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The background of this research is that students are often sleepy during class hours, students often fall asleep during distance learning so they don't participate, students' school grades decrease, parents or guardians of students say that while at home their children play online games more often, students spend time playing games. from after the evening prayer until just before dawn, students forget to eat and worship because they are preoccupied with playing online games, students also experience imsonia (sleep disturbance), the purpose of this study is to determine the effect of group guidance with modeling techniques to reduce online game addiction for students of SMK Negeri 1 Sukamara . The research method used is true experimental with pretest-posttest control group design. The population in this study were all students of class XI ATPH SMK Negeri 1 Sukamara, totaling 65 students consisting of two classes, namely class XI ATPH 1 and XI ATPH 2. The try out will be held in class XI ATPH 1 with a total of 32 students. The sampling technique used is simple random sampling technique. The analysis used to test the validity is the product moment and reliability using the alpha formula. The final conclusion is based on the results of data analysis that the pretest results in the experimental group with an average of 45.8 and the control group with an average of 50.1, while the posttest results in the experimental group with an average of 63.3 and the control group with an average average 59.8. In addition, from the results of the t-test analysis, the difference between the posttest between the experimental group and the control group for online game addiction using the t-test formula was obtained at 10.3 ttable at 2.021 at a significant level of 5%, so tcount is greater than the mean ttable, meaning Ho is rejected and Ha is accepted, so that it can be concluded by going through the hypothesis that says "there is an effect of group guidance with modeling techniques to reduce online game addiction for students at SMK Negeri 1 Sukamara. Suggestions that can be conveyed by researchers are that supervising teachers at schools provide advanced services regarding online game addiction.

Multiwavelength studies indicate that nuclear activity and bulge properties are closely related, but the details remain unclear. To study this further, we combine $Hubble~Space~Telescope$ bulge structural and photometric properties with 1.5 GHz, $e$-MERLIN nuclear radio continuum data from the LeMMINGs survey for a large sample of 173 `active' galaxies (LINERs and Seyferts) and `inactive' galaxies (H IIs and absorption line galaxies, ALGs). Dividing our sample into active and inactive, they define distinct (radio core luminosity)$-$(bulge mass), L_R,core-M_*,bulge, relations, with a mass turnover at M_*, bulge ~ 10^(9.8 +- 0.3) M_sun (supermassive black hole mass M_BH ~ 10^(6.8 +- 0.3) M_sun), which marks the transition from AGN-dominated nuclear radio emission in more massive bulges to that mainly driven by stellar processes in low-mass bulges. None of our 10/173 bulgeless galaxies host an AGN. The AGN fraction increases with increasing M_*, bulge such that f_optical_AGN $\propto$ M_*,bulge^(0.24 +- 0.06) and f_radio_AGN $\propto$ M_*,bulge^(0.24 +- 0.05). Between M_*,bulge ~ 10^8.5 and 10^11.3 M_sun, f_optical_AGN steadily rises from 15 +- 4 to 80 +- 5 per cent. We find that at fixed bulge mass, the radio loudness, nuclear radio activity and the (optical and radio) AGN fraction exhibit no dependence on environment. Radio-loud hosts preferentially possess an early-type morphology than radio-quiet hosts, the two types are however indistinguishable in terms of bulge S\'ersic index and ellipticity, while results on the bulge inner logarithmic profile slope are inconclusive. We finally discuss the importance of bulge mass in determining the AGN triggering processes, including potential implications for the nuclear radio emission in nearby galaxies., Comment: 27 pages, 15 figures, 4 tables, accepted for publication in MNRAS

Cancer stem cells (CSC) within non–small cell lung carcinoma (NSCLC) tumors drive NSCLC progression, metastasis, relapse, and intrinsic chemoresistance. Understanding the mechanisms that support the malignant phenotypes of NSCLC CSCs may provide insights for improved NSCLC therapeutic interventions. Here, we report that expression of RAB27B, a small GTPase, is significantly upregulated in NSCLC CSCs when compared with bulk cancer cells (BCC). Short hairpin RNA–mediated knockdown of RAB27B leads to a loss of stem cell marker gene expression and reduced NSCLC spheroid growth, clonal expansion, transformed growth, invasion, and tumorigenicity. We find that NSCLC CSCs secrete significantly more extracellular vesicles (EV) than BCCs, and that this is RAB27B-dependent. Furthermore, CSC-derived EVs, but not BCC-derived EVs, induce spheroid growth, clonal expansion, and invasion in BCCs. Finally, RAB27B is required for CSC-derived EV-induced stemness in BCCs. Taken together, our results indicate that RAB27B is required for maintenance of a highly tumorigenic, cancer-initiating, invasive stem-like cell population in NSCLC and RAB27B is involved in propagating EV-mediated communication from NSCLC CSCs to BCCs. Our findings further suggest that inhibition of RAB27B-dependent EV secretion may be a potential therapeutic strategy for NSCLC. Significance: Expression of RAB27B in CSCs leads to elevated levels of EVs that mediate communication between CSCs and BCCs that maintains a stem-like phenotype in NSCLC cells.

