistry due to their improved solubility. Indole derivatives, such as carbothioamide, oxadiazole, and triazole, have been reported to act as anti-cancer drugs due to their ability to disrupt the mitotic spindle and prevent human cancer cell proliferation, expansion, and invasion. Objectives: To synthesize new 5-bromoindole-2-carboxylic acid derivatives that function as EGFR tyrosine kinase inhibitors as deduced through molecular docking studies. Methods: Different derivatives of indole (carbothioamide, oxadiazole, tetrahydro pyridazine-3,6-dione, and triazole) were synthesized and evaluated through different chemical, spectroscopic methods (IR, 1HNMR, 13CNMR, and MS) and assessed in silico and in vitro for their antiproliferative activities against A549, HepG2, and MCF-7 cancer cell lines. Results: According to molecular docking analyses, compounds 3a, 3b, 3f, and 7 exhibited the strongest EGFR tyrosine kinase domain binding energies. In comparison to erlotinib, which displayed some hepatotoxicity, all of the evaluated ligands displayed good in silico absorption levels, did not appear to be cytochrome P450 inhibitors, and were not hepatotoxic. The new indole derivatives were found to decrease cell growth of three different types of human cancer cell lines (HepG2, A549, and MCF-7), with compound 3a being the most powerful while still being cancer-specific. Cell cycle arrest and the activation of apoptosis were the results of compound 3a's inhibition of EGFR tyrosine kinase activity. Conclusion: The novel indole derivatives, compound 3a in particular, are promising anti-cancer agents which inhibit cell proliferation by inhibiting EGFR tyrosine kinase activity.

Metal-Organic Frameworks (MOFs) have been developed as solid sorbents for CO2 capture applications and their properties can be controlled by tuning the chemical blocks of their crystalline units. A number of MOFs (e.g., HKUST-1) have been developed but the question remains how to deploy them for gas–solid contact. Unfortunately, the direct use of MOFs as nanocrystals would lead to serious problems and risks. Here, for the first time, we report a novel MOF-based hybrid sorbent that is produced via an innovative in-situ microencapsulated synthesis. Using a custom-made double capillary microfluidic assembly, double emulsions of the MOF precursor solutions and UV-curable silicone shell fluid are produced. Subsequently, HKUST-1 MOF is successfully synthesized within the droplets enclosed in the gas permeable microcapsules. The developed MOF-bearing microcapsules uniquely allow the deployment of functional nanocrystals without the challenge of handling ultrafine particles, and further, can selectively reject undesired compounds to protect encapsulated MOFs.

Our purpose was to characterize radiation treatment interruption (RTI) rates and their potential association with sociodemographic variables in an urban population before and during the COVID-19 pandemic.Electronic health records were retrospectively reviewed for patients treated between January 1, 2015, and February 28, 2021. Major and minor RTI were defined as ≥5 and 2 to 4 unplanned cancellations, respectively. RTI was compared across demographic and clinical factors and whether treatment started before or after COVID-19 onset (March 15, 2020) using multivariate logistic regression analysis.Of 2240 study cohort patients, 1938 started treatment before COVID-19 and 302 started after. Patient census fell 36% over the year after COVID-19 onset. RTI rates remained stable or trended downward, although subtle shifts in association with social and treatment factors were observed on univariate and multivariate analysis. Interaction of treatment timing with risk factors was modest and limited to treatment length and minor RTI. Despite the stability of cohort-level findings showing limited associations with race, geospatial mapping demonstrated a discrete geographic shift in elevated RTI toward Black, underinsured patients living in inner urban communities. Affected neighborhoods could not be predicted quantitatively by local COVID-19 transmission activity or social vulnerability indices.This is the first United States institutional report to describe radiation therapy referral volume and interruption patterns during the year after pandemic onset. Patient referral volumes did not fully recover from an initial steep decline, but local RTI rates and associated risk factors remained mostly stable. Geospatial mapping suggested migration of RTI risk toward marginalized, minority-majority urban ZIP codes, which could not otherwise be predicted by neighborhood-level social vulnerability or pandemic activity. These findings signal that detailed localization of highest-risk communities could help focus radiation therapy access improvement strategies during and after public health emergencies. However, this will require replication to validate and broaden relevance to other settings.

