1. Race is associated with differences in airway inflammation in patients with asthma
- Author
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Nyenhuis, Sharmilee M, Krishnan, Jerry A, Berry, Alalia, Calhoun, William J, Chinchilli, Vernon M, Engle, Linda, Grossman, Nicole, Holguin, Fernando, Israel, Elliot, Kittles, Rick A, Kraft, Monica, Lazarus, Stephen C, Lehman, Erik B, Mauger, David T, Moy, James N, Peters, Stephen P, Phipatanakul, Wanda, Smith, Lewis J, Sumino, Kaharu, Szefler, Stanley J, Wechsler, Michael E, Wenzel, Sally, White, Steven R, and Ackerman, Steven J
- Subjects
Adult ,Male ,corticosteroid ,Allergy ,Neutrophils ,Clinical Trials and Supportive Activities ,Immunology ,Black People ,body mass index ,airway inflammation ,White People ,Leukocyte Count ,Young Adult ,Adrenal Cortex Hormones ,Clinical Research ,Forced Expiratory Volume ,Eosinophilia ,Humans ,eosinophil ,African American ,race ,Lung ,Whites ,Inflammatory and immune system ,Sputum ,clinical trial ,Immunoglobulin E ,Middle Aged ,Blacks ,Asthma ,Phenotype ,induced sputum ,Respiratory ,Female - Abstract
BackgroundAfrican American subjects have a greater burden from asthma compared with white subjects. Whether the pattern of airway inflammation differs between African American and white subjects is unclear.ObjectiveWe sought to compare sputum airway inflammatory phenotypes of African American and white subjects treated or not with inhaled corticosteroids (ICSs; ICS+ and ICS-, respectively).MethodsWe performed a secondary analysis of self-identified African American and white subjects with asthma enrolled in clinical trials conducted by the National Heart, Lung, and Blood Institute-sponsored Asthma Clinical Research Network and AsthmaNet. Demographics, clinical characteristics, and sputum cytology after sputum induction were examined. We used a sputum eosinophil 2% cut point to define subjects with either an eosinophilic (≥2%) or noneosinophilic (
- Published
- 2017