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Background: Renal cancer is the commonest renal tumor and is usually treated by radical nephrectomy. Development of laparoscopic surgery was associated with reduction of post-surgical complications and the invent of mini-laparoscopic devices proposed to be associated with marked reduction of postoperative complications. Objective: to compare between mini and conventional laparoscopic nephrectomy as regards perioperative complications. Patient and Methods: Eligible patients underwent transperitoneal conventional or minilaparoscopy (ML) or conventional laparoscopy depending on surgeon preference. Preoperatively, patients were evaluated by history and clinical examination, with routine Lab and radiological investigations. Both operative and postoperative data were collected and documented. Results: both groups were comparable as patient demographics, associated medical diseases, preoperative data or the type of nephrectomy. However, operative time was significantly shorter, while blood loss was significantly larger in conventional group. In addition, postoperative pain was significantly higher and duration of hospital stay was significantly longer in conventional group. Finally, total cosmoses score was statistically decreased in conventional group. Conclusion: Compared with mini-laparoscopy, conventional laparoscopy showed better intraoperative parameters as shorter operative time, blood loss and less need for conversion to open surgery. However, the overall complications were comparable for both groups.