Search

Objectives Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths, due to high morbidity, a low early diagnosis rate, and poor prognosis. It is essential to explore competitive endogenous RNA (ceRNA) arrays for early diagnosis and prognosis of HCC. Methods The original gene expression profiles of differentially expressed lncRNA, miRNA and mRNA in HCC were downloaded from TCGA database. Differentially expressed lncRNA-miRNA and miRNA-mRNA interaction pairs were extracted from miRcode and starBase, a ceRNA network was constructed, and GO annotation and KEGG pathway analyses were performed. Cox regression and Kaplan-Meier survival analysis screening identified core genes in the network associated with HCC survival, centering on miRNA, which were screened using ceRNA arrays. qRT-PCR was used to detect the expression level of key genes in clinical samples. Dual luciferase reporter gene assays were used to verify the target binding relationship among lncRNA, mRNA, and miRNA. ROC curves were used to analyze the diagnostic efficacy of the ceRNA array. Results A total of 8 lncRNAs, 5 miRNAs, and 21 mRNAs were used to construct a ceRNA network. Functional enrichment analysis showed that mRNAs in the ceRNA network were mainly enriched in 14 signaling pathways, especially microRNAs in cancer. Survival analysis showed that lncRNA FOXD2-AS1 and miRNA miR-9-5p were related to the prognosis of HCC, and the targeted binding relationships between mRNAs. STMN1, COL15A1, and CCNE2 and miR-9-5p from the TargetScan, starBase, miRDB, and PicTar databases were reliable. qRT-PCR showed that expression levels of FOXD2-AS1, miR-9-5p, STMN1, COL15A1, and CCNE2 were upregulated in HCC tissues. Dual luciferase reporter assays showed that FOXD2-AS1 and STMN1 had a targeted binding relationship with miR-9-5p, but not with COL15A1 or CCNE2. The area under the curve of the candidate ceRNA array (FOXD2-AS1/miR-9-5p/STMN1/COL15A1/CCNE2) was higher than that of each member and ceRNA combination (FOXD2-AS1/miR-9-5p/STMN1). Conclusions The candidate ceRNA array formed by FOXD2-AS1/miR-9-5p/STMN1/COL15A1/CCNE2 could be a biomarker for early diagnosis and prognosis of HCC.

Parkinson's disease (PD) is a common neurodegenerative disease. The main pathological feature is the degeneration and loss of dopaminergic neurons in the substantia nigra, which leads to the significant decrease of dopamine content in the striatum. Our recent studies have shown that scorpion venom heat-resistant synthetic peptide (SVHRSP) have protective effects on neuroinflammation. In this study, using C. elegans induced by 6-hydroxydopamine (6-OHDA) as neurodegenerative model, we investigated the effect of SVHRSP on dopaminergic neurons neurotoxicity. Our results implied that SVHRSP treatment could improve the motor capacity in 6-OHDA-induced C. elegans and improve dopaminergic neuron mediated food sensitivity behavior. After SVHRSP treatment, dopaminergic neuron degeneration induced by 6-OHDA was significantly prevented along with a decreased α-synuclein aggregation and restored lipid deposition in C. elegans induced by 6-OHDA. We also observed the reduced levels of reactive oxygen species (ROS) after SVHRSP treatment in model-building C. elegans. In addition, the genes related to apoptosis, oxidative stress, like ctl-1, egl-1and cat-2 in C. elegans induced by 6-OHDA upregulated after treatment with SVHRSP. In conclusion, SVHRSP may impose anti-PD effect through its neuroprotective action on dopaminergic neurons. This study elucidates the effect and related mechanism of SVHRSP on PD and provides evidences for the therapeutic treatment of PD.

