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This study explores the nexus between digital and green transformations—the so-called “twin” transition—in European regions in an effort to identify the impact of digital and environmental technologies on the greenhouse gas (GHG) emissions originating from industrial production. We conduct an empirical analysis based on an original dataset that combines information on environmental and digital patent applications with information on GHG emissions from highly polluting plants for the period 2007–2016 at the metropolitan region level in the European Union and the UK. Results show that the local development of environmental technologies reduces GHG emissions, while the local development of digital technologies increases them, albeit in the latter case different technologies seem to have different impacts on the environment, with big data and computing infrastructures being the most detrimental. We also find differential impacts across regions depending on local endowment levels of the respective technologies: the beneficial effect of environmental technologies is stronger in regions with large digital technology endowments and, conversely, the detrimental effect of digital technologies is weaker in regions with large green technology endowments. Policy actions promoting the “twin” transition should take this evidence into account, in light of the potential downside of the digital transformation when not combined with the green transformation.

Abstract: Symptoms of cognitive impairment are rather common since the early stage of Parkinson’s disease (PD); they aggravate with disease progression and may lead to dementia in a significant proportion of cases. Worsening of cognitive symptoms in PD patients depends on the progression of subcortical dopaminergic damage as well as the involvement of other brain neurotransmitter systems in cortical and subcortical regions. Beyond the negative impact on disability and quality of life, the presence and severity of cognitive symptoms may limit adjustments of dopamine replacement therapy along the disease course. This review focuses on the consequences of the administration of monoamine-oxidase type Binhibitors (MAOB-I) on cognition in PD patients. Two drugs (selegiline and rasagiline) are available for the treatment of motor symptoms of PD as monotherapy or in combination with L-DOPA or dopamine agonists in stable and fluctuating patients; a further drug (safinamide) is usable in fluctuating subjects solely. The results of available studies indicate differential effects according to disease stage and drug features. In early, non-fluctuating patients, selegiline and rasagiline ameliorated prefrontal executive functions, similarly to other dopaminergic drugs. Benefit on some executive functions was maintained in more advanced, fluctuating patients, despite the tendency of worsening prefrontal inhibitory control activity. Interestingly, high-dose safinamide improved inhibitory control in fluctuating patients. The benefit of high-dose safinamide on prefrontal inhibitory control mechanisms may stem from its dual mechanism of action, allowing reduction of excessive glutamatergic transmission, in turn secondary to increased cortical dopaminergic input.

Osteoporosis is a metabolic disease in cases of bone fragility. It is noteworthy that 60-minute physical exercises, 2 to 3 times a week, are affective in the long term for combating the disease. However, the reduction of physical activities may be related to the early onset of osteoporosis, a fact thay may increase the risk of injury, as low bone density is a predisposing factor for some types of fracture.

The challenges posed by the environmental sustainability and circular transition of food chains increasingly see the emergence of practices that link strategies and policies to territorial pilot projects that connect physical and digital infrastructures. This aspect is particularly evident in the change of urban production–transformation–distribution–consumption models. They are the basis of a complex system that influences individual and collective behaviours, life within neighbourhoods and the intertwining of incoming and outgoing food flows as the waste flow. The article will discuss the insight emerging from REFLOW, an EU H2020-funded project. It runs from June 2019 to May 2022, aiming to build an integrated approach for developing new participatory design and co-design practices dedicated to innovative and circular urban metabolisms to promote circular solutions capable of bringing environmental, social and economic benefits. In particular, the Milan Pilot involves the municipality of Milan, local makerspaces and FabLabs, agri-food enterprises and other local stakeholders. They collectively worked on municipal food markets to upgrade them into circularity hubs. The Milan Pilot – named ‘Food Market 4.0’ – concerns the design and prototyping of three product–service systems solutions to increase the circularity of the municipal covered markets and their offer service related to agri-food products. The solutions implemented are linked to a data layer that will be the basis of a city-wide renewal process of the 22 other ones. The prototypes could represent some of the building blocks of the datafication of the food distribution metabolisms and the start of a new interactive process of selling connected with other possible service offers.

With Katherena Vermette’s novel The Break (2016) as a case study, this paper analyses a narrative that portrays an attempt of an Indigenous Canadian community to reclaim its voice, identity, and space. The plot is centred around the reconnection with land and culture, while tackling the complicated topic of epistemic violence inside Métis Canadian communities. The novel’s title already frames the narrative and the importance of space in this story and in Indigenous cultures: indeed, the ‘break’ is the name of the land where the sexual assault takes place. This word is used to symbolize and anticipate the ‘brokenness’ that will define the narration: sexual violence creates a crack inside an individual, but also in society. On a more metaphorical level, the ‘break’ symbolizes a fracture that Indigenous communities have experienced in their personal and cultural histories and that has led to intergenerational cycles of violence. It is a metaphor of how Indigenous spaces and cultures have been shattered and violated, both physically and symbolically, by white colonialism. Throughout the story the characters are confronting the epistemic violence consequential to colonialism that has created a division within and between them, while they try to reunite with their own identities and one another through acts of ‘resurgence.’ Despite The Break is highly characterized by trauma and ‘brokenness’, this paper highlights how its powerful narrative deals with the possibility of healing from intergenerational trauma and of breaking cycles of violence that have been imposed on Indigenous communities.