Clinicians must individualize pharmacotherapy for patients with acute neurological injury based on multiple factors, including age, comorbidities, and chronic medication use. Many pharmacokinetic and pharmacodynamic properties are altered during acute illness, particularly absorption, distribution, metabolism, and elimination, which may result in loss of drug effect or toxicity. This article provides clinicians with general pharmacologic knowledge of the following drug regimens commonly prescribed to neurocritically ill adults: sedatives, analgesics, osmotherapy, antiseizure medications, antishivering agents, vasoactive agents, and antithrombotic reversal agents.

in this Study, Activated Carbon was Created by Physically Activating Potato Peel Waste (PPW) with Carbon Dioxide. the Potential of this Approach, which Uses Carbon Dioxide to Produce Actuation Carbon (AC) from Precursor Potato Peel Waste, has been Investigated. Utilizing x-Ray Diffraction Analysis, Scanning Electron Microscopy, and Atomic Force Microscopy, the Microstructure of the Activated Carbon was Examined. the Average Crystallite Size was Affected by Employing Varied Periods for the Activation Process, as Seen by the Crystallite Size of the High-Intensity Peaks of the Precursor Potato Peel Waste at Various Drying Times and the Activated Products. after 60 Minutes of Drying, the Activation Stage was under Ideal Conditions, and in Comparison to the other Times, a Size of 325 Nm was Also Attained with the Rest of the Periods, as well as a High Adhesion Elevation Surface Region for the Carbon. the Activated Carbon Produced Using Physical Activation Showed a Surface Area as High as 1733 m2/g with a Pore Volume of 0.45 cm3/g, whereas the Precursor Showed a Surface Area of < 4 m2/g. this Investigation Aims to Modify the Surface of Activated Carbon without Significantly Altering its Structural Parameters for Use in Future Renewable Energy Sources and to Make the Synthesis of such Materials more Potent, more Eco-Friendly, and Less Expensive.

Background and Purpose Randomized trials proved the benefits of mechanical thrombectomy (MT) for select patients with large vessel occlusion (LVO) within 24 hours of last-known-well (LKW). Recent data suggest that LVO patients may benefit from MT beyond 24 hours. This study reports the safety and outcomes of MT beyond 24 hours of LKW compared to standard medical therapy (SMT).Methods This is a retrospective analysis of LVO patients presented to 11 comprehensive stroke centers in the United States beyond 24 hours from LKW between January 2015 and December 2021. We assessed 90-day outcomes using the modified Rankin Scale (mRS).Results Of 334 patients presented with LVO beyond 24 hours, 64% received MT and 36% received SMT only. Patients who received MT were older (67±15 vs. 64±15 years, P=0.047) and had a higher baseline National Institutes of Health Stroke Scale (NIHSS; 16±7 vs.10±9, PP=0.19). MT was associated with mRS 0–2 at 90 days (adjusted odds ratio [aOR] 5.73, P=0.026), less mortality (34% vs. 63%, PPPP=0.017), Alberta Stroke Program Early Computed Tomography (ASPECTS) score ≥8 (aOR 3.06, P=0.041), and collaterals scores (aOR 1.41, P=0.027) were associated with 90-day functional independence.Conclusion In patients with salvageable brain tissue, MT for LVO beyond 24 hours appears to improve outcomes compared to SMT, especially in patients with severe strokes. Patients’ age, ASPECTS, collaterals, and baseline NIHSS score should be considered before discounting MT merely based on LKW.