In China, 45% of stroke patients suffer from poststroke shoulder pain, which brings about many obstacles to further rehabilitation. To date, there have been a few studies evaluating the effects of acupuncture or massage in treating poststroke shoulder pain, and good effects have been shown. However, better clinical treatments are still needed.To explore a more effective treatment for poststroke shoulder pain, the clinical effects of moxibustion plus acupuncture were assessed.Sixty patients were randomly divided into the control and intervention groups. The control group received a standard stroke treatment protocol including acupuncture, and the intervention group was given moxibustion combined with acupuncture. The visual analogue scale (VAS), National Institutes of Health Stroke Scale (NIHSS), Fugl-Meyer motor assessment, Barthel Index, and 17-item Hamilton Rating Scale for Depression (HAMD-17) were applied, and differences were analyzed.After 4 weeks of treatment, compared with the control group, the intervention group demonstrated significant improvement in Fugl-Meyer motor assessment and HAMD-17 (both p0.01) as well as in the VAS, NIHSS, and Barthel Index (all p0.05).Moxibustion plus acupuncture treatment can alleviate poststroke shoulder pain, improve upper limb motor function and the ability to perform activities of daily living, and relieve patients' depression.Hintergrund: In China leiden 45% der Schlaganfallpatienten an Schulterschmerzen nach dem Schlaganfall, wodurch die weitere Rehabilitation erheblich erschwert wird. Die Auswirkungen von Akupunktur oder Massage auf die Behandlung von Schulterschmerzen nach einem Schlaganfall wurden bislang in einigen wenigen Studien untersucht, und es waren positive Effekte zu beobachten. Dennoch sind auch weiterhin bessere klinische Behandlungen erforderlich. Ziel: Die klinischen Effekte von Moxibustion in Kombination mit Akupunktur wurden be­wertet, um eine wirksamere Behandlung von Schulterschmerzen nach einem Schlaganfall zu erforschen. Methoden: Sechzig Patienten wurden randomisiert einer Kontroll- und einer Interventionsgruppe zugewiesen. Die Kontrollgruppe erhielt eine Behandlung nach dem Standard-Behandlungsprotokoll für Schlaganfall einschließlich Akupunktur, und die Interventionsgruppe wurde mit Moxibustion in Kombination mit Akupunktur behandelt. Zur Anwendung kamen die visuelle Analog­skala (VAS), die National Institutes of Health Stroke Scale (NIHSS), das Fugl-Meyer-Assessment der Motorik, der Barthel-Index sowie die Hamilton Depression Scale mit 17 Items (HAMD-17), und die Unterschiede wurden analy­siert. Ergebnisse: Nach vier Behandlungswochen zeigte die Interventionsgruppe im Vergleich zur Kontrollgruppe eine signifikante Verbesserung im Fugl-Meyer-Assessment der Motorik und in der HAMD-17 (beide p0,01) sowie in der VAS, NIHSS und im Barthel-Index (alle p0,05). Schlussfolgerung: Moxibustion in Kombination mit einer Akupunkturbehandlung kann Schulterschmerzen nach einem Schlaganfall lindern, die motorische Funktion der oberen Extremitäten und die Fähigkeit, Alltagsakti­vitäten zu verrichten, verbessern sowie die Depression der Patienten mildern.

Mitochondria determine the physiological status of most eukaryotes. Mitochondrial dynamics plays an important role in maintaining mitochondrial homeostasis, and the disorder in mitochondrial dynamics could affect cellular energy metabolism leading to tumorigenesis. In recent years, disrupted mitochondrial dynamics has been found to influence the biological behaviors of gastrointestinal cancer with the potential to be a novel target for its individualized therapy. This review systematically introduced the role of mitochondrial dynamics in maintaining mitochondrial homeostasis, and further elaborated the effects of disrupted mitochondrial dynamics on the cellular biological behaviors of gastrointestinal cancer as well as its association with cancer progression. We aim to provide clues for elucidating the etiology and pathogenesis of gastrointestinal cancer from the perspective of mitochondrial homeostasis and disorder.

Helicobacter pylori (H. pylori) is one of the globally recognized causative factors of gastric cancer (GC). Currently, no definite therapy and drugs for H. pylori-related GC have been widely acknowledged although H. pylori infection could be eradicated in early stage. Inflammation and immune response are spontaneous essential stages during H. pylori infection. H pylori may mediate immune escape by affecting inflammation and immune response, leading to gastric carcinogenesis. As an important component of transcriptome, non-coding RNAs (ncRNAs) have been proven to play crucial roles in the genesis and development of H. pylori-induced GC. This review briefly described the effects of ncRNAs on H. pylori-related GC from the perspective of inflammation and immune response, as well as their association with inflammatory reaction and immune microenvironment. We aim to explore the potential of ncRNAs as markers for the early diagnosis, prognosis, and treatment of H. pylori-related GC. The ncRNAs involved in H. pylori-related GC may all hold promise as novel therapeutic targets for immunotherapy.