Background: Hypothalamic-pituitary region lymphoma is rare and diabetes insipidus (DI) represents one of the most common endocrine manifestations. We report the first case of hypothalamic lymphoma associated with both the syndrome of inappropriate antidiuresis (SIAD) and DI. Case report: A 64-year-old woman with a history of stage IV large B-cell non-Hodgkin lymphoma, underwent atypical right lung resection for pulmonary nodules. A few days after surgery, the patient presented severe normovolemic hyponatremia and serum hypo-osmolarity, therefore, we suspected a paraneoplastic syndrome (SIAD) related to the lung neoplasm, histologically diagnosed as typical carcinoid. The brain magnetic resonance imaging (MRI) showed a 9 mm lesion in the hypothalamic region that significantly increased one month later with the onset of neurological symptoms. A trans-sphenoidal biopsy showed localization of the large B-cell lymphoma. After surgery, the patient presented with polyuria and polydipsia, so desmopressin therapy was started. In the following days, serum osmolarity and sodium fluctuated between normal and low values, then DI was excluded, and SIAD became more likely. Desmopressin therapy was discontinued and hyponatremia was treated with sodium infusion. Hypothalamic lymphoma was treated with chemotherapy and radiotherapy with substantial shrinkage. The hyponatremia persisted during anticancer treatments and improved only after radiotherapy, confirming paraneoplastic SIAD. Conclusion: Lymphomas of the hypothalamic region can cause electrolyte imbalance for various causes. The differential diagnosis between SIAD, DI and impaired thirst centers may not be straightforward and they must be evaluated step by step in all different stages of the disease.

— A new species of liana, Dicranostyles yrypoana (Convolvulaceae) is described from the Central Amazon rainforest in Brazil. The specimens of D. yrypoana remained with dubious identification in herbaria for at least 60 yr. This new species is distinguished from other species of Dicranostyles mainly for its tomentose leaves, in addition to its cylindric glabrous ovary, short style (0.5‐0.6 mm long), and globose stigma. The specific epithet yrypoana refers to yripo, which means liana in the language of the Sateré-Mawé people that originally live in the region of occurrence of this new species. We provide morphological and palynologic descriptions, a distribution map, illustrations, taxonomy comments, an identification key, and comparisons with similar species. Dicranostyles yrypoana is informally assessed as Endangered (EN) based on IUCN criteria and guidelines. Keywords—Central Amazon, endangered plant, lianas, Maripeae, Solanales, taxonomy of angiosperms.

Hirundo rustica erythrogaster es nidificante en América del Norte, y desde 1980 también lo es en América del Sur, inicialmente en Argentina (desde Buenos Aires, expandiéndose a otras provincias) y desde el 2017 también en Uruguay. Con el objetivo principal de actualizar aspectos de su alcance reproductivo, se presentan registros en la Patagonia y Cuyo, Argentina, los cuales generan además otras novedades: ampliación de su distribución geográfica reproductiva hacia el oeste, unos 250 km (valor medio) a lo largo de un frente de avance de unos 940 km N-S que alcanza a cinco provincias, con registros a solo 45 km del límite internacional con Chile (se presentan aspectos de dicho frente); primeros registros reproductivos para la provincia de Mendoza; registros reproductivos de mayor altitud para América del Sur; nidificación a la intemperie, en compuertas metálicas de vertederos; nidos morfológicamente diferentes para América del Sur; apreciaciones y valores extremos sobre rasgos y parámetros en patrones de elección del lugar de nidificación y construcción de nidos; nexo entre características de las nidadas, cantidad de nidadas por obra antrópica, y franja etaria de individuos; nueva especie con pico deformado para la Argentina. Esto muestra su gran plasticidad, no solo en lo geográfico-ambiental, ampliando incesantemente su distribución geográfica reproductiva, sino también en el espectro de utilización de obras antrópicas para nidificar (diferentes tipos y materiales) tanto a resguardo como a la intemperie. Todo esto va integrándose a un abanico creciente de semejanzas y diferenciaciones de patrones reproductivos respecto a las de las otras latitudes.

ESR1 mutation ( ESR1m) is a frequent cause of acquired resistance to aromatase inhibitor (AI) plus cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i), which is a first-line therapy for hormone-receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC). Camizestrant is a next-generation oral selective estrogen receptor degrader (SERD) that in a phase II study significantly improved progression-free survival (PFS) over fulvestrant (also a SERD) in ER+/HER2- ABC. SERENA-6 (NCT04964934) is a randomized, double-blind, phase III study evaluating the efficacy and safety of switching from an AI to camizestrant, while maintaining the same CDK4/6i, upon detection of ESR1m in circulating tumor DNA before clinical disease progression on first-line therapy for HR+/HER2- ABC. The aim is to treat ESR1m clones and extend the duration of control of ER-driven tumor growth, delaying the need for chemotherapy. The primary end point is PFS; secondary end points include chemotherapy-free survival, time to second progression event (PFS2), overall survival, patient-reported outcomes and safety.