Agus Yusuf Ariyanto. NPM. 17110050.” Kecenderungan Perilaku Mencontek Melalui Bimbingan Kelompok Dengan Media Permainan Monopoli Siswa Di Ma Taqwiyatul Waton Mranggen Demak”. Skripsi. Program Studi Bimbingan Dan Konseling Fakultas Ilmu Pendidikan Universitas Pgri Semarang 2023. Adapun berdasarkan dari wawancara dengan guru BK disekolah, ada beberapa siswa yang sering mencontek di sekolah, sering tidak memperhatikan saat guru menjelaskan mata pelajaran, siswa telat masuk sekolah dan siswa sering membolos saat ulangan dikelas. Perilaku siswa diperkuat dengan adanya laporan dari bebrapa guru seperti guru Bahasa jawa yang mendapati ada 12 siswa yang menyontek Ketika ulangan, dan ada guru Bahasa arab yang mendapati 10 orang siswa yang menyontek Ketika ulangan tengah semester. Tujuan dari penelitian ini adalah untuk mengetahui tingkat perilaku menyontek siswa setelah diberikanya layanan bimbingan kelompok dengan media permainan monopoli pada siswa di MA Taqwiyatul Waton Mranggen Demak Desain penelitian ini menggunakan metode penelitian true experimental desain dengan desain pretest dan postest control grup. Layanan bimbingan kelompok merupakan suatu kegiatan (konselor) dengan anggota kelompok (konseli/peserta didik) yang memanfaatkan dinamika kelompok. Layanan bimbingan kelompok. Akan lebih baik apabila dalam bimbingan kelompok ditambahkan dengan metode serta media yang telah diinovasi untuk kebutuhan anggota kelompok.Permainan monopoli ini di inovasikan dengan tujuan dapat digunakan dalam layanan guna menyampaikan informasi tentang mencegah perilaku menyontek. Layanan bimbingan kelompok menggunakan teknik permainan monopoli dapat memberikan pengaruh terhadap kecenderungan perilaku menyontek, karena dalam pelaksanaannya siswa sebagai anggota kelompok mempunyai kesempatan untuk melatih kepercayaan diri atas kemampuan akademik yang dimilikinya dan dapat mengembangkan pengetahuan akademik anggota kelompok.

Introduction: A free flap is part of reconstructive surgery. This technique takes tissue or bone flaps along with their original vascular supply and performs microvascular anastomosis of the pedicle arteries and veins at the recipient site. Several risk factors that influence the occurrence of flap failure are still a major concern, such as age, gender, defect size, duration of surgery, length of tissue ischemic time, nutritional status, etc. This is further associated with higher morbidity, the potential for flap failure, higher costs, and increased length of stay in the hospital. This study aimed to determine the factors associated with free flap viability at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: Cross-sectional analytic observational study. A total of 33 research subjects participated in this study. Observation of risk factors was carried out using SPSS univariate and bivariate. Results: Gender and ischemic time factors are related to free flap viability. Male gender and ischemic time < 60 minutes increase the success of free flap viability. Conclusion: Gender and length of ischemic time are associated with free flap viability at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

The government has the authority to control and guarantee the availability of natural resources for the benefit of society. Within its authority, the government has regulated and provided guidelines for the exploitation of natural resources in the mining sector in Indonesia through Law No. 4 of 2009 concerning Mineral and Coal Mining (Minerba Constitution). This research aims to determine criminal liability and criminal law enforcement of the mining of uruk soil without a Mining Business License (IUP). The method used in this research is normative legal research. The results showed that several conditions must be filled for a person or legal entity to be sentenced, including the existence of a criminal act committed, the ability to be responsible and the element of error of intentionality or negligence. As stipulated in article 158 of the Law of the Republic of Indonesia number 4 of 2009 concerning Mineral and Coal mining. Law enforcement by the police of the Directorate of Special Criminal Investigation of East Java Regional Police, through investigation, has succeeded in finding suspects on behalf of supono or supo. Based on witness statements, expert statements, suspect statements, and evidences, it have fulfilled the criminal elements of mining uruk and sand land without being equipped with a Mining Business License (IUP) as stipulated in article 158 of RI Law number 4/2009 concerning Mineral and Coal mining.

Penelitian ini dilatarbelakangi oleh munculnya karakteristik kurang resilien yang ditandai dengan adanya siswa merasa pesimis terhadap tuntutan sekolah, respon ketidaksiapan siswa ketika menerima ulangan dadakan dan adanya siswa yang masih tidak percaya diri dan merasa malu ketika ditunjuk di depan kelas. Hal ini diperkuat dengan hasil AKPD yang menunjukan bidang pribadi mencapai 41,90%. Tujuan dari penelitian ini untuk mengungkap hubungan pola asuh orang tua generasi milenial dengan resiliensi siswa. Penelitian ini merupakan jenis penelitian kuantitatif korelasional. Sampel dalam penelitian ini menggunakan teknik purposive sampling sebanyak 85 siswa. Alat pengumpulan data yang digunakan yaitu skala pskilogis. Teknik analisis data menggunakan analisis regresi linier berganda. Hasil penelitian ini menunjukkan bahwa pola asuh otoriter, permisif dan uninvolved tidak memiliki pengaruh terhadap resiliensi, namun demikian, pola asuh demokratis menunjukan adanya pengaruh terhadap resiliensi. Adapun pola asuh secara simultan terhadap resiliensi menunjukan adanya pengaruh terhadap resiliensi.