ObjectivesA bibliometric analysis for non-coding RNA and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) was performed to describe international research status and visualize the research scope and emerging trends over the last two decades on this topic.Materials and methodsResearch data of non-coding RNA and HBV-related HCC were retrieved and extracted from the Web of Science Core Collection (WoSCC) database from 1 January 2003 to 13 June 2022 and then analyzed by means of bibliometric methods. A total of 1,036 articles published in this field were assessed for specific characteristics, including the year of publication, journal, author, institution, country/region, references, and keywords. VOSviewer was employed to perform co-authorship, co-occurrence, and co-citation analyses accompanied by constructing a visual network.ResultsOverall, 1,036 reports on non-coding RNA and HBV-related HCC from 2003 to 2022 were retrieved from WoSCC. The publication has gradually increased during the last two decades with 324 journals involved. Most research records (748 publications and 23,184 citations) were concentrated in China. A co-occurrence cluster analysis for the top 100 keywords was performed and four clusters were generated: (1) non-coding RNA as a molecular marker for the diagnosis and prognosis of HBV-related HCC; (2) dysregulation of non-coding RNA by hepatitis B virus X protein (HBx); (3) non-coding RNA affecting the biological behaviors of HBV-related HCC; and (4) epidemiological study for the effects of non-coding RNA on the risk of HBV-related HCC.ConclusionThe publications and citations involved in non-coding RNA and HBV-related HCC have increased over the last two decades associated with many countries, institutions, and authors. Our study revealed current development trends, global cooperation models, basic knowledge, research hotspots, and emerging frontiers in this field.

BACKGROUND AND PURPOSE Microglia-related inflammation is associated with the pathology of Parkinson's disease. Functional voltage-gated sodium channels (VGSCs) are involved in regulating microglial function. Here, we aim to investigate the effects of scorpion venom heat-resistant synthesized peptide (SVHRSP) on 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease-like mouse model and reveal its underlying mechanism. EXPERIMENTAL APPROACH Unilateral brain injection of 6-OHDA was performed to establish Parkinson's disease mouse model. After behaviour test, brain tissues were collected for morphological analysis and protein/gene expression examination. Primary microglia culture was used to investigate the role of sodium channel Nav 1.6 in the regulation of microglia inflammation by SVHRSP. KEY RESULTS SVHRSP treatment attenuated motor deficits, dopamine neuron degeneration, activation of glial cells and expression of pro-inflammatory cytokines induced by 6-OHDA lesion. Primary microglia activation and the production of pro-inflammatory cytokines induced by lipopolysaccharide (LPS) were also suppressed by SVHRSP treatment. In addition, SVHRSP could inhibit mitogen-activated protein kinases (MAPKs) pathway, which plays pivotal roles in the pro-inflammatory response. Notably, SVHRSP treatment suppressed the overexpression of microglial Nav 1.6 induced by 6-OHDA and LPS. Finally, it was shown that the anti-inflammatory effect of SVHRSP in microglia was Nav 1.6 dependent and was related to suppression of sodium current and probably the consequent Na+ /Ca2+ exchange. CONCLUSIONS AND IMPLICATIONS SVHRSP might inhibit neuroinflammation and protect dopamine neurons via down-regulating microglial Nav 1.6 and subsequently suppressing intracellular Ca2+ accumulation to attenuate the activation of MAPKs signalling pathway in microglia.