DRAM is a key driver of performance and cost in public cloud servers. At the same time, a significant amount of DRAM is underutilized due to fragmented use across servers. Emerging interconnects such as CXL offer a path towards improving utilization through memory pooling. However, the design space of CXL-based memory systems is large, with key questions around the size, reach, and topology of the memory pool. At the same time, using pools requires navigating complex design constraints around performance, virtualization, and management. This paper discusses why cloud providers should deploy CXL memory pools, key design constraints, and observations in designing towards practical deployment. We identify configuration examples with significant positive return of investment. Accepted version

this article is an academic elaboration which responds to the comments of three prominent scholars, Susan Woodward, Pal Kolsto and Radhika Mohanram about the content of my book, Liquid Nationalist and State Partitions in Europe, Edward Elgar, Cheltenham, 2017. Actually it was a book simposium of the journal

Background and Aims Implantation of a transjugular intrahepatic portosystemic shunt (TIPS) improves survival in patients with cirrhosis with refractory ascites and portal hypertensive bleeding. However, the indication for TIPS in older adult patients (greater than or equal to 70 years) is debated, and a specific prediction model developed in this particular setting is lacking. The aim of this study was to develop and validate a multivariable model for an accurate prediction of mortality in older adults. Approach and Results We prospectively enrolled 411 consecutive patients observed at four referral centers with de novo TIPS implantation for refractory ascites or secondary prophylaxis of variceal bleeding (derivation cohort) and an external cohort of 415 patients with similar indications for TIPS (validation cohort). Older adult patients in the two cohorts were 99 and 76, respectively. A cause-specific Cox competing risks model was used to predict liver-related mortality, with orthotopic liver transplant and death for extrahepatic causes as competing events. Age, alcoholic etiology, creatinine levels, and international normalized ratio in the overall cohort, and creatinine and sodium levels in older adults were independent risk factors for liver-related death by multivariable analysis. Conclusions After TIPS implantation, mortality is increased by aging, but TIPS placement should not be precluded in patients older than 70 years. In older adults, creatinine and sodium levels are useful predictors for decision making. Further efforts to update the prediction model with larger sample size are warranted.

Chemically defined culture media (CDCMs) have their compositions qualitatively and quantitatively known. They are constituted of components able to meet the nutritional requirements of microorganisms. This study evaluated the employability of a multivitamin as the basis for the elaboration of a CDCM for experiments with yeasts. Candida albicans reference strains ATCC®90028™ and SC5314 were used. YNB® without amino acid (Difco Co.) was used as the standard in evaluations. For the preparation of the experimental culture medium (MycoDef), commercial multivitamin tablets had their coatings removed and were crushed until obtaining a fine powder; missing constituents were added. Comparisons were carried out evaluating aerobic and anaerobic planktonic growth rate, biofilm formation rate, whole-cell protein patterns by SDS-PAGE, minimum inhibitory concentrations and minimal fungicidal concentrations for clotrimazole, fluconazole, nystatin, and griseofulvin. Growth in MycoDef and YNB® did not differ between them (p>0.05) in both normoxic and anoxic conditions. Regarding employability for sensitivity testing, MycoDef showed performance like YNB®. The protein profiles of cells grown on both media did not differ in the number and positioning of bands. The results obtained allowed us to infer that MycoDef is a reliable low-cost culture medium useful for trials involving C. albicans.

Background: The relevance of enabling beginning students of engineering courses to solve problems directly related to their future professional activities, already in the initial subjects of mathematics, implies the need to elaborate such problems, implement them and analyse their potential in terms of construction and application of mathematical knowledge in different contexts. Objectives: In this article, we analyse the cognitive dysfunctions evidenced by the students during the process of solving a problem articulating the real functions of a real variable to the study of the characteristic curve of a semiconductor diode, content linked to the analogical electronics. Design: This qualitative-nature investigation is characterised, as field research, of exploratory-descriptive combined type. Environment and participants: the research subjects, seven students in the first semester of an engineering course offered by a private institution in the state of São Paulo, with an interest in following the control and automation qualification, participated voluntarily in the study. Data collection and analysis: three synchronous meetings were held in remote modality. For data collection, we used audio and video recordings of the discussions and the written productions of the students in such moments. In this article, we present the analysis of the first meeting. Results: We evidenced, among other aspects, cognitive dysfunctions that can lead to obstacles in the transposition of mathematical knowledge to extra-mathematical contexts. Conclusions: The results obtained allow, in the future, the planning of adequate mediations so that the teacher can help the students to convert the identified dysfunctions into sufficiently developed cognitive functions.

Empirical Demodulation (ED) is a technique used to build a discrete signal, called an empirical envelope, from a modulated time sequence. For example, in three-phase induction motors, this envelope can carry fault frequency data that allows the machine health status to be evaluated during a spectral analysis. However, due to mathematical reasons, the method is very sensitive to the amplitude oscillations within the signal. When these oscillations are unwanted, as in the presence of measurement noise, the results can be strongly affected. This work proposes an iterative and adjustable version of the ED that considerably reduces its sensitivity to the presence of high frequency noise, thus eliminating the need for signal pre-filtering. To prove the effectiveness of the Fitted Empirical Demodulation, the authors applied the new tool in motor current signals for analysis of the rotor bars conditions.

