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Introduction Global longitudinal strain is recommended by the European Society of Cardiology to detect subclinical left ventricular (LV) dysfunction, but is markedly load-dependent. Myocardial work was recently introduced as a clinical tool to study LV function by pressure-strain analysis. Since myocardial work incorporates afterload, it is assumed to be less afterload-dependent than strain, but the relationship with afterload is incompletely understood. Hypothesis Myocardial work is a better tool than strain, to measure myocardial function during elevated afterload. Methods In eleven anesthetized dogs, LV volume and longitudinal strain were measured by sonomicrometry, and pressure by micromanometry. Myocardial work was calculated by pressure-strain analysis. Additionally, stroke work was calculated as the area of the pressure-volume loop. Afterload was instantly increased by aortic constriction using a pneumatic cuff around the ascending aorta. Measurements were performed at baseline, during moderate- and marked afterload elevations. Results Table 1 summarizes the results. LV pressure (LVP) successively increased with moderate and marked afterload elevation, while longitudinal strain was successively reduced. Myocardial work and stroke work, on the other hand, increased with moderate afterload elevation, but was then reduced at marked afterload increase (Figure 1 and Table 1). Stroke volume and ejection fraction corresponded to strain and were reduced with afterload elevation. Conclusions Longitudinal strain and myocardial work have qualitatively different responses to increased afterload. While moderate changes in afterload cause reductions in strain that can be falsely interpreted as reductions in contractility, myocardial work increases as it incorporates the increased workload at moderately elevated afterload. Funding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): The Norwegian Health Association

The diagnostic accuracy of Doppler ultrasound in the detection of renal arterial disease has been assessed in a prospective study of 61 hypertensive patients. The findings of Doppler ultrasound were compared with the results of renal angiography. In 15 patients (24.5%) no accurate Doppler signs could be obtained and the Doppler ultrasound examination was considered a technical failure. Of the remaining 46 patients, 24 had renal artery stenosis. Nine of the stenoses were not detected by Doppler ultrasound and in three patients a false positive diagnosis of renal artery stenosis was made. The sensitivity of Doppler ultrasound was 62.5%, the specificity 86.4% and the overall diagnostic accuracy was 73.9%. By comparing the 15 patients in whom Doppler ultrasound failed with the 46 in whom it was successful, age appeared to be higher and creatinine clearance lower in the failure group. By comparing the 34 patients with true positive and true negative results with the 12 patients with false results, no significant differences were found. In a multivariate analysis, higher age showed a significant relation to failure of Doppler ultrasound. Doppler ultrasound has limited value in the screening of hypertensive patients for renal artery stenosis.