Improving healthy life expectancy by targeting aging-related pathological changes has been the spotlight of geroscience. Scorpions have been used in traditional medicine in Asia and Africa for a long time. We have isolated heat-resistant peptides from scorpion venom of Buthusmartensii Karsch (SVHRP) and found that SVHRP can attenuate microglia activation and protect

In the paper, ZnO-deposited activated carbon composite (ZnO-AC) was firstly prepared in a simple two-step preparation process, and then covered with nano-graphene oxide to give the NGO-ZnOAC composite. The successful deposition of ZnO and NGO on the AC surface was demonstrated by various experiments, and the ZnO nanoparticles showed a mean diameter size mainly within about 10 nm. The specific surface area of the NGO-AC and NGO-ZnO-AC decreased from 67.74 m²/g of the parent AC to 32.54 and 11.43 m²/g, respectively. The fabricated NGO-ZnO-AC showed excellent adsorptive behaviors towards CrO2-₄ and Cu2+ ions, outperforming both ZnO-AC and AC.

Contains fulltext : 252162.pdf (Publisher’s version ) (Closed access)

Gastric cancer (GC) is one of the major malignancies worldwide. This study was conducted to explore the mechanism by which GREM2 maintains biological properties of GC stem cells (GCSCs), and proved that GREM2 could potentially regulate the proliferation, apoptosis, invasion, migration and tumorigenic ability of GCSCs through the regulation of the JNK signaling pathway. In silico analysis was utilized to retrieve expression microarray related to GC, and differential analysis was conducted. The cell line with the highest GREM2 expression was overexpressed with GREM2 mimic, silencing GREM2 by siRNA, or treated with activator or inhibitor of the JNK signaling pathway. Subsequently, expression of GREM2, JNK signaling pathway-, apoptosis- or migration and invasion-associated factors were determined. Proliferation, migration, invasion, apoptosis of GCSCs in vitro and tumorigenic ability and lymph node metastasis of GCSCs in vivo were determined. Based on the in silico analysis of GSE49051, GREM2 was determined to be overexpressed in GC and its expression was the highest in the MKN-45 cell line, which was selected for the subsequent experiments. Silencing of GREM2 or inhibition of the JNK signaling pathway suppressed the proliferation, migration and invasion, while promoting apoptosis of GCSCs in vitro as well as inhibiting tumorigenesis and lymph node metastasis in vivo. In conclusion, the aforementioned findings suggest that the silencing of GREM2 suppresses the activation of the JNK signaling pathway, thereby inhibiting tumor progression. Therefore, GREM2-mediated JNK signaling pathway was expected to be a new therapeutic strategy for GC.

Background and Aims: Although autologous bone marrow stem cell (BMSC) transplantation is an effective treatment for liver cirrhosis, there are few reports describing the optimal delivery route and number of injected BMSCs. Methods: A literature search was conducted using PubMed, ISI Web of Science, Cochrane Central Register of Controlled Trials, and EBSCO. A meta-analysis was performed to assess the effect of BMSCs on liver and coagulation function indices. Subgroup analysis was performed based on number of injected BMSCs, delivery route, and length of follow-up. Results: A total of 15 studies were selected from among 1903 potential studies for analysis. Autologous BMSC transplantation significantly improved aspartate aminotransferase, total bilirubin, albumin, prothrombin time, prothrombin activity, prothrombin concentration, Child-Pugh score, and model for end-stage liver disease. In the subgroup analysis of cell numbers, all four of the indices were significantly improved when the number of BMSCs was >4 × 108. The subgroup analysis referring to the delivery route showed that arterial infusion increased the therapeutic effect over venous infusion. Finally, in the subgroup analysis of follow-up length, the results showed that BMSC therapy significantly improved liver function at 2 weeks after transplantation. In addition, this therapy improved coagulation 4 weeks after the transplant, with a maintenance of efficacy for up to 24 weeks. Conclusions: Autologous BMSC therapy is beneficial for liver improvement and coagulation in patients with liver cirrhosis. The therapeutic effect was generated at 2–4 weeks after transplantation. The effect lasted for 24 weeks but no more than 48 weeks. The greatest benefit to patients was observed with a 4 × 108 autologous BMSC transplant via the hepatic artery.