Perusahaan yang bergerak di bisnis perdagangan komoditas hasil pertambangan dan energi dan juga pabrik perakitan umum. Penelitian ini bertujuan mengetahui dan memberikan bukti empiris terdapat perbedaan potensi kebangkrutan pada perusahaan pertambangan subsektor batu bara yang terdaftar di Indonesian Stock Exchange. Meningkatnya jumlah kegagalan perusahaan sebagaimana disebutkan di atas dan potensinya berdampak pada pekerjaan, kehidupan masyarakat dan ekonomi secara umum berarti bahwa sangat penting untuk dapat memprediksi peristiwa ini di Indonesia sebelum terjadi. Beberapa pemangku kepentingan seperti pemerintah, karyawan, debitur, pemegang saham, dan investor lainnya kehilangan secara substansial dalam kegagalan perusahaan ini. Populasi adalah keseluruhan kelompok orang, kejadian, benda-benda yang menarik peneliti untuk ditelaah. Sampel dalam penelitian ini adalah sub sektor pertambangan tahun 2017-2020 yang terdaftar in indonesia stock exchange. Berdasarkan pengambilan keputusan Uji Wilcoxon jika nilai Asymp. Sig 0,05 maka dapat ditarik kesimpulan ada perbedaan antara hasil prediksi kondisi keuangan perusahaan dengan menggunakan model Zavgren dan Altman

Neurodegenerative diseases are mostly experienced by postmenopausal women and are often caused by estrogen deficiency, so it is necessary to replace the hormone estrogen in the form of phytoestrogens. One of the plants that contain phytoestrogens is Marsilea crenata. The objective of this study is to see if giving rotenone-induced zebrafish a 96% ethanol extract of M. crenata leaves increases locomotor activity. This research was conducted by inducing 5 µg/L rotenone as a compound that will interfere with the locomotor activity of zebrafish. Next, treatment was given with 96% ethanol extract of clover in each group with a dose of 2.5; 5; 10; and 20 mg/mL to determine the effect of the extract on increasing locomotor activity of rotenone-induced zebrafish. Observations were made by looking at the quantity of zebrafish swimming every five minutes until day 28. The treatment of 96% ethanol extract of M. crenata leaves could significantly increase zebrafish motility at the optimum dose of 2.5 mg/mL, because every week the zebrafish locomotor activity increased compared to the negative control. M. crenata leaves extract is proven to prevent neurodegenerative diseases. However, further research needs to be done on the degenerative effects of rotenone every week.

Background: Vertical transmission of HIV infection may occur during pregnancy, at childbirth or through breastfeeding. Recommendations on the safety of breastfeeding of HIV-infected women on effective antiretroviral treatment are not univocal among international guidelines (WHO 2010, EACS 2017, DHHS 2017), leaving space for variability at the patient’s level. Methods: We collected clinical, laboratory and outcome data from 13 HIV-infected pregnant women who, between March 2017 and June 2021, elected to breastfeed their children against specific medical advice. All mothers were on antiretroviral therapy with darunavir or raltegravir plus emtricitabine/tenofovir disoproxil and remained HIV-RNA undetectable and >400 cells/mmc CD4+ lymphocytes during pregnancy and breastfeeding. Prophylactic antiretroviral therapy (zidovudine for 4 weeks) was started immediately after birth in all newborns. The mean duration of breastfeeding was 5.4 months. Newborns were tested for HIV-RNA multiple times: at birth, 1, 3, and 6 months after birth, and 1, 3 and 6 months after the end of breastfeeding. Results: None of the infants were infected by HIV. Conclusions: Our experience, gathered in the setting of freedom of choice on the patient’s side, while insufficient to address the eventual safety of breastfeeding in HIV-infected mothers since the represented cohort is numerically irrelevant, supports the extension of the U=U (Undetectable Equals Untransmittable) paradigm to this setting. Since breastfeeding is often requested by women with HIV planning pregnancy, more extensive comparative studies should be performed.

This paper intends to describe bureaucratic interventions in academic activities that have contents the potential that lead to create corruption in the university environment. If there is no serious treatment from the authorities to prevent it, then it is not impossible that the situation will explode into a real corruption. It's just a matter of time, when officials process it legally. This situation will clearly disrupt the productivity and reputation of academics staf in higher education in the future.

The purpose of this study is to describe the process of health care that involves a triad of legal subjects, namely doctors, patients, and hospitals. The relationship between the three legal subjects is placed in a standard contract called informed consent. This research method uses a quantitative approach, which is measured by statistics. Necessary to carry out medical actions, legal subjects are doctors or hospitals, as drafters of agreements that contain the rights and obligations of all parties. The results of the analysis in practice in hospitals indicate an indication of competency gaps between legal subjects. The doctor or hospital must explain as easily as possible to the patient or the patient's family, leading and a complete understanding. Unclear from the patient or the patient's family, on the explanation of the hospital doctor. That informed consent is the legal basis for the rights and obligations of each.