The Internet of Things (IoT) is a cutting-edge innovation that facilitates the cost-effective development of smart system architectures. Although current regulations necessitate installing an analog fire alarm system, such a system lacks the intelligence to instantly notify the appropriate parties in a timely fashion. In addition, since people are not always present, an analog fire alarm will not be able to prevent immediate danger or damage in the event of a fire. Therefore, the incident must be reported as soon as possible to the appropriate party in order to lessen the impact of a fire. In this study, we suggest a smart fire-alarm system made of a fire sensor and a sound sensor that can both detect fire and noise as well as the status of the analog fire alarm system to ascertain whether the analog fire alarm system is operational. We first tested our proposed smart fire alarm system to determine its effectiveness before putting it into use. From there, we ran experiments to determine how well it worked. The outcomes show that the system is trustworthy in a range of scenarios.

Alzheimer's disease (AD) is a neurodegenerative ailment that causes cognitive deterioration due to changes in brain structure. Individuals usually see diagnostic symptoms after irreversible brain damage has occurred. In order to slow the course of the illness and enhance the quality of life for AD patients, early diagnosis is crucial. Recent advances in machine learning and scanning have made the use of these methods to detect AD in its earliest stages possible. This article uses deep learning using CNN methods to extract picture characteristics from ADNI (Alzheimer's Disease Neuroimaging Initiative) datasets to improve Alzheimer's disease diagnosis techniques. This descriptor will be used in conjunction with the CNN to categorize the illness and add new characteristics that are more accurate, quicker, and stable than the current features. In this process, an Alzheimer's detection System will be implemented to mitigate the adverse effects of data imbalance on recognition performance, and an integrated multi-depth architectural technology will be introduced to boost recognition quality. Using the suggested model of the convolution neural network (CNN) technique, classification accuracy results were obtained above 97%.

Due to the importance of the multi-level fully rough interval linear programming (MLFRILP) problem to address a wide range of management and optimization challenges in practical applications, such as policymaking, supply chain management, energy management, and so on, few researchers have specifically discussed this point. This paper presents an easy and systematic roadmap of studies of the currently available literature on rough multi-level programming problems and improvements related to group procedures in seven basic categories for future researchers and also introduces the concept of multi-level fully rough interval optimization. We start remodeling the problem into its sixteen crisp linear programming LP problems using the interval method and slice sum method. All crisp LPs can be reduced to four crisp LPs. In addition, three different optimization techniques were used to solve the complex multi-level linear programming issues. A numerical example is also provided to further clarify each strategy. Finally, we have a comparison of the methods used for solving the MLFRILP problem.

Oral health is essential to quality of life because it promotes social and physical well-being and serves as a reflection of general health. According to some estimates, dental and oro-dental conditions are the most prevalent illnesses in the world. One important known predisposing factor for various oral illnesses is poor oral hygiene. Since the beginning of recorded history, mankind has suffered from oral diseases in all of its manifestations. Ancient Chinese, Greek, Roman, Egyptian, Arabic, and Indian surgical and medical treatises all discuss mouth illnesses at some point. Many renowned Unani physicians have too mentioned about various oral diseases and unhygienic conditions in their respective books. They have clearly mentioned how to maintain oral health and treat various oral conditions in their respective rich Unani texts. Present review paper is an attempt to throw some light over oral hygiene, its historical background and diseases which occur due to poor oral health light of the Unani literature.

Amyotrophic Lateral Sclerosis (ALS) is an incurable neurodegenerative condition. Despite significant advances in pre-clinical models that enhance understanding of disease pathobiology, translation of candidate drugs to effective human therapies has been disappointing. There is increasing recognition of the need for a precision medicine approach toward drug development, as many failures in translation can be attributed in part to disease heterogeneity in humans. PRECISION-ALS is an academic industry collaboration between clinicians, Computer Scientists, Information engineers, technologists, data scientists and industry partners that will address the key clinical, computational, data science and technology associated research questions to generate a sustainable precision medicine based approach toward new drug development. Using extant and prospectively collected population based clinical data across nine European sites, PRECISION-ALS provides a General Data Protection Regulation (GDPR) compliant framework that seamlessly collects, processes and analyses research-quality multimodal and multi-sourced clinical, patient and caregiver journey, digitally acquired data through remote monitoring, imaging, neuro-electric-signaling, genomic and biomarker datasets using machine learning and artificial intelligence. PRECISION-ALS represents a first-in-kind modular transferable pan-European ICT framework for ALS that can be easily adapted to other regions that face similar precision medicine related challenges in multimodal data collection and analysis. ispartof: AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION vol:24 issue:5-6 ispartof: location:England status: Published online