A motivação para escrevermos este trabalho origina-se de nossa conscientização da necessidade de definir os termos que a pesquisadora mexicana Patricia Camarena não havia considerado na constituição da Teoria A Matemática no Contexto das Ciências concebida por ela e que, a nosso ver poderiam contribuir para um melhor entendimento em relação ao que é esperado do egresso de cursos no qual a Matemática está a serviço, relativamente às competências para mobilizar conceitos matemáticos. Neste artigo temos por objetivo expor o resultado da investigação que permitiu a construção de uma concepção semântica (significado e âmbito de aplicação) do termo pensamento matemático de um profissional que estivesse ligada aos paradigmas e ao pressuposto filosófico-educacional da mencionada teoria. Esta investigação qualitativa, de caráter bibliográfico, foi realizada a partir do método das reduções comparativas em fase um. Após a determinação da concepção semântica para o termo, identificamos que seus componentes nucleares são a observação e a reflexão científica de fenômenos de diferentes áreas de atuação profissional e nestas as contextualizações de conhecimentos matemáticos, ambos relacionados simultaneamente às cinco dimensões que constituem o pensamento matemático de um profissional: cognitiva, atitudinal, axiológica, de aplicação e reflexiva. Finalmente, estabelecemos três níveis para o desenvolvimento do pensamento matemático de um profissional: baixo, médio e alto. Palavras-chave: Pensamento Matemático de um Profissional. Teoria a Matemática no Contexto das Ciências. Concepção Semântica. Método das Reduções Comparativas. AbstractThe motivation to write this paper comes from our awareness of the need to define the terms that the Mexican researcher Patricia Camarena had not considered in the constitution of the Theory Mathematics in the Context of Sciences that she conceived and that, in our view, could contribute to a better understanding of what is expected from the students of courses in which mathematics is taught, regarding the competences to mobilize mathematical concepts. In this article we aim to expose the result of the investigation that allowed the construction of a semantic conception (meaning and scope of application) of the term mathematical thinking of a professional that was linked to the paradigms and to the philosophical-educational assumption of the mentioned theory. This qualitative, bibliographical research was carried out using the method of comparative reductions in phase one. After determining the semantic conception for the term, we identified that its core components are the observation and scientific reflection of phenomena from different areas of professional performance and in these the contextualization of mathematical knowledge, both simultaneously related to the five dimensions that constitute the mathematical thinking of a professional: cognitive, attitudinal, axiological, application and reflexive. Finally, we established three levels for the development of a professional's mathematical thinking: low, medium and high. Keywords: Mathematical Thinking of a Professional. Theory Mathematics in the Context of Sciences. Semantic Conception. Method of Comparative Reductions.

The Ordovician documented in southeastern Europe reflects different sedimentary environments, from shallow water to basin, belonging to diverse palaeogeographical domains. Some of these geological sectors and their palaeontological content have been well described for a long time such as the Carnic Alps, which represent one of the most continuous Paleozoic sequences in the world. For some other areas, the quality of the data is variable and the knowledge is less detailed, sometimes with lithostratigraphic units still to be formalized, which also reflects the fragmentary nature of the outcrops. The Ordovician stratigraphy of southeastern Europe with its diverse successions has been revised herein and integrated with new data in an attempt to develop a global scenario for this critical time interval in the evolution of life.

Different labelling strategies adopted to mark α-synuclein affect differently the aggregation of this peptide in vitro. By using super-resolved correlative STED–AFM microscopy we discriminate between fluorescent and non fluorescent aggregates.

Endovascular aortic repair (EVAR), currently the preferred treatment for abdominal aortic aneurysm (AAA), has been described also for penetrating aortic ulcers (PAU) of the infrarenal aorta. However, data on its performance in this particular setting are still sparse in the literature. Aim of this study is to compare patient clinical characteristics, aorto-iliac features, and post-operative outcomes between infrarenal PAU and AAA treated by standard EVAR.In this retrospective observational case-control multicenter study, the patients treated for infrarenal PAU (G1) with EVAR in 2 high-volume European centers from January 2014 to December 2019 were prospectively entered into a dedicated database and retrospectively analyzed. A 4-fold control group (G2) of infrarenal AAA patients, homogeneous for age and gender, was also considered. Preoperative clinical characteristics, aorto-iliac features (rupture, aortic maximum diameter, proximal neck diameter and length, aortic bifurcation diameter, distance between the lowest renal artery and the aortic bifurcation [RA-AoBi], severe aortic calcification), technical success, 30-day (morbidity, reintervention, complications, mortality) and follow-up outcomes (freedom from reintervention [FFR] and survival) were compared in the 2 groups (chi square/Fisher exact test, t-student test, Mann-Whitney test, logistic regression and Kaplan-Meier analysis).Seventy-three patients (age 78 ± 7 years; male 84.9%) were included in G1 and 299 (age 78.4 ± 6.6 years; male 89.3%) in G2. At the time of diagnosis, G1 patients were more often symptomatic compared with G2 (odds ratio OR 10.21, 95% confidence interval CI 4.17-24.99, P 0.001). At preoperative computed tomography angiography, G1 patients had more ruptures (OR 8.11, 95% CI 3.50-18.78, P 0.001), smaller maximum diameter (OR 1.05, 95% CI 1.03-1.08, P 0.001), longer and narrower proximal neck (OR 0.97, 95% CI 0.95-0.99, P = 0.020 and OR 1.47, 95% CI 1.32-1.64, P 0.001, respectively) narrower aortic bifurcation (OR 1.34, 95% CI 1.24-1.45, P 0.001), lower RA-AoBi (OR 1.09, 95% CI 1.07-1.12, P 0.001), and more severe aortic calcification (OR 57, 95% CI 16-198, P = 0.001). Technical success (G1 98.6% vs G2 95.7% P = 0.320), 30-day morbidity (G1 2.7% vs G2 8.7% P = 0.133), reintervention (G1 2.7% vs G2 2.3% P = 0.691), complications (G1 6.8% vs G2 8% P = 0.737) and mortality (G1 1.4% vs 2% P = 0.720) were comparable in the 2 groups. The mean follow-up was 17.7 ± 16.4 months in G1 and 18.8 ± 15.1 in G2 (P = 0.576). Late FFR and survival were comparable in the 2 groups (1-year FFR: G1 94.8% vs G2 97.5%, P = 0.995; 1-year survival: G1 91.7% vs G2 92.3%, P = 0.960).Infrarenal PAU are more often symptomatic with a higher rupture rate compared to infrarenal AAA. Despite some negative anatomical characteristics (narrower aortic bifurcation, lower RA-AoBi, extensive calcification), the results of EVAR are extremely satisfactory in this setting, suggesting that endovascular exclusion could be considered a valid treatment for infrarenal PAU.