There has been an increase in cases of early marriage nationwide during the Covid-19 pandemic. Based on data from the Central Java DP3AP2KB, there were 11,301 cases of early childhood marriages for girls and 1,671 for boys. This also happened in Semarang Regency, Central Java, which was caused by the decline in the economic level of the community so that marrying underage children was considered as an alternative problem solving. For this reason, it is necessary to have an early marriage prevention program in the form of changing people's mindsets, especially mothers and children, which also provide solutions to the problems of early marriage. The program that is run as an effort to prevent early marriage is the Early Marriage Community Partnership Program (PKM) from Psychosocial, Cultural and Reproductive Health Perspectives. This is considered important because psychosocial, cultural problems and lack of understanding of reproductive health are the drivers of early marriage. Education for PKK mothers, youth and youth organizations has succeeded in increasing perceptions of the negative impact of early marriage. Education participants also made an agreement to jointly reduce the number of early marriages by involving youth in Karang Taruna activities.

Polished yellow konjac (Amorphophallus muelleri Blume) flour (PYKF) from the centrifugal milling process still contains a relatively high level of impurities that may be harmful to health, especially calcium oxalate. The extraction process using ethanol is needed to reduce the amount of impurities surrounding the glucomannan granules and hence to improve the purity of the latter. This study was aimed at determining the effects of process conditions including ethanol concentration, solvent to flour ratio and extraction time on the physicochemical properties of purified yellow konjac flour (PrYKF) using Response Surface Methodology. The desired characteristics of PrYKF were low calcium oxalate content and a high degree of whiteness (DoW), viscosity, and glucomannan content. The calcium oxalate content, viscosity, and glucomannan content of PrYKF were affected by ethanol concentration, solvent to flour ratio, and extraction time. In contrast, the DoW was only affected by ethanol concentration. The prediction of the optimum condition by Design-Expert was found at 46.36% of ethanol concentration, 8.33 mL/g of solvent to flour ratio, and 63.01 mins. Under these conditions, the characteristics were as follows: 0.12±0.00%w.b. calcium oxalate, 68.76±0.00 DoW, 29012±0.00 cP viscosity, and 84.59±0.00% d.b. glucomannan content. The actual verification was closely related (p > 0.05) compared to the Design-Expert software prediction by paired t-test. The fast maceration is a successful method to improve the characteristics of PYKF to PrYKF in a shorter time.

Severe left outflow tract obstruction (LVOTO) is not always associated with hypoplastic left heart syndrome (HLHS). Aortic valvar atresia or complex LVOTO in the presence of a large ventricular septal defect (VSD) are a rare group of lesions that offer the possibility of biventricular repair. The Yasui procedure is the commonest surgical approach which can be performed as a primary neonatal correction or as a staged procedure with a Norwood followed by a subsequent Rastelli. This article reviews the surgical outcomes and decision-making process. Both strategies are reasonable with the trend toward staged procedure in the setting of the additional interrupted arch, with neonatal survival of > 90% in the modern era and excellent long-term survival. Re-intervention is mostly related to conduit revision and the need for re-operation for LVOTO is rare. Deciding between conventional repair and the Yasui in cases of LVOTO/VSD can be difficult and there are no uniform accepted criteria. In a typical neonate, an aortic annulus < 4.5 mm is generally the limit of acceptability for a conventional repair. In selected cases of LVOTO/VSD, an alternative to the Yasui is the Ross-Konno. Retrospective comparisons between the 2 techniques are difficult due to differing patient characteristics (especially associated with mitral valve disease) but the neonatal Ross has been associated with higher early mortality.

Iklan dapat dipromosikan dengan menggunakan media poster dan tayangan televisi pada acara olahraga. Namun demikian, belum ada penelitian yang mengukur tingkat efektivitasnya secara khusus pada level atensi. Penelitian ini bertujuan untuk mengukur tingkat atensi dalam penempatan iklan yang berbeda pada olahraga sepak bola dan MotoGP. Penempatan iklan pada poster dibagi menjadi dua yaitu inner dan outer area. Sedangkan penempatan iklan pada video dibagi menjadi tiga penempatan, yaitu penempatan di atas, di bawah, dan penempatan penuh. Delapan instrumen digunakan dalam penelitian ini yang terdiri dari delapan poster dan empat video. Indikator eye-tracking yang digunakan dalam penelitian ini untuk mengukur tingkat atensi yang diperoleh adalah Time Viewed (CFT), Time to 1st View (TFF), dan Number of Fixation (NF). Iklan dalam poster yang ditempatkan di area aksi (inner area) mendapat tingkat perhatian yang lebih tinggi dari pada iklan yang ditempatkan di area luar. Sedangkan pada video, penempatan iklan sepakbola terbaik adalah pada penempatan iklan penuh. Namun, penempatan iklan di posisi bawah juga dapat disarankan. Penempatan iklan pada MotoGP yang mendapat perhatian lebih adalah pada iklan penuh. Namun, saat adegan diperbesar, iklan bisa ditempatkan di posisi bawah.