Purpose: The most frequent issue among workers who perform repetitive upper extremity activity in their line of work is neck pain. Hairdressers who cut hair frequently use their shoulders in their picking and holding of the scissors. The muscles, ligaments, and soft tissues of the musculoskeletal system are put under more strain by this repetitive activity. Consequently, the objective of the current study is to ascertain, how prevalent neck pain is among hairdressers. The study’s objective is to determine the frequency of neck pain in hairdressers of Multan. Methodology: Cross-sectional study design was employed in this investigation. Information was gathered from Multan hairdressers. The technique of simple random sampling was used to gather the data from hairdressers. A total of 100 hair stylists were included in the study. Workers between the ages of 20 and 40 who have been employed for more than six months without a neck injury, trauma, or neurological or musculoskeletal problem were included. Participants were given questionnaires, and the answers were recorded. Data was manually coded, entered, and analysed using SPSS version 21. Results were described using frequency distributions, percentages, means, and standard deviations. Findings: Non Parametric Test was used to analyze data. In this study, only 44% of hairdressers reported having neck pain, while the rest reported mild, moderate, or no pain. The study demonstrates that hairdressers between the ages of 31 and 40 with more than five years of experience in their field frequently experience neck pain, which may be brought on by repetitive shoulder motion and poor posture at the workplace. Recommendations: The results of this study showed that hairdressers in Multan frequently experience neck pain. Physiotherapy campaigns should be conducted to raise awareness among hairdressers. It is suggested to use a random sampling technique instead of convenience sampling in future research to enhance the generalizability of the findings. Considering that the study had a short duration, it is advisable to allocate a longer time frame for conducting future studies to obtain a more comprehensive understanding of the topic.

In this work, we investigate solution processable MoS2 based MOS (metal oxide semiconductor) capacitor device for data storage and in-memory light sensing. The MOS capacitor exhibits a good memory window of about 2.5 V with the operating voltage of +6/-6 V and good endurance of 1000 cycles without any degradation. The device shows a good memory window from 0.4 V to 5 V when the operating voltage was varied from 4/-4 to 8/-8. Importantly, the memory window of the device was increased from 2.5 V to more than 5 V when optical light with different wavelengths was induced onto the device. These promising features of the device make it suitable for data storage and in-memory light sensing.

MoS2 is a promising 2D material for solar energy harvesting applications due to its size-dependent tunable bandgap and attractive magnetic, optical, and electrical properties. This study shows an easy way to deposit a 2D layer of MoS2 nanoparticles on top of AZO/Quartz, AZO/Si, and bare Si. We investigate their UV-Vis spectral responses and potential for application in optoelectronic systems. Initial results indicate modification of the absorption spectrum over the UV-Vis range with an evident increase in the higher visible and lower UV range.

In the current study, two-dimensional pyrite thin films were produced on various substrates using a plasma-assisted, radio frequency (RF)-powered sputtering process. The photosensitivity of pyrite thin films with varying thicknesses was investigated. The sputtering process was carried out at room temperature under argon gas flow. The pressure was maintained at 3 mTorrs, and the RF power was held at 70 watts. The thickness was adjusted by changing the sputtering time from 20 to 90 minutes. The purpose of this work was to investigate the suitability of these films for use in photovoltaic applications. The growth rate, film thickness, and behaviour of as-grown pyrite thin films were analyzed using various characterization techniques. These films displayed favourable absorption in the UV/Vis range.