Background An improvement in progression-free survival was shown with trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer in the progression-free survival interim analysis of the DESTINY-Breast03 trial. The aim of DESTINY-Breast03 was to compare the efficacy and safety of trastuzumab deruxtecan versus trastuzumab emtansine. Methods This open-label, randomised, multicentre, phase 3 trial was done in 169 study centres in North America, Asia, Europe, Australia, and South America. Eligible patients were aged 18 or older, had HER2-positive unresectable or metastatic breast cancer previously treated with trastuzumab and a taxane, had an Eastern Cooperative Oncology Group performance status 0-1, and at least one measurable lesion per Response Evaluation Criteria in Solid Tumours version 1.1. Patients were randomly assigned (1:1) to receive trastuzumab deruxtecan 5 center dot 4 mg/kg or trastuzumab emtansine 3 center dot 6 mg/kg, both administered by intravenous infusion every 3 weeks. Randomisation was stratified by hormone receptor status, previous treatment with pertuzumab, and history of visceral disease, and was managed through an interactive web-based system. Within each stratum, balanced block randomisation was used with a block size of four. Patients and investigators were not masked to the treatment received. The primary endpoint was progression-free survival by blinded independent central review. The key secondary endpoint was overall survival and this prespecified second overall survival interim analysis reports updated overall survival, efficacy, and safety results. Efficacy analyses were performed using the full analysis set. Safety analyses included all randomly assigned patients who received at least one dose of study treatment. This study is registered with ClinicalTrials.gov, NCT03529110. Findings Between July 20, 2018, and June 23, 2020, 699 patients were screened for eligibility, 524 of whom were enrolled and randomly assigned to receive trastuzumab deruxtecan (n=261) or trastuzumab emtansine (n=263). Median duration of study follow-up was 28 center dot 4 months (IQR 22 center dot 1-32 center dot 9) with trastuzumab deruxtecan and 26 center dot 5 months (14 center dot 5-31 center dot 3) with trastuzumab emtansine. Median progression-free survival by blinded independent central review was 28 center dot 8 months (95% CI 22 center dot 4-37 center dot 9) with trastuzumab deruxtecan and 6 center dot 8 months (5 center dot 6-8 center dot 2) with trastuzumab emtansine (hazard ratio [HR] 0 center dot 33 [95% CI 0 center dot 26-0 center dot 43]; nominal p

Diante dos problemas ambientais, uma educação ambiental crítica deve possibilitar a revisão dos padrões de relação ser humano–natureza a eles subjacentes. A fotografia pode servir como possibilidade para esse trabalho, permitindo trabalhar com as dimensões de conhecimentos, valores e participação política voltadas a esse objetivo. Assim considerando, a partir de um estudo documental de caráter qualitativo, analisamos fotografias envolvendo a relação ser humano-natureza presentes nos Cadernos de Ciências oferecidos às escolas estaduais pelo programa São Paulo Faz Escola em 2018. Identificamos fotos nas concepções utilitarista, sustentável e reparadora, mas neste texto abordaremos somente a utilitarista, que prevaleceu no material. Os resultados indicaram que as fotos poderiam favorecer um trabalho mais adequado, propiciando uma reflexão mais ampla da questão e uma compreensão mais apropriada da relação ser humano-natureza vigente, contribuindo para um tratamento crítico da questão ambiental.

As abelhas são responsáveis por polinizar 90% das plantas com flores, estimando-se a ocorrência de 300 espécies de abelhas sem ferrão nos diferentes biomas brasileiros. Devido à facilidade no manejo, a meliponicultura tem se destacado como atividade econômica e recreativa em Santa Catarina. Este trabalho teve o objetivo de avaliar aspectos socioeconômicos de meliponicultores em Santa Catarina. As informações foram obtidas por meio da aplicação de questionário online abordando temas relacionados à criação de abelhas sem ferrão. Foram obtidas 62 respostas de criadores de 31 municípios distribuídos em seis regiões do Estado. A meliponicultura é praticada por criadores de 26 a 45 anos que ingressaram na atividade há menos de três anos. Dos entrevistados, 75,8% estão em áreas urbanas, tendo a atividade como hobby. A espécie de abelha mais criada é a jataí (Tetragonisca angustula). Este é o primeiro estudo sobre o perfil dos meliponicultores de Santa Catarina que permitiu conhecer suas características, identificar as demandas e melhorias que podem ser feitas no setor.

A integração entre a saúde e educação na perspectiva da melhoria da saúde do usuário pode ser ampliada quando em conjunto com outros setores, abrangendo questões que envolvam a autonomia dos indivíduos e coletividade, oportunizando a participação crítica destes atores nas decisões que envolvem suas vidas. Em consequência a esta crescente demanda, os serviços de urgência no país enfrentam múltiplos problemas evidenciados pela superlotação das unidades, dimensionamento de pessoal inadequado, rotatividade dos pacientes, processo de trabalho fragmentado, conflitos de poder, números de pacientes superior à quantidade de leitos, sobrecarga de trabalho e pouca articulação das redes assistenciais. A pesquisa tem como objetivo analisar a eficiência e eficácia da prática da educação permanente em saúde nos serviços de enfermagem na urgência e emergência. Trata-se de uma pesquisa bibliográfica, exploratória, qualitativa na qual a seleção dos estudos foi realizada por meio da base de dados eletrônica Portal Regional da BVS. Discutindo a utilização das metodologias ativas na educação permanente em saúde pode corroborar com o realinhamento das práticas assistenciais, sistematizando o cuidado, gerenciando as ações e otimizando o tempo de atendimento na urgência e emergência.