Neuroinflamasi dapat menyebabkan Parkinson Disease (PD), dengan salah satu mekanismenya adalah aktivasi berlebih toll-like receptor 2 (TLR2) akibat abnormalitas dan agregasi α-synuclein. Pada penelitian sebelumnya, daun semanggi (Marsilea crenata Presl.) terbukti menghambat progresivitas neuroinflamasi melalui jalur estrogen-receptor (ER) dependent. Penelitian ini bertujuan untuk memprediksi efek antineuroinflamasi daun semanggi pada jalur penghambatan aktivasi TLR2 (3A7B) dengan studi in silico. Senyawa hasil metabolite profiling sekunder dari ekstrak etanol 96% daun semanggi dipreparasi dengan ChemDraw Ultra 12.0, kemudian dilihat sifat farmakokinetik dan farmakodinamiknya dengan webtool SwissADME. Optimasi geometri pada senyawa dilakukan menggunakan Avogadro 1.0.1 dan molecular docking senyawa terhadap reseptor 3A7B dilakukan menggunakan Autodock vina (PyRx 0.8). Tahap visualisasi interaksi dilakukan dengan Biovia Discover Studio 2021, sedangkan nilai toksisitas senyawa dianalisis menggunakan ProTox II online tool. Hasil penelitian menunjukkan terdapat empat senyawa yang memenuhi kriteria farmakokinetik, farmakodinamik, toksisitas, serta mempunyai kemiripan dengan native ligand N-acetyl-D-glucosamine. Oleh karena itu, ekstrak etanol 96% daun semanggi diprediksi memiliki potensi sebagai penghambat progresifitas PD dengan mekanisme antineuroinflamasi.

Quality is a factor to increase the competitiveness of a product. By increasing quality, the production costs will be reduced, thus it will eventually reduce waste. The failure of a product can be caused by the availability of raw materials, machines, equipment, human resources, and environmental factors during the production process. Quality control is a method used to keep the product needed by the market to be within controlled limits. This study aims to determine the quality of Tempe SS products at the Sirajussa’adah Islamic Boarding School in Limo Depok. It is carried out to see whether the quality is still within control limits or not by using the Six Sigma method with several stages of DMAIC (Define, Measure, Analyze, Improve and Control) implementation. In this research, calculations are carried out using the checksheet, flow chart, histogram, Pareto Hart, control, scatter diagram and fishbone diagram methods of production. Based on the results, it can be concluded that for 25 times the study, it is obtained the value of the center line (CL) of 0.0036, the value of the upper control limit (UCL) of 0.0050, and the value of the lower control limit (LCL) of 0. It is also found that there are a number of variations in the process that are outside the control limit (out of control) and within the control limit (in control) in the production process of Tempe SS at the Sirajussa Islamic Boarding School in Limo Depok. However, this is still inadequate for the fermentation process infrastructure, equipment for packaging is still manual and environmental factors determine the cause of the number of defective products.

The problem of this research is how to adjust to the learning activities of SMP Negeri 27 Semarang students during the Covid-19 Pandemic? The goal to be achieved in this study is to determine the level of adjustment in student learning activities. This type of research is qualitative with a phenomenological approach. Field observations were carried out by observing the object of research, namely students at SMP Negeri 27 Semarang. Field observations also collect documents in the form of student learning outcomes. The interview process was carried out with student and teacher sources. The data in this study were obtained through observation and interviews. The results of the analysis regarding adjustment in student learning activities during the pandemic showed a relationship between each superordinate theme, which appeared in more than half of the participants. The conclusion shows that the adjustment in learning activities of SMP Negeri 27 Semarang students during the Covid-19 pandemic is quite good. This is indicated by the behavior shown, such as seeking solutions, releasing emotions (catharsis) and seeking social support. Student adjustment is quite good because of the support from parents and friends and able to find solutions when experiencing problems in online learning. Students also show feelings of depression by releasing emotions. Suggestions that researchers can convey, BK teachers should be able to provide services that are in accordance with the conditions of students in order to overcome helping students make adjustments during learning both online and offline.

This study aim to determine priorities in the management of coastal areas in Pasar Banggi, Rembang Regency. Analytical Hierarchy Process (AHP) used to prioritise coastal area management strategy. A total of 15 people were taken as a sample of respondents using purposive sampling consisting of fishermen, coastal community leaders, the Department of Fisheries and Marine Affairs, the Department of Culture and Tourism, the Department of Environment and Academics. The results show that in managing the coastal area at Pasar Banggi, Rembang Regency, the main factor that must be considered is the environment (Ecology) with the most important aspects including mangrove ecosystems, coral reefs, and fish resources. While overall (overall) shows that the priority scale of criteria and alternative management of coastal areas in Pasar Banggi, Rembang Regency with AHP in order of priority is Silvofishery, Ecotourism and Artisanal Fisheries. Thus, the Silvofishery development strategy becomes a top priority in the management of coastal areas in Pasar Banggi, Rembang Regency. Silvofishery is fish farming in the mangrove ecosystem area without having to convert or damage the mangrove ecosystem so that the sustainability of the mangrove ecosystem is maintained. Penelitian ini bertujuan untuk menentukan prioritas dalam pengelolaan Kawasan pesisir di Pasar Banggi Kabupaten Rembang. Analysis Hierarchy Process (AHP) digunakan untuk menentukan prioritas dalam pengelolaan kawasan. Sebanyak 15 orang diambil sebagai sampel responden dengan menggunakan purposive sampling yang terdiri dari nelayan, tokoh masyarakat pesisir, Dinas Perikanan dan Kelautan, Dinas Kebudayaan dan Pariwisata, Dinas Lingkungan Hidup dan Akademisi. Hasil penelitian menunjukkan bahwa dalam mengelola Kawasan pesisir di Pasar Banggi Kabupaten Rembang faktor utama yang harus diperhatikan adalah lingkungan (Ekologi) dengan aspek yang paling penting diantaranya ekosistem mangrove, terumbu karang, dan sumberdaya ikan. Sedangkan secara secara keseluruhan (overall) menunjukkan bahwa skala prioritas kriteria dan alternatif pengelolaan wilayah pesisir di Pasar Banggi Kabupaten Rembang dengan AHP dengan urutan prioritas adalah Silvofishery, Ecotourism dan Artisanal Fisheries. Dengan demikian strategi pengembangan Silvofishery menjadi prioritas utama di dalam pengelolaan wilayah pesisir di Pasar Banggi Kabupaten Rembang. Silvofishery merupakan budidaya ikan di Kawasan ekosistem mangrove tanpa harus mengkonversi atau merusak ekosistem mangrove sehingga keberlanjutan ekosistem mangrove tetap terjaga.

