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1. Additional file 2 of Design of a multinational randomized controlled trial to assess the effects of structured and individualized exercise in patients with metastatic breast cancer on fatigue and quality of life: the EFFECT study

Author

Hiensch, Anouk E., Monninkhof, Evelyn M., Schmidt, Martina E., Zopf, Eva M., Bolam, Kate A., Aaronson, Neil K., Belloso, Jon, Bloch, Wilhelm, Clauss, Dorothea, Depenbusch, Johanna, Lachowicz, Milena, Pelaez, Mireia, Rundqvist, Helene, Senkus, Elzbieta, Stuiver, Martijn M., Trevaskis, Mark, Urruticoechea, Ander, Rosenberger, Friederike, van der Wall, Elsken, de Wit, G. Ardine, Zimmer, Philipp, Wengström, Yvonne, Steindorf, Karen, and May, Anne M.

Abstract

Additional file 2: Appendix II. Add-on measurements.

Published
2022
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2. Additional file 1 of Design of a multinational randomized controlled trial to assess the effects of structured and individualized exercise in patients with metastatic breast cancer on fatigue and quality of life: the EFFECT study

Author

Hiensch, Anouk E., Monninkhof, Evelyn M., Schmidt, Martina E., Zopf, Eva M., Bolam, Kate A., Aaronson, Neil K., Belloso, Jon, Bloch, Wilhelm, Clauss, Dorothea, Depenbusch, Johanna, Lachowicz, Milena, Pelaez, Mireia, Rundqvist, Helene, Senkus, Elzbieta, Stuiver, Martijn M., Trevaskis, Mark, Urruticoechea, Ander, Rosenberger, Friederike, van der Wall, Elsken, de Wit, G. Ardine, Zimmer, Philipp, Wengström, Yvonne, Steindorf, Karen, and May, Anne M.

Abstract

Additional file 1: Appendix I. Organizational aspects of the trial.

Published
2022
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3. Additional file 1 of Validation and reliability of the Dutch version of the EORTC QLQ-NMIBC24 Questionnaire Module for patients with non-muscle-invasive bladder cancer

Author

Ripping, Theodora M., Westhoff, Ellen, Aaronson, Neil K., Van Hemelrijck, Mieke, Rammant, Elke, Witjes, J. Alfred, Kiemeney, Lambertus. A., Aben, Katja K. H., and Vrieling, Alina

Abstract

Additional file 1. Four questions added to the T12mo + 2wk QLQ-NMIBC24 questionnaire to assess whether symptoms – in terms of urinary, bowel, sexual and total function – had decreased, remained the same or increased compared to the T12mo questionnaire.

Published
2021
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4. Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations

Author

Bancroft, Elizabeth K, Saya, Sibel, Page, Elizabeth C, Myhill, Kathryn, Thomas, Sarah, Pope, Jennifer, Chamberlain, Anthony, Hart, Rachel, Glover, Wayne, Cook, Jackie, Rosario, Derek J, Helfand, Brian T, Hutten Selkirk, Christina, Davidson, Rosemarie, Longmuir, Mark, Eccles, Diana M, Gadea, Neus, Brewer, Carole, Barwell, Julian, Salinas, Monica, Greenhalgh, Lynn, Tischkowitz, Marc, Henderson, Alex, Evans, David Gareth, Buys, Saundra S, IMPACT Study Steering Committee, IMPACT Collaborators, Eeles, Rosalind A, Aaronson, Neil K, Bancroft, Elizabeth K [0000-0002-5482-5660], and Apollo - University of Cambridge Repository

Subjects
psychosocial, Adult, Male, Psychiatric Status Rating Scales, Health Knowledge, Attitudes, Practice, Depression, Genes, BRCA2, Genes, BRCA1, #pcsm, Prostatic Neoplasms, Anxiety, Middle Aged, BRCA1, BRCA2, #ProstateCancer, quality of life, Risk Factors, Case-Control Studies, Surveys and Questionnaires, Mutation, Humans, Perception, Longitudinal Studies, Early Detection of Cancer
Abstract

OBJECTIVES: To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. PARTICPANTS AND METHODS: Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. RESULTS: A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. CONCLUSION: This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.

