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Aim: Developments in diagnostic methods and advances in the treatment of pediatric rheumatic diseases (PRDs) have improved the quality of life in this patient group. However, vaccine-preventable infectious diseases are still outstanding causes of morbidity and mortality in immunocompromised patients more than in healthy population. Pediatric rheumatologists play a critical role in increasing vaccination rates since they have ample opportunity to administer vaccinations. The aim of this study is to determine the knowledge, attitudes, and behaviors of pediatric rheumatologists about vaccination in rheumatic diseases. Material and Method: Between March 2022-May 2022, an online questionnaire of 20 items was used to evaluate the knowledge, attitudes, and behaviors of pediatric rheumatologists in Turkey with respect to vaccination. Results: A total of 81 participants answered all survey questions completely. The ages of the study group ranged from 30 to 48 years, at a mean of 37.5±3.8 years. Most of the pediatric rheumatologists (n:76, 93.8%) were working in a tertiary pediatric hospital; 27.2% did not consider themselves primarily responsible for the vaccination of children with PRDs, and 30.9% did not refer their patients to the department that administers the vaccine either before or during immunosuppressive therapy. In addition, it was found that only 14.8% regularly questioned the vaccination history of patients at each outpatient visit. One-third of study group recommended the implementation of non-scheduled vaccines and the most recommended non-scheduled vaccine was seasonal influenza (n:48, 59.3%). The comparative analysis between pediatric rheumatology residents and staff physicians showed no statistically significant difference in the level of knowledge except in the question concerning live vaccines. Conclusion: This study revealed that there are still serious problems in clinical practice about the vaccination of PRDs patients. For this purpose, pediatric rhematologists’ awareness and knowledge about vaccination should be increased with a special education program.

Böbrekapsesi çocukluk çağında nadir görülür ve özgün belirtileri olmadığından tanıdagüçlükler olabilir. Hastaların tanısında klinik, laboratuar ve görüntülemeyöntemleri yardımcıdır. Tanıyı takiben hızla antibiyotik tedavisibaşlanmalıdır. Bazı olgularda perkütan ve/veya cerrahi drenaj, ciddi olgulardaise nefrektomi gerekebilir. Bu çalışmada böbrek apsesi olan 5 hasta tartışılmışve literatür gözden geçirilmiştir. RENALABSCESS IN CHILDHOOD: REPORT OF FIVE CASES AND REVIEW OF LITERATURESUMMARYRenal abscess isuncommon in childhood there may be diagnostic difficulties due to nonspecificclinical features. Clinical features, laboratory findings and imaging modalitiesare helpful in diagnosis. Following diagnosis, antibiotic treatment should beinitiated promptly. In some cases, percutaneous drainage or surgery is needed.In severe cases, even nephrectomy is indicated. In this study, five patientswith renal abscess are discussed and literature is reviewed.

Çocuklardaüriner sistem taş hastalıkları son yıllarda çok daha fazla tanı almayabaşlamıştır. Erken tanı, ortaya çıkabilecek ciddi morbiditeleri önlemekaçısından önem taşır. Çocuklarda taş oluşumu altta yatan anatomik veyametabolik bir bozukluktan kaynaklanabilir. Klinik bulgular, çocuğun yaşı, taşınlokalizasyonu ve büyüklüğü ve altta yatan hastalığa bağlı olarak değişmektedir.Tedavide altta yatan nedenin ortadan kaldırılması önemlidir. Tedavi sonrasında yenitaş oluşumunun önlenmesi için yeterli sıvı alımının sağlanması, diyet ve yaşamtarzının düzenlenmesi gereklidir.

Urinarytract infections are very common in children. The most common pathogensisolated in urinary tract infections are Escherichia coli. Theincidence of Urinary tract infections in children 4-8 %in girls and 1-2 % in boys. Urinary tract infections in children is of concern because it can be associatedwith urosepsis, renal scarring,hypertension, and chronic renal insufficiency. In this reviewwe aim to describe the diagnosis and management of acute and recurrent urinarytract infections in the pediatric population., İdraryolu enfeksiyonları çocuklarda oldukça sık görülmektedir. En sık izole edilenajan Escherichia Coli’dir. İnsisdansı kız çocuklarda % 4-8 iken erkeklerde %1-2’dir.Çocuklarda ürosepsis, renal hasar, hipertansiyon, kronik renal yetmezlik ileilişkili olması sebebiyle endişe vericidir. Bu derlemede çocukluk çağı akut vekronik idrar yolu enfeksiyonunun tedavisini ve izlemi anlatılmasıamaçlanmıştır.

Publication in the conference proceedings of EUSIPCO, Aalborg, Denmark, 2010

Speech boundary detection contributes to performance of speech based applications such as speech recognition and speaker recognition. Speech boundary detector implemented in this study works on broadcast audio as a pre-processor module of a keyword spotter. Speech boundary detection is handled in 3 steps. At first step, audio data is segmented into homogeneous regions in an unsupervised manner. After an ACTIVITY/NON-ACTIVITY decision is made for each region, ACTIVITY regions are classified as Speech/Non-speech via Gaussian Mixture Model (GMM) based classification. GMM's are trained using a novel feature, Spectral Flow Direction (SFD), and an improved multi-band harmonicity feature in addition to widely used Mel Frequency Cepstral Coefficients (MFCC's).

Background: atypical hemolytic uremic syndrome (aHUS) occurs due to defective regulation of the alternative complement pathway (ACP) on vascular endothelial cells. Plasma based therapy (PT) was the mainstay of the treatment for aHUS for many years until the introduction of therapies targeting blockage of the complement system. The aim of this study was to evaluate patients with aHUS who had been treated with plasma based therapies alone. Methods: the outcomes of seven genetically confirmed aHUS patients (2 girls, 5 males) were evaluated by means of clinical presentation, response to plasma therapy, course of the disease during the follow-up period and last status. Results: the median age of the patients at admission was 6.7 years (IQR 0.7-7.8). Three patients received plasma exchange therapy and the other four patients were treated with plasma infusions. One patient was lost to follow-up after one year; the median duration of follow-up for other patients was 3.7 years (IQR 2.7-6.5). During the follow up, two patients from our historical records when complement blocking therapies had not been in clinical use yet in Turkey, underwent kidney transplantation. One transplant patient experienced an acute rejection episode without graft loss. The remaining five patients had a glomerular filtration rate of more than 90 ml/min./1.73 m(2) at the last visit. Conclusion: although we had a relatively small patient population, our findings indicate that PT might still be considered in selected patients particularly in countries where complement blocking therapies are difficult to reach due to their unavailability or costs that are not covered by the health care systems., Hacettepe University Scientific Research and Development Office