The people of each region always have different characteristics and uniqueness of each, especially between rural communities which tend to be homogeneous and have strong elements of customs compared to urban communities which tend to be heterogeneous and begin to reduce the elements of their customs. Building rural communities through empowerment is the main key to mobilizing the potential of the Indonesian agricultural sector. Surya Tani farmer group is a farmer group located in Mekaragung village, Cigundi village. The farmer group was founded on the initiative of Mr. Deddy, who was diligent as a farmer in the broad and narrow sense. From the results of surveys and interviews with members of the Surya Tani farmer group, the researchers wanted to know how to apply supply chains and market expansion to the marketing of products or crops at the Surya Tani farmer group in Cibadak, Lebak – Banten. Methods of collecting data were observations, interviews and questionnaires to the chairman and members of the Surya Tani farmer group. The data analysis technique was carried out with a descriptive qualitative approach. From the results of the study, it was found that the Surya Tani farmer group had not implemented a supply chain but the Surya Tani farmer group was able to expand the market to market their agricultural products out of the Lebak-Banten area market to the DKI Jakarta main market. However, it is different in the distribution process, which is experiencing delays in delivery due to the implementation of PSBB in the era of the covid-19 pandemic.

Background The Israel Mental Health Act of 1991 stipulates a process for court-ordered involuntary psychiatric hospitalization. As in many Western countries, this process is initiated when an individual is deemed “not criminally responsible by reason of mental disorder (NCR-MD)” or “incompetent to stand trial (IST).” A patient thus hospitalized may be discharged by the district psychiatric committee (DPC). The decision rendered by the DPC is guided by an amendment to the Mental Health Act that states that the length of the hospitalization should be in accordance with the maximum time of incarceration associated with the alleged crime. Little empirical research has been devoted to the psychiatric, medical, and social outcome of short versus long-term hospitalization under court order. Methods In our study we examined the outcomes of court-ordered criminal commitments over a 10-year period (2005–2015) at the Jerusalem Mental Health Center with a catchment area of 1.5 million. We found 136 cases (between the ages of 18 and 60) of criminal commitments during that period and used the average length of hospitalization, 205 days, as a cutoff point between short and long stays. We compared the outcomes of short and long hospitalizations of discharged patients using a follow-up phone survey (at least 7 years post-discharge) and data extracted from the Israel National Register to include recidivism, patient satisfaction and trust in the system, readmission, and demise. Results We found no statistically significant difference between short-term and long-term hospitalizations for reducing instances of re-hospitalization (p = 0.889) and recidivism (p = 0.54), although there was a slight trend toward short-term hospitalization vis-à-vis reduced recidivism. We did not find a statistical difference in mortality or incidents of suicide between the two groups, but the absolute numbers are higher than expected in both of them. Moreover, our survey showed that short-term hospitalization inspired more trust in the legal process (conduct of the DPC), in pharmacological treatment satisfaction, and in understanding the NCR-MD as a step toward avoiding future hospitalization and that it resulted in a higher level of patient satisfaction. Conclusions The results we present show that as far as recidivism and readmission are concerned, there is no evidence to suggest that there is an advantage to long-term hospitalization. Although there may be unmeasured variables not investigated in the present study that might have contributed to the discrepancy between long- and short-term hospitalization, we believe that longer hospitalizations may not serve the intended treatment purpose. Additionally, the high cost of long-term hospitalization and overcrowded wards are obviously major practical drawbacks. The impact of the clinical outcomes should be reflected in medico-legal legislation and in court-ordered hospitalization in particular.

Supplementary Table S1: Primers and shRNAs used in Experimental Procedures

Supplementary Figure S4: Characterization of RAB27B knockdown NSCLC CSC derived EVs

Supplementary Figure S1: RAB27B expression in CSC cultures

Cancer stem cells (CSC) within non–small cell lung carcinoma (NSCLC) tumors drive NSCLC progression, metastasis, relapse, and intrinsic chemoresistance. Understanding the mechanisms that support the malignant phenotypes of NSCLC CSCs may provide insights for improved NSCLC therapeutic interventions. Here, we report that expression of RAB27B, a small GTPase, is significantly upregulated in NSCLC CSCs when compared with bulk cancer cells (BCC). Short hairpin RNA–mediated knockdown of RAB27B leads to a loss of stem cell marker gene expression and reduced NSCLC spheroid growth, clonal expansion, transformed growth, invasion, and tumorigenicity. We find that NSCLC CSCs secrete significantly more extracellular vesicles (EV) than BCCs, and that this is RAB27B-dependent. Furthermore, CSC-derived EVs, but not BCC-derived EVs, induce spheroid growth, clonal expansion, and invasion in BCCs. Finally, RAB27B is required for CSC-derived EV-induced stemness in BCCs. Taken together, our results indicate that RAB27B is required for maintenance of a highly tumorigenic, cancer-initiating, invasive stem-like cell population in NSCLC and RAB27B is involved in propagating EV-mediated communication from NSCLC CSCs to BCCs. Our findings further suggest that inhibition of RAB27B-dependent EV secretion may be a potential therapeutic strategy for NSCLC.Significance:Expression of RAB27B in CSCs leads to elevated levels of EVs that mediate communication between CSCs and BCCs that maintains a stem-like phenotype in NSCLC cells.