The antiferromagnetic (AFM) interlayer coupling effective field in a ferromagnetic/non-magnetic/ferromagnetic (FM/NM/FM) sandwich structure, as a driving force, can dramatically enhance the ferromagnetic resonance (FMR) frequency. Changing the non-magnetic spacer thickness is an effective way to control the interlayer coupling type and intensity, as well as the FMR frequency. In this study, FeCoB/Ru/FeCoB sandwich trilayers with Ru thickness (t Ru) ranging from 1 Å to 16 Å are prepared by a compositional gradient sputtering (CGS) method. It is revealed that a stress-induced anisotropy is present in the FeCoB films due to the B composition gradient in the samples. A t Ru-dependent oscillation of interlayer coupling from FM to AFM with two periods is observed. An AFM coupling occurs in a range of 2 Å ≤ t Ru ≤ 8 Å and over 16 Å, while an FM coupling is present in a range of t Ru < 2 Å and 9 Å ≤ t Ru ≤ 14.5 Å. It is interesting that an ultrahigh optical mode (OM) FMR frequency in excess of 20 GHz is obtained in the sample with t Ru = 2.5 Å under an AFM coupling. The dynamic coupling mechanism in trilayers is simulated, and the corresponding coupling types at different values of t Ru are verified by Layadi’s rigid model. This study provides a controllable way to prepare and investigate the ultrahigh FMR films.

Identifying arrhythmias from electrocardiogram(ECG) signals remains an intractable challenge. This study aims to develop an effective and non-invasive approach to realize the recognition of arrhythmias based on 12-lead ECG for the PhysioNet/Computing in Cardiology Challenge2020. To this end, we propose a deep learning-based diagnosis approach, called EASTNet which captures the characteristics of cardiac abnormalities and correlation between heartbeats sampled randomly from 12-lead ECG records by a 34-layer 1D-deep squeeze-and-excitation network. Experimenting in the multi-label arrhythmia classification task, our team, EASTBLUE, was unable to rank and score in the hidden validation and test sets, but achieved diagnostic performance with 0.7030 ± 0.0090 metric score using 5-fold cross-validation on the training set. We also investigate the effect of beat sampling on diagnostic performance, and find that the beat sampling plays a role in data augmentation that effectively alleviates network overfitting. These results demonstrate that our approach has good potential application prospects in clinical practice, especially in the auxiliary diagnosis of abnormalities.

Batch experiments were conducted to investigate the adsorption characteristics and mechanism of monothioarsenate (MTA) (99%) on sand, soil sediment, and goethite under different pH and solid-liquid ratio conditions. Results showed the following. ① When MTA ranged from 0.14 to 23.59, 0.19 to 41.27, and 0.27 to 32.02 mg·L

The sequences of the primers in this study. (DOCX 12Â kb)

The sequences of the primers in this study. (DOCX 12Â kb)

In order to better respond to market competition, national broadcast service providers such as cable network enterprises have to recognize customer preference and forecast customer churn intention before their rivals do so. In this paper, data recorded by the digital set-top box and consuming records in cable network's finance system is used for analyzing customer churn. First, the results of this research indicate that customer watching intensity, customer consumption amount and customer paying habits have significant influence on customer churn. And the effect of customer watching intensity on customer churn is moderated by customer watching preference. Second, this research uses logistic regression to build the prediction model. Finally, we propose different user retention strategies targeting the churn customers. This study demonstrates that our proposed user churn factors are efficient and capable of providing effective marketing strategies for cable network enterprises.

Paeonol is one of main medicinal ingredients of Cortex Moutan. Paeonol has the functions of sedative, hypnosis, anti-bacterial, antibiosis, anti-inflammation, antioxidation, reducing blood pressure and so on. Paeonol has extensive biological activities and has broad prospects of exploitation and utilization. This paper reviews the latest progress of its pharmacology.

Themicro-grid technology is an effective way to promote renewable energydevelopment and utilization. Low voltage micro-grid can absorb photovoltaic,wind power and other large number of scattered random distributed power supply,and the system may be three-phase asymmetry while operation, randomness of thepower output and load is stronger. Therefore an improved bidirectional power flow algorithm is putforward suitable for low voltage micro-grid. According to the physicalstructure components of the micro-grid and different kinds of micro powersupply, the types of micro-grid in power flow calculation is studied to dealwith complex node in the micro-grid, improved Zbus algorithm is proposed tocalculate the power flow of micro -grid .IEEE-69 is taken as an example for simulation, the resultsshow that the proposed method is better for the biggest error ratio of voltagedrop and calculation time than traditional method. Atthe same time the algorithm is also suitable for island operation state of the microgrid.