In this paper, a shallow foundation (strip footing), 1 m in width is assumed to be constructed on fully saturated and partially saturated Iraqi soils, and analyzed by finite element method. A procedure is proposed to define the H – modulus function from the soil water characteristic curve which is measured by the filter paper method. Fitting methods are applied through the program (SoilVision). Then, the soil water characteristic curve is converted to relation correlating the void ratio and matric suction. The slope of the latter relation can be used to define the H – modulus function. The finite element programs SIGMA/W and SEEP/W are then used in the analysis. Eight nodded isoparametric quadrilateral elements are used for modeling both the soil skeleton and pore water pressure. A parametric study was carried out and different parameters were changed to study their effects on the behavior of partially saturated soil. These parameters include the degree of saturation of the soil (S) and depth of water table. The study reveals that when the soil becomes partially saturated by dropping water table at different depths with different degrees of saturation, the bearing capacity of shallow foundation increases about (4 – 7) times higher than the bearing capacity of the same soil under saturated conditions. This result is attributed to matric suction value (i.e negative pore water pressure). The behavior of soil in partially saturated condition is likethat of fully saturated condition but with smaller values of displacement. It is found that the settlement is reduced when the water table drops to a depth of 2 m (i.e. twice the foundation width) by about (92 %).

Background and Aim: Rheumatoid arthritis (RA) patients are more susceptible to the initiation of severe periodontitis which can ultimately intensify their systemic inflammation associated with RA. The present study aimed to determine the incidence of periodontitis in rheumatoid arthritis patients. Materials and Methodology: A cross-sectional analytical study was carried out on 168 rheumatoid arthritis patients in the Department of Dentistry and Internal Medicine of a Tertiary Care Hospital of Lahore, Pakistan from January 2022 to December 2022. All the patients were inquired about their demographic details, medical history and smoking habits. A detailed periodontal examination of full mouth was done and plaque index, clinical attachment level (CAL) and probing pocket depth (PPD) was measured. Rheumatoid factor (RF)’s presence, number of tender and swollen joints, erythrocyte sedimentation rate (ESR); Disease Activity Index (DAS) and hand radiographs were the different RA parameters which were recorded. Periodontal conditions were then associated and correlated with RA parameters. Results: Out of the total 168 RA patients, there were 142 (84.5%) females and 26 (15.5%) male patients. The overall mean age was 48.6 ± 8.64 years. The overall mean DAS score and disease duration was 4.58 ± 1.32 and 9.58 ± 6.8 years respectively.

Friction stir spot welding (FSSW) is a relatively new welding process that may have significant advantages compared to the fusion processes as follows joining of conventionally non-fusion weldable alloys, reduced distortion and improved mechanical properties of weldable alloys joints due to the pure solidstate joining of metals. In this paper, a three-dimensional model based on finite element analysis is used to study the thermal history in the spot-welding of aluminum alloy 2024. The model take place the thermomechanical property on the process of the welded metals. The thermal history and the evolution results with numerical model at the measured point in the friction stirred spot weld have a good matching, then the prediction of the temperature history from the numericalmodel in the welded plates is acceptable.The experimental results of measuring the shear force of the welded plates show that there is a good agreement with the increase of the rotational speed of the tool with shear force.

This article examines the interaction between the Covid-19 pandemic (pandemic) and entrepreneurship in the United Kingdom (UK). It contends that although the pandemic has obliterated several businesses and their concomitant partners throughout the world, particularly the UK, a new swathe of entrepreneurial activities have evolved to spur socio-economic ventures in stabilising the frontiers of society. The article also synthesises the dimensions critical for successful creation of entrepreneurship by exploring the effects of the pandemic, leadership, including the financial sector as key constituents in revving new ventures. Whilst weak institutions often induced corrupt practices to stifle enterprising initiatives, the article further argues that good leadership reposes confidence in a beleaguered society by motivating people to carve for themselves and community, economic fortunes stemming out of the crisis and destructions. Lastly, the article concludes that whilst there is a complimentary relationship between a country’s endowment and the rate of entrepreneurships springing up in the UK, the converse is the case in most developing countries in the south.