Infrastructure networks are crucial elements to ensure the sustainability of the current development model in which the movement of people and goods is essential. On the other hand, transport assets are increasingly exposed to several issues, including climatic conditions changing, vulnerability and exposure to natural hazards such as hydraulic, geomorphological, landslides and seismic phenomena, which can affect the structural integrity causing damages and deteriorations. The context is made even more serious by the degradation of materials and the progressive ageing of infrastructure, often accelerated by environmental conditions and inadequate, or not always effective, maintenance actions. This requires the investigation of novel methods for the large-scale detection of network-scale linear infrastructures, and simultaneously, of detail to diagnose causes and determine the priorities for the most effective countermeasures. The proposed solution is based on a Data-Fusion approach, merging data coming from multi-source and multi-scale data, to enhance the interpretation process in a holistic sense. The information comes from spaceborne Multi-temporal SAR Interferometry, complemented by more detailed aerial data, detected by UAVs and Ground Based Non-Destructive Testing Methods, including laser scanner surveys for resolution and digital integrability, high-resolution camera measurements assisted by artificial intelligence for the surface degradation and from prospecting data collected by Ground Penetrating Radar technology. All these data can be simultaneously analyzed into a comprehensive digital platform, providing a useful tool to support operators and public bodies to prioritize maintenance actions. The digital platform can be investigated also using augmented reality tools, capable of generating and reproducing the Digital Twin of the inspected infrastructure into a real environment. This allows any monitoring evaluation through a diagnostic technique that integrates spatial, aerial, ground-based and geophysical surveys, allowing navigation within the infrastructure. Potential applications are numerous, ranging from mapping of wide areas affected by potential criticality to the definition of the main vulnerabilities related to the seismic and hydraulic risks, the analysis of land changes surrounding the assets following extreme natural events, and the reconstruction of historical deformative trends of roads, railways and bridges through the interpretation of SAR data. Acknowledgments This research is supported by the Italian Ministry of Education, University, and Research under the National Project “EXTRA TN”, PRIN2017, Prot. 20179BP4SM. In addition, this research is supported by the Project “MLAZIO” funded by Lazio Region (Italy).

One of the main priorities for road administrations and stakeholders is the management and monitoring of critical infrastructures, especially transportation infrastructures. In this context, Building Information Modeling (BIM) can be one of the more effective methodologies to be used to optimize the management process. In Italy, several laws and regulations have been issued, making the use of BIM procedures mandatory for the design of new infrastructures and emphasizing its role in the management of existing civil works [1, 2].Monitoring operations of transportation infrastructures are generally conducted by on-site surveys. Non-Destructive Testing methods (i.e., GPR, LiDAR, Laser Profilometer, InSAR, etc.) have been used to perform these inspections as their outputs have been proven to be effective in determining the conditions of the infrastructure and its assets [3]. Moreover, BIM methodology could prove a valuable tool to manage the data provided by these surveys, as it consists in the creation of digital models capable of containing information related to the object that they are representing. These models can be used to store over time the different information obtained by the NDT surveys to carry out integrated analysis on the conditions of the infrastructure [4].This study aims to analyze a potential BIM process capable of integrating different NDT surveys’ outputs, to generate an informative digital model of an infrastructure and its assets. The proposed methodology is then able to merge the data provided by the inspections, which is typically obtained by different operators and comes in different file formats, in a single BIM model. The main goal of the research is to provide a process to optimize the management procedures of transportation infrastructures, by creating digital models capable of reducing the problems typically associated with the monitoring and maintenance of these critical civil works. By merging different information in a single environment and relying on survey data that are commonly analyzed separately, an integrated analysis of the infrastructure can be carried out and data loss can be reduced.The study was developed by relying on real data, obtained from on-site surveys carried out over Italian infrastructures. As different outputs have been collected, BIM models of different assets of the analyzed infrastructures were defined. Preliminary results have shown that the proposed methodology can be a viable tool for optimizing the management process of these critical civil works.AcknowledgementsThe research is supported by the Italian Ministry of Education, University and Research under the National Project “Extended resilience analysis of transport networks (EXTRA TN): Towards a simultaneously space, aerial and ground sensed infrastructure for risks prevention”, PRIN 2017. Prot. 20179BP4SM.References[1] MIT, 2018. Ministero delle Infrastrutture e dei Trasporti, D. Lgs 109/2018[2] MIT, 2021. Ministero delle Infrastrutture e dei Trasporti, D.M. 312/2021[3] D’Amico F. et al., 2020. Integration of InSAR and GPR Techniques for Monitoring Transition Areas in Railway Bridges. NDT&E Int[4] D’Amico, F. et al., 2022. Integrating Non-Destructive Surveys into a Preliminary BIM-Oriented Digital Model for Possible Future Application in Road Pavements Management. Infrastructures 7, no. 1