Published
2020
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5. Additional file 1 of Dutch translation and linguistic validation of the U.S. National Cancer Institute’s Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™)

Author

Evalien Veldhuijzen, Walraven, Iris, Mitchell, Sandra A., Moore, Elizabeth Yohe, McKown, Shawn M., Lauritzen, Matthew, Kim, Katherine J., Belderbos, José S. A., and Aaronson, Neil K.

Subjects
education
Abstract

Additional file 1 Table S1. Frequency table of participants debriefed by PRO-CTCAE symptom term and proportions endorsing difficulties with comprehension or judgement in Round 1.

Published
2020
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6. Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations

Author

Bancroft, Elizabeth K, Saya, Sibel, Page, Elizabeth C, Myhill, Kathryn, Thomas, Sarah, Pope, Jennifer, Chamberlain, Anthony, Hart, Rachel, Glover, Wayne, Cook, Jackie, Rosario, Derek J, Helfand, Brian T, Selkirk, Christina Hutten, Davidson, Rosemarie, Longmuir, Mark, Eccles, Diana M, Gadea, Neus, Brewer, Carole, Barwell, Julian, Salinas, Monica, Greenhalgh, Lynn, Tischkowitz, Marc, Henderson, Alex, Evans, David Gareth, Buys, Saundra S, Eeles, Rosalind A, Aaronson, Neil K, Eeles, Rosalind, Bancroft, Elizabeth, Page, Elizabeth, Kote-Jarai, Zsofia, Ardern-Jones, Audrey, Bangma, Chris, Castro, Elena, Dearnaley, David, Falconer, Alison, Foster, Christopher, Gronberg, Henrik, Hamdy, Freddie C, Johannsson, Oskar Thor, Khoo, Vincent, Eccles, Diana, Lilja, Hans, Evans, Gareth, Eyfjord, Jorunn, Lubinski, Jan, Maehle, Lovise, Mikropoulos, Christos, Millner, Alan, Mitra, Anita, Offman, Judith, Moynihan, Clare, Rennert, Gad, Suri, Mohnish, Dias, Alex, Taylor, Natalie, D'Mello, Lucia, Pope, Jenny, James, Paul, Mitchell, Gillian, Shanley, Sue, Richardson, Kate, McKinley, Joanne, Petelin, Lara, Murphy, Morgan, Mascarenhas, Lyon, Murphy, Declan, Lam, Jimmy, Taylor, Louise, Miller, Cathy, Stapleton, Alan, Chong, Michael, Suthers, Graeme, Poplawski, Nicola, Tucker, Katherine, Andrews, Lesley, Duffy, Jessica, Millard, Richard, Ward, Robyn, Williams, Rachel, Stricker, Phillip, Kirk, Judy, Bowman, Michelle, Patel, Manish, Harris, Marion, O'Connell, Shona, Hunt, Clare, Smyth, Courtney, Frydenberg, Mark, Lindeman, Geoffrey, Shackleton, Kylie, Morton, Catherine, Susman, Rachel, McGaughran, Julie, Boon, Melanie, Pachter, Nicholas, Townshend, Sharron, Schofield, Lyn, Nicholls, Cassandra, Spigelman, Allan, Gleeson, Margaret, Amor, David, Burke, Jo, Patterson, Briony, Swindle, Peter, Scott, Rodney, Foulkes, William, Boshari, Talia, Aprikian, Armen, Jensen, Thomas, Bojeson, Anders, Osther, Palle, Skytte, Anne-Bine, Cruger, Dorthe, Tondering, Majbritt Kure, Gerdes, Anne-Marie, Schmutzler, Rita, Rhiem, Kerstin, Wihler, Petra, Kast, K, Griebsch, C, Johannsson, Oskar, Stefansdottir, Vigdis, Murthy, Vedang, Sarin, Rajiv, Awatagiri, Kasturi, Ghonge, Sujata, Kowtal, Pradnya, Mulgund, Gouri, Gallagher, David, Bambury, Richard, Farrell, Michael, Gallagher, Fergal, Kiernan, Ingrid, Friedman, Eitan, Chen-Shtoyerman, Rakefet, Basevitch, Alon, Leibovici, Dan, Melzer, Ehud, Ben-Yehoshua, Sagi Josefsberg, Nicolai, Nicola, Radice, Paolo, Valdagni, Riccardo, Magnani, Tiziana, Gay, Simona, Teo, Soo Hwang, Tan, Hui Meng, Yoon, Sook-Yee, Thong, Meow