With the 2407 and VC33 double DSP system as the foundation of hardware, the basic idea is using a modified voltage model, implementation, and equivalent amplitude and phase characteristic of integral operation. Motor steady-state operation, the rotor counter electromotive force signal is a sine wave. And an ideal sinusoidal signal frequency for omega after integral link operation, output phase lag, amplitude to times. Observations can be found from the experiment of flux linkage and rotor counter electromotive force signal on the output phase and phase is obtained by pure integral part still have a little deviation, it will need a further study on the compensation link, how to make the compensation phase completely equivalent to the integral effect. From the point of the results of the experiment of 5 Hz low speed estimation error, verify the theory in this paper. One step closer to the test is more slow speed estimation.

We have mental heat treatment for 22MnB5 steel with seven different experimental schemes and have mechanical property test on the seven steels. Then the microstructure and mechanical property of treated steels are studied, and the results show that 300°C is the optimum preservation temperature, at which we can get the optimum specific elongation of 22MnB5 steel. The tensile strength of steel thermal insulated at 300°C for 3 minutes is better than that of steel tempered at 300°C for 3 minutes, while as for specific elongation , the latter one is better. And we can also get homogeneous lath martensite after die quenching. The experiment lays foundations of the actual production process of hot forming.

In this paper, a new method that extracting and fixing load characteristic curve in the power system network state estimation is proposed, based on the combination of The data mining technology in the critical meams assorts algorithm and effective index standards. In the course of the study, this paper put forward a new algorithm ,which simulates used matlab software programming and combined with the actual load data, and extracts load characteristic curve for amended. Revised characteristic curve will serve as a typical load model used to add system state estimation of pseudo measure. The simulation results fully support that the proposed method is rational and effective.

Biodiesel produced by esterification from molar ratio of methanol to free fatty acid (FFA) as 25:1 in presence of triglyceride was carried out with cation-exchange resin as a heterogeneous catalyst in three different scales of fixed bed reactors from minireactor (6.8 mm × 110 mm) to pilot scale reactor (70 mm × 1260 mm) at 338 K. The kinetic study of esterification was undertaken in terms of pseudo-homogeneous mechanism and performed as a first order reaction with elimination of the solid-liquid internal and external mass transfer resistances. Moreover, a kinetic model of FFA esterification was developed to illustrate the relationship between the FFA conversion and the catalyst bed height of fixed bed reactor. The model was also suitable for various resins in fixed bed reactor. The theoretical predictions were in agreement with the experimental data with root mean square (RMS) errors

Hawthorn is a traditional Chinese medicine and has the effect of improving digestion and activating circulation to remove blood stasis. The present study indicates that extract of hawthorn leaf has the effects of lipid regulation, anti-myocardial ischemia, anti-atherosclerosis, cardiotonic and so on. Because of comprehensive treatment effects and less side effects, hawthorn leaves is becoming the research hotspot.

Regular arrays of micro-pillars and nano-grooves structures on the silicon wafer are fabricated by using soft lithography, and the three dimension morphology of textured surface is observed by using scanning electron microscopy (SEM) and atomic force microscope (AFM). The static water contact angles are measured by using contact angle meter to characterize the wettabilities of these surfaces. To investigate how the presence of topography and the variations of wettability affect the haemocompatibility of textured surface contacted with blood, different patterned surfaces are designed and fabricated, and blood platelet adhesion test is carried out on these surfaces. The adhesion and coagulation of platelets are inspected by scanning electron microscopy (SEM). Experimental data presented in this paper indicate that different surface roughness and wettability are the important factors for blood platelet adhesion. The amount of adsorbed blood platelet is low on textured surfaces, compared with that on the flat surface. Especially, there is no coagulation and activation on the surface with nanometer grooves. That is to say, the superhydrophobic surface is apt to decrease blood platelet adhesion. The study suggests that surface with suitable wettabililty and textured structures exhibits superior blood compatibility.