Background: In Pakistan, healthcare policies have been implemented to improve children's oral health, including the provision of dental services at primary healthcare centers, the inclusion of dental care services in health insurance schemes, and the promotion of oral health education among the public. However, it is unclear whether these policies have resulted in uniform changes in pediatric dental coverage and visits across different regions and socioeconomic groups. Objective: This study aimed to investigate variations in pediatric dental coverage and visits following the implementation of healthcare policies in Pakistan. Methods: A cross-sectional survey design was used, with a sample size of 200 children aged 0-18 years. Data on pediatric dental coverage and visits were collected through structured interviews with the children and their parents or guardians. The data were analyzed using descriptive statistics and chi-square tests to identify any significant variations in the pediatric dental coverage and visits across different regions and socioeconomic groups. Results: The study found that there were significant variations in pediatric dental coverage and visits across different regions and socioeconomic groups.

Ubiquitin specific protease 30 (USP30) has been attributed to mitochondrial dysfunction and impediment of mitophagy in Parkinson’s disease (PD). This happens once ubiquitin that supposed to bind with deformed mitochondria at the insistence of Parkin, it’s been recruited by USP30 via the distal ubiquitin binding domain. This is a challenge when PINK1 and Parkin loss their functions due to mutation. Although, there are reports on USP30s’ inhibitors but no study on the repurposing of inhibitors approved against MMP-9 and SGLT-2 as potential inhibitors of USP30 in PD. Thus, the highlight therein, is to repurpose approved inhibitors of MMP-9 and SGLT-2 against USP30 in PD using extensive computational modelling framework. 3D structures of Ligands and USP30 were obtained from PubChem and protein database (PDB) servers respectively, and were subjected to molecular docking, ADMET evaluation, DFT calculation, molecular dynamics simulation (MDS) and free energy calculations. Out of the 18 drugs, 2 drugs showed good binding affinity to the distal ubiquitin binding domain, moderate pharmacokinetic properties and good stability. The findings showed canagliflozin and empagliflozin as potential inhibitors of USP30. Thus, we present these drugs as repurposing candidates for the treatment of PD. However, the findings in this current study needs to be validated experimentally. Communicated by Ramaswamy H. Sarma

A growing body of studies suggests that Ca2+ signaling controls a variety of biological processes in brain elements. Activation of L-type voltage-operated Ca2+ channels (VOCCs) plays a role in the development of oligodendrocyte (OL) lineage loss, and indicates that the blocking of these channels may be an effective way to inhibit OL lineage cell loss. For this study, 10.5-day-old male Sprague–Dawley rats were used to generate cerebellar tissue slices. The slice tissues were cultured and randomly allocated to one of four groups (six each) and treated as follows: Group I, (sham control); Group II, 0.1% dimethyl sulfoxide (DMSO) only (vehicle control); Group III, injury (INJ); Group IV, (INJ and treatment with NIF). The injury was simulated by exposing the slice tissues to 20 min of oxygen–glucose deprivation (OGD). At 3 days post-treatment, the survival, apoptosis, and proliferation of the OL lineages were measured and compared. Results: In the INJ group, there was a decrease in mature myelin basic protein+ OLs (MBP+ OLs) and their precursors, NG2+ OPCs (Nerve-glia antigen 2+ oligodendrocyte precursor cell), compared with controls. A significant elevation was observed in the NG2+ OPCs and apoptotic MBP+ OLs as confirmed by a TUNEL assay. However, the cell proliferation rate was decreased in NG2+ OPCs. NIF increased OL survival as measured by apoptosis rate in both OL lineages and preserved the rate of proliferation in the NG2+ OPCs. Conclusions: Activation of L-type VOCCs may contribute to OL pathology in association with reduced mitosis of OPCs following brain injury as a strategy to treat demyelinating diseases.