Keong, Vasen, Hans, Ringleberg, Janneke, van Asperen, Christi, Kiemeney, Bart, van Zelst-Stams, Wendy, Ausems, Margreet GEM, van der Luijt, Rob B, van Os, Theo, Ruijs, Marielle WG, Adank, Muriel A, Oldenburg, Rogier A, Helderman-van den Enden, A Paula TJM, Caanen, BAH, Oosterwijk, Jan C, Moller, Pal, Brennhovd, Bjorn, Medvik, Heidi, Hanslien, Eldbjorg, Grindedal, Eli Marie, Cybulski, Cezary, Wokolorczyk, Dominika, Teixeira, Manuel, Maia, Sofia, Peixoto, Ana, Henrique, Rui, Oliveira, Jorge, Goncalves, Nuno, Araujo, Luis, Seixas, Manuela, Souto, Joao Paulo, Nogueira, Pedro, Copakova, Lucia, Zgajnar, Janez, Krajc, Mateja, Vrecar, Alenka, Capella, Gabriel, Ramon y Cajal, Teresa, Fisas, David, Mora, Josefina, Esquena, Salvador, Balmana, Judith, Morote, Juan, Liljegren, Annelie, Hjalm-Eriksson, Marie, Ekdahl, Karl-Johan, Carlsson, Stefan, George, Angela, Kemp, Zoe, Wiggins, Jennifer, Moss, Cathryn, Van As, Nicholas, Thompson, Alan, Ogden, Chris, Woodhouse, Christopher, Kumar, Pardeep, Evans, D Gareth, Bulman, Barbara, Rothwell, Jeanette, Tricker, Karen, Wise, Gillian, Mercer, Catherine, McBride, Donna, Costello, Philandra, Pearce, Allison, Torokwa, Audrey, Paterson, Joan, Clowes, Virginia, Taylor, Amy, Newcombe, Barbara, Walker, Lisa, Halliday, Dorothy, Stayner, Barbara, Fleming-Brown, D, Snape, Katie, Hanson, Helen, Hodgson, Shirley, Brice, Glen, Homfray, Tessa, Hammond, Carrie, Kohut, Kelly, Anjum, Uruj, Dearing, Audrey, Mencias, Mark, Potter, Alison, Renton, Caroline, Searle, Anne, Hill, Kathryn, Goodman, Selina, Garcia, Lynda, Devlin, Gemma, Everest, Sarah, Nadolski, Maria, Douglas, Fiona, Jobson, Irene, Paez, Edgar, Donaldson, Alan, Tomkins, Sue, Langman, Caroline, Jacobs, Chris, Pichert, Gabriella, Shaw, Adam, Kulkarni, Anju, Tripathi, Vishakha, Rose, Sarah, Compton, Cecilia, Watson, Michelle, Reinholtz, Cherylin, Brady, Angela, Dorkins, Huw, Melville, Athalie, Kosicka-Slawinska, Monika, Cummings, Carole, Kiesel, Vicki, Bartlett, Marion, Randhawa, Kashmir, Ellery, Natalie, Side, Lucy, Male, Alison, Simon, Kate, Rees, Katie, Tidey, Lizzie, Gurasashvili, Jana, Nevitt, Louise, Ingram, Stuart, Howell, Alice, Rosario, Derek, Catto, James, Howson, Joanne, Ong, Kai-Ren, Chapman, Cyril, Cole, Trevor, Heaton, Tricia, Hoffman, Jonathan, Burgess, Lucy, Huber, Camilla, Islam, Farah, Watt, Cathy, Duncan, Alexis, Kockelbergh, Roger, Mzazi, Shumikazi, Dineen, Amy, Sattar, Ayisha, Kaemba, Beckie, Sidat, Zahirah, Patel, Nafisa, Siguake, Kas, Birt, Angela, Poultney, Una, Umez-Eronini, Nkem, Mom, Jaswant, Sutton, Vivienne, Cornford, Philip, Bermingham, Nicola, Yesildag, Pembe, Treherne, Katy, Griffiths, Julie, Cogley, Lyn, Gott, Hannah, Rubinstein, Wendy S, Hulick, Peter, McGuire, Michael, Shevrin, Daniel, Kaul, Karen, Weissman, Scott, Newlin, Anna, Vogel, Kristen, Weiss, Shelly, Hook, Nicole, Buys, Saundra, Goldgar, David, Conner, Tom, Venne, Vickie, Stephenson, Robert, Dechet, Christopher, Domchek, Susan, Powers, Jacquelyn, Rustgi, Neil, Strom, Sara, Arun, Banu, Davis, John W, Yamamura, Yuko, Obeid, Elias, Giri, Veda, Gross, Laura, Bealin, Lisa, Cooney, Kathy, Stoffel, Elena, Okoth, Linda, Comm, IMPACT Study Steering, Collaborators, IMPACT, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Targeted Gynaecologic Oncology (TARGON), General Practice, Urology, and Clinical Genetics