Supplementary Figure S3: RAB27B is required for NSCLC tumorigenicity in vivo

Supplementary Figure S2: RAB27B is required for the stem-like phenotype of NSCLC CSCs

Supplementary Figure S5: Cellular uptake of DiI-labeled BCC and CSC EVs

The ferry port of Likupang is the path that connects the island of Celebes with Sitaro Islands District, which is managed by the Department of Transportation North Minahasa. The ferry port of Likupang still a pioneer and still get subsidies from the government each year. In the calculation of subsidies to local authorities still use the subsidy calculation based Director General of Land Transportation Regulation Number SK.218 / AP.204 / DrJD / 2018 on Income and Cost Component Counts In Operation Activity ferries transport Pilot which has been repealed and replaced by Director General of Land Transportation Regulation Number SK.5856 / AP.204 / DrJD / 2018 regarding Calculation and Transport Subsidy Funding Procedures Pioneer Crossing. Therefore, it warrants further evaluation regarding ferry transport subsidies KMP Lohoraung in Likuoang-Biaro Tracking North Celebes using the calculation ofSK 5856 / AP.201 / DrJD / 2018. The research method used is observation and interview vessel operators as well as literature. Based on the analysis of the government should provide subsidy in accordance with applicable regulations, namelyDirector General of Land Transportation Regulation Number SK.5856 / AP.204 / DrJD / 2018 on Procedures Calculation and Pioneer Ferries transport Subsidy Funding for Rp.3.145.418.407, - and writer suggest the making of leaflets in the form of a schedule and departure times are propagated to the service user to increase the size of the load factor so that the vessel can potentially increase the income of the ship itself.

Antropologi Hukum sebagai ilmu dipengaruhi oleh Antropologi dan Ilmu Hukum, maka memahami Antropologi dan Ilmu Hukum adalah prasyarat untuk dapat mengerti Antropologi Hukum. Antropologi hukum merupakan spesialisasi dari antropologi budaya, yang secara khusus mengamati perilaku manusia dalam kaitannya dengan aturan hukum. Aturan hukum yang dimaksud tidak hanya terbatas pada hukumnormatif, tetapi juga meliputi hukum adat dan juga budaya perilaku manusianya. Meskipun merupakan pengembangan dari antropologi budaya, antropologi hukum tidak bersifat etnosentris, artinya tidak membatasi pada kebudayaan tertentu. Objekpenelitiannya adalah melihat hubungan antara hukum dengan aspek kebudayaan dan organisasi sosial.

In the volumes that compile the history of Concepción and its surrounding areas, the African and/or Afro-descendant presence during colonial times is usually reduced to trivial events. Unlike what happens in other Chilean regions, no systematic studies mention the permanence of this population in the study area during the Spanish domination. Hence, the local sociocultural imaginary does not recognize the historical depth of their presence and relevance. This research aims to carry out the first systematic compilation exercise regarding the presence of Afro-descendants in Concepcion and its surrounding areas, registering their mentions in currently available primary and secondary sources. As a result, we were able to identify a continued presence of Afro-descendants between the 16th and 19th centuries. Finally, we discuss their estrangement in historical volumes and the development of a paradigm that has made them historically invisible as part of the current social fabric in Concepcion.

Stoichiometric troilite (FeS) is a common phase in differentiated and undifferentiated meteorites. It is the endmember of the iron sulfide system. Troilite is important for investigating shock metamorphism in meteorites and studying spectral properties and space weathering of planetary bodies. Thus, obtaining coarse-grained meteoritic troilite in quantities is beneficial for these fields. The previous synthesis of troilite was achieved by pyrite or pyrrhotite heating treatments or chemical syntheses. However, most of these works lacked a visual characterization of the step by step process and the final product, the production of large quantities, and they were not readily advertised to planetary scientists or the meteoritical research community. Here, we illustrate a two-step heat treatment of pyrite to synthesize troilite. Pyrite powder was decomposed to pyrrhotite at 1023-1073 K for 4-6 h in Ar; the run product was then retrieved and reheated for 1 h at 1498-1598 K in N-2 (gas). The minerals were analyzed with a scanning electron microscope, X-ray diffraction (XRD) at room temperature, and in situ high-temperature XRD. The primary observation of synthesis from pyrrhotite to troilite is the shift of a major diffraction peak from similar to 43.2 degrees 2 theta to similar to 43.8 degrees 2 theta. Troilite spectra matched an XRD analysis of natural meteoritic troilite. Slight contamination of Fe was observed during cooling to troilite, and alumina crucibles locally reacted with troilite. The habitus and size of troilite crystals allowed us to store it as large grains rather than powder; 27 g of pyrite yielded 17 g of stochiometric troilite.