Em meio a grandes retrocessos educacionais que vive o Brasil, o presente trabalho tem o objetivo de analisar, àluz do Ciclo de Políticas, como a política de formação de professores/as tem influenciado o funcionamento doPrograma Institucional de Bolsa de Iniciação à Docência (PIBID). Utilizando a pesquisa documental, buscou-sepor meio dos ordenamentos legais lançados no interstício de 2007, no governo Lula, até 2020, no governoBolsonaro, como se comportou a política de formação de professores/as e o PIBID em seu contexto da influênciae da produção do texto. Após análise, percebeu-se que o programa sofre influência direta do que acontece napolítica nacional, caracterizando-se em três fases: uma de crescimento, outra de estabilidade e uma marcada porum projeto de descontinuidade do programa, cabendo, então, neste momento, à sociedade civil, aos movimentosde educadores/as e pesquisadores/as, serem resistentes quanto ao retrocesso e serem transformadores dessarealidade cruel.

Instrumentos de avaliação dos investimentos externos (IAIEs) são mecanismos de controle e avaliação sobre o ingresso de investimentos diretos oriundos de jurisdições estrangeiras. Neste artigo, parte-se do diagnóstico de aumento da institucionalização e implementação desses IAIEs e do perfil diversificado das economias que têm implementado esses mecanismos. Considerando isso, foram selecionados quinze IAIEs para uma análise descritiva de suas estruturas organizacionais: África do Sul, Alemanha, Austrália, Canadá, China, Coreia do Sul, Espanha, Estados Unidos, Índia, Japão, México, Portugal, Reino Unido, Rússia e União Europeia (UE). A partir de suas experiências, o que se observou foram tendências convergentes quanto aos motivos de controle e avaliação do investimento externo, ancorados no conceito de segurança nacional e suas derivações, mas uma diversidade relevante quanto ao perfil da instituição responsável pela avaliação, ao âmbito de sua competência e seus procedimentos para avaliação. Para além desta análise, também são apontados, mais genericamente, alguns questionamentos críticos sobre esses IAIEs presentes na literatura e experienciados nesta pesquisa.

O trauma é definido como uma força que é exercida através de um objeto em movimento que impacta o indivíduo, podendo causar diversas lesões, e politraumatismo é um termo médico utilizado para definir múltiplas lesões de diversas naturezas que podem comprometer diversos órgãos e sistemas (PHTLS, 2017). Trata-se de um estudo descritivo, observacional quantitativo e qualitativa realizado com os profissionais que atuam na Sala vermelha de um hospital no interior do estado de Rondônia, foram observados cerca de 46 atendimentos a pacientes politraumatizados no período de março a junho de 2022. Com o objetivo de evidenciar como é realizado a assistência de enfermagem durante o atendimento ao paciente vítima de trauma multissistêmico em um hospital público de Urgência e Emergência. Discutir sobre a padronização da assistência voltada às vítimas de trauma é essencial para realização de um atendimento de qualidade, visto que contribui para uma assistência mais ágil e eficiente, levando em consideração às diferentes formas de apresentação, gravidade e complexidade em particular de cada paciente. Diante disso, faz-se necessário investigar quais ações são executadas durante o atendimento ao paciente vítima de múltiplos traumas, e se há alguma forma de padronização durante o atendimento prestado.

The allelophaty expressed by soil cover crops over weed varies according to species, quality and quantity of material produced. The purpose of this study was to evaluate the potential of cover crops and in the management of weeds and their effects on soybean yield. The experiment was laid in tri-factorial randomized block design with four replication. Factor A was cover crops (oats, forage chicory, quinoa and fallow), factor B was application of paraquat 400 g i.a ha

A ventilação mecânica invasiva é um recurso ventilatório altamente indicado para os pacientes que apresentam alguma falha ventilatória. Para isso, a intubação orotraqueal é requerida juntamente com um cuff cujo objetivo é proteger e isolar a via aérea, e para isso o cuff precisa ser insuflado em pressões ideais. O objetivo do presente estudo é avaliar a pressão intra-cuff de pacientes intubados admitidos na UTI no Hospital de Emergência HEURO de Cacoal – RO. Para isso foi realizado um estudo transversal, desenvolvido com pacientes sob ventilação mecânica com tubo orotraqueal no Hospital de Emergência HEURO de Cacoal – RO, cuja amostra foi estabelecida por conveniência conforme a admissão de novos pacientes em um período de 3 meses. Após a seleção dos pacientes através dos critérios elegibilidade, foram coletados dados de gênero, índice de massa corporal – IMC, temperatura, tamanho do tubo orotraqueal – TOT, decúbito no momento da aferição do cuffometro e por fim a aferição da pessão do cuff manômetro de um esfigmomanômetro. Como resultados, quanto à aferição da pressão do cuff, 16 pacientes apresentaram cuffs insuflados acima de 30 cmH2O, 4 pacientes apresentaram cuffs insuflados entre 0 e 15cmH2O e 1 paciente apresentou cuff insuflado entre 25 a 30 cmH2O. Ressalta-se que o monitoramento da pressão do cuff em pacientes com tubo orotraqueal é imprescindível para uma ventilação mecânica de qualidade, eficaz e sobretudo segura.

O presente estudo tem por objetivo apresentar e discutir dados sobre a Formação Inicial de Professores de Matemática no Brasil, no período de 2010 a 2019, a partir de resultados do Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira, a fim de compreender onde e como essa formação tem ocorrido e o que pensam os concluintes desses cursos a respeito do exercício do magistério. Os dados foram, por nós, sistematizados, interpretados e expostos utilizando-se da Estatística Descritiva. Refletimos sobre algumas questões levantadas a partir das contribuições de Gatti e Saviani. Os resultados mostram uma redução de matrículas nos cursos presenciais e a ampliação na modalidade a distância; que a média de concluintes é muito baixa comparada à média de matrículas e que cerca de 64% dos alunos prestes a concluir o curso pretendem atuar no magistério como carreira principal.