Subjects
psychosocial, Male, Health Knowledge, Attitudes, Practice, Urological Oncology, Genes, BRCA2, Genes, BRCA1, #pcsm, RISK PERCEPTION, Anxiety, Hospital Anxiety and Depression Scale, FAMILY-HISTORY, PSA, 0302 clinical medicine, Quality of life, QUALITY-OF-LIFE, Risk Factors, Surveys and Questionnaires, Medicine, 030212 general & internal medicine, Longitudinal Studies, Depressió psíquica, Early Detection of Cancer, POPULATION, Prostatic Neoplasms/diagnosis, education.field_of_study, Prostate cancer, Depression, Anxiety/etiology, Urology & Nephrology, Middle Aged, Distress, Prostate cancer screening, Mental depression, #ProstateCancer, Estudi de casos, 030220 oncology & carcinogenesis, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Cohort, HEALTH, medicine.symptom, Psychosocial, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], Adult, medicine.medical_specialty, Urology, Depression/etiology, Population, HOSPITAL ANXIETY, Early Detection of Cancer/psychology, OVARIAN-CANCER, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, BRCA1/2, Internal medicine, Humans, education, Psychiatric Status Rating Scales, Càncer de pròstata, business.industry, Prostatic Neoplasms, BRCA1, BRCA2, quality of life, Case-Control Studies, Mutation, Perception, Case studies, business, PSYCHOLOGICAL IMPACT
Abstract

OBJECTIVES: To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. PARTICIPANTS AND METHODS: Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. RESULTS:A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. CONCLUSION: This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.

Published
2019

8. QOLP-29. SYMPTOM CLUSTERS IN NEWLY DIAGNOSED GLIOMA PATIENTS: WHICH CLUSTERS ARE ASSOCIATED WITH FUNCTIONING AND GLOBAL HEALTH STATUS?