This service aims to provide online learning guidance during the COVID-19 pandemic which was carried out at the Permata Harapan Vocational School in Batam. This training was carried out for 4 meetings using the zoom application. Community service activities in the form of educational development for Permata Harapan Vocational High School students can provide benefits by applying the methods of implementing training activities, discussions and questions and answers. This service was attended by Mr. Miftahul Ilmi and Mrs. Lolita as teachers at Permata Harapan school and also attended by 20 students. The results obtained from this activity are: the ability of students to the digital world increases, especially for the applications used and the available tools. Students also feel they have a high curiosity to understand the applications used and are interested in the menus offered. The ability to adapt to the online learning system is very necessary for current conditions, where the presenter also conveys motivation to students to continue to be able to follow the lesson well.

The aims of this research is to analyze and prove the impact of profitability as proxied by return on assets, liquidity proxied by current ratio and solvency as proxied by debt to equity ratio partially and simultaneously on firm value in mining companies that listed on IDX for the 2015-2020 period. The research was conducted with a quantitative approach, with a purposive sampling technique. The analysis technique used is multiple linear regression with partial test hypothesis testing (t test), simultaneous test (F test), and multiple determination coefficient test (R2) with the help of SPSS version 25 program. The results of the study show that 1) profitability is proven significant effect on firm value with a regression coefficient of -0.719; 2) liquidity is proven to have a significant effect on firm value with a regression coefficient of -1.160; 3) solvency has a significant effect on firm value with a regression coefficient of -1.354; and 4) profitability, liquidity and solvency proved to have a significant effect on firm value with a regression coefficient of 0.236. It is mean that profitability, liquidity, and solvency variables simultaneously and partially affect the firm value because the value of sig < 5%. This proves that in a mining company to increase the value of the company, it must pay attention to the profitability, liquidity, and solvency of the company.

Indonesia merupakan negara yang luas, dengan kondisi geografis diantara dua benua yaitu Benua Asia dan Benua Australia. Kondisi ini membuat Indonesia memiliki potensi yang besar untuk mendapatkan serangan dalam bentuk pertahanan dan keamanan dari dalam maupun luar negeri. Oleh karena itu, Indonesia harus mempersiapkan kemandirian berteknologi sejak dini. Pengembangan roket merupakan salah satu kemandirian teknologi dalam pertahanan dan keamanan. Roket balistik dapat dibuat dengan jarak dan waktu tempuh yang diinginkan. Roket harus melalui beberapa tahapan penting yang harus dilakukan sebelum Roket dapat diluncurkan dan diproduksi massal. Roket yang diluncurkan tanpa mengetahui sudut yang tepat akan mengakibatkan roket bergerak dengan tidak sesuai dengan jarak jangkau yang diinginkan. Oleh karena itu, penentuan sudut awal peluncuran roket diperlukan agar dapat mengetahui sudut yang tepat untuk peluncuran roket. Sudut awal peluncuran merepresentasikan sudut operasional roket yang digunakan sebagai missile permukaan ke udara. Sudut awal peluncuran divariasikan dimulai 20̊ hingga 60̊ dengan menggunakan Matlab dan Matlab Simulink, variasi sudut awal peluncuran bertujuan untuk mengetahui sudut yang ideal untuk digunakan pada saat peluncuran roket. pergerakan horizontal range pada sudut 20̊ hingga 55̊ mengalami pergerakan yang semakin jauh, akan tetapi saat sudut awal peluncuran sebesar 60̊ pergerakan roket balistik 122 mm semakin kecil. Roket Balistik dengan sudut awal peluncuran sebesar 50̊ merupakan sudut yang tepat untuk digunakan dengan horizontal range sejauh 27.466 meter.

Two unique Pre-Viking Age ship burials were found from Salme village, Saaremaa Island, eastern Baltic Sea, containing remains of seven men in the smaller and 34 men in the larger ship. According to the archaeological interpretations, these ships belonged to a viking crew possibly from the Stockholm-Mälaren region, eastern Sweden. Geoarchaeological research was conducted in the area to reconstruct Late-Holocene relative sea-level (RSL) changes and shoreline displacement to provide environmental context to these burials. In this paper we present a Late-Holocene shore displacement curve for the Saaremaa Island and GIS-based palaeogeographic reconstructions for the Salme area. The curve shows an almost linear RSL fall from 5.5 to 0.8 m a.s.l. between 1000 BC and 1300 AD with an average rate of 2 mm/year. A slowdown in regression may be attributed to accelerated sea-level rise after the Little Ice Age and during the industrial period, being consistent with the tide-gauge measurements from the 20th century. Palaeogeographic reconstructions indicate the existence of a strait in the Salme area during the burial of the ships. The eastern part of the strait with water depth up to 2.8 m was about 80–100 m wide. The relatively steep and wind-protected shores in that part of the strait were probably the best places in the area for landing the viking ships. According to sedimentological evidence and diatom data, the narrowing of Salme palaeostrait occurred between 1270 and 1300 AD. Salme I and II ships were buried at 650–770 AD into the sandy-gravelly coastal deposits which had accumulated there in the open coastal zone about 710–450 years earlier. Reconstructions show that the ships were located about 2–2.5 m above coeval sea level and more than 100 m from the coastline. Thus, both ships were probably moved from the shore to the higher ground for burial.