Supplemental Digital Content is available in the text, Background: Osteoporotic vertebral compression fractures (OVCFs) constitute an age-related health problem that affects approximately 200 million people worldwide. Currently, various treatments are performed with the goal of reducing pain, stabilizing the vertebrate, and restoring mobility. In this study, we aimed to assess the efficacy and safety of vertebroplasty (VP), kyphoplasty (KP), and conservative treatment (CT) for the treatment of OVCFs. Methods: We performed a network meta-analysis. PubMed and Embase databases were searched to identify randomized controlled trials (RCTs) that contained at least one of the following outcomes: visual analog scale (VAS), Roland–Morris Disability Questionnaire (RDQ), European Quality of Life-5 Dimensions (EQ-5D), and new fractures. Odds ratios with 95% confidence intervals (CIs) were used to calculate the risk of new fractures, and mean differences (MDs) with 95% CIs were utilized to express RDQ, EQ-5D, and VAS outcomes. Results: Sixteen RCTs with 2046 participants were included in this meta-analysis. Compared with CT, patients treated with VP had improved pain relief, daily function, and quality of life; however, no significant differences were found between VP and KP for these 3 outcomes. All treatment options were associated with comparable risk of new fractures. When the rank probability was assessed to distinguish subtle differences between the treatments, VP was the most effective treatment for pain relief, followed by KP and CT; conversely, KP was the most effective in improving daily function and quality of life and decreasing the incidence of new fractures, followed by VP and CT. Conclusion: VP might be the best option when pain relief is the principle aim of therapy, but KP was associated with the lowest risk of new fractures and might offer better outcomes in terms of daily function and quality of life.

In order to make the minimum living standard security system develop evenly throughout the country, the financial transfer payment between the governments at different levels has to play a more active role, especially the central authorities should provide more funds. Hence, to proceed from the purposes that arouse the local governments' enthusiasm of developing the minimum living standard security system and make the minimum living standard security system develop evenly throughout the country, this paper puts forward a mechanism for determining the financial transfer payment from the central finance to the local finances, and analyses its applications. Although there are some aspects in this paper need further investigation in depth, the issues and the ideas on solving the problem that this paper suggests will contribute to promoting solving the problem, thereby promote a sound progress of the minimum living standard security system.

In order to implement a distributed calculation of power flow and static security analysis in distributed EMS (DEMS), a new distributed dynamic power flow algorithm based on asynchronous iteration for multi-area interconnected system is presented in this paper. Based on online tracing Thevinan equivalence for exterior-network, the proposed algorithm can follow the change on system state and give a consistent result with power flow calculation for whole power system. Constructing a fix-point iteration scheme about boundary state variable, the proposed method gradually corrects equivalent injection power of exterior-network to match the power flow result for each sub-system with that for whole system. Some measures are adopted to assure that the accustomed modeling methods for sub-systems can be maintained. The outstanding feature of this method is the independence of load flow calculation for each sub-system. That means, a sub-system can give an acceptable local power flow result even when the distributed calculation can not be performed. Any sub-system can join into or move back from the distributed calculation scheme. So, this method is very suitable for the application of DEMS under recent condition of data exchanging between control centers. Since the network equivalent information has been tracked during the calculation, the algorithm has a good convergence, which has been testified by an example of IEEE-118 system and a real-life system.

The second conference on waterfront, ports and shipping brought together 200 odd representatives of waterfront employers, unions, shipping companies, port authorities, importers and exporters, politicians, academics, government representatives and many other parties. The conference played a part in throwing light on the important matter of maritime reform.

Based on IEC61400-21, and through measurements of typical grid connected variable speed constant frequency wind power plant, characteristics of power quality of the doubly-fed wind generator are analyzed. A simulation method based on Monte Carlo method to simulate the outage and load change of wind power plant is presented. The changes of power quality caused by doubly-fed wind generator are simulated. Compared the simulation results with the measured data, the simulation model is proved suitable for the evaluation of doubly-fed wind generator caused effects on power quality. Studies show that the wind speed have direct effect on voltage fluctuation and flicker caused by wind power plant, and the short-circuit capacity on the connection point of wind power plant to power grid has big effect on voltage flicker. Rational system design and operation arrangement can reduce voltage flicker.