Author

Coomans, Marijke, Dirven, Linda, Aaronson, Neil, Baumert, Brigitta, van den Bent, Martin, Bottomley, Andrew, Brandes, Alba, Chinot, Olivier, Coens, Corneel, Gorlia, Thierry, Herrlinger, Ulrich, Keime-Guibert, Florence, Malmström, Annika, Martinelli, Francesca, Stupp, Roger, Talacchi, Andrea, Weller, Michael, Wick, Wolfgang, Reijneveld, Jaap, and J.B. Taphoorn, Martin

Subjects
Abstracts, Cancer Research, Oncology, Neurology (clinical)
Abstract

INTRODUCTION: Symptom management in glioma patients remains a challenge, as patients suffer from various concurrent occurring symptoms. This study aimed to identify symptom clusters and to examine the relation between these symptom clusters and functioning. METHODS: We prospectively included individual patient data from previously published international randomized controlled trials (RCTs) in glioma patients. Symptom prevalence and level of functioning were assessed with EORTC QLQ-C30 and QLQ-BN20 questionnaires. The magnitude of the associations between symptoms were examined with Spearman correlation coefficients and correlation matrices. Hierarchical cluster analyses (looking at euclidean distances) were performed to identify symptom clusters. Multivariable regression analyses were performed to analyze associations between the symptom clusters and functioning, adjusted for confounding variables. RESULTS: Data of 3595 newly diagnosed glioma patients who completed the questionnaires before randomization indicated that many patients (44%) suffered from 5–10 symptoms simultaneously. The most prevalent symptoms were fatigue, drowsiness and motor dysfunction, experienced by 86%, 59% and 55% of the patients respectively. Five symptom clusters were identified with hierarchical cluster analyses: motor cluster, fatigue cluster, headache cluster, gastrointestinal/seizures cluster and hair loss/itchy skin cluster. Having symptoms in the motor cluster had a clinically relevant and significant negative influence (≥10points difference) on the global health status/quality of life scale, and physical, role, cognitive and social functioning (Beta’s ranged from -10.9 to -18.6, all p

Published
2018

9. Erratum: Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

Author

Mikropoulos, Christos, Christina Hutten, Saya, Sibel, Bancroft, Elizabeth, Vertosick, Emily, Dadaev, Tokhir, Brendler, Charles, Page, Elizabeth, Dias, Alexander, Evans, D. Gareth, Rothwell, Jeanette, Maehle, Lovise, Axcrona, Karol, Richardson, Kate, Eccles, Diana, Jensen, Thomas, Osther, Palle J., Asperen, Christi J., Vasen, Hans, Kiemeney, Lambertus A., Ringelberg, Janneke, Cybulski, Cezary, Wokolorczyk, Dominika, Hart, Rachel, Glover, Wayne, Lam, Jimmy, Taylor, Louise, Salinas, Monica, Feliubadaló, Lidia, Oldenburg, Rogier, Cremers, Ruben, Verhaegh, Gerald, Zelst-Stams, Wendy A., Oosterwijk, Jan C., Cook, Jackie, Rosario, Derek J., Buys, Saundra S., Conner, Tom, Domchek, Susan, Powers, Jacquelyn, Ausems, Margreet Gem, Teixeira, Manuel R., Maia, Sofia, Izatt, Louise, Schmutzler, Rita, Rhiem, Kerstin, Foulkes, William D., Boshari, Talia, Davidson, Rosemarie, Ruijs, Marielle, Helderman-Van Den Enden, Apollonia Tjm, Andrews, Lesley, Walker, Lisa, Snape, Katie, Henderson, Alex, Jobson, Irene, Lindeman, Geoffrey J., Liljegren, Annelie, Harris, Marion, Adank, Muriel A., Kirk, Judy, Taylor, Amy, Susman, Rachel, Chen-Shtoyerman, Rakefet, Pachter, Nicholas, Spigelman, Allan, Side, Lucy, Zgajnar, Janez, Mora, Josefina, Brewer, Carole, Gadea, Neus, Brady, Angela F., Gallagher, David, Os, Theo, Donaldson, Alan, Stefansdottir, Vigdis, Barwell, Julian, James, Paul A., Murphy, Declan, Friedman, Eitan, Nicolai, Nicola, Greenhalgh, Lynn, Obeid, Elias, Murthy, Vedang, Copakova, Lucia, Mcgrath, John, Teo, Soo-Hwang, Strom, Sara, Kast, Karin, Leongamornlert, Daniel A., Chamberlain, Anthony, Pope, Jenny, Newlin, Anna C., Aaronson, Neil, Ardern-Jones, Audrey, Bangma, Chris, Castro, Elena, Dearnaley, David, Eyfjörð, Jórunn Erla, Falconer, Alison, Foster, Christopher S., Gronberg, Henrik, Hamdy, Freddie C., Johannsson, Oskar, Khoo, Vincent, Lubinski, Jan, Grindedal, Eli Marie, Mckinley, Joanne, Shackleton, Kylie, Mitra, Anita V., Moynihan, Clare, Rennert, Gad, Suri, Mohnish, Tricker, Karen, Moss, Sue, Kote-Jarai, Zsofia, Vickers, Andrew, Lilja, Hans, Helfand, Brian T., Eeles, Rosalind A., Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, Epidemiology and Data Science, CCA - Cancer Treatment and quality of life, VU University medical center, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Targeted Gynaecologic Oncology (TARGON), Clinical Genetics, Urology, Human Genetics, and CCA - Cancer Treatment and Quality of Life

