1. ChemInform Abstract: A Cytotoxic Diterpene from Alomia myriadenia
- Author
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Rogério O. Queiroz, Geoffrey A. Cordell, Elita S. Fontes, Carlos L. Zani, Tânia M. A. Alves, and Young G. Shin
- Subjects
biology ,Traditional medicine ,General Medicine ,Asteraceae ,biology.organism_classification ,High-performance liquid chromatography ,Labdane ,Terpene ,chemistry.chemical_compound ,chemistry ,Epimer ,Alomia ,Diterpene ,Cytotoxicity - Abstract
An extract of the aerial parts from Alomia myriadenia Schultz-Bip. ex Baker (Asteraceae) showed significant cytotoxicity against a panel of human cancer cell lines in a screening of extracts from Brazilian Atlantic Forest plant species. Employing a bioassay-linked HPLC-electrospray/MS method, followed by semi-preparative HPLC, the active component was isolated and characterized as a mixture of epimers of the labdane diterpene 12S,16-dihydroxy-ent-labda-7,13-dien-15,16-olide.
- Published
- 2010
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