Neste estudo inventariamos a produção acadêmica de teses relacionadas ao Pensamento Algébrico delimitando lacunas e tendências da área e contribuindo para o direcionamento de novos estudos. Apresentamos o panorama das teses produzidas no Brasil (quinze), Espanha (seis), Estados Unidos (seis) e Portugal (nove) no período de 2010-2019. Para a análise, destacamos os dados físicos das teses (autor, orientador, país, título e ano de defesa); os aspectos abordados sobre o Pensamento Algébrico, tendo sido abordadas treze características; a relação com a Teoria Elementar dos Números, que não é citada diretamente, tendo sido abordada a Teoria dos Números em dez teses, quatro relacionando temas a serem abordados para desenvolver o Pensamento Algébrico e seis destacando sua importância na formação dos professores; e os Conhecimentos Docentes que foram abordados em onze teses citando quarenta e três obras.

We study the regularity of the flow $${\varvec{X}}(t,y)$$ X ( t , y ) , which represents (in the sense of Smirnov or as regular Lagrangian flow of Ambrosio) a solution $$\rho \in L^\infty ({\mathbb {R}}^{d+1})$$ ρ ∈ L ∞ ( R d + 1 ) of the continuity equation $$\begin{aligned} \partial _t \rho + {{\,\textrm{div}\,}}(\rho {\varvec{b}}) = 0, \end{aligned}$$ ∂ t ρ + div ( ρ b ) = 0 , with $${\varvec{b}}\in L^1_t {{\,\textrm{BV}\,}}_x$$ b ∈ L t 1 BV x . We prove that $${\varvec{X}}$$ X is differentiable in measure in the sense of Ambrosio–Malý, that is $$\begin{aligned} \frac{{\varvec{X}}(t,y+rz) - {\varvec{X}}(t,y)}{r} \underset{r \rightarrow 0}{\rightarrow }\ W(t,y) z \quad \text {in measure}, \end{aligned}$$ X ( t , y + r z ) - X ( t , y ) r → r → 0 W ( t , y ) z in measure , where the derivative W(t, y) is a BV function satisfying the ODE $$\begin{aligned} \frac{\textrm{d}}{\textrm{d}t} W(t, y) = \frac{(D {\varvec{b}})_y(\textrm{d}t)}{J(t-,y)} W(t-, y), \end{aligned}$$ d d t W ( t , y ) = ( D b ) y ( d t ) J ( t - , y ) W ( t - , y ) , where $$(D{\varvec{b}})_y(\textrm{d}t)$$ ( D b ) y ( d t ) is the disintegration of the measure $$\int D {\varvec{b}}(t,\cdot ) \, \textrm{d}t$$ ∫ D b ( t , · ) d t with respect to the partition given by the trajectories $${\varvec{X}}(t, y)$$ X ( t , y ) and the Jacobian J(t, y) solves $$\begin{aligned} \frac{\textrm{d}}{\textrm{d}t} J(t,y) = ({{\,\textrm{div}\,}}{\varvec{b}})_y(\textrm{d}t) = \textrm{Tr}(D{\varvec{b}})_y(\textrm{d}t). \end{aligned}$$ d d t J ( t , y ) = ( div b ) y ( d t ) = Tr ( D b ) y ( d t ) . The proof of this regularity result is based on the theory of Lagrangian representations and proper sets introduced by Bianchini and Bonicatto in [16], on the construction of explicit approximate tubular neighborhoods of trajectories, and on estimates that take into account the local structure of the derivative of a $${{\,\textrm{BV}\,}}$$ BV vector field.

The cut-off point of a diagnostic test is the determination of the minimum value at which an individual can be diagnosed as sick. To obtain a good position, an analysis is carried out using a statistical ROC Curve (Receiver Operating Characteristic), which is used in determining the value of the diagnosis with the highest sensitivity and specificity. The cut-off value of glutathione peroxidase (GSH-Px) for the diagnosis of uterine diseases is not described. The minimum tolerable value can be described for 130 U/g Hb; the value has been used as a limit under which it has a marginal deficiency of Se. Therefore, the objective of this work was to determine the cut-off point of the GSH-Px values that allows diagnosing cows with endometritis, in dairy herds in the province of Santa Fe, Argentina. We used 115 Holstein cows between 21 and 56 postpartum days, from dairy establishments in the province of Santa Fe, Argentina. Blood samples were obtained by puncturing the coccygeal vein for determination of GSH-Px. At the same time, the uterine status of the cows was characterized in two groups: healthy cows (VS, by its initials in Spanish) and cows with endometritis, either clinical and subclinical (VE, by its initials in Spanish). To create a ROC curve, the VS and VE diagnoses must be entered under a binary system as 0 (VS) and 1 (VE). The obtained results indicate that the point or cut value for the GSH-Px was of 222 U/g Hb with a sensitivity of 81.4% and a specificity of 33.9%. That is to say, above that value, the possibility of suffering endometritis decreases significantly. We can conclude that the cut-off point of 222 U/g Hb obtained for this group of cows from establishments in the province of Santa Fe, could be considered in the future as a complementary tool to diagnose endometritis.