Subjects
Male, Oncology, Cancer Research, IMPACT, Prostate Specific Antigen Velocity, 030232 urology & nephrology, Genetics & Genomics, urologic and male genital diseases, PSA velocity, INCREASE, WINDOW, predictive model, 0302 clinical medicine, BRCA2 MUTATION CARRIERS, Early Detection of Cancer, RISK, IMPACT study collaborators, BRCA1 Protein, DEATH, Middle Aged, prostate cancer, 3. Good health, Prostate cancer screening, 030220 oncology & carcinogenesis, Kallikreins, Corrigendum, Erfðarannsóknir, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, Blöðruhálskirtilskrabbamein, 1117 Public Health and Health Services, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Internal medicine, Journal Article, medicine, Genetic predisposition, Humans, Genetic Predisposition to Disease, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, Germ-Line Mutation, Aged, Krabbamein, BRCA2 Protein, Science & Technology, business.industry, Prostatic Neoplasms, Cancer, Prostate-Specific Antigen, BRCA1, medicine.disease, BRCA2, Logistic Models, CURABILITY, Neoplasm Grading, business, genetic predisposition
Abstract

Background: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort. Methods: PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV. Results: 1634 participants had 3 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml−l, PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P=0.031) and BRCA2 status and PSAV (P=0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers. Conclusions: PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone., This research is coordinated by the Institute of Cancer Research, London, UK and is supported by grants from Cancer Research UK (Grant references (C5047/A21332, C5047/A13232 and C5047/A17528) and The Ronald and Rita McAulay Foundation. Mr and Mrs Jack Baker for the study in NorthShore University HealthSystem, Evanston, Illinois and Myriad Genetics Laboratory, Salt Lake City, Utah, for providing research BRCA testing rates for NorthShore University HealthSystem participants. We acknowledge funding from the NIHR to the Biomedical Research Center at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, at Central Manchester Foundation Trust and the Oxford Biomedical Research Centre Program. We acknowledge that in Australia, this project was co-funded by Cancer Council Tasmania and Cancer Australia, grant number 1006349 (2011–2013), Prostate Cancer Foundation of Australia, grant number PCFA PRO4 (2008) and Cancer Councils of Victoria and South Australia, grant number 400048 (2006–2008), The Victorian Cancer Agency Clinical Trial Capacity CTCB08_14, Cancer Australia & Prostate Cancer Foundation of Australia (2014–2016) grant number 1059423, and Translational grants EOI09_50. The Association of International Cancer Research funded data collection in The Netherlands (AICR 10–0596). We acknowledge funding from the Basser Center for BRCA (to S Domchek). We acknowledge funding from the National Cancer Institute [P30-CA008748], the Sidney Kimmel Center for Prostate and Urologic Cancers, and David H. Koch through the Prostate Cancer Foundation, the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre Program in UK, Swedish Cancer Society (Cancerfonden project no. 11–0624), and the Swedish Research Council (VR-MH project no. 2016–02974). We acknowledge funding from the Slovenian Research Agency, Research programme P3–0352. Elena Castro acknolwedges funding from a Juan de la Cierva’ fellowship from MINIECO (grant reference IJCI- 2014–19129). We acknowledge the support of the Asociación Española Contra el Cáncer (AECC), the Instituto de Salud Carlos III (organismo adscrito al Ministerio de Economía y Competitividad) and ‘Fondo Europeo de Desarrollo Regional (FEDER), una manera de hacer Europa’ (PI10/01422, PI13/00285, PIE13/00022, PI16/00563 and CIBERONC) and the Institut Català de la Salut and Autonomous Government of Catalonia (2009SGR290, 2014SGR338 and PERIS Project MedPerCan).

