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2. The radioprotective effects of vasopressin on the gastrointestinal tract of mice

Author

G.H. Johnson, Joel D. Olsen, Leo D. Lagasse, and Altan T. Rappleye

Subjects
Pathology, medicine.medical_specialty, Vasopressin, Gastrointestinal tract, Mice, Inbred BALB C, business.industry, Vasopressins, Significant difference, Radiation-Protective Agents, Radiation Dosage, Lethal Dose 50, Radiation Effects, Mice, medicine.anatomical_structure, Jejunum, Medicine, Abdomen, Animals, Radiology, Nuclear Medicine and imaging, Acute irradiation, business, Survival rate, Digestive System
Abstract

Three-hundred Balb/C mice were used to assess the effect of vasopressin on the response of the gastrointestinal tract to irradiation. Median lethal doses were determined for control and vasopressin treated animals in which the whole abdomen was irradiated. There was a significant difference in LD50/6 (882 +/- 27 for controls vs. 1051 +/- 23 for vasopressin-treated animals). In addition studies demonstrated a significant difference in the survival rate of jejunal crypts at 800 and 1,000 rads.

Published
1975

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