Published
2018

10. LBA-02 A multicenter randomized phase III trial of neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy in resectable gastric cancer: first results from the CRITICS study

Author

C. T. van Grieken Nicole, Marcel Verheij, P. M. Jansen Edwin, H. van Tinteren, A. Lind Pehr, Hein Putter, Henk Boot, Annemieke Cats, K. Aaronson Neil, J. H. Van De Velde Cornelis, E. Meershoek Klein Kranenbarg, and Marianne Nordsmark

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, Cancer, Hematology, medicine.disease, Chemotherapy regimen, Surgery, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, medicine, business, Neo adjuvant chemotherapy, Chemoradiotherapy
Published
2016

13. Additional file 1: of Understanding the quality of life (QOL) issues in survivors of cancer: towards the development of an EORTC QOL cancer survivorship questionnaire

Author

Leeuwen, Marieke Van, Husson, Olga, Alberti, Paola, Arraras, Juan, Chinot, Olivier, Costantini, Anna, Anne-Sophie Darlington, Dirven, Linda, Eichler, Martin, Hammerlid, Eva, Holzner, Bernhard, Johnson, Colin, Kontogianni, Meropi, Trille KjĂŚr, Morag, Ofir, Nolte, Sandra, Nordin, Andrew, Pace, Andrea, Pinto, Monica, Polz, Katja, Ramage, John, Reijneveld, Jaap, Serpentini, Samantha, Tomaszewski, Krzysztof, Vassiliou, Vassilios, Leeuw, Irma Verdonck-De, Vistad, Ingvild, Young, Teresa, Aaronson, Neil, and Poll-Franse, Lonneke Van De

Subjects
3. Good health
Abstract

The list of 134 articles included in the review. (PDF 118Â kb)

14. Additional file 1: of Understanding the quality of life (QOL) issues in survivors of cancer: towards the development of an EORTC QOL cancer survivorship questionnaire

Author

Leeuwen, Marieke Van, Husson, Olga, Alberti, Paola, Arraras, Juan, Chinot, Olivier, Costantini, Anna, Anne-Sophie Darlington, Dirven, Linda, Eichler, Martin, Hammerlid, Eva, Holzner, Bernhard, Johnson, Colin, Kontogianni, Meropi, Trille KjĂŚr, Morag, Ofir, Nolte, Sandra, Nordin, Andrew, Pace, Andrea, Pinto, Monica, Polz, Katja, Ramage, John, Reijneveld, Jaap, Serpentini, Samantha, Tomaszewski, Krzysztof, Vassiliou, Vassilios, Leeuw, Irma Verdonck-De, Vistad, Ingvild, Young, Teresa, Aaronson, Neil, and Poll-Franse, Lonneke Van De

Subjects
3. Good health
Abstract

The list of 134 articles included in the review. (PDF 118Â kb)

15. International validation of the EORTC QLQ-CAT

Author

Petersen, Morten Aa, Aaronson, Neil K., Conroy, Thierry, Costantini, Anna, Hammerlid, Eva, Holzner, Bernhard, Johnson, Colin, Kieffer, Jacobien M., Leeuwen, Marieke, Nolte, Sandra, Tomaszewski, Krzysztof A., Waldmann, Annika, Young, Teresa, Paola Zotti, and Groenvold, Mogens

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